NO970296L - Semi-syntetiske taksaner med anti-tumoral aktivitet - Google Patents

Semi-syntetiske taksaner med anti-tumoral aktivitet

Info

Publication number: NO970296L
Authority: NO; Norway
Prior art keywords: semi; tumor activity; synthetic taxanes; taxanes; synthetic
Prior art date: 1994-07-26

Application number

NO970296A

Other languages

English (en)

Other versions

NO315116B1 (no

NO970296D0 (no

Inventor

Ezio Bombardelli

Paolo De Bellis

Bruno Gabetta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-26

Filing date

1997-01-23

Publication date

1997-03-12

1994-07-26 Priority claimed from ITMI941592A external-priority patent/IT1274356B/it

1995-06-19 Priority claimed from IT95RM000413A external-priority patent/IT1278108B1/it

1997-01-23 Application filed by Indena Spa filed Critical Indena Spa

1997-01-23 Publication of NO970296D0 publication Critical patent/NO970296D0/no

1997-03-12 Publication of NO970296L publication Critical patent/NO970296L/no

2003-07-14 Publication of NO315116B1 publication Critical patent/NO315116B1/no

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
229940123237 Taxane Drugs 0.000 title 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
231100000433 cytotoxic Toxicity 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical class O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)

NO19970296A 1994-07-26 1997-01-23 Semi-syntetiske taksaner med anti-tumoral aktivitet NO315116B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI941592A IT1274356B (it)	1994-07-26	1994-07-26	Tassani semisintetici odtati di attivita' antitumorale
IT95RM000413A IT1278108B1 (it)	1995-06-19	1995-06-19	Secotassani dotati di attivita' antitumorale.
PCT/EP1995/002896 WO1996003394A1 (en)	1994-07-26	1995-07-21	Semi-synthetic taxanes with anti-tumoural activity

Publications (3)

Publication Number	Publication Date
NO970296D0 NO970296D0 (no)	1997-01-23
NO970296L true NO970296L (no)	1997-03-12
NO315116B1 NO315116B1 (no)	2003-07-14

Family

ID=26331178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19970296A NO315116B1 (no)	1994-07-26	1997-01-23	Semi-syntetiske taksaner med anti-tumoral aktivitet

Country Status (24)

