NO943861L - Trisyklisk forbindelse til bruk som tachykinin-antagonist - Google Patents

Trisyklisk forbindelse til bruk som tachykinin-antagonist

Info

Publication number
NO943861L
NO943861L NO943861A NO943861A NO943861L NO 943861 L NO943861 L NO 943861L NO 943861 A NO943861 A NO 943861A NO 943861 A NO943861 A NO 943861A NO 943861 L NO943861 L NO 943861L
Authority
NO
Norway
Prior art keywords
tricyclic compound
tachykinin antagonist
group
compound
conr
Prior art date
Application number
NO943861A
Other languages
English (en)
Other versions
NO943861D0 (no
Inventor
Vincenzo Pavone
Angelina Lombardi
Carlo Pedone
Carlo Alberto Maggi
Laura Quartara
Original Assignee
Menarini Farma Ind
Guidotti & C Spa Labor
Malesci Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind, Guidotti & C Spa Labor, Malesci Sas filed Critical Menarini Farma Ind
Publication of NO943861L publication Critical patent/NO943861L/no
Publication of NO943861D0 publication Critical patent/NO943861D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Trisyklisk forbindelse med den generelle formel. der X„ X, X, X, Xs og Xuavhengig er valgt blant gruppen bestående av -NR'-CO-, -CONR'-, der R' er H eller C,.-alkyl, Y er valgt blant gruppen bestående av -CONR-, -NRCO-, -OCO-, -COO-, -CH-NR-, -NR-CH-, -SS-, -CH-CH, cis eller trans -CH=CH-, der R er H eller C,.-alkyl, R„ R, Rog R, er hver en hydrofob gruppe, og n og m er uavhengig et heltall fra 1 til 4.Forbindelsen anvendes som tachykinin-antagonist.
NO943861A 1992-04-15 1994-10-13 Trisyklisk forbindelse til bruk som tachykinin-antagonist NO943861D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI920089A IT1262902B (it) 1992-04-15 1992-04-15 Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.
PCT/EP1993/000893 WO1993021227A1 (en) 1992-04-15 1993-04-13 Tachykinin antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds

Publications (2)

Publication Number Publication Date
NO943861L true NO943861L (no) 1994-10-13
NO943861D0 NO943861D0 (no) 1994-10-13

Family

ID=11350056

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943861A NO943861D0 (no) 1992-04-15 1994-10-13 Trisyklisk forbindelse til bruk som tachykinin-antagonist

Country Status (28)

Country Link
EP (1) EP0636146B1 (no)
JP (1) JPH08500331A (no)
KR (1) KR950700935A (no)
CN (1) CN1039126C (no)
AT (1) ATE156135T1 (no)
AU (1) AU671118B2 (no)
BG (1) BG99110A (no)
BR (1) BR9306248A (no)
CA (1) CA2118253A1 (no)
CZ (1) CZ254294A3 (no)
DE (1) DE69312698T2 (no)
DK (1) DK0636146T3 (no)
ES (1) ES2105265T3 (no)
FI (1) FI944838A (no)
GR (1) GR3024348T3 (no)
HR (1) HRP930814A2 (no)
HU (1) HUT70189A (no)
IL (1) IL105381A (no)
IT (1) IT1262902B (no)
MX (1) MX9302161A (no)
NO (1) NO943861D0 (no)
NZ (1) NZ251969A (no)
RO (1) RO112872B1 (no)
RU (1) RU94045890A (no)
SK (1) SK124294A3 (no)
TW (1) TW234718B (no)
WO (1) WO1993021227A1 (no)
ZA (1) ZA932644B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1277835B1 (it) * 1995-03-13 1997-11-12 Menarini Farma Ind Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche
IT1283171B1 (it) * 1996-03-01 1998-04-16 Interdipartimentale Di Ricerca Composti solubili antagonisti delle tachichinine loro preparazione e loro uso in composizioni farmaceutiche
IT1291776B1 (it) 1997-02-07 1999-01-21 Menarini Ricerche Spa Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista
IT1307809B1 (it) 1999-10-21 2001-11-19 Menarini Ricerche Spa Composti monociclici basici ad azione nk-2 antagonista, processi difabbricazione e formulazioni che li contengono.
EP1297826A1 (en) * 2001-09-27 2003-04-02 Menarini Ricerche S.p.A. Nasal pharmaceutical compositions containing a NK-2 antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8807246D0 (en) * 1988-03-25 1988-04-27 Merck Sharp & Dohme Therapeutic agents
DE3915361A1 (de) * 1989-05-11 1990-11-15 Merck Patent Gmbh Cyclopeptide

