NO961655L - Visse sammensmeltede pyrrolkarboksanilider; en ny klasse GABA-hjernereseptorligander - Google Patents

Visse sammensmeltede pyrrolkarboksanilider; en ny klasse GABA-hjernereseptorligander

Info

Publication number: NO961655L
Authority: NO; Norway
Prior art keywords: straight; carbon atoms; branched chain; chain lower; lower alkyl
Prior art date: 1993-10-27

Application number

NO961655A

Other languages

English (en)

Other versions

NO306399B1 (no

NO961655D0 (no

Inventor

Pamela Albaugh

Alan Hutchison

Original Assignee

Neurogen Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-27

Filing date

1996-04-25

Publication date

1996-06-10

1996-04-25 Application filed by Neurogen Corp filed Critical Neurogen Corp

1996-04-25 Publication of NO961655D0 publication Critical patent/NO961655D0/no

1996-06-10 Publication of NO961655L publication Critical patent/NO961655L/no

1999-11-01 Publication of NO306399B1 publication Critical patent/NO306399B1/no

Links

210000004556 brain Anatomy 0.000 title 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
MZPAQCAPWLAKSD-UHFFFAOYSA-N n-phenyl-1h-pyrrole-2-carboxamide Chemical class C=1C=CNC=1C(=O)NC1=CC=CC=C1 MZPAQCAPWLAKSD-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 27
125000004432 carbon atom Chemical group C* 0.000 abstract 23
229910052739 hydrogen Inorganic materials 0.000 abstract 13
239000001257 hydrogen Chemical group 0.000 abstract 13
150000002431 hydrogen Chemical group 0.000 abstract 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 7
-1 3,4-methylenedioxy Chemical group 0.000 abstract 7
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 7
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 7
125000003884 phenylalkyl group Chemical group 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 5
150000002367 halogens Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000005936 piperidyl group Chemical group 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
101150047265 COR2 gene Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
101100467189 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) QCR2 gene Proteins 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001721 carbon Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Toxicology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Multicomponent Fibers (AREA)
Compositions Of Macromolecular Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO961655A 1993-10-27 1996-04-25 Kondenserte pyrrolkarboksyanilider NO306399B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/144,138 US5484944A (en)	1993-10-27	1993-10-27	Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
PCT/US1994/012300 WO1995011885A1 (en)	1993-10-27	1994-10-26	Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands

Publications (3)

Publication Number	Publication Date
NO961655D0 NO961655D0 (no)	1996-04-25
NO961655L true NO961655L (no)	1996-06-10
NO306399B1 NO306399B1 (no)	1999-11-01

Family

ID=22507244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO961655A NO306399B1 (no)	1993-10-27	1996-04-25	Kondenserte pyrrolkarboksyanilider

Country Status (21)

Country	Link
US (2)	US5484944A (no)
EP (2)	EP0725775B1 (no)
JP (1)	JP3542356B2 (no)
KR (1)	KR0181383B1 (no)
CN (1)	CN1099413C (no)
AT (1)	ATE168673T1 (no)
AU (1)	AU701151B2 (no)
CA (1)	CA2175204C (no)
CZ (1)	CZ288027B6 (no)
DE (1)	DE69411939T2 (no)
DK (1)	DK0725775T3 (no)
ES (1)	ES2122504T3 (no)
FI (1)	FI961776A (no)
HU (1)	HU219715B (no)
NO (1)	NO306399B1 (no)
NZ (2)	NZ275968A (no)
PL (1)	PL180027B1 (no)
RU (2)	RU2125989C1 (no)
SE (2)	SE9601563L (no)
SK (2)	SK282994B6 (no)
WO (1)	WO1995011885A1 (no)

