NO941520L - Kinolyl-dihydropyridinestere, fremgangsmåte for fremstilling derav og anvendelse derav i legemidler - Google Patents

Kinolyl-dihydropyridinestere, fremgangsmåte for fremstilling derav og anvendelse derav i legemidler

Info

Publication number
NO941520L
NO941520L NO941520A NO941520A NO941520L NO 941520 L NO941520 L NO 941520L NO 941520 A NO941520 A NO 941520A NO 941520 A NO941520 A NO 941520A NO 941520 L NO941520 L NO 941520L
Authority
NO
Norway
Prior art keywords
nitro
pharmaceuticals
cyano
preparation
quinolyl
Prior art date
Application number
NO941520A
Other languages
English (en)
Other versions
NO941520D0 (no
Inventor
Jurgen Stoltefuss
Siegfried Goldmann
Alexander Straub
Martin Bechem
Rainer Gross
Siegbert Hebisch
Joachim Hutter
Howard-Paul Rounding
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO941520D0 publication Critical patent/NO941520D0/no
Publication of NO941520L publication Critical patent/NO941520L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Det er beskrevet nye 4-klnolyl-dihydropyrldlnestere med generell formel (I): hvori R1 og R5 er like eller forskjellige og står for rettkjedet eller forgrenet alkyl med RS¿S^- |] 'l Inntil 8 karbonatomer. R2 står for nitro eller cyano, eller (D R1 og R2 danner sammen en laktonrlng med formelen 0_ hvor R*" kan ha flere betydninger og f.eks. bety hydrogen, halogen eller rettkjedet eller forgrenet alkyl, R3 kan ha flere betydninger og blant annet bety aryl med 6 til 10 karbonatoner son eventuelt er substituert Inntil 2 ganger, med Ilke eller forskjellige substituenter valgt fra blant andre halogen, nitro, cyano eller hydroksy, R4 kan blant annet stå for cyano, nltro eller formyl eller R4 og Rg danner sanroen en laktonrlng med formelen og salter derav. Det er videre beskrevet en fremgangsmåte for fremstilling av forbindelsene samt deres anvendelse l legemidler, spesielt l midler for behandling av hJerte-kretsløpssykdcraDer.
NO941520A 1993-04-27 1994-04-26 Kinolyl-dihydropyridinestere, fremgangsmåte for fremstilling derav og anvendelse derav i legemidler NO941520L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4313697A DE4313697A1 (de) 1993-04-27 1993-04-27 Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln

Publications (2)

Publication Number Publication Date
NO941520D0 NO941520D0 (no) 1994-04-26
NO941520L true NO941520L (no) 1994-10-28

Family

ID=6486455

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941520A NO941520L (no) 1993-04-27 1994-04-26 Kinolyl-dihydropyridinestere, fremgangsmåte for fremstilling derav og anvendelse derav i legemidler

Country Status (16)

Country Link
US (1) US5508406A (no)
EP (1) EP0622368A1 (no)
JP (1) JPH06321938A (no)
CN (1) CN1100099A (no)
AU (1) AU675497B2 (no)
CA (1) CA2121999A1 (no)
CZ (1) CZ99694A3 (no)
DE (1) DE4313697A1 (no)
FI (1) FI941913A (no)
HU (1) HUT70483A (no)
IL (1) IL109436A0 (no)
NO (1) NO941520L (no)
NZ (1) NZ260381A (no)
SK (1) SK47794A3 (no)
TW (1) TW273552B (no)
ZA (1) ZA942881B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0985667A4 (en) * 1997-04-25 2000-03-22 Ajinomoto Kk NEW DIHYDROPYRIDINE DERIVATIVE
AU2004272078A1 (en) * 2003-09-10 2005-03-24 Synta Pharmaceuticals Corp. Dihydropyridine compounds for treating or preventing metabolic disorders
JP5506788B2 (ja) * 2008-06-09 2014-05-28 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換４−（インダゾリル）−１，４−ジヒドロピリジン類およびそれらの使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE4011105A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5204472A (en) * 1990-04-06 1993-04-20 Bayer Aktiengesellschaft Quinoline and isoquinoline intermediates
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
DE4117750A1 (de) * 1991-05-30 1992-12-24 Bayer Ag Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4118707A1 (de) * 1991-06-07 1992-12-10 Bayer Ag Pharmazeutische verwendung von 3-formyl-1,4-dihydropyridinen, neue verbindungen und verfahren zu ihrer herstellung
DE4134760A1 (de) * 1991-10-22 1993-07-08 Bayer Ag Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4313692A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE4313691A1 (de) * 1993-04-27 1994-11-03 Bayer Ag 2,6-Disubstituierte 4-Chinolyl-dihydropyridine

