NZ296562A - Recombinant peptides and secretory mehods for their preparation - Google Patents

Recombinant peptides and secretory mehods for their preparation

Info

Publication number
NZ296562A
NZ296562A NZ296562A NZ29656295A NZ296562A NZ 296562 A NZ296562 A NZ 296562A NZ 296562 A NZ296562 A NZ 296562A NZ 29656295 A NZ29656295 A NZ 29656295A NZ 296562 A NZ296562 A NZ 296562A
Authority
NZ
New Zealand
Prior art keywords
peptide
sequence
mehods
secretory
preparation
Prior art date
Application number
NZ296562A
Inventor
Thien Nguyen Ngoc
Hans Binz
Mathias Uhlen
Stefan Stahl
Per Ake Nygren
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of NZ296562A publication Critical patent/NZ296562A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method for secreting a biologically active recombinant peptide as an analogue of a natural peptide having at least one hydrophobic region, by culturing cells transformed by a nucleic acid construct comprising elements for the expression and secretion of the peptide by the cell, and a sequence coding for a peptide with an amino acid sequence that differs from the natural peptide sequence in that it has at least one modification in a non-transmembrane hydrophobic region of the peptide; and by recovering the peptide and/or cells carrying the recombinant peptide. The resulting recombinant peptide, a corresponding DNA sequence, and a bacterium containing same, are also disclosed.
NZ296562A 1994-11-07 1995-11-07 Recombinant peptides and secretory mehods for their preparation NZ296562A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9413307A FR2726576B1 (en) 1994-11-07 1994-11-07 PRODUCTION OF HYDROPHOBIC PEPTIDE-LIKE PEPTIDES, RECOMBINANT PEPTIDE, CORRESPONDING DNA SEQUENCE
PCT/FR1995/001464 WO1996014409A1 (en) 1994-11-07 1995-11-07 Production of recombinant peptides as natural hydrophobic peptide analogues

Publications (1)

Publication Number Publication Date
NZ296562A true NZ296562A (en) 1999-11-29

Family

ID=9468565

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ296562A NZ296562A (en) 1994-11-07 1995-11-07 Recombinant peptides and secretory mehods for their preparation

Country Status (8)

Country Link
EP (1) EP0791059A1 (en)
JP (1) JPH10508479A (en)
AU (1) AU704594B2 (en)
CA (1) CA2204511A1 (en)
FR (1) FR2726576B1 (en)
NZ (1) NZ296562A (en)
WO (1) WO1996014409A1 (en)
ZA (1) ZA959417B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789653A (en) * 1995-01-10 1998-08-04 University Of Edinburgh Secretory gene trap
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
AUPO026596A0 (en) * 1996-06-05 1996-06-27 Biomolecular Research Institute Limited Viral peptide
FR2766192B1 (en) * 1997-07-17 2001-07-13 Pf Medicament EPITOPES OF RSV AND ANTIBODIES COMPRISING SAME, USEFUL IN DIAGNOSIS AND THERAPY
EP2267026A1 (en) 2000-04-12 2010-12-29 Human Genome Sciences, Inc. Albumin fusion proteins
FR2819810B1 (en) * 2001-01-23 2004-05-28 Pf Medicament NON-GLYCOSYL PEPTIDES DERIVED FROM RSV PROTEIN G AND THEIR USE IN A VACCINE
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
PT1463751E (en) 2001-12-21 2013-08-26 Human Genome Sciences Inc Albumin fusion proteins
US10066240B2 (en) * 2014-02-14 2018-09-04 Symvivo Corporation Nucleic acid vectors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01501357A (en) * 1986-01-14 1989-05-18 ユニバ−シテイ・オブ・ノ−ス・カロライナ Vaccines for human respiratory viruses
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
US4925784A (en) * 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein
EP0249477A3 (en) * 1986-06-12 1988-01-20 Immunex Corporation Functional recombinant analog polypeptides devoid of hydrophobic amino acids
US5223254A (en) * 1987-09-29 1993-06-29 Praxis Biologics, Inc. Respiratory syncytial virus: vaccines
ES2176174T3 (en) * 1988-12-22 2002-12-01 Genentech Inc PROCEDURE FOR PREPARATION OF WATER SOLUBLE POLYPEPTIDES.

Also Published As

Publication number Publication date
AU704594B2 (en) 1999-04-29
CA2204511A1 (en) 1996-05-17
ZA959417B (en) 1996-06-11
WO1996014409A1 (en) 1996-05-17
EP0791059A1 (en) 1997-08-27
JPH10508479A (en) 1998-08-25
FR2726576A1 (en) 1996-05-10
FR2726576B1 (en) 1997-01-31
AU4120096A (en) 1996-05-31

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