NO995030L - 5- (2-Imidazolinylamino) benzimidazole compounds useful as <alpha> 2-adrenoceptor agonists - Google Patents

5- (2-Imidazolinylamino) benzimidazole compounds useful as <alpha> 2-adrenoceptor agonists

Info

Publication number
NO995030L
NO995030L NO995030A NO995030A NO995030L NO 995030 L NO995030 L NO 995030L NO 995030 A NO995030 A NO 995030A NO 995030 A NO995030 A NO 995030A NO 995030 L NO995030 L NO 995030L
Authority
NO
Norway
Prior art keywords
imidazolinylamino
alpha
adrenoceptor agonists
compounds useful
benzimidazole compounds
Prior art date
Application number
NO995030A
Other languages
Norwegian (no)
Other versions
NO995030D0 (en
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Glen Edward Mieling
Nick Nikolaides
Raymond Todd Henry
Russell James Sheldon
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO995030D0 publication Critical patent/NO995030D0/en
Publication of NO995030L publication Critical patent/NO995030L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

5-(2-imidazoIinylamino)bcnzimidazoIforbindelser nyttige som a-2- adrenoseptoragonister Det er beskrevet forbindelser som har struktur (1) som angitt i kravene, samt deres enantiomere, optiske isomere, stereoisomere, diastereomere, tautomere, addisjonssalter, biohydrolyserbare amider og estere derav, så vel som far- masøytiske sammensetninger omfattende slike nye forbindel- ser. Det er også beskrevet anvendelser av slike forbindel- ser for å forebygge eller behandle lidelser modulert av alpha -2-adrenoceptorer.5- (2-Imidazolinylamino) benzimidazole compounds useful as α-2-adrenoceptor agonists Compounds having structure (1) as claimed, and their enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolysers thereof, are disclosed. , as well as pharmaceutical compositions comprising such new compounds. Uses of such compounds have also been described to prevent or treat disorders modulated by alpha -2 adrenoceptors.

NO995030A 1997-04-15 1999-10-15 5- (2-Imidazolinylamino) benzimidazole compounds useful as <alpha> 2-adrenoceptor agonists NO995030L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4231697P 1997-04-15 1997-04-15
PCT/IB1998/000540 WO1998046595A1 (en) 1997-04-15 1998-04-09 5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2 adrenoceptor agonists

Publications (2)

Publication Number Publication Date
NO995030D0 NO995030D0 (en) 1999-10-15
NO995030L true NO995030L (en) 1999-12-15

Family

ID=21921202

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995030A NO995030L (en) 1997-04-15 1999-10-15 5- (2-Imidazolinylamino) benzimidazole compounds useful as <alpha> 2-adrenoceptor agonists

Country Status (12)

Country Link
EP (1) EP0975627A1 (en)
JP (1) JP2001519828A (en)
KR (1) KR20010006440A (en)
CN (1) CN1256691A (en)
AU (1) AU6514498A (en)
BR (1) BR9808904A (en)
CA (1) CA2285610A1 (en)
HU (1) HUP0002242A2 (en)
ID (1) ID24081A (en)
IL (1) IL132384A0 (en)
NO (1) NO995030L (en)
WO (1) WO1998046595A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU704972B2 (en) 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
PL340711A1 (en) * 1997-11-24 2001-02-26 Procter & Gamble Derivatives of 5-(2-imidazolinamino)-benzimidazole, their production and application of them as antagonists of alpha-adrenergic receptors of improved metabolic stability
US20040167194A1 (en) 2003-02-20 2004-08-26 Randall Jared Lynn Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
CN110540523B (en) * 2018-07-05 2021-02-19 安徽圣诺贝化学科技有限公司 Method for preparing sulfo-substituted benzimidazole and derivative thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
AU704972B2 (en) * 1994-08-04 1999-05-13 H. Lundbeck A/S Novel benzimidazole derivatives

Also Published As

Publication number Publication date
EP0975627A1 (en) 2000-02-02
AU6514498A (en) 1998-11-11
BR9808904A (en) 2005-02-22
NO995030D0 (en) 1999-10-15
CA2285610A1 (en) 1998-10-22
ID24081A (en) 2000-07-06
WO1998046595A1 (en) 1998-10-22
IL132384A0 (en) 2001-03-19
JP2001519828A (en) 2001-10-23
HUP0002242A2 (en) 2001-04-28
KR20010006440A (en) 2001-01-26
CN1256691A (en) 2000-06-14

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Legal Events

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