NO974727L - Immunogenic and immunostimulatory oligosaccharide compositions and methods for their preparation - Google Patents
Immunogenic and immunostimulatory oligosaccharide compositions and methods for their preparationInfo
- Publication number
- NO974727L NO974727L NO974727A NO974727A NO974727L NO 974727 L NO974727 L NO 974727L NO 974727 A NO974727 A NO 974727A NO 974727 A NO974727 A NO 974727A NO 974727 L NO974727 L NO 974727L
- Authority
- NO
- Norway
- Prior art keywords
- compositions
- immunogenic
- oligosaccharide
- antigen
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Det er beskrevet immunogene oligosakkaridsammensetninger og fremgangsmåter for fremstilling av disse og anvendelser derav. Sammensetningene omfatter spesielt oligosakkarider kovalentlig koblet til bærerprotein, hvori det resulterende konjugatet er blitt vist å inneholde spesifikke immunogene epitoper og utløser en beskyttende immunogen respons. Det er også tilveiebrakt sammensetninger som omfatter et oligosakkarid av S. pneumoniae serotype 8 nyttig for stimulering av en immunrespons mot et antigen, fremgangsmåte for tilveiebringing av beskyttende immunisering mot et bakterielt patogen ved anvendelse av disse sammensetningene, fremgangsmåte for å forøke en immunogen respons mot et antigen ved administrering av disse S. pneumoniae serotype 8 oligosakkarid sammensetningene sammen med antigenet, og fremgangsmåte for fremstilling av immunstimulatoriske sammensetninger beskrevet ovenfor.Immunogenic oligosaccharide compositions and methods for their preparation and applications are disclosed. In particular, the compositions comprise oligosaccharides covalently linked to carrier protein, wherein the resulting conjugate has been shown to contain specific immunogenic epitopes and triggers a protective immunogenic response. Compositions comprising an oligosaccharide of S. pneumoniae serotype 8 are also useful for stimulating an immune response to an antigen, a method of providing protective immunization against a bacterial pathogen using these compositions, a method of enhancing an immunogenic response to an antigen by administering these S. pneumoniae serotype 8 oligosaccharide compositions together with the antigen, and method of preparing immunostimulatory compositions described above.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/482,626 US5695768A (en) | 1995-06-07 | 1995-06-07 | Immunostimulating activity of Streptococcus pneumoniae serotype 8 oligosaccharides |
US08/477,497 US5866132A (en) | 1995-06-07 | 1995-06-07 | Immunogenic oligosaccharide compositions |
CA002153730A CA2153730A1 (en) | 1995-07-12 | 1995-07-12 | Immunostimulating activity of streptococcus pneumoniae serotype 8 oligosaccharides |
CA002153733A CA2153733A1 (en) | 1995-07-12 | 1995-07-12 | Immunogenic oligosaccharide compositions |
PCT/CA1996/000387 WO1996040225A1 (en) | 1995-06-07 | 1996-06-06 | Immunogenic and immunostimulatory oligosaccharide compositions and methods of making and using them |
Publications (2)
Publication Number | Publication Date |
---|---|
NO974727D0 NO974727D0 (en) | 1997-10-13 |
NO974727L true NO974727L (en) | 1997-12-08 |
Family
ID=27427244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO974727A NO974727L (en) | 1995-06-07 | 1997-10-13 | Immunogenic and immunostimulatory oligosaccharide compositions and methods for their preparation |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0831894A1 (en) |
JP (1) | JPH11506110A (en) |
KR (1) | KR19990007777A (en) |
AU (1) | AU725279B2 (en) |
CZ (1) | CZ327897A3 (en) |
IL (1) | IL121585A0 (en) |
MX (1) | MX9707944A (en) |
NO (1) | NO974727L (en) |
NZ (1) | NZ309713A (en) |
WO (1) | WO1996040225A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69708318T3 (en) | 1996-08-27 | 2006-11-16 | Novartis Vaccines and Diagnostics, Inc., Emeryville | NEISSERIA MENINGITIDIS SEROGRUPPE B GLYCOCONJUGATES AND METHOD FOR THEIR USE |