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US5750702A (en) *	1993-10-27	1998-05-12	Neurogen Corporation	Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
WO1996039404A1 (en) *	1995-06-05	1996-12-12	Neurogen Corporation	Novel substituted aryl and cycloalkyl imidazolones; a new class of gaba brain receptor ligands
US5804686A (en) *	1996-01-19	1998-09-08	Neurogen Corporation	fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US6211365B1 (en)	1996-01-19	2001-04-03	Neurogen Corporation	Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
AU2218997A (en) *	1996-03-22	1997-10-10	Neurogen Corporation	Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) *	1996-04-26	1998-03-03	Neurogen Corporation	Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
GB9622370D0 (en)	1996-10-28	1997-01-08	Merck Sharp & Dohme	Therapeutic agents
GT199800179A (es) *	1997-11-13	2000-05-02		Procedimiento de sintesis de pirrol amidas.
CN1508129A (zh)	1997-11-13	2004-06-30	�Ʒ�	吡咯酰胺的合成方法
WO1999041239A1 (en) *	1998-02-10	1999-08-19	Novartis Ag	B cell inhibitors
AU2879799A (en) *	1998-02-26	1999-09-15	Neurogen Corporation	4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands
GB9812038D0 (en)	1998-06-04	1998-07-29	Merck Sharp & Dohme	Therapeutic compound
GB9900222D0 (en)	1999-01-06	1999-02-24	Merck Sharp & Dohme	Therapeutic compounds
AU4038000A (en)	1999-03-29	2000-10-16	Neurogen Corporation	4-substituted quinoline derivatives as gaba receptor ligands
US20050014939A1 (en) *	1999-08-31	2005-01-20	Neurogen Corporation	Fused pyrrolecarboxamides: GABA brain receptor ligands
CZ2002614A3 (cs) *	1999-08-31	2002-08-14	Neurogen Corporation	Kondenzované pyrrolkarboxamidy jako ligandy mozkových GABA-receptorů
US6310212B1 (en)	2000-03-28	2001-10-30	Neurogen Corporation	4-substituted quinoline derivatives
US6528649B2 (en) *	2000-05-30	2003-03-04	Neurogen Corporation	Imidazoloisoquinolines
US7112594B2 (en)	2000-08-09	2006-09-26	Mitsubishi Pharma Corporation	Fused bicyclic amide compounds and medicinal use thereof
US6861529B2 (en) *	2001-07-06	2005-03-01	Pfizer Inc	Cycloalkypyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives
EP1472252A1 (en) *	2002-02-07	2004-11-03	Neurogen Corporation	Substituted fused pyrazolecarboxylic acid arylamides and related compounds
ES2528195T3 (es)	2003-04-11	2015-02-05	Ptc Therapeutics, Inc.	Compuestos de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
ES2349310T3 (es)	2005-07-28	2010-12-29	F. Hoffmann-La Roche Ag	Derivados de ácido 2-hidroxi-propiónico y derivados de 3 hidroxi-benzofuran-2-ona con afinidad para el receptor gaba-b.
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
CN101263139A (zh)	2005-09-19	2008-09-10	弗·哈夫曼-拉罗切有限公司	作为GABA Aα5逆激动剂的异唑衍生物
AU2006304787A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) *	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
AU2007223036A1 (en) *	2006-03-08	2007-09-13	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
EP2007365A2 (en) *	2006-03-30	2008-12-31	PTC Therapeutics, Inc.	Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
US20100009983A1 (en) *	2006-05-09	2010-01-14	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2021000A2 (en)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenesis by modulating angiotensin
EP2026813A2 (en) *	2006-05-09	2009-02-25	Braincells, Inc.	5 ht receptor mediated neurogenesis
JP2010502722A (ja) *	2006-09-08	2010-01-28	ブレインセルス，インコーポレイティド	４−アシルアミノピリジン誘導体を含む組み合わせ
CA2663347A1 (en) *	2006-09-19	2008-03-27	Braincells, Inc.	Ppar mediated modulation of neurogenesis
WO2008046135A1 (en)	2006-10-16	2008-04-24	Bionomics Limited	Novel anxiolytic compounds
US10954231B2 (en)	2006-10-16	2021-03-23	Bionomics Limited	Anxiolytic compounds
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
WO2012116415A1 (en)	2011-03-02	2012-09-07	Bionomics Limited	Novel small-molecules as therapeutics
US9133188B2 (en)	2011-05-12	2015-09-15	Bionomics Limited	Methods for preparing naphthyridines
EP3113619A4 (en)	2014-03-06	2017-09-13	PTC Therapeutics, Inc.	Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
MX2018005361A (es)	2015-10-30	2018-06-07	Ptc Therapeutics Inc	Metodos para tratar epilepsia.

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US5243049A (en) *	1992-01-22	1993-09-07	Neurogen Corporation	Certain pyrroloquinolinones: a new class of GABA brain receptor ligands

1993
- 1993-10-27 US US08/144,138 patent/US5484944A/en not_active Expired - Lifetime
1994
- 1994-10-26 WO PCT/US1994/012300 patent/WO1995011885A1/en active IP Right Grant
- 1994-10-26 KR KR1019960702266A patent/KR0181383B1/ko not_active IP Right Cessation
- 1994-10-26 AT AT95900440T patent/ATE168673T1/de not_active IP Right Cessation
- 1994-10-26 CN CN94194657A patent/CN1099413C/zh not_active Expired - Fee Related
- 1994-10-26 SK SK290-2001A patent/SK282994B6/sk unknown
- 1994-10-26 EP EP95900440A patent/EP0725775B1/en not_active Expired - Lifetime
- 1994-10-26 PL PL94314136A patent/PL180027B1/pl not_active IP Right Cessation
- 1994-10-26 RU RU96110289/04A patent/RU2125989C1/ru not_active IP Right Cessation
- 1994-10-26 JP JP51280795A patent/JP3542356B2/ja not_active Expired - Fee Related
- 1994-10-26 RU RU98115589/04A patent/RU2157367C2/ru not_active IP Right Cessation
- 1994-10-26 SK SK524-96A patent/SK282817B6/sk unknown
- 1994-10-26 AU AU81265/94A patent/AU701151B2/en not_active Ceased
- 1994-10-26 ES ES95900440T patent/ES2122504T3/es not_active Expired - Lifetime
- 1994-10-26 CA CA002175204A patent/CA2175204C/en not_active Expired - Fee Related
- 1994-10-26 EP EP97117241A patent/EP0825193A1/en not_active Ceased
- 1994-10-26 NZ NZ275968A patent/NZ275968A/en unknown
- 1994-10-26 HU HU9601106A patent/HU219715B/hu not_active IP Right Cessation
- 1994-10-26 DK DK95900440T patent/DK0725775T3/da active
- 1994-10-26 DE DE69411939T patent/DE69411939T2/de not_active Expired - Fee Related
- 1994-10-26 NZ NZ330023A patent/NZ330023A/xx unknown
- 1994-10-26 CZ CZ19961129A patent/CZ288027B6/cs not_active IP Right Cessation
1995
- 1995-06-07 US US08/473,509 patent/US5608079A/en not_active Expired - Fee Related
1996
- 1996-04-24 SE SE9601563A patent/SE9601563L/xx unknown
- 1996-04-25 FI FI961776A patent/FI961776A/fi unknown
- 1996-04-25 NO NO961655A patent/NO306399B1/no not_active IP Right Cessation
1999
- 1999-07-09 SE SE9902648A patent/SE9902648L/xx unknown

