NO985904D0 - TIE-2-reseptorligander (TIE-ligand-3, TIE-ligand-4), samt anvendelse derav - Google Patents

TIE-2-reseptorligander (TIE-ligand-3, TIE-ligand-4), samt anvendelse derav

Info

Publication number: NO985904D0
Authority: NO; Norway
Prior art keywords: tie; ligand; provides; tie ligand; growth
Prior art date: 1996-06-19

Application number

NO985904A

Other languages

English (en)

Other versions

NO985904L (no

Inventor

David M Valenzuela

Pamela F Jones

George D Yancopoulos

Original Assignee

Regeneron Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-19

Filing date

1998-12-16

Publication date

1998-12-16

1996-06-19 Priority claimed from US08/665,926 external-priority patent/US5851797A/en

1998-12-16 Application filed by Regeneron Pharma filed Critical Regeneron Pharma

1998-12-16 Publication of NO985904D0 publication Critical patent/NO985904D0/no

1999-02-19 Publication of NO985904L publication Critical patent/NO985904L/no

Links

239000003446 ligand Substances 0.000 title abstract 2
108010090091 TIE-2 Receptor Proteins 0.000 title 1
102000012753 TIE-2 Receptor Human genes 0.000 title 1
102100022007 Tyrosine-protein kinase receptor Tie-1 Human genes 0.000 abstract 8
230000012010 growth Effects 0.000 abstract 3
102000005450 TIE receptors Human genes 0.000 abstract 2
108010006830 TIE receptors Proteins 0.000 abstract 2
230000000903 blocking effect Effects 0.000 abstract 2
230000004069 differentiation Effects 0.000 abstract 2
150000007523 nucleic acids Chemical class 0.000 abstract 2
102000039446 nucleic acids Human genes 0.000 abstract 2
108020004707 nucleic acids Proteins 0.000 abstract 2
230000001737 promoting effect Effects 0.000 abstract 2
206010029113 Neovascularisation Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
210000004204 blood vessel Anatomy 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
230000004614 tumor growth Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
- C07K14/17—Porcine transmissible gastroenteritis virus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

NO985904A 1996-06-19 1998-12-16 TIE-2-reseptorligander (TIE-ligand-3, TIE-ligand-4), samt anvendelse derav NO985904L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US08/665,926 US5851797A (en)	1996-06-19	1996-06-19	Tie ligand-3, methods of making and uses thereof
US2108796P	1996-07-02	1996-07-02
US2299996P	1996-08-02	1996-08-02
PCT/US1997/010728 WO1997048804A2 (en)	1996-06-19	1997-06-19	Tie-2 receptor ligands (tie ligand-3; tie ligand-4) and their uses

Publications (2)

Publication Number	Publication Date
NO985904D0 true NO985904D0 (no)	1998-12-16
NO985904L NO985904L (no)	1999-02-19

Family

ID=27361571

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO985904A NO985904L (no)	1996-06-19	1998-12-16	TIE-2-reseptorligander (TIE-ligand-3, TIE-ligand-4), samt anvendelse derav

Country Status (20)

