NO903941L - ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DIAZEPINON DERIVATIVES. - Google Patents
ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DIAZEPINON DERIVATIVES.Info
- Publication number
- NO903941L NO903941L NO90903941A NO903941A NO903941L NO 903941 L NO903941 L NO 903941L NO 90903941 A NO90903941 A NO 90903941A NO 903941 A NO903941 A NO 903941A NO 903941 L NO903941 L NO 903941L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- lower alkyl
- diazepinon
- derivatives
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Det beskrives fremstilling av kondenserte diazepinoner med den generelle formel. hvor } (b) utgjør en av de toverdige restene. X er en =CH-gruppe eller et nitrogenatom, R er en lavere alkylrest, som dessuten eventuelt kan være substituert med fenyl som eventuelt er substituert med halogen, metyl eller metoksy, Rogutgjør hydrogen, halogen eller lavere alkyl, Rer hydrogen, klor eller metyl, Rog Rer lavere alkyl,. hvor Re dessuten også kan bety halogen, og m, n, o og p er. tallene 1 eller 2, idet summen m+n+o+p må være lik eller mindre enn 6. Forbindelsene utmerker seg ved høy selektivitet og egner seg som legemidler bl.a. til behandling av kolinergt betingede spasmer og motilitetsforstyrrelser.The preparation of condensed diazepinones of the general formula is described. where} (b) constitutes one of the divalent residues. X is a = CH group or a nitrogen atom, R is a lower alkyl radical, which may also be optionally substituted by phenyl which is optionally substituted by halogen, methyl or methoxy, Rye constitutes hydrogen, halogen or lower alkyl, R , Rog Rer lower alkyl,. where Re can also mean halogen, and m, n, o and p are. the numbers 1 or 2, as the sum m + n + o + p must be equal to or less than 6. The compounds are distinguished by high selectivity and are suitable as drugs, e.g. for the treatment of cholinergic spasms and motility disorders.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3930262A DE3930262A1 (en) | 1989-09-11 | 1989-09-11 | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO903941D0 NO903941D0 (en) | 1990-09-10 |
| NO903941L true NO903941L (en) | 1991-03-12 |
Family
ID=6389152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO90903941A NO903941L (en) | 1989-09-11 | 1990-09-10 | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DIAZEPINON DERIVATIVES. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0417631A3 (en) |
| JP (1) | JPH03209382A (en) |
| KR (1) | KR910006286A (en) |
| AU (1) | AU626452B2 (en) |
| CA (1) | CA2025005A1 (en) |
| DD (1) | DD299308A5 (en) |
| DE (1) | DE3930262A1 (en) |
| FI (1) | FI904469A0 (en) |
| HU (1) | HU206882B (en) |
| IL (1) | IL95622A (en) |
| NO (1) | NO903941L (en) |
| NZ (1) | NZ235270A (en) |
| PL (1) | PL165197B1 (en) |
| PT (1) | PT95259A (en) |
| RU (1) | RU2017740C1 (en) |
| YU (1) | YU47372B (en) |
| ZA (1) | ZA907199B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3930266A1 (en) * | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
| WO2004005293A2 (en) | 2002-07-05 | 2004-01-15 | Targacept, Inc. | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof |
| SE0202133D0 (en) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| SE0303090D0 (en) | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
| SE0303541D0 (en) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
| US8809552B2 (en) * | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
| LT2861566T (en) * | 2012-06-13 | 2017-02-10 | F. Hoffmann-La Roche Ag | New diazaspirocycloalkane and azaspirocycloalkane |
| CA2878442A1 (en) | 2012-09-25 | 2014-04-03 | F. Hoffmann-La Roche Ag | Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases |
| AR095079A1 (en) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO |
| SI3074400T1 (en) | 2013-11-26 | 2018-03-30 | F. Hoffmann-La Roche Ag | Octahydro-cyclobuta (1,2-c;3,4-c')dipyrrole derivatives as autotaxin inhibitors |