Country	Link
US (1)	US5756776A (no)
EP (1)	EP0773938B1 (no)
JP (1)	JP2986550B2 (no)
KR (1)	KR100220490B1 (no)
CN (4)	CN1073105C (no)
AT (1)	ATE176464T1 (no)
AU (1)	AU684218B2 (no)
BG (1)	BG62851B1 (no)
CA (1)	CA2195844C (no)
CZ (1)	CZ293076B6 (no)
DE (1)	DE69507702T2 (no)
DK (1)	DK0773938T3 (no)
ES (1)	ES2126919T3 (no)
FI (1)	FI120398B (no)
GR (1)	GR3029309T3 (no)
HK (1)	HK1011687A1 (no)
HU (1)	HU222496B1 (no)
NO (1)	NO315116B1 (no)
PL (1)	PL187579B1 (no)
RO (2)	RO116549B1 (no)
RU (1)	RU2134688C1 (no)
SI (1)	SI9520078B (no)
SK (1)	SK281526B6 (no)
WO (1)	WO1996003394A1 (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6107332A (en)	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
US6395770B1 (en) *	1995-10-26	2002-05-28	Baker Norton Pharmaceuticals, Inc.	Method and compositions for administering taxanes orally to human patients
FR2745814B1 (fr) *	1996-03-06	1998-04-03	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
WO1998013359A1 (de) *	1996-09-24	1998-04-02	Marigen S.A.	Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
US5773464A (en) *	1996-09-30	1998-06-30	Bristol-Myers Squibb Company	C-10 epoxy taxanes
US5977386A (en) *	1996-12-24	1999-11-02	Bristol-Myers Squibb Company	6-thio-substituted paclitaxels
US5902822A (en) *	1997-02-28	1999-05-11	Bristol-Myers Squibb Company	7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US5912264A (en) *	1997-03-03	1999-06-15	Bristol-Myers Squibb Company	6-halo-or nitrate-substituted paclitaxels
US6017935A (en) *	1997-04-24	2000-01-25	Bristol-Myers Squibb Company	7-sulfur substituted paclitaxels
CZ9904244A3 (cs) *	1997-05-27	2001-10-17	Baker Norton Pharmaceuticals, Inc.	Pouľití taxanů, jejich derivátů, analogů nebo předléků pro přípravu farmaceutického prostředku pro perorální podávání
IT1308636B1 (it) *	1999-03-02	2002-01-09	Indena Spa	Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
EP2266607A3 (en)	1999-10-01	2011-04-20	Immunogen, Inc.	Immunoconjugates for treating cancer
IT1317731B1 (it) *	2000-01-18	2003-07-15	Indena Spa	Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
US6649632B2 (en) *	2000-02-02	2003-11-18	Fsu Research Foundation, Inc.	C10 ester substituted taxanes
EP1129991A1 (de) *	2000-03-02	2001-09-05	Degussa AG	Verfahren zur Herstellung eines titanhaltigen Zeolithen
US7064980B2 (en) *	2003-09-17	2006-06-20	Sandisk Corporation	Non-volatile memory and method with bit line coupled compensation
PE20050693A1 (es) *	2004-02-13	2005-09-27	Univ Florida State Res Found	Taxanos sustituidos con esteres de ciclopentilo en c10
US20060189679A1 (en) *	2005-02-14	2006-08-24	Florida State University Research Foundation, Inc.	C10 cyclopropyl ester substituted taxane compositions
ITMI20050415A1 (it) *	2005-03-15	2006-09-16	Indena Spa	Derivati tassanici semi-sintetici ad attivita' antitumorale
ITMI20062479A1 (it) *	2006-12-21	2008-06-22	Indena Spa	Processo per la preparazione di secotassani
EP2183234A4 (en) *	2007-08-22	2012-02-29	Canada Inc 6570763	PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III IN DOCETAXEL OR PACLITAXEL
JP2011517455A (ja) *	2008-03-31	2011-06-09	フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド	Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン
EP2331140B1 (en)	2008-08-11	2018-07-04	Nektar Therapeutics	Multi-arm polymeric alkanoate conjugates
US20130338216A1 (en) *	2010-12-22	2013-12-19	Nektar Therapeutics	Deuterated and/or fluorinated taxane derivatives
WO2012088422A1 (en)	2010-12-22	2012-06-28	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012088391A1 (en) *	2010-12-22	2012-06-28	Nektar Therapeutics	Non-ring hydroxy substituted taxanes and methods for synthesizing the same
WO2012088445A1 (en)	2010-12-22	2012-06-28	Nektar Therapeutics	Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
WO1993002067A1 (fr) *	1991-07-17	1993-02-04	Nippon Steel Corporation	Compose antitumoral nsc-lsc1 et son procede de production
US5399726A (en) *	1993-01-29	1995-03-21	Florida State University	Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
FR2688499B1 (fr) *	1992-03-10	1994-05-06	Rhone Poulenc Rorer Sa	Procede de preparation de la beta-phenylisoserine et de ses analogues.
US5200534A (en) *	1992-03-13	1993-04-06	University Of Florida	Process for the preparation of taxol and 10-deacetyltaxol