Also Published As

Publication number Publication date
CA2118253A1 (en) 1993-10-28
HRP930814A2 (en) 1996-12-31
ATE156135T1 (de) 1997-08-15
ITFI920089A1 (it) 1993-10-15
HUT70189A (en) 1995-09-28
TW234718B (no) 1994-11-21
FI944838A0 (fi) 1994-10-14
ES2105265T3 (es) 1997-10-16
NZ251969A (en) 1997-12-19
EP0636146A1 (en) 1995-02-01
SK124294A3 (en) 1995-07-11
MX9302161A (es) 1994-05-31
DE69312698D1 (de) 1997-09-04
IL105381A (en) 1998-02-22
ZA932644B (en) 1993-10-22
AU671118B2 (en) 1996-08-15
BG99110A (bg) 1995-09-29
BR9306248A (pt) 1998-06-23
CN1080916A (zh) 1994-01-19
DE69312698T2 (de) 1997-12-04
ITFI920089A0 (it) 1992-04-15
RU94045890A (ru) 1996-09-10
IT1262902B (it) 1996-07-22
AU4039593A (en) 1993-11-18
CZ254294A3 (en) 1995-07-12
EP0636146B1 (en) 1997-07-30
GR3024348T3 (en) 1997-11-28
WO1993021227A1 (en) 1993-10-28
KR950700935A (ko) 1995-02-20
HU9402977D0 (en) 1995-02-28
RO112872B1 (ro) 1998-01-30
DK0636146T3 (da) 1998-02-23
CN1039126C (zh) 1998-07-15
NO943861D0 (no) 1994-10-13
FI944838A (fi) 1994-10-14
JPH08500331A (ja) 1996-01-16

Similar Documents

Publication Publication Date Title
YU47099B (sh) Postupak za dobijanje makrolidnih jedinjenja
UA39869C2 (uk) Похідні аспартаму або їх фізіологічно прийнятні солі, спосіб їх отримання та підсолоджувальна композиція
MX9203165A (es) Derivados de succinimida y composicion farmaceutica que los contiene .
DE60317884D1 (de) Natriumkanalblocker
ES469567A1 (es) Un procedimiento para la produccion de derivados de ciclos- porina
ES8505970A1 (es) Procedimiento para la produccion de nuevos derivados de n-(2-nitrofenil)-4-aminopirimidina.
IE840182L (en) Des-proline vasopressin antagonists
BR9206823A (pt) Preparação de piperidinas substituídas
MX9101236A (es) Procedimiento para la preparacion de compuestos azabiciclicos
LV10949A (lv) Aizvietoti 4-fenil-4piperidinkarboksamidi to iegusanas panemiens farmaceitiska kompozicija
NO943861L (no) Trisyklisk forbindelse til bruk som tachykinin-antagonist
ES473787A1 (es) Un procedimiento para la preparacion de derivados de oxadia-zolopirimidina.
ES2002663A6 (es) Procedimiento para la preparacion de diazaoxaespirodecanos sustituidos como estabilizadores para polimeros
DK0484966T3 (da) 7-Acryl-3-(substitueret carbamoyloxy)cephemforbindelser, anvendelse deraf og fremgangsmåde deraf
DE3788149D1 (de) Prostazyklin-(PGI2)-Analoge.
ES8506011A1 (es) Procedimiento para la obtencion de un derivado de tetrahidrobenzotiazol
IE832886L (en) Treatment of migraine with n-alkyl-piperidinyl benzoate¹derivatives
IE42478L (en) Pharmaceutical composition
JPS644656A (en) Flame-retarding resin composition
EP0794178A4 (en) CHINAZOLIN DERIVATIVES
ES459298A1 (es) Un metodo para la produccion de nuevos derivados de cromona.
ES8705426A1 (es) Un procedimiento para la preparacion de un derivado de piperazina.
JPS53101308A (en) Derivative of 5,6-dihydro-2h-pyran and its preparation
SE8100122L (sv) Nya 2-aminometyl-6-halo-fenoler, framstellning derav och farmaceutiska kompositioner innehallande dessa
JPS53147059A (en) Brominated cyclic ether having alkoxycarbonyl group and its preparation