NO980694L - Sulfonamidsubstituerte kromaner, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostika såvel som medikamenter inneholdende dem - Google Patents

Sulfonamidsubstituerte kromaner, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostika såvel som medikamenter inneholdende dem

Info

Publication number
NO980694L
NO980694L NO980694A NO980694A NO980694L NO 980694 L NO980694 L NO 980694L NO 980694 A NO980694 A NO 980694A NO 980694 A NO980694 A NO 980694A NO 980694 L NO980694 L NO 980694L
Authority
NO
Norway
Prior art keywords
drugs
treatment
arrhythmias
hydrogen
preparation
Prior art date
Application number
NO980694A
Other languages
English (en)
Other versions
NO980694D0 (no
Inventor
Hans Jochen Lang
Joachim Brendel
Uwe Gerlach
Klaus Weidmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO980694D0 publication Critical patent/NO980694D0/no
Publication of NO980694L publication Critical patent/NO980694L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Abstract

Kromaner med formel I (D hvor R(l) og R(2) uavhengig av hverandre står for hydrogen, CF3, C2F5, C3F7, alkyl med 1-6 C-atomer eller fenyl, som eventuelt kan være substituert, eller R(l) og R(2) står for en alkylenkjede, R(A) står for hydroksy, alkanoyloksy eller alkylsulfonyloksy og R(B) står for hydrogen; eller R(A) og R(B) sammen danner en binding; R(3) står for R(9)-CnH2n[NR(l l)]m.; R(4) står for R(12)-C,H2r; R(5), R(6), R(7) og R(8) står uav- hengig av hverandre for hydrogen, halogen, alkyl, cykloalkyl, -CN, -CF3, -C2F5, -C3F7, -Nj, -N02> -CONR(13)R(14), -COOR(15), R(16)-C,H2s-Y- eller fenyl, imidlertid med den betydning at to av substituentene R(5), R(6), R(7) og R(8) ikke er hydrogen, er fremragende egnet for fremstilling av et medikament for blokkering av K+-kanalen som blir åpnet av cyklisk adenosynmonofosfat (cAMP); dessuten for fremstilling av et medi- kament for hemming av magesyresekresjon; for behandling av sår i mage og det intesti- nale området, spesielt tovlfingertarmen, for behandling av Refluxoesophagitis, for be- handling av diarésykdommer, for behandling og forhindring av alle typer arrytmier, in- kludert atrial, ventrikulær og superventrikulær arrytmi, såvel som for kontroll av Reen- try-arrytmier og forhindring av plusteslig hjertedød på grunn av kammerflimmer.
NO980694A 1997-02-20 1998-02-19 Sulfonamidsubstituerte kromaner, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostika såvel som medikamenter inneholdende dem NO980694L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19706675A DE19706675A1 (de) 1997-02-20 1997-02-20 Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (2)

Publication Number Publication Date
NO980694D0 NO980694D0 (no) 1998-02-19
NO980694L true NO980694L (no) 1998-08-21

Family

ID=7820907

Family Applications (1)

Application Number Title Priority Date Filing Date
NO980694A NO980694L (no) 1997-02-20 1998-02-19 Sulfonamidsubstituerte kromaner, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostika såvel som medikamenter inneholdende dem

Country Status (21)

Country Link
US (1) US6071953A (no)
EP (1) EP0860440A1 (no)
JP (1) JPH10231293A (no)
KR (1) KR19980071530A (no)
CN (1) CN1194982A (no)
AR (1) AR011153A1 (no)
AU (1) AU5539798A (no)
BR (1) BR9800708A (no)
CA (1) CA2229947A1 (no)
CZ (1) CZ48598A3 (no)
DE (1) DE19706675A1 (no)
HR (1) HRP980086A2 (no)
HU (1) HUP9800374A3 (no)
IL (1) IL123360A0 (no)
NO (1) NO980694L (no)
NZ (1) NZ329788A (no)
PL (1) PL324942A1 (no)
SK (1) SK20998A3 (no)
TR (1) TR199800253A2 (no)
TW (1) TW474929B (no)
ZA (1) ZA981376B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0895994A3 (de) 1997-08-05 1999-12-15 Hoechst Marion Roussel Deutschland GmbH Sulfonamid-substituierte Pyranopyridine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19742509A1 (de) * 1997-09-26 1999-04-01 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
DE19742508A1 (de) 1997-09-26 1999-04-01 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
DE19748469A1 (de) * 1997-11-03 1999-05-06 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Benzopyranderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
JP2002524457A (ja) * 1998-09-04 2002-08-06 ザ プロクター アンド ギャンブル カンパニー 抗不整脈薬として有用な置換ジヒドロベンゾピラン
DE19858253A1 (de) 1998-12-17 2000-06-21 Aventis Pharma Gmbh Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
WO2000058300A1 (fr) * 1999-03-25 2000-10-05 Nissan Chemical Industries, Ltd. Derives du chroman
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US7368582B2 (en) 2003-10-17 2008-05-06 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 2-(4-sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-yl compounds, a process and intermediates for their production, and pharmaceutical compositions containing them
EP2595623B1 (en) 2010-07-19 2018-02-28 The U.S.A. as represented by the Secretary, Department of Health and Human Services Use of delta tocopherol for the treatment of lysosomal storage disorders
WO2014078573A2 (en) 2012-11-16 2014-05-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Tocopherol and tocopheryl quinone derivatives as correctors of lysosomal storage disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006195A1 (fr) * 1987-02-13 1988-08-25 Centre De Recherches Metallurgiques-Centrum Voor R Installation pour la fabrication en continu d'une feuille metallique extra-mince par depot electrolytique
FR2639349B1 (fr) * 1988-11-23 1991-02-22 Sanofi Sa Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
EP0807629B1 (de) * 1996-05-15 2004-03-03 Aventis Pharma Deutschland GmbH Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
BR9800708A (pt) 1999-07-20
HUP9800374A2 (en) 2000-07-28
HRP980086A2 (en) 1998-10-31
CA2229947A1 (en) 1998-08-20
NO980694D0 (no) 1998-02-19
AR011153A1 (es) 2000-08-02
HUP9800374A3 (en) 2001-02-28
TR199800253A2 (xx) 1998-09-21
CN1194982A (zh) 1998-10-07
DE19706675A1 (de) 1998-08-27
PL324942A1 (en) 1998-08-31
JPH10231293A (ja) 1998-09-02
EP0860440A1 (de) 1998-08-26
KR19980071530A (ko) 1998-10-26
ZA981376B (en) 1998-08-20
AU5539798A (en) 1998-08-27
HU9800374D0 (en) 1998-04-28
IL123360A0 (en) 1998-09-24
SK20998A3 (en) 1998-10-07
US6071953A (en) 2000-06-06
NZ329788A (en) 1999-06-29
TW474929B (en) 2002-02-01
CZ48598A3 (cs) 1998-09-16

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FC2A Withdrawal, rejection or dismissal of laid open patent application