1995
- 1995-07-21 DE DE69507702T patent/DE69507702T2/de not_active Expired - Lifetime
- 1995-07-21 DK DK95927699T patent/DK0773938T3/da active
- 1995-07-21 SI SI9520078A patent/SI9520078B/sl not_active IP Right Cessation
- 1995-07-21 RU RU97102722A patent/RU2134688C1/ru not_active IP Right Cessation
- 1995-07-21 CN CN95194333A patent/CN1073105C/zh not_active Expired - Fee Related
- 1995-07-21 CZ CZ1997199A patent/CZ293076B6/cs not_active IP Right Cessation
- 1995-07-21 AU AU31641/95A patent/AU684218B2/en not_active Ceased
- 1995-07-21 AT AT95927699T patent/ATE176464T1/de active
- 1995-07-21 CA CA002195844A patent/CA2195844C/en not_active Expired - Fee Related
- 1995-07-21 KR KR1019970700442A patent/KR100220490B1/ko not_active IP Right Cessation
- 1995-07-21 RO ROA200000502A patent/RO116549B1/ro unknown
- 1995-07-21 SK SK100-97A patent/SK281526B6/sk not_active IP Right Cessation
- 1995-07-21 WO PCT/EP1995/002896 patent/WO1996003394A1/en active IP Right Grant
- 1995-07-21 ES ES95927699T patent/ES2126919T3/es not_active Expired - Lifetime
- 1995-07-21 RO RO97-00125A patent/RO115875B1/ro unknown
- 1995-07-21 HU HU9700206A patent/HU222496B1/hu not_active IP Right Cessation
- 1995-07-21 EP EP95927699A patent/EP0773938B1/en not_active Expired - Lifetime
- 1995-07-21 JP JP8505456A patent/JP2986550B2/ja not_active Ceased
- 1995-07-21 PL PL95318289A patent/PL187579B1/pl not_active IP Right Cessation
- 1995-07-24 US US08/505,924 patent/US5756776A/en not_active Expired - Lifetime
1997
- 1997-01-23 BG BG101165A patent/BG62851B1/bg unknown
- 1997-01-23 NO NO19970296A patent/NO315116B1/no not_active IP Right Cessation
- 1997-01-23 FI FI970271A patent/FI120398B/fi not_active IP Right Cessation
1998
- 1998-12-07 HK HK98112903A patent/HK1011687A1/xx not_active IP Right Cessation
1999
- 1999-02-09 GR GR990400393T patent/GR3029309T3/el unknown
2000
- 2000-09-29 CN CN00129056A patent/CN1128795C/zh not_active Expired - Fee Related
- 2000-09-29 CN CN00129054A patent/CN1120161C/zh not_active Expired - Fee Related
- 2000-09-29 CN CN00129055A patent/CN1130356C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE176464T1 (de)	1999-02-15
HU222496B1 (hu)	2003-07-28
NO315116B1 (no)	2003-07-14
NO970296D0 (no)	1997-01-23
DK0773938T3 (da)	1999-09-20
HK1011687A1 (en)	1999-07-16
AU3164195A (en)	1996-02-22
RU2134688C1 (ru)	1999-08-20
SK281526B6 (sk)	2001-04-09
CN1332163A (zh)	2002-01-23
PL187579B1 (pl)	2004-08-31
ES2126919T3 (es)	1999-04-01
CZ19997A3 (en)	1997-07-16
HUT76829A (en)	1997-11-28
DE69507702T2 (de)	1999-08-26
BG62851B1 (bg)	2000-09-29
WO1996003394A1 (en)	1996-02-08
US5756776A (en)	1998-05-26
JP2986550B2 (ja)	1999-12-06
CA2195844C (en)	2001-10-09
AU684218B2 (en)	1997-12-04
SI9520078B (sl)	1998-12-31
FI970271A0 (fi)	1997-01-23
EP0773938A1 (en)	1997-05-21
JPH09512827A (ja)	1997-12-22
GR3029309T3 (en)	1999-05-28
RO116549B1 (ro)	2001-03-30
CN1128795C (zh)	2003-11-26
CZ293076B6 (cs)	2004-02-18
SI9520078A (en)	1997-06-30
CN1308073A (zh)	2001-08-15
KR100220490B1 (ko)	1999-09-15
SK10097A3 (en)	1997-08-06
CN1073105C (zh)	2001-10-17
EP0773938B1 (en)	1999-02-03
CN1308072A (zh)	2001-08-15
PL318289A1 (en)	1997-06-09
FI120398B (fi)	2009-10-15
RO115875B1 (ro)	2000-07-28
DE69507702D1 (de)	1999-03-18
CN1120161C (zh)	2003-09-03
CA2195844A1 (en)	1996-02-08
CN1130356C (zh)	2003-12-10
FI970271A (fi)	1997-03-19
CN1154109A (zh)	1997-07-09
BG101165A (en)	1997-08-29

Legal Events

Date	Code	Title	Description
2013-03-11	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO970296D0 (no)	1997-01-23	Semi-syntetiske taksaner med anti-tumoral aktivitet
ITMI920528A1 (it)	1993-09-06	14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
FI950207A (fi)	1995-01-18	Taksaani, jolla on kasvaimenvastaista vaikutusta
ATE334115T1 (de)	2006-08-15	Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte
MX9307644A (es)	1994-06-30	Medicamento que incluye 2-amino-6-n-propil-amino-4,5, 6, 7,-tetrahidrobenzotiazol con efecto antidepresivo.
RU93004623A (ru)	1996-03-20	Производные таксана iii, способы их получения
ATE295363T1 (de)	2005-05-15	Beta-laktame zur herstellung von taxanen mit furyl oder thienyl substituierter seitenkette
IT1275936B1 (it)	1997-10-24	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
BR0014687A (pt)	2002-11-19	Compostos de taxano pentacìclico
IT1274356B (it)	1997-07-17	Tassani semisintetici odtati di attivita' antitumorale
IT1278108B1 (it)	1997-11-17	Secotassani dotati di attivita' antitumorale.
FR2693193B1 (fr)	1994-09-02	Nouveaux dérivés de la désacétyl-10 baccatine III, leur préparation et les compositions pharmaceutiques qui les contiennent.
CA2558908A1 (en)	1996-09-26	10-deacetylbaccatine iii and 10-deacetyl 14.beta.-hydroxybaccatine iii derivatives and intermediates useful in the preparation thereof