| UA118582C2 (en) | 2014-03-26 | 2019-02-11 | Ф. Хоффманн-Ля Рош Аг | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| CN106029667B (en) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | Condensed [1,4] diaza * compound as autocrine motility factor (ATX) and lysophosphatidic acid (LPA) production inhibitor |
| MA41898A (en) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | BICYCLIC QUINAZOLINONE DERIVATIVES |
| MX2020004504A (en) | 2015-09-04 | 2021-11-10 | Hoffmann La Roche | Phenoxymethyl derivatives. |
| MX2017015034A (en) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | New bicyclic compounds as dual atx/ca inhibitors. |
| JP6846414B2 (en) | 2015-09-24 | 2021-03-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Bicyclic compounds as ATX inhibitors |
| BR112018006080A2 (en) | 2015-09-24 | 2018-10-09 | F. Hoffmann-La Roche Ag | new bicyclic compounds as dual action inhibitors of atx / ca |
| CA2991615A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| WO2018167001A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual atx/ca inhibitors |
| CN110382484B (en) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | Novel bicyclic compounds as ATX inhibitors |
| EP3679043B9 (en) * | 2017-09-05 | 2023-09-27 | Neumora Therapeutics, Inc. | Vasopressin receptor antagonists and products and methods related thereto |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210648A (en) * | 1977-05-31 | 1980-07-01 | Boehringer Ingelheim Gmbh | II-Aminoacyl-5,11-dihydro-6H-pyrido(2,3-B) (1,4)benzodiazepin-6-ones and salts thereof |
| DE3204153A1 (en) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED THIENOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT |
| DE3204403A1 (en) * | 1982-02-09 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW PYRIDOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
| DE3726908A1 (en) * | 1987-08-13 | 1989-02-23 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3930266A1 (en) * | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
-
1989
- 1989-09-11 DE DE3930262A patent/DE3930262A1/en not_active Withdrawn
-
1990
- 1990-09-05 EP EP19900117078 patent/EP0417631A3/en not_active Withdrawn
- 1990-09-10 DD DD90343932A patent/DD299308A5/en not_active IP Right Cessation
- 1990-09-10 NO NO90903941A patent/NO903941L/en unknown
- 1990-09-10 IL IL9562290A patent/IL95622A/en not_active IP Right Cessation
- 1990-09-10 CA CA002025005A patent/CA2025005A1/en not_active Abandoned
- 1990-09-10 HU HU905852A patent/HU206882B/en not_active IP Right Cessation
- 1990-09-10 PT PT95259A patent/PT95259A/en not_active Application Discontinuation
- 1990-09-10 YU YU171590A patent/YU47372B/en unknown
- 1990-09-11 JP JP2241064A patent/JPH03209382A/en active Pending
- 1990-09-11 PL PL90286835A patent/PL165197B1/en unknown
- 1990-09-11 ZA ZA907199A patent/ZA907199B/en unknown
- 1990-09-11 NZ NZ235270A patent/NZ235270A/en unknown
- 1990-09-11 FI FI904469A patent/FI904469A0/en not_active Application Discontinuation
- 1990-09-11 AU AU62352/90A patent/AU626452B2/en not_active Ceased
- 1990-09-11 KR KR1019900014616A patent/KR910006286A/en not_active Application Discontinuation
-
1992
- 1992-03-18 RU SU925011116A patent/RU2017740C1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IL95622A (en) | 1994-04-12 |
| FI904469A0 (en) | 1990-09-11 |
| NO903941D0 (en) | 1990-09-10 |
| RU2017740C1 (en) | 1994-08-15 |
| PT95259A (en) | 1991-05-22 |
| EP0417631A2 (en) | 1991-03-20 |
| JPH03209382A (en) | 1991-09-12 |
| HUT55393A (en) | 1991-05-28 |
| HU206882B (en) | 1993-01-28 |
| AU626452B2 (en) | 1992-07-30 |
| NZ235270A (en) | 1991-11-26 |
| ZA907199B (en) | 1992-05-27 |
| DE3930262A1 (en) | 1991-03-21 |
| YU47372B (en) | 1995-01-31 |
| KR910006286A (en) | 1991-04-29 |
| PL165197B1 (en) | 1994-11-30 |
| HU905852D0 (en) | 1991-03-28 |
| YU171590A (en) | 1993-05-28 |
| PL286835A1 (en) | 1991-08-26 |
| IL95622A0 (en) | 1991-06-30 |
| EP0417631A3 (en) | 1991-12-11 |
| AU6235290A (en) | 1991-03-14 |
| DD299308A5 (en) | 1992-04-09 |
| CA2025005A1 (en) | 1991-03-12 |
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