BR9811475A (en) * | 1997-07-17 | 2000-08-15 | North American Vaccine Inc | Immunogenic conjugates comprising a group b meningococcal porin and an h polysaccharide. influenzae |
US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
AU760669B2 (en) * | 1998-04-28 | 2003-05-22 | Galenica Pharmaceuticals, Inc. | Polysaccharide-antigen conjugates |
US6436653B1 (en) | 1998-12-15 | 2002-08-20 | Exiqon A/S | Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces |
IL153558A0 (en) * | 2000-06-20 | 2003-07-06 | Shire Biochem Inc | Streptococcus antigens |
EP3461496B1 (en) * | 2009-06-22 | 2023-08-23 | Wyeth LLC | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
EP2870974A1 (en) * | 2013-11-08 | 2015-05-13 | Novartis AG | Salmonella conjugate vaccines |
AU2015208821B2 (en) * | 2014-01-21 | 2017-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
EP3000820A1 (en) * | 2014-09-26 | 2016-03-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synthetic vaccines against Streptococcus pneumoniae serotype 8 |
CA2961694C (en) * | 2014-09-26 | 2022-11-01 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Vaccines against streptococcus pneumoniae serotype 8 |
US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
SG11201900794PA (en) | 2016-08-05 | 2019-02-27 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
CA3031797A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
CA3074714A1 (en) * | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein |
AU2019215216A1 (en) | 2018-02-05 | 2020-07-23 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
AU2019215212A1 (en) | 2018-02-05 | 2020-07-23 | Sk Bioscience Co., Ltd. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US11951162B2 (en) | 2018-04-18 | 2024-04-09 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharides and immunogenic conjugate thereof |
EP3893926A1 (en) * | 2018-12-12 | 2021-10-20 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
CN113607939A (en) * | 2021-08-05 | 2021-11-05 | 艾美探索者生命科学研发有限公司 | Method for measuring adsorption rate of various combined stock solutions of pneumococcal polysaccharide combined vaccine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1187753B (en) * | 1985-07-05 | 1987-12-23 | Sclavo Spa | GLYCOPROTEIC CONJUGATES WITH TRIVALENT IMMUNOGENIC ACTIVITY |
EP0302887B1 (en) * | 1986-04-16 | 1994-06-22 | The Brigham And Women's Hospital, Inc. | Bacterial antigens, antibodies, vaccines, and methods of manufacture |
US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
ATE137981T1 (en) * | 1990-12-18 | 1996-06-15 | Univ Washington | DIALYSAT PRODUCTION SYSTEM WITH PILLS |
CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
-
1996
- 1996-06-06 NZ NZ309713A patent/NZ309713A/en unknown
- 1996-06-06 IL IL12158596A patent/IL121585A0/en unknown
- 1996-06-06 WO PCT/CA1996/000387 patent/WO1996040225A1/en not_active Application Discontinuation
- 1996-06-06 JP JP9500049A patent/JPH11506110A/en not_active Ceased
- 1996-06-06 EP EP96917311A patent/EP0831894A1/en not_active Withdrawn
- 1996-06-06 CZ CZ973278A patent/CZ327897A3/en unknown
- 1996-06-06 KR KR1019970707283A patent/KR19990007777A/en not_active Application Discontinuation
- 1996-06-06 AU AU59944/96A patent/AU725279B2/en not_active Ceased
-
1997
- 1997-10-13 NO NO974727A patent/NO974727L/en not_active Application Discontinuation
- 1997-10-15 MX MX9707944A patent/MX9707944A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0831894A1 (en) | 1998-04-01 |
WO1996040225A1 (en) | 1996-12-19 |
AU725279B2 (en) | 2000-10-12 |
MX9707944A (en) | 1998-06-30 |
KR19990007777A (en) | 1999-01-25 |
NO974727D0 (en) | 1997-10-13 |
CZ327897A3 (en) | 1998-02-18 |
AU5994496A (en) | 1996-12-30 |
NZ309713A (en) | 1999-11-29 |
JPH11506110A (en) | 1999-06-02 |
IL121585A0 (en) | 1998-02-08 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |