NO945020L - Self-stabilizing oligonucleotides as therapeutic agents - Google Patents

Self-stabilizing oligonucleotides as therapeutic agents

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Publication number
NO945020L
NO945020L NO945020A NO945020A NO945020L NO 945020 L NO945020 L NO 945020L NO 945020 A NO945020 A NO 945020A NO 945020 A NO945020 A NO 945020A NO 945020 L NO945020 L NO 945020L
Authority
NO
Norway
Prior art keywords
self
oligonucleotides
therapeutic agents
stabilizing oligonucleotides
nucleic acid
Prior art date
Application number
NO945020A
Other languages
Norwegian (no)
Other versions
NO945020D0 (en
Inventor
Sudhir Agrawal
Jin-Yan Tang
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1993/006326 external-priority patent/WO1994001550A1/en
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of NO945020D0 publication Critical patent/NO945020D0/en
Publication of NO945020L publication Critical patent/NO945020L/en

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Abstract

Forbedrede antisens oligonukleotider som er reslstente for nukleolytlske degradering er beskrevet. Silke oligonukleotider blir betegnet som selv-stablllserende oligonukleotder og omfatter to regioner: en mål- hybrldlserende region som har en nukleotldsekvens som er komplementær med en nuklelnsyresekvens som er fra et virus, en patogen organisme eller et cellulært gen; og en selv-komplementær region som har en ollgonukleotld- sekvens som er komplementær med en nuklelnsyresekvens som er Innenfor det selv-stablllserte ollgonukleotldet.Enhanced antigen oligonucleotides that are resistant to nucleolytic degradation are described. Silk oligonucleotides are termed self-stabilizing oligonucleotides and comprise two regions: a target hybridizing region having a nucleotide sequence complementary to a nucleic acid sequence that is from a virus, a pathogenic organism, or a cellular gene; and a self-complementary region having an oligonucleotide sequence complementary to a nucleic acid sequence which is within the self-stabilized oligonucleotide.

NO945020A 1992-07-02 1994-12-23 Self-stabilizing oligonucleotides as therapeutic agents NO945020L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90906992A 1992-07-02 1992-07-02
PCT/US1993/006326 WO1994001550A1 (en) 1992-07-02 1993-07-02 Self-stabilized oligonucleotides as therapeutic agents

Publications (2)

Publication Number Publication Date
NO945020D0 NO945020D0 (en) 1994-12-23
NO945020L true NO945020L (en) 1995-02-28

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ID=26786853

Family Applications (1)

Application Number Title Priority Date Filing Date
NO945020A NO945020L (en) 1992-07-02 1994-12-23 Self-stabilizing oligonucleotides as therapeutic agents

Country Status (1)

Country Link
NO (1) NO945020L (en)

Also Published As

Publication number Publication date
NO945020D0 (en) 1994-12-23

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