Country	Link
US (2)	US6432667B1 (no)
EP (1)	EP0939809B1 (no)
JP (1)	JP2000513932A (no)
KR (1)	KR20000022028A (no)
CN (1)	CN1227603A (no)
AT (1)	ATE235551T1 (no)
AU (1)	AU724467B2 (no)
CA (1)	CA2258526A1 (no)
CZ (1)	CZ421898A3 (no)
DE (1)	DE69720241T2 (no)
DK (1)	DK0939809T3 (no)
ES (1)	ES2194203T3 (no)
FI (1)	FI982745A (no)
HU (1)	HUP0004320A3 (no)
IL (1)	IL127623A0 (no)
NO (1)	NO985904L (no)
NZ (1)	NZ333374A (no)
PL (1)	PL330705A1 (no)
PT (1)	PT939809E (no)
WO (1)	WO1997048804A2 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5972338A (en)	1997-09-19	1999-10-26	Genentech, Inc.	Tie ligands homologues
US6350450B1 (en)	1997-09-19	2002-02-26	Genentech, Inc.	TIE ligand homologue antibody
US6057435A (en)	1997-09-19	2000-05-02	Genentech, Inc.	Tie ligand homologues
US6030831A (en)	1997-09-19	2000-02-29	Genetech, Inc.	Tie ligand homologues
US6348350B1 (en)	1997-09-19	2002-02-19	Genentech, Inc.	Ligand homologues
AU4643699A (en) *	1998-06-24	2000-01-10	Compugen Ltd.	Angiopoietin-like growth factor sequences
EP1508337A3 (en) *	1998-11-20	2006-04-19	Genentech, Inc.	Uses for eph receptor antagonists and agonists to treat vascular disorders
ATE293989T1 (de) *	1998-11-20	2005-05-15	Genentech Inc	Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
AU776393B2 (en)	1998-12-23	2004-09-09	Regeneron Pharmaceuticals, Inc.	Method of enhancing the biological activity of ligands
AU2002335085A1 (en)	2001-10-25	2003-05-06	Regeneron Pharmaceuticals, Inc.	Angiopoietins and methods of use thereof
US8298532B2 (en)	2004-01-16	2012-10-30	Regeneron Pharmaceuticals, Inc.	Fusion polypeptides capable of activating receptors
US7296991B2 (en) *	2004-12-10	2007-11-20	Irwin Jere F	Adjustable extruder die assembly die lip adjustment apparatus
US20080119367A1 (en) *	2004-12-17	2008-05-22	Mayo Foundation For Medical Education And Research	Prognosis of Renal Cell Carcinoma
WO2007030658A2 (en) *	2005-09-08	2007-03-15	Children's Hospital Medical Center	Compositions useful for and methods of modulating angiogenesis
US20080080059A1 (en) *	2006-09-28	2008-04-03	Pacific Biosciences Of California, Inc.	Modular optical components and systems incorporating same
MX2018004019A (es)	2015-09-29	2018-09-06	ProdrugXtend Pty Ltd	Formulacion novedosa y metodos de tratamiento.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5332671A (en)	1989-05-12	1994-07-26	Genetech, Inc.	Production of vascular endothelial cell growth factor and DNA encoding same
WO1994000469A1 (en)	1992-06-26	1994-01-06	Immunex Corporation	Novel tyrosine kinase
CN1173991C (zh)	1992-11-13	2004-11-03	马克斯普朗克科学促进协会	作为血管内皮生长因子受体的f1k-1
US5643755A (en) *	1994-10-07	1997-07-01	Regeneron Pharmaceuticals Inc.	Nucleic acid encoding tie-2 ligand
US5814464A (en) *	1994-10-07	1998-09-29	Regeneron Pharma	Nucleic acids encoding TIE-2 ligand-2
NZ300808A (en) *	1994-12-23	1999-04-29	Ludwig Inst Cancer Res	A method of detecting a ligand capable of binding the receptor protein nyk
CA2216963C (en) *	1995-04-06	2010-06-22	Regeneron Pharmaceuticals, Inc.	Tie-2 ligands, methods of making and uses thereof
US5851797A (en) *	1996-06-19	1998-12-22	Regeneron Pharmaceuticals, Inc.	Tie ligand-3, methods of making and uses thereof

