NO994136L - Faktor X delesjonsmutanter samt analoger derav - Google Patents

Faktor X delesjonsmutanter samt analoger derav

Info

Publication number
NO994136L
NO994136L NO994136A NO994136A NO994136L NO 994136 L NO994136 L NO 994136L NO 994136 A NO994136 A NO 994136A NO 994136 A NO994136 A NO 994136A NO 994136 L NO994136 L NO 994136L
Authority
NO
Norway
Prior art keywords
analogs
factor
well
deletion mutants
mutants
Prior art date
Application number
NO994136A
Other languages
English (en)
Other versions
NO994136D0 (no
NO328022B1 (no
Inventor
Michele Himmelspach
Michael Pfleiderer
Falko-Guenter Falkner
Johann Eibl
Friedrich Dorner
Uwe Schlokat
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Publication of NO994136D0 publication Critical patent/NO994136D0/no
Publication of NO994136L publication Critical patent/NO994136L/no
Publication of NO328022B1 publication Critical patent/NO328022B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
NO19994136A 1997-02-27 1999-08-26 Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene NO328022B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0033697A AT405517B (de) 1997-02-27 1997-02-27 Faktor x-deletionsmutanten und analoge davon
PCT/AT1998/000046 WO1998038318A1 (de) 1997-02-27 1998-02-27 Faktor x-deletionsmutanten und analoge davon

Publications (3)

Publication Number Publication Date
NO994136D0 NO994136D0 (no) 1999-08-26
NO994136L true NO994136L (no) 1999-10-27
NO328022B1 NO328022B1 (no) 2009-11-09

Family

ID=3487892

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19994136A NO328022B1 (no) 1997-02-27 1999-08-26 Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene

Country Status (17)

Country Link
US (2) US6562598B1 (no)
EP (1) EP1012303B1 (no)
JP (1) JP4108761B2 (no)
AR (1) AR010119A1 (no)
AT (2) AT405517B (no)
AU (1) AU732953B2 (no)
BR (1) BR9807618A (no)
CA (1) CA2282728A1 (no)
CZ (1) CZ298296B6 (no)
DE (1) DE59813745D1 (no)
ES (1) ES2273405T3 (no)
HU (1) HU225247B1 (no)
IL (2) IL131171A0 (no)
NO (1) NO328022B1 (no)
PL (1) PL191778B1 (no)
SK (1) SK282369B6 (no)
WO (1) WO1998038318A1 (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
GB9826747D0 (en) * 1998-12-05 1999-01-27 Zeneca Ltd Chemical compounds
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
US20040102388A1 (en) * 2000-03-22 2004-05-27 High Katherine A. Modified blood clotting factors and methods of use
CA2520604A1 (en) * 2003-05-09 2004-11-25 Research Development Foundation Insertion of furin protease cleavage sites in membrane proteins and uses thereof
EP1728798A1 (en) * 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
MX336958B (es) 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
GB2433592A (en) 2005-12-23 2007-06-27 Pentapharm Ag Assay for thrombin inhibitors
EP1820508A1 (en) * 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
US20080050776A1 (en) * 2006-05-26 2008-02-28 Kenneth Neet Stable mutated pro nerve growth factors
EP2915564B1 (en) * 2007-09-28 2020-11-04 Portola Pharmaceuticals, Inc. Antidotes for factor XA inhibitors and methods of using the same
EP2364165B1 (en) 2008-11-14 2018-01-03 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents
EP3604510A1 (en) 2009-03-30 2020-02-05 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
JP6163304B2 (ja) 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
US9371522B2 (en) 2011-09-30 2016-06-21 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
JP2015507929A (ja) * 2012-02-14 2015-03-16 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子阻害剤に対する組み換え拮抗剤を製作するためのプロセス
NZ703148A (en) 2012-07-25 2016-08-26 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof
WO2014118677A1 (en) * 2013-01-31 2014-08-07 Pfizer Inc. Compositions and methods for counteracting factor xa inhibition
MY173548A (en) 2013-09-24 2020-02-04 Pfizer Fxa variant compositions
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
JP7370974B2 (ja) 2017-11-07 2023-10-30 ラニ セラピューティクス， エルエルシー 嚥下可能薬物送達デバイスを使用する腸管組織への送達のための凝固因子調製物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) * 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5028424A (en) 1987-10-16 1991-07-02 University Of Georgia Research Foundation Antibodies to receptor and antigen for natural killer and non-specific cytotoxic cells
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
EP0785273A1 (en) 1990-11-26 1997-07-23 Genetics Institute, Inc. Paired basic amino acid converting enzyme and DNA sequence encoding it
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
US6582598B2 (en) * 2000-12-14 2003-06-24 Hubert Patrovsky Wave filter for rotary filter

Also Published As

Publication number Publication date
CZ298296B6 (cs) 2007-08-22
US6562598B1 (en) 2003-05-13
JP4108761B2 (ja) 2008-06-25
JP2001513632A (ja) 2001-09-04
IL131171A (en) 2007-05-15
AR010119A1 (es) 2000-05-17
EP1012303A1 (de) 2000-06-28
ATA33697A (de) 1999-01-15
US20030138914A1 (en) 2003-07-24
NO994136D0 (no) 1999-08-26
ATE340862T1 (de) 2006-10-15
HUP0000826A3 (en) 2002-01-28
HUP0000826A1 (en) 2000-07-28
IL131171A0 (en) 2001-01-28
ES2273405T3 (es) 2007-05-01
BR9807618A (pt) 2000-02-15
AU6080898A (en) 1998-09-18
DE59813745D1 (de) 2006-11-09
PL191778B1 (pl) 2006-07-31
AT405517B (de) 1999-09-27
NO328022B1 (no) 2009-11-09
US6905846B2 (en) 2005-06-14
PL335379A1 (en) 2000-04-25
SK282369B6 (sk) 2002-01-07
CA2282728A1 (en) 1998-09-03
WO1998038318A1 (de) 1998-09-03
EP1012303B1 (de) 2006-09-27
SK117099A3 (en) 2000-05-16
HU225247B1 (en) 2006-08-28
CZ303199A3 (cs) 2000-01-12
AU732953B2 (en) 2001-05-03

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