NO963984L - New, 1,4-disubstituted piperidine derivatives useful as drugs acting on glutamate receptors - Google Patents
New, 1,4-disubstituted piperidine derivatives useful as drugs acting on glutamate receptorsInfo
- Publication number
- NO963984L NO963984L NO963984A NO963984A NO963984L NO 963984 L NO963984 L NO 963984L NO 963984 A NO963984 A NO 963984A NO 963984 A NO963984 A NO 963984A NO 963984 L NO963984 L NO 963984L
- Authority
- NO
- Norway
- Prior art keywords
- new
- glutamate receptors
- derivatives useful
- piperidine derivatives
- drugs acting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Det beskrives forbindelser med formel- I R1¿Z¿X¿N 0), så vel som fremstilling av dem og anvendelse av dem i legemidler.Compounds of formula I are described, as well as their preparation and use in pharmaceuticals.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4410822A DE4410822A1 (en) | 1994-03-24 | 1994-03-24 | New piperidine derivatives |
PCT/DE1995/000442 WO1995025721A1 (en) | 1994-03-24 | 1995-03-23 | New 1,4-disubstituted piperidine derivatives useful as medicaments acting on the glutamate receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
NO963984D0 NO963984D0 (en) | 1996-09-23 |
NO963984L true NO963984L (en) | 1996-09-23 |
Family
ID=6514110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO963984A NO963984L (en) | 1994-03-24 | 1996-09-23 | New, 1,4-disubstituted piperidine derivatives useful as drugs acting on glutamate receptors |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0751936A1 (en) |
JP (1) | JPH09510460A (en) |
KR (1) | KR970701695A (en) |
CN (1) | CN1145618A (en) |
AU (1) | AU2212595A (en) |
CA (1) | CA2186010A1 (en) |
CZ (1) | CZ277096A3 (en) |
DE (1) | DE4410822A1 (en) |
FI (1) | FI963786A (en) |
HU (1) | HUT75653A (en) |
IL (1) | IL113103A0 (en) |
NO (1) | NO963984L (en) |
PL (1) | PL316382A1 (en) |
SK (1) | SK120196A3 (en) |
WO (1) | WO1995025721A1 (en) |
ZA (1) | ZA952431B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9610736B (en) | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
PT885004E (en) * | 1996-03-08 | 2002-08-30 | Hoffmann La Roche | USING 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS BLOCKERS OF NMDA RECEPTOR SUBTYPES |
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
US5824662A (en) | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
EP1005348A1 (en) | 1996-09-27 | 2000-06-07 | Guilford Pharmaceuticals Inc. | Naaladase compositions and methods for treating glutamate abnormality and effecting neuronal activity in animals |
US6242450B1 (en) * | 1998-07-27 | 2001-06-05 | Eli Lilly And Company | 5-HT1F antagonists |
ATE266400T1 (en) * | 1998-07-31 | 2004-05-15 | Lilly Co Eli | HETEROCYCLYL SULPHONAMIDE DERIVATIVES |
EP1190710A4 (en) * | 1999-05-13 | 2003-04-02 | Shionogi & Co | Preventive or therapeutic drugs for diabetes |
TWI254043B (en) * | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
DK1136475T3 (en) | 2000-03-22 | 2004-12-27 | Hoffmann La Roche | Piperidine and piperazine derivatives for use in the treatment of Alzheimer's |
US6407235B1 (en) | 2000-08-21 | 2002-06-18 | Hoffmann-La Roche Inc. | Prodrug acid esters of [2-(4-benzyl-3-hydroxy-piperidin-1-yl)-ethansulfonyl]phenol |
US6770659B2 (en) | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
GB0224084D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
EP4092013A1 (en) | 2017-06-20 | 2022-11-23 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
CN110437136A (en) * | 2019-07-30 | 2019-11-12 | 东南大学 | 1- virtue oxygen ethyl piperidine -4- base methanone derivatives and its preparation method and application |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
DE2827566A1 (en) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1,2-DIHYDRO-CHINOLIN-2-ON DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
WO1982003861A1 (en) * | 1981-05-08 | 1982-11-11 | Tominaga Michiaki | Aniline derivatives,process for their preparation,and cardiotonics |
PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
FR2534580A1 (en) * | 1982-10-13 | 1984-04-20 | Synthelabo | PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM |
DK623586A (en) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | PIPERIDE INGREDIENTS OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS |
US4868181A (en) * | 1986-08-04 | 1989-09-19 | E. I. Du Pont De Nemours And Company | 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity |
KR910006138B1 (en) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | Cyclic amine derivatives |
EP0294183B1 (en) * | 1987-06-02 | 1994-03-30 | Ajinomoto Co., Inc. | Use of ethylamine derivatives as antihypertensive agents |
EP0424525B1 (en) * | 1987-12-11 | 1994-12-21 | Mitsui Petrochemical Industries, Ltd. | Novel amines and their use |
SU1731048A3 (en) * | 1988-05-27 | 1992-04-30 | Эйсай Ко., Лтд (Фирма) | Process for preparing piperidine derivatives of pharmacolocically acceptable salts thereof |
FR2632641B1 (en) * | 1988-06-13 | 1990-10-12 | Irceba | ((ARYL-4-PIPERAZINYL-1) -2 ETHOXY) -3 P-CYMENE, ORTHO DERIVATIVES, META, PARA MONOSUBSTITUTED OR DISUBSTITUTED ON THE PHENYL CORE OF THIS PRODUCT, THE PROCESS FOR THE PREPARATION OF SUCH DERIVATIVES, AND THE MEDICINAL PRODUCTS AS ACTIVE PRINCIPLE |
US5153198A (en) * | 1989-03-15 | 1992-10-06 | Santen Pharmaceutical Co., Ltd. | Agent for treatment of disorders of the cerebro-neural transmission system |
US5116846A (en) * | 1990-03-28 | 1992-05-26 | Du Pont Merck Pharmaceutical Company | N-aralkyl piperidine derivatives as psychotropic drugs |
FR2681319B1 (en) * | 1991-09-12 | 1995-02-17 | Synthelabo | 1- (PHENOXYALKYL) PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
ES2060547B1 (en) * | 1992-06-04 | 1995-06-16 | Ferrer Int | IMPROVEMENTS IN THE PURPOSE OF THE INVENTION PATENT N / 9201158 THAT REFERS TO "PROCEDURE FOR OBTAINING NEW DERIVATIVES OF 4-BENCILPIPERIDINE". |
FR2705343B1 (en) * | 1993-05-17 | 1995-07-21 | Fournier Ind & Sante | Beta, beta-dimethyl-4-piperidineethanamine derivatives, process for their preparation and their use in therapy. |
-
1994
- 1994-03-24 DE DE4410822A patent/DE4410822A1/en not_active Withdrawn
-
1995
- 1995-03-23 EP EP95915116A patent/EP0751936A1/en not_active Withdrawn
- 1995-03-23 CA CA002186010A patent/CA2186010A1/en not_active Abandoned
- 1995-03-23 SK SK1201-96A patent/SK120196A3/en unknown
- 1995-03-23 HU HU9602607A patent/HUT75653A/en unknown
- 1995-03-23 PL PL95316382A patent/PL316382A1/en unknown
- 1995-03-23 AU AU22125/95A patent/AU2212595A/en not_active Abandoned
- 1995-03-23 WO PCT/DE1995/000442 patent/WO1995025721A1/en not_active Application Discontinuation
- 1995-03-23 IL IL11310395A patent/IL113103A0/en unknown
- 1995-03-23 KR KR1019960705269A patent/KR970701695A/en not_active Application Discontinuation
- 1995-03-23 CZ CZ962770A patent/CZ277096A3/en unknown
- 1995-03-23 JP JP7524306A patent/JPH09510460A/en active Pending
- 1995-03-23 CN CN95192230A patent/CN1145618A/en active Pending
- 1995-03-25 ZA ZA952431A patent/ZA952431B/en unknown
-
1996
- 1996-09-23 NO NO963984A patent/NO963984L/en unknown
- 1996-09-23 FI FI963786A patent/FI963786A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1995025721A1 (en) | 1995-09-28 |
DE4410822A1 (en) | 1995-09-28 |
EP0751936A1 (en) | 1997-01-08 |
AU2212595A (en) | 1995-10-09 |
KR970701695A (en) | 1997-04-12 |
HU9602607D0 (en) | 1996-11-28 |
NO963984D0 (en) | 1996-09-23 |
SK120196A3 (en) | 1997-10-08 |
CA2186010A1 (en) | 1995-09-28 |
FI963786A0 (en) | 1996-09-23 |
CN1145618A (en) | 1997-03-19 |
CZ277096A3 (en) | 1997-01-15 |
IL113103A0 (en) | 1995-06-29 |
HUT75653A (en) | 1997-05-28 |
ZA952431B (en) | 1995-12-19 |
JPH09510460A (en) | 1997-10-21 |
MX9604201A (en) | 1997-12-31 |
PL316382A1 (en) | 1997-01-06 |
FI963786A (en) | 1996-09-23 |
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