NO960268L - New dialkoxypyridinylbenzimidazole derivatives - Google Patents

New dialkoxypyridinylbenzimidazole derivatives

Info

Publication number
NO960268L
NO960268L NO960268A NO960268A NO960268L NO 960268 L NO960268 L NO 960268L NO 960268 A NO960268 A NO 960268A NO 960268 A NO960268 A NO 960268A NO 960268 L NO960268 L NO 960268L
Authority
NO
Norway
Prior art keywords
compounds
methyl
new
dialkoxypyridinylbenzimidazole
derivatives
Prior art date
Application number
NO960268A
Other languages
Norwegian (no)
Other versions
NO960268D0 (en
Inventor
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Per Oskar Sverker Von Unge
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO960268L publication Critical patent/NO960268L/en
Publication of NO960268D0 publication Critical patent/NO960268D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye optisk rene forbindelser, dvs de enantiomere enkeltforbindelsene (+)-5- karbometoksy-6-metyl-2-[[(3,4-dimetoksy-2-pyridinyl)metyl]sulfmyl]-l-[mandel- oyloksymetyl]-! H-benzimidazol og (-)-5-karbometoksy-6-metyl-2-[[(3,4-dimetoksy-2- pyridinyl)metyl]sulfinyl]-1 -[mandeloyloksymetyl]-1 H-benzimidazol eller et terapeutisk akseptabelt salt derav, slik som Na+, Mg2+, Li+, K+, Ca2+og N+(R)4 salter, hvor R er en alkylgruppe med 1-4 karbonatomer, fremgangsmåter for fremstilling derav og farma- søytiske preparater inneholdende forbindelsene som aktive bestanddeler, anvendelse av forbindelsene i farmasøytiske preparater samt mellomprodukter oppnådd ved frem- ' stilling av forbindelsene.New optically pure compounds, i.e. the enantiomeric single compounds (+) - 5-carbomethoxy-6-methyl-2 - [[(3,4-dimethoxy-2-pyridinyl) methyl] sulfmyl] -1- [almond oyloxymethyl] -! H-benzimidazole and (-) - 5-carbomethoxy-6-methyl-2 - [[(3,4-dimethoxy-2-pyridinyl) methyl] sulfinyl] -1 - [mandeloyloxymethyl] -1H-benzimidazole or a therapeutically acceptable salts thereof, such as Na +, Mg 2+, Li +, K +, Ca 2+ and N + (R) 4 salts, wherein R is an alkyl group of 1-4 carbon atoms, processes for their preparation and pharmaceutical preparations containing the compounds as active ingredients, use of the compounds in pharmaceutical preparations as well as intermediates obtained by the preparation of the compounds.

NO960268A 1994-05-27 1996-01-23 New dialkoxypyridinylbenzimidazole derivatives NO960268D0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25617194A 1994-05-27 1994-05-27
SE9400511 1994-05-27
PCT/SE1995/000519 WO1995032959A1 (en) 1994-05-27 1995-05-11 Novel dialkoxy-pyridinyl-benzimidazole derivatives

Publications (2)

Publication Number Publication Date
NO960268L true NO960268L (en) 1996-01-23
NO960268D0 NO960268D0 (en) 1996-01-23

Family

ID=20392945

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960268A NO960268D0 (en) 1994-05-27 1996-01-23 New dialkoxypyridinylbenzimidazole derivatives

Country Status (18)

Country Link
EP (1) EP0712401A1 (en)
JP (1) JPH09504557A (en)
CN (1) CN1128997A (en)
AU (1) AU2633095A (en)
BR (1) BR9506235A (en)
CA (1) CA2166988A1 (en)
CZ (1) CZ24396A3 (en)
EE (1) EE9600011A (en)
FI (1) FI960367A0 (en)
HU (1) HU9600005D0 (en)
IL (1) IL113604A0 (en)
IS (1) IS4321A (en)
MA (1) MA23563A1 (en)
NO (1) NO960268D0 (en)
PL (1) PL312692A1 (en)
TN (1) TNSN95062A1 (en)
WO (1) WO1995032959A1 (en)
ZA (1) ZA954125B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
KR100619200B1 (en) 1998-11-18 2006-09-05 아스트라제네카 아베 Improved Chemical Process and Pharmaceutical Formulation
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
AU2009215514B9 (en) 2008-02-20 2014-01-30 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
AU2009290712A1 (en) 2008-09-09 2010-03-18 Astrazeneca Ab Method for delivering a pharmaceutical composition to patient in need thereof
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
CA2860231A1 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2083606C (en) * 1990-06-20 2001-08-21 Arne Elof Brandstrom Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
DE4035455A1 (en) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab ENANTIOMER SEPARATION

Also Published As

Publication number Publication date
FI960367A (en) 1996-01-26
BR9506235A (en) 1997-08-12
CZ24396A3 (en) 1996-06-12
CA2166988A1 (en) 1995-12-07
WO1995032959A1 (en) 1995-12-07
IL113604A0 (en) 1995-08-31
EE9600011A (en) 1996-04-15
FI960367A0 (en) 1996-01-26
ZA954125B (en) 1995-11-27
CN1128997A (en) 1996-08-14
AU2633095A (en) 1995-12-21
HU9600005D0 (en) 1996-03-28
IS4321A (en) 1996-01-17
MA23563A1 (en) 1995-12-31
PL312692A1 (en) 1996-05-13
EP0712401A1 (en) 1996-05-22
JPH09504557A (en) 1997-05-06
NO960268D0 (en) 1996-01-23
TNSN95062A1 (en) 1996-02-06

Similar Documents

Publication Publication Date Title
MY121192A (en) New compounds.
NO960268L (en) New dialkoxypyridinylbenzimidazole derivatives
NO160204C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE ALKALISTS OF 5-METOXY-2 (((4-METOXY-3,5-DIMETHYL-2-PYRIDINYL) -METHYL) -SULPHINYL) -1H-BENZIMIDAZOLE.
FI872864A0 (en) Process for the preparation of pharmaceutically active benzimidazole derivatives
NO166126C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE QUINOLONCARBOXYLIC ACID DERIVATIVES.
NO171915C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1-AZABICYCLO (4.2.0) OCT-2-DERIVATIVES
IL57324A (en) 3-substituted-6-alkanoylamino-1,3,5-triazine-2,4-diones,process for their preparation and pharmaceutical compositions containing them
DE3767114D1 (en) STABILIZED MEDICINAL PRODUCTS.
IL92799A0 (en) Benzimidazole derivatives with gastric acid inhibition and process for its preparation
ES8100263A1 (en) and analogy processes for the manufacture thereof.
NO960267L (en) Newly substituted benzimidazoles
ES8303418A1 (en) Benzo (4,5) pyrano (2,3c) pyrroles, processes for their preparation and pharmaceutical preparations containing same.
JO1871B1 (en) Novel substituted benzimidazoles
JO1870B1 (en) Novel dialkoxy - pyridinyl-benzimidazole derivatives
EP0192393A3 (en) Alkylaminofuranone derivatives
FI893570A0 (en) Process for the preparation of 1H-imidazo [1,2-b] pyrazole derivatives useful as medicaments
AU617849B2 (en) New benzopyrrolidinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
DE69000806D1 (en) INDOL DERIVATIVES.
AU586707B2 (en) New 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and salts thereof, processes for their preparation and pharmaceutical products containing these
DK210387A (en) HETEROCYCLIC RELATIONS AND PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL AGENTS CONTAINING THESE