NO953067L - Expression of protective antigens - Google Patents
Expression of protective antigensInfo
- Publication number
- NO953067L NO953067L NO953067A NO953067A NO953067L NO 953067 L NO953067 L NO 953067L NO 953067 A NO953067 A NO 953067A NO 953067 A NO953067 A NO 953067A NO 953067 L NO953067 L NO 953067L
- Authority
- NO
- Norway
- Prior art keywords
- fragment
- antigen
- enzyme
- expression
- integration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Denne oppfinnelse tilveiebringer en fremgangsmåte for ekspresjon av et enzymantigen som i naturen er et parasitt- tarmmembranbundet eller et fragment derav som har lignende enzym- og/eller antigen-aktivitet, hvori pattedyrvertsceller blir transfektert med en vektor tilpasset til å uttrykke nevnte enzymantigen eller fragment derav, karakterisert ved at vertscellene før transformasjon er i alt vesentlig fri for endogene enzymer som har (a) den samme funksjon og (b) den samme cellemembranintegrasjon eller mangel på integrasjon, som nevnte parasittenzymantigen eller fragment derav. En slik fremgangsmåte er særlig anvendelig for ekspresjon av integrale membranaminopeptidaseantigener fra innvollsormer.This invention provides a method for expressing an enzyme antigen which is by nature a parasitic intestinal membrane bound or a fragment thereof having similar enzyme and / or antigen activity, wherein mammalian host cells are transfected with a vector adapted to express said enzyme antigen or fragment thereof. , characterized in that the host cells prior to transformation are substantially free of endogenous enzymes having (a) the same function and (b) the same cell membrane integration or lack of integration, as said parasite enzyme antigen or fragment thereof. Such a method is particularly useful for expression of integral membrane aminopeptidase antigens from intestinal worms.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939302302A GB9302302D0 (en) | 1993-02-05 | 1993-02-05 | Process |
| PCT/GB1994/000204 WO1994018320A1 (en) | 1993-02-05 | 1994-02-04 | Expression of protective antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO953067D0 NO953067D0 (en) | 1995-08-04 |
| NO953067L true NO953067L (en) | 1995-10-04 |
Family
ID=10729928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO953067A NO953067L (en) | 1993-02-05 | 1995-08-04 | Expression of protective antigens |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0682702A1 (en) |
| JP (1) | JPH08506726A (en) |
| AU (1) | AU682488B2 (en) |
| BG (1) | BG61574B1 (en) |
| BR (1) | BR9406442A (en) |
| CA (1) | CA2155120A1 (en) |
| CZ (1) | CZ285042B6 (en) |
| FI (1) | FI953682A (en) |
| GB (1) | GB9302302D0 (en) |
| HU (1) | HU219539B (en) |
| NO (1) | NO953067L (en) |
| NZ (1) | NZ261144A (en) |
| PL (1) | PL178330B1 (en) |
| RU (1) | RU2126045C1 (en) |
| UA (1) | UA32437C2 (en) |
| WO (1) | WO1994018320A1 (en) |
| ZA (1) | ZA94740B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9209993D0 (en) * | 1992-05-08 | 1992-06-24 | Munn Edward A | Vaccines |
| GB9322702D0 (en) | 1993-11-03 | 1993-12-22 | Agricultural & Food Res | Vaccines |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8619293D0 (en) * | 1986-08-07 | 1986-09-17 | Munn E A | Anthelmintic agents |
| GB8906156D0 (en) * | 1989-03-17 | 1989-05-04 | Munn Edward A | Production and use of anthelmintic agents and protective immunogens |
| JP2700088B2 (en) * | 1991-07-25 | 1998-01-19 | 房則 濱島 | Immunosuppressants |
| GB9209993D0 (en) * | 1992-05-08 | 1992-06-24 | Munn Edward A | Vaccines |
| GB9322702D0 (en) * | 1993-11-03 | 1993-12-22 | Agricultural & Food Res | Vaccines |
-
1993
- 1993-02-05 GB GB939302302A patent/GB9302302D0/en active Pending
-
1994
- 1994-02-03 ZA ZA94740A patent/ZA94740B/en unknown
- 1994-02-04 RU RU95120188A patent/RU2126045C1/en active
- 1994-02-04 CZ CZ951994A patent/CZ285042B6/en not_active IP Right Cessation
- 1994-02-04 CA CA002155120A patent/CA2155120A1/en not_active Abandoned
- 1994-02-04 NZ NZ261144A patent/NZ261144A/en unknown
- 1994-02-04 HU HU9502311A patent/HU219539B/en not_active IP Right Cessation
- 1994-02-04 WO PCT/GB1994/000204 patent/WO1994018320A1/en not_active Application Discontinuation
- 1994-02-04 EP EP94905785A patent/EP0682702A1/en not_active Withdrawn
- 1994-02-04 PL PL94310109A patent/PL178330B1/en unknown
- 1994-02-04 UA UA95083782A patent/UA32437C2/en unknown
- 1994-02-04 BR BR9406442A patent/BR9406442A/en not_active Application Discontinuation
- 1994-02-04 AU AU59753/94A patent/AU682488B2/en not_active Ceased
- 1994-02-04 JP JP6517779A patent/JPH08506726A/en active Pending
-
1995
- 1995-08-02 FI FI953682A patent/FI953682A/en unknown
- 1995-08-04 NO NO953067A patent/NO953067L/en not_active Application Discontinuation
- 1995-08-28 BG BG99887A patent/BG61574B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08506726A (en) | 1996-07-23 |
| WO1994018320A1 (en) | 1994-08-18 |
| NO953067D0 (en) | 1995-08-04 |
| RU2126045C1 (en) | 1999-02-10 |
| UA32437C2 (en) | 2000-12-15 |
| FI953682A0 (en) | 1995-08-02 |
| GB9302302D0 (en) | 1993-03-24 |
| NZ261144A (en) | 1998-02-26 |
| HUT72990A (en) | 1996-06-28 |
| HU9502311D0 (en) | 1995-10-30 |
| EP0682702A1 (en) | 1995-11-22 |
| CA2155120A1 (en) | 1994-08-18 |
| HU219539B (en) | 2001-05-28 |
| AU682488B2 (en) | 1997-10-09 |
| BG99887A (en) | 1996-12-31 |
| AU5975394A (en) | 1994-08-29 |
| BG61574B1 (en) | 1997-12-30 |
| PL310109A1 (en) | 1995-11-27 |
| PL178330B1 (en) | 2000-04-28 |
| FI953682A (en) | 1995-08-02 |
| CZ285042B6 (en) | 1999-05-12 |
| CZ199495A3 (en) | 1996-02-14 |
| BR9406442A (en) | 1996-02-27 |
| ZA94740B (en) | 1994-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |