NO903211L - Salter av n5,n10-metylen-5-6-7-8-tetrahydrofolsyre samt fremgangsmaate for deres fremstilling. - Google Patents
Salter av n5,n10-metylen-5-6-7-8-tetrahydrofolsyre samt fremgangsmaate for deres fremstilling.Info
- Publication number
- NO903211L NO903211L NO90903211A NO903211A NO903211L NO 903211 L NO903211 L NO 903211L NO 90903211 A NO90903211 A NO 90903211A NO 903211 A NO903211 A NO 903211A NO 903211 L NO903211 L NO 903211L
- Authority
- NO
- Norway
- Prior art keywords
- salts
- methylene
- preparation
- procedure
- formulae
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Abstract
Salter av N,Nmetylen-5,6,7,8-tetranydrofolsyre med formlene (Ia) og (Ib). 1 form av (6RS)-diastereomerisomerblandli]ger eller i form av. enkelte (6R)- eller (6S)-diastereoisomerer der R er et flerverdig. organisk og/éller uorganisk kation; Rog R^ er et enverdig. organisk og/eller uorganisk kation hvorved R^ og R^ kan være like. og/eller forskjellige; og A er en rest med formelen. Forbindelsene med formel (Ia) og (Ib) rapporteres å ha interes-. sante farmakologiske egenskaper og kan anvendes for fremstilling. av legemidler for synergistisk påvirkning av kreftbekjempende. forbindelser og/eller for reduksjon av toksisiteten til en. kreftbekjempende forbindelse og/eller for beskyttelse av menneske-. lige og/eller animalske celler.Forbindelsenes fremstilling beskrives.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH273689A CH678854A5 (en) | 1989-07-21 | 1989-07-21 | N,N-methylene-5,6,7,8-tetra:hydro-folic acid salt (I) |
CH125690A CH680732A5 (en) | 1990-04-12 | 1990-04-12 | N,N-methylene-5,6,7,8-tetra:hydro-folic acid salt (I) |
Publications (2)
Publication Number | Publication Date |
---|---|
NO903211D0 NO903211D0 (no) | 1990-07-18 |
NO903211L true NO903211L (no) | 1991-01-22 |
Family
ID=25687132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO90903211A NO903211L (no) | 1989-07-21 | 1990-07-18 | Salter av n5,n10-metylen-5-6-7-8-tetrahydrofolsyre samt fremgangsmaate for deres fremstilling. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0409125B1 (no) |
JP (1) | JPH03128380A (no) |
AT (1) | ATE132498T1 (no) |
BR (1) | BR9003527A (no) |
CA (1) | CA2021042A1 (no) |
DE (1) | DE59010025D1 (no) |
ES (1) | ES2083983T3 (no) |
FI (1) | FI903692A0 (no) |
IE (1) | IE902656A1 (no) |
NO (1) | NO903211L (no) |
PT (1) | PT94782A (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2659330B1 (fr) * | 1990-03-09 | 1994-02-11 | Sapec Sa | Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits. |
US5217974A (en) * | 1991-03-29 | 1993-06-08 | Eli Lilly And Company | Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity |
CH683690A5 (de) * | 1991-12-21 | 1994-04-29 | Sapec Fine Chemicals | Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten. |
CH684644A5 (de) | 1992-07-13 | 1994-11-15 | Eprova Ag | 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen. |
GB9223352D0 (en) * | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
US7947662B2 (en) | 2008-02-20 | 2011-05-24 | Gnosis S.P.A. | Folates, compositions and uses thereof |
PT2245032E (pt) * | 2008-02-20 | 2015-07-21 | Gnosis Spa | Folatos, composições e suas utilizações |
EP3461826A1 (en) | 2017-09-29 | 2019-04-03 | Aprofol AG | Multifunctional folate salts |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2063027A1 (de) * | 1969-12-26 | 1971-07-01 | Yamanouchi Pharmaceutical Co Ltd , Tokio | Salz einer basischen Aminosäure der 5 6,7,8 Tetrahydrofolsaure |
FR2137186A1 (en) * | 1971-05-14 | 1972-12-29 | Mauvernay Centre Europ | Folic acid salts - used as neuro-stimulants and for dynamising muscular function |
GB1572138A (en) * | 1977-02-22 | 1980-07-23 | Bioresearch Sas Del Dr Livio C | Process for the preparation of d,1-5-methyltetrahydrofolic acid |
CH673459A5 (no) * | 1987-05-15 | 1990-03-15 | Eprova Ag | |
DE3821875C1 (no) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch |
-
1990
- 1990-07-12 CA CA002021042A patent/CA2021042A1/en not_active Abandoned
- 1990-07-15 AT AT90113546T patent/ATE132498T1/de not_active IP Right Cessation
- 1990-07-15 DE DE59010025T patent/DE59010025D1/de not_active Expired - Fee Related
- 1990-07-15 EP EP90113546A patent/EP0409125B1/de not_active Expired - Lifetime
- 1990-07-15 ES ES90113546T patent/ES2083983T3/es not_active Expired - Lifetime
- 1990-07-18 NO NO90903211A patent/NO903211L/no unknown
- 1990-07-19 JP JP2191854A patent/JPH03128380A/ja active Pending
- 1990-07-20 FI FI903692A patent/FI903692A0/fi not_active Application Discontinuation
- 1990-07-20 BR BR909003527A patent/BR9003527A/pt unknown
- 1990-07-20 IE IE265690A patent/IE902656A1/en unknown
- 1990-07-20 PT PT94782A patent/PT94782A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE59010025D1 (de) | 1996-02-15 |
FI903692A0 (fi) | 1990-07-20 |
AU5905990A (en) | 1991-01-24 |
NO903211D0 (no) | 1990-07-18 |
BR9003527A (pt) | 1991-08-27 |
EP0409125B1 (de) | 1996-01-03 |
PT94782A (pt) | 1991-04-18 |
AU619124B2 (en) | 1992-01-16 |
CA2021042A1 (en) | 1991-01-22 |
EP0409125A1 (de) | 1991-01-23 |
JPH03128380A (ja) | 1991-05-31 |
IE902656A1 (en) | 1991-02-27 |
ATE132498T1 (de) | 1996-01-15 |
ES2083983T3 (es) | 1996-05-01 |
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