NO944691D0 - Fremgangsmåte for fremstilling av N- karboksyalkyl-1,4,7,10-tetraazasyklododekan og N- yalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotradekanderivater og deres metallkomplekser - Google Patents

Fremgangsmåte for fremstilling av N- karboksyalkyl-1,4,7,10-tetraazasyklododekan og N- yalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotradekanderivater og deres metallkomplekser

Info

Publication number
NO944691D0
NO944691D0 NO944691A NO944691A NO944691D0 NO 944691 D0 NO944691 D0 NO 944691D0 NO 944691 A NO944691 A NO 944691A NO 944691 A NO944691 A NO 944691A NO 944691 D0 NO944691 D0 NO 944691D0
Authority
NO
Norway
Prior art keywords
carboxyalkyl
tri
tetraazacyclododecane
derivatives
metal complexes
Prior art date
Application number
NO944691A
Other languages
English (en)
Other versions
NO302232B1 (no
NO944691L (no
Inventor
Ulf Tilstam
Helmut Borner
Klaus Nickisch
Heinz Gries
Johannes Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO944691D0 publication Critical patent/NO944691D0/no
Publication of NO944691L publication Critical patent/NO944691L/no
Publication of NO302232B1 publication Critical patent/NO302232B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19944691A 1992-06-04 1994-12-05 Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser NO302232B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218744A DE4218744C2 (de) 1992-06-04 1992-06-04 Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
PCT/EP1993/001362 WO1993024469A1 (de) 1992-06-04 1993-05-28 VERFAHREN ZUR HERSTELLUNG VON N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,7,10-TETRAAZACYCLODODECAN- UND N-β-HYDROXYALKYL-TRI-N-CARBOXYALKYL-1,4,8,11-TETRAAZACYCLOTETRADECAN-DERIVATEN UND DEREN METALLKOMPLEXE

Publications (3)

Publication Number Publication Date
NO944691D0 true NO944691D0 (no) 1994-12-05
NO944691L NO944691L (no) 1994-12-05
NO302232B1 NO302232B1 (no) 1998-02-09

Family

ID=6460555

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19944691A NO302232B1 (no) 1992-06-04 1994-12-05 Fremgangsmate for fremstilling av N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,7,10-tetraazasyklododekan- og N-<beta>-hydroksyalkyl-tri-N-karboksyalkyl-1,4,8,11-tetraazasyklotetradekanderivater og deres metallkomplekser

Country Status (16)

Country Link
US (1) US5386028A (no)
EP (1) EP0643705B1 (no)
JP (1) JP3565843B2 (no)
KR (1) KR100269081B1 (no)
AT (1) ATE178321T1 (no)
CA (1) CA2137243C (no)
CZ (1) CZ282873B6 (no)
DE (2) DE4218744C2 (no)
DK (1) DK0643705T3 (no)
ES (1) ES2131582T3 (no)
GR (1) GR3030604T3 (no)
HU (1) HU213951B (no)
IL (1) IL105807A (no)
NO (1) NO302232B1 (no)
SK (1) SK281901B6 (no)
WO (1) WO1993024469A1 (no)

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ES2780599T3 (es) 2011-04-21 2020-08-26 Bayer Ip Gmbh Preparación de gadobutrol de alta pureza
CN107522664B (zh) 2011-10-27 2021-03-16 麻省理工学院 能够形成药物包封微球的在n末端上官能化的氨基酸衍生物
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KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법
KR101653064B1 (ko) * 2014-12-26 2016-09-09 에스티팜 주식회사 가도부트롤의 제조방법
PT3310764T (pt) 2015-06-19 2023-07-11 Massachusetts Inst Technology 2,5-piperazinadionas substituídas por alquenilo e o seu uso em composições para entregar um agente a um sujeito ou célula
BR112019006066A2 (pt) 2016-09-27 2019-06-18 Bayer Pharma AG método para produzir a forma cristalina de modificação a de calcobutrol
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
US20210284662A1 (en) * 2018-07-10 2021-09-16 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
WO2024030772A1 (en) * 2022-08-01 2024-02-08 Portland State University High relaxivity contrast agents and stereoselective preparation

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Also Published As

Publication number Publication date
EP0643705A1 (de) 1995-03-22
SK281901B6 (sk) 2001-09-11
US5386028A (en) 1995-01-31
CA2137243A1 (en) 1993-12-09
HU213951B (en) 1997-11-28
DE4218744C2 (de) 1997-11-06
GR3030604T3 (en) 1999-10-29
NO302232B1 (no) 1998-02-09
JPH07507067A (ja) 1995-08-03
CZ282873B6 (cs) 1997-11-12
KR950701918A (ko) 1995-05-17
CZ301594A3 (en) 1995-08-16
DE59309488D1 (de) 1999-05-06
IL105807A (en) 1998-12-06
WO1993024469A1 (de) 1993-12-09
SK148794A3 (en) 1995-07-11
EP0643705B1 (de) 1999-03-31
DE4218744A1 (de) 1993-12-09
DK0643705T3 (da) 1999-10-25
HUT71263A (en) 1995-11-28
JP3565843B2 (ja) 2004-09-15
ATE178321T1 (de) 1999-04-15
KR100269081B1 (ko) 2000-10-16
ES2131582T3 (es) 1999-08-01
CA2137243C (en) 2005-09-20
NO944691L (no) 1994-12-05
IL105807A0 (en) 1993-09-22
HU9403464D0 (en) 1995-03-28

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Legal Events

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Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

MK1K Patent expired