NO982249D0 - Platelet aggregation inhibitors - Google Patents

Platelet aggregation inhibitors

Info

Publication number
NO982249D0
NO982249D0 NO982249A NO982249A NO982249D0 NO 982249 D0 NO982249 D0 NO 982249D0 NO 982249 A NO982249 A NO 982249A NO 982249 A NO982249 A NO 982249A NO 982249 D0 NO982249 D0 NO 982249D0
Authority
NO
Norway
Prior art keywords
alkyl
pais
independently
assay
benzyl
Prior art date
Application number
NO982249A
Other languages
Norwegian (no)
Other versions
NO982249L (en
NO312965B1 (en
Inventor
Robert Scarborough
David Lawrence Wolf
Israel F Charo
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO982249(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NO982249L publication Critical patent/NO982249L/en
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Publication of NO982249D0 publication Critical patent/NO982249D0/en
Publication of NO312965B1 publication Critical patent/NO312965B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]

Abstract

An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R<1>2 N(CH2)4CHNHCO- wherein each R<1> is independently H, alkyl(1-6C) or at most one R<1> is R<2>-C=NR<3> wherein R<2> is H, alkyl(1-6C), phenyl or benzyl, or is NR<4>2 in which each R<4> is independently H or alkyl(1-6C) and R<3> is H, alkyl(1-6C), phenyl or benzyl, or R<2>-C=NR<3> is a radical selected from the group consisting of: <CHEM> where m is an integer of 2-3, and each R<5> is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.
NO19982249A 1989-06-16 1998-05-15 Platelet aggregation inhibitors NO312965B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US41802889A 1989-10-06 1989-10-06
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors
PCT/US1990/003417 WO1990015620A1 (en) 1989-06-16 1990-06-15 Platelet aggregation inhibitors

Publications (3)

Publication Number Publication Date
NO982249L NO982249L (en) 1992-01-31
NO982249D0 true NO982249D0 (en) 1998-05-15
NO312965B1 NO312965B1 (en) 2002-07-22

Family

ID=27408820

Family Applications (3)

Application Number Title Priority Date Filing Date
NO914962A NO304267B1 (en) 1989-06-16 1991-12-16 Analogous Process for Preparation of a Therapeutically Active Specific Platelet Aggregation Inhibitor (PAI) Peptide
NO19982249A NO312965B1 (en) 1989-06-16 1998-05-15 Platelet aggregation inhibitors
NO2000008C NO2000008I2 (en) 1989-06-16 2000-09-06 Analogous Procedure for Preparing a Therapeutically Active Specific Platelet Aggregation Inhibitor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO914962A NO304267B1 (en) 1989-06-16 1991-12-16 Analogous Process for Preparation of a Therapeutically Active Specific Platelet Aggregation Inhibitor (PAI) Peptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2000008C NO2000008I2 (en) 1989-06-16 2000-09-06 Analogous Procedure for Preparing a Therapeutically Active Specific Platelet Aggregation Inhibitor

Country Status (16)

Country Link
US (4) US5318899A (en)
EP (2) EP0477295B2 (en)
JP (1) JP3281370B2 (en)
KR (1) KR0180918B1 (en)
AT (1) ATE146969T1 (en)
CA (2) CA2059124C (en)
DE (2) DE19975072I2 (en)
DK (1) DK0477295T4 (en)
ES (1) ES2097150T5 (en)
FI (1) FI104364B (en)
HU (1) HU216318B (en)
LU (1) LU90488I2 (en)
NL (1) NL990043I2 (en)
NO (3) NO304267B1 (en)
RU (1) RU2156468C2 (en)
WO (1) WO1990015620A1 (en)

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Also Published As

Publication number Publication date
DE19975072I2 (en) 2011-01-20
RU2156468C2 (en) 2000-09-20
DE69029579T2 (en) 1997-07-24
EP0477295A1 (en) 1992-04-01
CA2059124C (en) 2002-08-20
ATE146969T1 (en) 1997-01-15
DE69029579D1 (en) 1997-02-13
US5318899A (en) 1994-06-07
EP0751219A1 (en) 1997-01-02
NO982249L (en) 1992-01-31
NO304267B1 (en) 1998-11-23
NO914962D0 (en) 1991-12-16
DK0477295T4 (en) 2005-12-12
EP0477295A4 (en) 1992-10-07
NO312965B1 (en) 2002-07-22
EP0477295B1 (en) 1997-01-02
KR920702627A (en) 1992-10-06
JP3281370B2 (en) 2002-05-13
FI104364B (en) 2000-01-14
HU216318B (en) 1999-06-28
CA2388770A1 (en) 1990-12-27
DE19975072I1 (en) 2000-03-09
AU636159B2 (en) 1993-04-22
DK0477295T3 (en) 1997-07-07
US5496724A (en) 1996-03-05
US5958732A (en) 1999-09-28
NO914962L (en) 1992-01-31
NL990043I2 (en) 2000-04-03
HUT59835A (en) 1992-07-28
KR0180918B1 (en) 1999-04-01
WO1990015620A1 (en) 1990-12-27
ES2097150T5 (en) 2006-06-16
JPH05500750A (en) 1993-02-18
FI915919A0 (en) 1991-12-16
AU6036990A (en) 1991-01-08
DE69029579T3 (en) 2006-06-22
EP0477295B2 (en) 2005-11-16
LU90488I2 (en) 2000-02-15
NL990043I1 (en) 2000-02-01
HU905490D0 (en) 1992-03-30
ES2097150T3 (en) 1997-04-01
US5736339A (en) 1998-04-07
NO2000008I2 (en) 2006-01-16
CA2059124A1 (en) 1990-12-17

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