Also Published As

Publication number	Publication date
NO306399B1 (no)	1999-11-01
CN1143953A (zh)	1997-02-26
SE9601563L (sv)	1996-05-22
SE9902648D0 (sv)	1999-07-09
NZ330023A (en)	1999-11-29
RU2157367C2 (ru)	2000-10-10
PL180027B1 (pl)	2000-12-29
US5484944A (en)	1996-01-16
EP0725775A1 (en)	1996-08-14
DK0725775T3 (da)	1999-04-26
JP3542356B2 (ja)	2004-07-14
RU2125989C1 (ru)	1999-02-10
ES2122504T3 (es)	1998-12-16
SK52496A3 (en)	1997-07-09
ATE168673T1 (de)	1998-08-15
EP0825193A1 (en)	1998-02-25
DE69411939T2 (de)	1999-03-25
SE9902648L (sv)	1999-07-09
AU701151B2 (en)	1999-01-21
EP0725775B1 (en)	1998-07-22
HU219715B (hu)	2001-06-28
DE69411939D1 (de)	1998-08-27
SK282994B6 (sk)	2003-01-09
SK282817B6 (sk)	2002-12-03
SE9601563D0 (sv)	1996-04-24
WO1995011885A1 (en)	1995-05-04
PL314136A1 (en)	1996-08-19
CA2175204A1 (en)	1995-05-11
CZ112996A3 (en)	1997-04-16
NO961655D0 (no)	1996-04-25
FI961776A0 (fi)	1996-04-25
CN1099413C (zh)	2003-01-22
NZ275968A (en)	1998-05-27
CZ288027B6 (cs)	2001-04-11
HU9601106D0 (en)	1996-07-29
AU8126594A (en)	1995-05-22
KR960705812A (ko)	1996-11-08
JPH09506082A (ja)	1997-06-17
HUT76064A (en)	1997-06-30
KR0181383B1 (ko)	1999-03-20
FI961776A (fi)	1996-06-14
US5608079A (en)	1997-03-04
CA2175204C (en)	1999-10-05

Legal Events

Date	Code	Title	Description
2004-10-11	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO961655D0 (no)	1996-04-25	Visse sammensmeltede pyrrolkarboksanilider; en ny klasse GABA-hjernereseptorligander
CO4900050A1 (es)	2000-03-27	Pirrolcarboxanilidas fusionadas; una nueva clase de ligan- dos receptores cerebrales de gaba
CO4970780A1 (es)	2000-11-07	Nuevos compuestos heterociclicos de piridazina
DE60129210D1 (de)	2007-08-16	Zyklische amid-derivate
NZ512731A (en)	2004-01-30	Tricyclic inhibitors of poly(ADP-ribose) polymerases
FI972460A0 (fi)	1997-06-10	Aniliinijohdannaiset joilla on typpimonoksidisyntaasiesto aktiivisuus
DK0637586T3 (da)	1999-12-06	2-(Piperidin-4-yl, pyridin-4-yl og tetrahydropyridin-4-yl)-benzofuran-7-carbamatderivater, deres fremstilling og anvendelse
EA200000614A1 (ru)	2001-02-26	2,3-замещенные соединения индола в качестве ингибиторов сох-2
NO954576D0 (no)	1995-11-13	AMPA antagonister og en fremgangsmåte til behandling med dem
ATE128463T1 (de)	1995-10-15	Piperidin und pyrrolidin derivate.
HRP20000508B1 (en)	2007-02-28	Substituted 2-benzylamino-2-phenyl-acetamide compounds
HUP0001165A2 (hu)	2000-11-28	NK1 és NK2 antagonista hatású acil-amino-alkil-amid-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra
DE69528189D1 (de)	2002-10-17	Diazepinoindole inhibitoren von phosphodiesterase iv
HUP0000768A2 (hu)	2001-05-28	Szubsztituált benzo[1,4]dioxánok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
ATE500241T1 (de)	2011-03-15	Phenyl- und pyridyl-piperidine mit tnf-wirkung
BR9812928A (pt)	2000-08-08	Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica
DK1140919T3 (da)	2002-12-30	1,4-Disubstituerede cyclohexanderivater til behandling af depression
ECSP951529A (es)	1997-05-16	Compuestos farmaceuticos
YU28701A (sh)	2003-12-31	N-(2-(heteroaril)etil)-3-fenilpiperidini, n-(2-(heteroaril) etil)-4-fenilpiperidin i srodna jedinjenja sa supstituentom u položaju 4 piperidinskog prstena