1997
- 1997-06-19 CA CA002258526A patent/CA2258526A1/en not_active Abandoned
- 1997-06-19 CN CN97197208A patent/CN1227603A/zh active Pending
- 1997-06-19 AT AT97930162T patent/ATE235551T1/de not_active IP Right Cessation
- 1997-06-19 PT PT97930162T patent/PT939809E/pt unknown
- 1997-06-19 KR KR1019980710426A patent/KR20000022028A/ko not_active Application Discontinuation
- 1997-06-19 IL IL12762397A patent/IL127623A0/xx unknown
- 1997-06-19 CZ CZ984218A patent/CZ421898A3/cs unknown
- 1997-06-19 PL PL97330705A patent/PL330705A1/xx unknown
- 1997-06-19 JP JP10503376A patent/JP2000513932A/ja not_active Withdrawn
- 1997-06-19 DE DE69720241T patent/DE69720241T2/de not_active Expired - Fee Related
- 1997-06-19 HU HU0004320A patent/HUP0004320A3/hu unknown
- 1997-06-19 ES ES97930162T patent/ES2194203T3/es not_active Expired - Lifetime
- 1997-06-19 DK DK97930162T patent/DK0939809T3/da active
- 1997-06-19 AU AU34061/97A patent/AU724467B2/en not_active Ceased
- 1997-06-19 WO PCT/US1997/010728 patent/WO1997048804A2/en not_active Application Discontinuation
- 1997-06-19 EP EP97930162A patent/EP0939809B1/en not_active Expired - Lifetime
- 1997-06-19 US US09/202,491 patent/US6432667B1/en not_active Expired - Lifetime
- 1997-06-19 NZ NZ333374A patent/NZ333374A/en unknown
1998
- 1998-12-16 NO NO985904A patent/NO985904L/no not_active Application Discontinuation
- 1998-12-18 FI FI982745A patent/FI982745A/fi unknown
2002
- 2002-08-08 US US10/214,812 patent/US6881395B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NO985904L (no)	1999-02-19
DE69720241T2 (de)	2003-12-11
WO1997048804A2 (en)	1997-12-24
US20030064470A1 (en)	2003-04-03
ATE235551T1 (de)	2003-04-15
AU724467B2 (en)	2000-09-21
AU3406197A (en)	1998-01-07
FI982745A (fi)	1999-02-04
ES2194203T3 (es)	2003-11-16
WO1997048804A3 (en)	1998-04-09
US6881395B2 (en)	2005-04-19
PT939809E (pt)	2003-08-29
US6432667B1 (en)	2002-08-13
IL127623A0 (en)	1999-10-28
JP2000513932A (ja)	2000-10-24
CZ421898A3 (cs)	1999-05-12
FI982745A0 (fi)	1998-12-18
DE69720241D1 (de)	2003-04-30
CA2258526A1 (en)	1997-12-24
PL330705A1 (en)	1999-05-24
EP0939809B1 (en)	2003-03-26
CN1227603A (zh)	1999-09-01
HUP0004320A2 (hu)	2001-06-28
EP0939809A2 (en)	1999-09-08
KR20000022028A (ko)	2000-04-25
HUP0004320A3 (en)	2005-11-28
DK0939809T3 (da)	2003-07-21
NZ333374A (en)	2000-06-23

Legal Events

Date	Code	Title	Description
2006-01-30	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO971557D0 (no)	1997-04-04	TIE-2-ligander, fremgangsmåte ved fremstilling samt anvendelse derav
HK1008230A1 (en)	1999-05-07	Tie-2 ligands, methods of making and uses thereof.
NO985904L (no)	1999-02-19	TIE-2-reseptorligander (TIE-ligand-3, TIE-ligand-4), samt anvendelse derav
EE05558B1 (et)	2012-08-15	Antikeha v?i selle antigeeni siduva fragmendi v?i lahustuva polpeptiidi kasutamine farmatseutilise kompositsiooni valmistamiseks
MXPA02008239A (es)	2004-08-12	Gen humano de la esquizofrenia.
WO2001064876A3 (en)	2002-04-18	Human schizophrenia gene
DE50015355D1 (de)	2008-10-23	Mit trp-proteinen verwandtes protein mtr1 und dieses codierende dna-sequenz
ATE298244T1 (de)	2005-07-15	Monoklonaler antikörper mit selektiver bindung an vgf und verwendung zur behandlung von vgf- erkrankungen
ATE364180T1 (de)	2007-06-15	Screeningverfahren mit bnpi und dnpi