NO984878L - Preparation and Use as Medicines of 3-Alkoxypyridine-2-Carboxylic Acid Amesters - Google Patents

Preparation and Use as Medicines of 3-Alkoxypyridine-2-Carboxylic Acid Amesters

Info

Publication number
NO984878L
NO984878L NO984878A NO984878A NO984878L NO 984878 L NO984878 L NO 984878L NO 984878 A NO984878 A NO 984878A NO 984878 A NO984878 A NO 984878A NO 984878 L NO984878 L NO 984878L
Authority
NO
Norway
Prior art keywords
alkoxypyridine
carboxylic acid
amesters
medicines
preparation
Prior art date
Application number
NO984878A
Other languages
Norwegian (no)
Other versions
NO984878D0 (en
Inventor
Klaus Weidmann
Karl-Heinz Baringhaus
Georg Tschank
Martin Bickel
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO984878D0 publication Critical patent/NO984878D0/en
Publication of NO984878L publication Critical patent/NO984878L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Det blir beskrevet 3-alkoksypyridin-2-karboksylsyreamidestere med formel (I), der R1, R2 og R3 betyr hydrogen, R4 betyr (Cj-C^-alkyl, A betyr en -CH2-gruppe, og et hydro- genatom kan bli erstattet med en metylgruppe, og B betyr -CO2G, hvori G betyr resten av en alkohol GOH, innbefattet fysiologisk virksomme salter; deres fremstilling, anven- delse for hemming av kollagenbiosyntese og deres anvendelse som legemiddel for be- handling av fibrotiske sykdommer.There are disclosed 3-alkoxypyridine-2-carboxylic acid amides of formula (I) wherein R 1, R 2 and R 3 are hydrogen, R 4 is (C 1 -C substituted by a methyl group, and B means -CO2G, wherein G means the residue of an alcohol GOH, including physiologically active salts;

NO984878A 1996-04-30 1998-10-19 Preparation and Use as Medicines of 3-Alkoxypyridine-2-Carboxylic Acid Amesters NO984878L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1996/001793 WO1997041103A1 (en) 1996-04-30 1996-04-30 3-alkoxypyridine-2-carboxylic acid amide esters, their preparation and their use as drugs

Publications (2)

Publication Number Publication Date
NO984878D0 NO984878D0 (en) 1998-10-19
NO984878L true NO984878L (en) 1998-12-29

Family

ID=8166212

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984878A NO984878L (en) 1996-04-30 1998-10-19 Preparation and Use as Medicines of 3-Alkoxypyridine-2-Carboxylic Acid Amesters

Country Status (7)

Country Link
EP (1) EP0900202A1 (en)
JP (1) JP2000509047A (en)
KR (1) KR20000065090A (en)
AU (1) AU5762896A (en)
CA (1) CA2253282A1 (en)
NO (1) NO984878L (en)
WO (1) WO1997041103A1 (en)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
FR2803592A1 (en) * 2000-01-06 2001-07-13 Aventis Cropscience Sa NOVEL DERIVATIVES OF 3-HYDROXYPICOLINIC ACID, PROCESS FOR THEIR PREPARATION AND FUNGICIDAL COMPOSITIONS CONTAINING SAME
WO2002074981A2 (en) 2001-03-21 2002-09-26 Isis Innovation Ltd. Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
DK2298301T3 (en) * 2001-12-06 2018-10-01 Fibrogen Inc MEDICINALS FOR TREATMENT OF ANEMIA ASSOCIATED WITH Kidney Disease
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
DK3357911T3 (en) 2006-06-26 2022-07-04 Akebia Therapeutics Inc PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE
EP2954899B1 (en) 2009-11-06 2020-01-08 Aerpio Therapeutics, Inc. Compositions and methods for treating colitis
NO2686520T3 (en) 2011-06-06 2018-03-17
CN103717214A (en) 2011-06-06 2014-04-09 阿克比治疗有限公司 Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
CA2894515C (en) 2012-12-28 2021-10-19 Dow Agrosciences Llc Synergistic fungicidal mixtures comprising (3s, 6s, 7r, 8r)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate and fluxapyroxad for fungal control in cereals
BR112015031027A2 (en) 2013-06-13 2017-08-29 Akebia Therapeutics Inc USE OF A COMPOUND, IN VITRO METHOD, PHARMACEUTICAL COMPOSITION AND SINGLE DOSAGE FORM
RU2021125455A (en) 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. SOLID FORMS {[5- (3-CHLOROPHENYL) -3-HYDROXYPIRIDINE-2-CARBONYL] AMINO} ACETIC ACID, THEIR COMPOSITIONS AND APPLICATIONS
JP6742319B2 (en) 2014-12-30 2020-08-19 ダウ アグロサイエンシィズ エルエルシー Picolinamide compound having fungicidal activity
JP6629862B2 (en) 2014-12-30 2020-01-15 ダウ アグロサイエンシィズ エルエルシー Picolinamide with fungicidal activity
AU2015374378B2 (en) * 2014-12-30 2018-02-15 Dow Agrosciences Llc Use of picolinamide compounds with fungicidal activity
RU2708392C2 (en) 2014-12-30 2019-12-06 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Picolinamide compounds with fungicidal activity
JP2018500361A (en) 2014-12-30 2018-01-11 ダウ アグロサイエンシィズ エルエルシー Use of picolinamide as a fungicide
CA2974691A1 (en) 2015-01-23 2016-07-28 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
PL3277270T3 (en) 2015-04-01 2022-02-14 Akebia Therapeutics, Inc. Compositions and methods for treating anemia
JP6814134B2 (en) * 2015-05-28 2021-01-13 日本たばこ産業株式会社 How to treat or prevent diabetic nephropathy
TW201842851A (en) 2017-05-02 2018-12-16 美商陶氏農業科學公司 Synergistic mixtures for fungal control in cereals
TWI774761B (en) 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 Synergistic mixtures for fungal control in cereals
EP3618626A4 (en) 2017-05-02 2020-12-02 Dow Agrosciences LLC Use of an acyclic picolinamide compound as a fungicide for fungal diseases on turfgrasses
BR102019004480B1 (en) 2018-03-08 2023-03-28 Dow Agrosciences Llc PICOLINAMIDES AS FUNGICIDES
CN112088155A (en) 2018-05-09 2020-12-15 阿克比治疗有限公司 Process for the preparation of 2- [ [5- (3-chlorophenyl) -3-hydroxypyridine-2-carbonyl ] amino ] acetic acid
KR20210076072A (en) 2018-10-15 2021-06-23 코르테바 애그리사이언스 엘엘씨 Method for the synthesis of oxypicolinamide
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0650960B1 (en) * 1993-11-02 1997-03-05 Hoechst Aktiengesellschaft Substituted heterocyclic carboxylic acid amide esters, their preparation and their us as medicaments

Also Published As

Publication number Publication date
JP2000509047A (en) 2000-07-18
AU5762896A (en) 1997-11-19
KR20000065090A (en) 2000-11-06
WO1997041103A1 (en) 1997-11-06
NO984878D0 (en) 1998-10-19
EP0900202A1 (en) 1999-03-10
CA2253282A1 (en) 1997-11-06

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