NO972526L - Tachykinin antagonists - Google Patents

Tachykinin antagonists

Info

Publication number
NO972526L
NO972526L NO972526A NO972526A NO972526L NO 972526 L NO972526 L NO 972526L NO 972526 A NO972526 A NO 972526A NO 972526 A NO972526 A NO 972526A NO 972526 L NO972526 L NO 972526L
Authority
NO
Norway
Prior art keywords
phenyl
sulfur
tachykinin antagonists
indol
pyridyl
Prior art date
Application number
NO972526A
Other languages
Norwegian (no)
Other versions
NO972526D0 (en
Inventor
Soo Young Ko
Christopher Walpole
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9425085.9A external-priority patent/GB9425085D0/en
Priority claimed from GBGB9426016.3A external-priority patent/GB9426016D0/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO972526L publication Critical patent/NO972526L/en
Publication of NO972526D0 publication Critical patent/NO972526D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Abstract

Forbindelse med formel I, Rj -(CHj)^- I«-C-*I-----CH-C-N-----CH-C-Z-CH-Rj 1^ (b) (C) (I) hvori Rj^ er mono- eller disubstituert fenyl, n er null eller 1, Xj^ er oksygen, svovel eller =NCN, Xj og X3 er oksygen eller svovel, R2 er hydrogen eller metyl, R3 er fenyl, halogen- substituert fenyl, 2-naftyl, lH-indol-3-yl eller 1-metyl- indol-3-yl, Z er -N(CH3)- eller -CHj-, R4 er fenyl, 3,5-bis- (trifluormetyl)fenyl eller pyridyl og R5 er hydrogen, fenyl, 3,5-bis(trifluormetyl)fenyl eller pyridyl, hvorved, når X3 er svovel, er Z -N(CH3)-, og syreaddisjonssalt derav har tachykininantagonistaktivitet og er anvendbare som farma- søytiske midler, f.eks. for behandling av smerte.Compound of Formula I, R 1 - (CH 2) 2 - I 1 -C- * I ----- CH-CN ----- CH-C 2 -CH-R 1 (b) (C) (I) wherein R 1 is mono- or disubstituted phenyl, n is zero or 1, X 2 is oxygen, sulfur or = NCN, X 2 and X 3 are oxygen or sulfur, R 2 is hydrogen or methyl, R -Naphthyl, 1H-indol-3-yl or 1-methyl-indol-3-yl, Z is -N (CH 3) - or -CH 2 -, R 4 is phenyl, 3,5-bis- (trifluoromethyl) phenyl or pyridyl and R 5 is hydrogen, phenyl, 3,5-bis (trifluoromethyl) phenyl or pyridyl, where, when X 3 is sulfur, Z is -N (CH 3) - instance. for the treatment of pain.

NO972526A 1994-12-13 1997-06-03 Tachykinin antagonists NO972526D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9425085.9A GB9425085D0 (en) 1994-12-13 1994-12-13 Organic compounds
GBGB9426016.3A GB9426016D0 (en) 1994-12-22 1994-12-22 Organic compounds
PCT/EP1995/004910 WO1996018643A1 (en) 1994-12-13 1995-12-12 Tachykinin antagonists

Publications (2)

Publication Number Publication Date
NO972526L true NO972526L (en) 1997-06-03
NO972526D0 NO972526D0 (en) 1997-06-03

Family

ID=26306161

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972526A NO972526D0 (en) 1994-12-13 1997-06-03 Tachykinin antagonists

Country Status (17)

Country Link
EP (1) EP0797583A1 (en)
JP (1) JPH10511935A (en)
AR (1) AR001332A1 (en)
AU (1) AU4343796A (en)
BR (1) BR9509997A (en)
CA (1) CA2204130A1 (en)
CO (1) CO4700289A1 (en)
CZ (1) CZ179097A3 (en)
FI (1) FI971685A (en)
HU (1) HUT77002A (en)
IL (1) IL116323A0 (en)
NO (1) NO972526D0 (en)
PE (1) PE38997A1 (en)
PL (1) PL320217A1 (en)
SK (1) SK74697A3 (en)
TR (1) TR199501568A2 (en)
WO (1) WO1996018643A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502311A (en) * 1996-10-07 2001-02-20 メルク シヤープ エンド ドーム リミテツド CNS permeable NK-1 receptor antagonist as antidepressant and / or anxiolytic
US6117855A (en) * 1996-10-07 2000-09-12 Merck Sharp & Dohme Ltd. Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
EP1930021A3 (en) 1999-02-18 2008-06-18 Kaken Pharmaceutical Co., Ltd. Novel amide derivatives as growth hormone secretagogues
KR101412339B1 (en) 2004-07-15 2014-06-25 알바니 몰레큘라 리써치, 인크. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8362075B2 (en) 2005-05-17 2013-01-29 Merck Sharp & Dohme Corp. Cyclohexyl sulphones for treatment of cancer
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
EP1940842B1 (en) 2005-09-29 2012-05-30 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2008039327A2 (en) 2006-09-22 2008-04-03 Merck & Co., Inc. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
PL2336120T3 (en) 2007-01-10 2014-12-31 Msd Italia Srl Combinations containing amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
CA2676357A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
US8106086B2 (en) 2007-04-02 2012-01-31 Msd K.K. Indoledione derivative
CA2690191C (en) 2007-06-27 2015-07-28 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
WO2009111354A2 (en) 2008-03-03 2009-09-11 Tiger Pharmatech Tyrosine kinase inhibitors
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
WO2010132487A1 (en) 2009-05-12 2010-11-18 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
US9034899B2 (en) 2009-05-12 2015-05-19 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
KR101830447B1 (en) 2009-05-12 2018-02-20 알바니 몰레큘라 리써치, 인크. 7-([1,2,4]TRIAZOLO[1,5-α]PYRIDIN-6-YL)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
PE20121172A1 (en) 2009-10-14 2012-09-05 Merck Sharp & Dohme PIPERIDINS SUBSTITUTED WITH ACTIVITY IN HDM2
US8999957B2 (en) 2010-06-24 2015-04-07 Merck Sharp & Dohme Corp. Heterocyclic compounds as ERK inhibitors
CA2805265A1 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
CA2807307C (en) 2010-08-17 2021-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
EP2608669B1 (en) 2010-08-23 2016-06-22 Merck Sharp & Dohme Corp. NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
EP2632472B1 (en) 2010-10-29 2017-12-13 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
IN2013MN02170A (en) 2011-04-21 2015-06-12 Piramal Entpr Ltd
WO2013063214A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP2844261B1 (en) 2012-05-02 2018-10-17 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
MX363243B (en) 2012-11-28 2019-03-14 Merck Sharp & Dohme Compositions and methods for treating cancer.
BR112015013611A2 (en) 2012-12-20 2017-11-14 Merck Sharp & Dohme compound and pharmaceutical composition
EP2951180B1 (en) 2013-01-30 2018-05-02 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Circular polynucleotides
WO2019094311A1 (en) 2017-11-08 2019-05-16 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
US20210277009A1 (en) 2018-08-07 2021-09-09 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
JPH05186498A (en) * 1991-12-27 1993-07-27 Japan Tobacco Inc Proline derivative