Also Published As

Publication number Publication date
TW273552B (no) 1996-04-01
FI941913A0 (fi) 1994-04-25
HUT70483A (en) 1995-10-30
CA2121999A1 (en) 1994-10-28
ZA942881B (en) 1995-01-16
EP0622368A1 (de) 1994-11-02
NZ260381A (en) 1996-02-27
US5508406A (en) 1996-04-16
JPH06321938A (ja) 1994-11-22
AU5922194A (en) 1994-11-03
CZ99694A3 (en) 1994-11-16
CN1100099A (zh) 1995-03-15
IL109436A0 (en) 1994-07-31
AU675497B2 (en) 1997-02-06
NO941520D0 (no) 1994-04-26
HU9401201D0 (en) 1994-08-29
SK47794A3 (en) 1995-04-12
FI941913A (fi) 1994-10-28
DE4313697A1 (de) 1994-11-03

Similar Documents

Publication Publication Date Title
ATE89559T1 (de) Camptothecin-derivate und verfahren zu ihrer herstellung.
ATE254594T1 (de) Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate
CZ158295A3 (en) Substituted pyrazole per se and for treating diseases, pharmaceutical compositions based thereon and intermediates for their preparation
DE69603117T2 (de) Camptothecinderivat und dessen Verwendung als Antitumormittel
ES2132284T3 (es) Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
ATE205199T1 (de) Quinolin- oder quinazolinderivate, deren herstellung und verwendung
ATE202087T1 (de) Verfahren zur herstellung von 4-substituierten azetidinon-derivaten
ATE13178T1 (de) 2-oxoazetidin-derivate, ihre herstellung und verwendung.
US3714170A (en) 2-SUBSTITUTED OR NON-SUBSTITUTED-NON-THIAZALO [5,4-f] QUINALINE-8-CARBOXYLATES COMPOUNDS AND THEIR METHOD OF PREPARATION
ES8603184A1 (es) Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico
NO941520L (no) Kinolyl-dihydropyridinestere, fremgangsmåte for fremstilling derav og anvendelse derav i legemidler
DE3786109D1 (de) Pyrido(2,3-d)pyrimidin-derivate.
ES8707934A1 (es) Un procedimiento para la preparacion de derivados de piridina.
NO871339D0 (no) Fremgangsmaate for fremstilling av nye pyridinkarboksylsyrederivater.
AU655869B2 (en) An amphoteric tricyclic compound
ES500810A0 (es) Procedimiento de preparacion de aminoalcoxipirazoles
PT84803A (en) Process for the preparation of puridyl cyclopropane carboxamides having fungicidal properties
EP0367671A3 (en) Novel beta-d-phenylthioxylosides, their method of preparation and their use as pharmaceuticals
HUP0100407A2 (hu) Eljárás kinolin-karbamoil- és kinolin-tiokarbamoil-származékok előállítására és az eljárás intermedierjei
ES8500937A1 (es) Un procedimiento de preparacion de nuevos benzopirano-(2,3-d)-v-triazoles.
JPS5549372A (en) Production of macrocyclic lactone
JPS5551065A (en) Aminopyrrole derivative
JPS57116052A (en) Quinazoline derivative and its preparation
GB1141697A (en) Esters derived from quinoline and preparation thereof
GB1417392A (en) Isoindolo 7,1,2-hij- quinolines