NO923249L - THERAPEUTIC ACTIVE PYRIMIDINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION - Google Patents

THERAPEUTIC ACTIVE PYRIMIDINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION

Info

Publication number
NO923249L
NO923249L NO92923249A NO923249A NO923249L NO 923249 L NO923249 L NO 923249L NO 92923249 A NO92923249 A NO 92923249A NO 923249 A NO923249 A NO 923249A NO 923249 L NO923249 L NO 923249L
Authority
NO
Norway
Prior art keywords
group
preparation
hydrogen
pyrimidine derivatives
procedure
Prior art date
Application number
NO92923249A
Other languages
Norwegian (no)
Other versions
NO923249D0 (en
Inventor
Hiroaki Nomura
Toru Haneda
Yoshihiko Kotake
Norihiro Ueda
Kyosuke Kitoh
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO923249D0 publication Critical patent/NO923249D0/en
Publication of NO923249L publication Critical patent/NO923249L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Nye pyrimidinderivater med utmerket antitumoraktivitet og med følgende generelle formel (I) eller farmakologisk talbare salter derav: (CH:)n-A-Rs-CONH-CH-CO,R! CHsCHjCOiR (I) hvori R1 er hydroksyl eller amino, R2 er fenylen, pyridin- diyl, tiendiyl, furandiyl eller tiazoldiyl, -CC^R5 og -C02R6 er like eller forskjellige og er hver karboksyl eller en ^ N v. karboksylsyreester, delen X-Y-Z- er N-CH2-CH2-, N-CH=CH- \ s* ^ "" ^ eller CH-CH2-CH2, A er oksygen, en gruppe med formelen: \ R3 :-C- (hvori R3 og R4 er like eller forskjellige og er hver R4 hydrogen eller halogen eller en hydrokarbongruppe som kan være substituert, eller R3 og R4 kan eventuelt sammen i danne en alkylidengruppe som kan være substituert) eller en gruppe med formelen: R70 (hvori R70 er hydrogen eller ; -N- en hydrokarbongruppe), og n er et helt tall fra l til 3, med den betingelse at forbindelsen hvor R1 er oksygen og hydrogen er bundet til nitrogen i 3-stillingen er inkludert i den ovennevnte definisjon. En fremgangsmåte for fremstilling av derivatene er også beskrevet sammen med antitumormedi- kamenter inneholdende de samme.Novel pyrimidine derivatives having excellent antitumor activity and having the following general formula (I) or pharmacologically salable salts thereof: (CH:) n-A-Rs-CONH-CH-CO, R! CH 3 CH 2 CO 1 R (I) wherein R 1 is hydroxyl or amino, R 2 is phenylene, pyridinediyl, tenenedyl, furanediyl or thiazole diyl, -C C - is N-CH2-CH2-, N-CH = CH- \ s * "" "or CH-CH2-CH2, A is oxygen, a group of the formula: \ R3: -C- (wherein R3 and R4 are the same or different and each R 4 is hydrogen or halogen or a hydrocarbon group which may be substituted, or R 3 and R 4 may optionally form together an alkylidene group which may be substituted) or a group of the formula: R 70 (wherein R 70 is hydrogen or; -N - a hydrocarbon group), and n is an integer from 1 to 3, provided that the compound wherein R 1 is oxygen and hydrogen is bonded to nitrogen at the 3-position is included in the above definition. A process for the preparation of the derivatives is also disclosed in conjunction with anti-tumor drugs containing the same.

NO92923249A 1991-08-21 1992-08-19 THERAPEUTIC ACTIVE PYRIMIDINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION NO923249L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20925291 1991-08-21
JP25154891 1991-09-30
JP21767092A JP3144903B2 (en) 1991-08-21 1992-08-17 Condensed pyrimidine derivative

Publications (2)

Publication Number Publication Date
NO923249D0 NO923249D0 (en) 1992-08-19
NO923249L true NO923249L (en) 1993-02-22

Family

ID=27328976

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92923249A NO923249L (en) 1991-08-21 1992-08-19 THERAPEUTIC ACTIVE PYRIMIDINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION

Country Status (9)

Country Link
JP (1) JP3144903B2 (en)
KR (1) KR950011740B1 (en)
CN (1) CN1070402A (en)
AU (1) AU655051B2 (en)
CA (1) CA2076431A1 (en)
FI (1) FI923697A (en)
HU (1) HUT70180A (en)
NO (1) NO923249L (en)
TW (1) TW202451B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107041A (en) * 1992-09-25 2000-02-17 Lilly Co Eli Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids
US8252804B2 (en) 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
US20110082158A1 (en) * 2008-10-01 2011-04-07 Aleem Gangjee Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same
CN106188060A (en) * 2015-04-29 2016-12-07 厦门大学 Pyrimido azoles, its preparation method, Pharmaceutical composition and application thereof
CN113788834B (en) * 2021-09-18 2022-11-29 河南奥思恩医药科技有限公司 2,4-dichloro-6,7-dihydro-5H-pyrrolo [3,4-d ] pyrimidine hydrochloride preparation method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use

Also Published As

Publication number Publication date
NO923249D0 (en) 1992-08-19
CN1070402A (en) 1993-03-31
TW202451B (en) 1993-03-21
KR930004307A (en) 1993-03-22
AU2115792A (en) 1993-02-25
CA2076431A1 (en) 1993-02-22
JPH05186437A (en) 1993-07-27
AU655051B2 (en) 1994-12-01
HUT70180A (en) 1995-09-28
JP3144903B2 (en) 2001-03-12
FI923697A (en) 1993-02-22
FI923697A0 (en) 1992-08-18
KR950011740B1 (en) 1995-10-09

Similar Documents

Publication Publication Date Title
EG19650A (en) Derivatives of indol and their use for treatment of megraine
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
BG103984A (en) Gastrokinetic monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
MY108261A (en) Water soluble camptothecin derivatives
FI890689A0 (en) 3-ALKENYL-1-AZABICYCLO- / 3.2.0 / -HEPT-2-EN-2-CARBOXYLSYRAFOERENINGAR.
ES2006623A6 (en) Amino-5,6,7,8-tetrahydro-naphtho[2,3b]furan derivatives, processes for their preparation and pharmaceutical compositions containing them.
DE69409796T2 (en) NEW USE TO HETEROCYCLIC COMPOUNDS AND THEIR COMPOSITIONS
NO923249L (en) THERAPEUTIC ACTIVE PYRIMIDINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
KR900012893A (en) Substituted-acetamide compounds and methods for preparing the same
YU46706B (en) PROCEDURE FOR OBTAINING AMIDE COMPOUNDS
PE25998A1 (en) DERIVATIVES OF OCTAHIDRO-PIRROLO (1,2-a) -PIRAZINA 2,7-SUBSTITUTED
CA2200578A1 (en) N-substituted piperidinyl bicyclic benzoate derivatives
EP0332190A2 (en) Condensed quinoline system compound, condensed acridine system compound, process for preparing the same, and carcinostatic composition containing the same
HUT50176A (en) Process for production of derivatives of heterocyclic lactane and medical compositions containing them as active substance
AP9901559A0 (en) Tricyclic 3-keto derivatives of 6-0-methylerythromycin.
ZA875345B (en) Tetracyclic indole derivatives
IL82946A (en) 1-t-butyl-6-methylergoline-8-methanol derivatives,their preparation and pharmaceutical compositions containing them
TH54463A3 (en) 4- (Aminomethyl) - Piperidine Benzamate for the treatment of diseases of the stomach and intestines.