Also Published As

Publication number Publication date
TR199501568A2 (en) 1996-07-21
FI971685A (en) 1997-08-13
PL320217A1 (en) 1997-09-15
FI971685A0 (en) 1997-04-18
HUT77002A (en) 1998-03-02
IL116323A0 (en) 1996-03-31
SK74697A3 (en) 1997-11-05
BR9509997A (en) 1997-12-30
PE38997A1 (en) 1997-10-02
AU4343796A (en) 1996-07-03
JPH10511935A (en) 1998-11-17
CO4700289A1 (en) 1998-12-29
EP0797583A1 (en) 1997-10-01
AR001332A1 (en) 1997-10-22
CA2204130A1 (en) 1996-06-20
CZ179097A3 (en) 1997-10-15
MX9703957A (en) 1997-09-30
WO1996018643A1 (en) 1996-06-20
NO972526D0 (en) 1997-06-03

Similar Documents

Publication Publication Date Title
NO972526L (en) Tachykinin antagonists
ATE242625T1 (en) CHELATE PREPARATIONS CONTAINING OXIME COMPOUNDS
NO20101069L (en) Use of certain NMDA affinity antagonists as antidepressants
EE04310B1 (en) Benzimidazole compounds, pharmaceutical compositions containing these compounds and their use
DK1105393T3 (en) Bicyclic piperidine and piperazine compounds with 5-HT6 receptor affinity
BG105271A (en) 1h-imidazopyridine derivatives
DE69929689D1 (en) HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF HEART FAILURE AND OTHER DISEASES
PT641328E (en) AZA-BICYCLIC DERIVATIVES IN BRIDGE AS ANTAGONISTS OF SUBSTANCE P
NO20000325L (en) Absorbent composition for the purification of gases containing acidic components
NO944919L (en) Method of inhibiting atrophy of the skin or vagina
DK0463945T3 (en) Chalcon derivatives, processes for their preparation and pharmaceutical compositions containing the derivatives
HUP0100732A2 (en) Synergetic fungicidal composition comprising amide compound and azole derivative and its use
ATE283268T1 (en) 2-ADAMANTYLETHYLAMINES AND THEIR USE IN THE TREATMENT OF ABNORMALITIES IN GLUTAMATE TRANSMISSION
HUP0001164A2 (en) Cyclic depsipeptide pf1022 derivatives
MX9600842A (en) Cyclic amide derivatives for protecting against ultraviolet rays.
DK0538192T3 (en) New 17beta-substituted aza-androstan derivatives
NO944926L (en) Methods for Inhibiting Myeloperoxidase Activity
ATE168105T1 (en) MELAMINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER
NO971142L (en) Bis- (2-haloethyl) aminophenyl-substituted distamycin derivatives as antitumor and antiviral agents
JPS6440449A (en) Substituted 2-nitromethaphenylenediamine, manufacture and hair dye composition
DE69329944T2 (en) Composition for dyeing based on hydroxyindoline derivatives
HUP9902119A2 (en) Diphenyl stilbene derivatives as cox-2 inhibitors and pharmaceutical compositions of the same
NO922151L (en) GINGEROL AND GINGERDIOLD DERIVATIVES AS HYPOCOLESTEROLEMIC AND ANTIATHEROSCLEROTIC AGENTS
ATE172960T1 (en) CARBAMOYLCARBONIC ACID AMIDES
DE69706355D1 (en) Alkylenediamine derivatives as a medicine for the treatment of ulcers and inhibition of Helicobacter pylori