NO892761L - PROCEDURE FOR MANUFACTURING INHIBITORS FOR 3-KETO-HMG-COA REDUCTASE. - Google Patents

Abstract

Forbindelser med formel (I) og (II):. hvor Rer eventuelt substituert c_alkyl, C_-alkoxy, C_-alkenyl, eventuelt substituert C_g-cycloalkyl, eventuelt substituert fenyl, eventuelt substituert amino, piperidinyl, pyrroli-dinyl, piperazinyl, morfolinyl, thio-morfolinyl eller RS hvor er C_-alkyl eller eventuelt substituert fenyl, Rer H, CHeller CHOH, Z er hydrogen, eventuelt substituert C-alkyl hvor substituenten er valgt fra fenyl, dimethylamino og acetylamino, eller 2,3-hydroxypropyl, og a er en enkeltbinding eller en dobbeltbinding, samt farmasøyt-isk akseptable salter av forbindelse (II) hvor Z er hydrogen. Forbindelsene er HMG-CoA-reduktaseinhibitorer.Mellomprodukter og fremstillingen av forbindelsene er beskrevet.Compounds of formula (I) and (II):. wherein R 1 is optionally substituted C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkenyl, optionally substituted C 1-8 cycloalkyl, optionally substituted phenyl, optionally substituted amino, piperidinyl, pyrrolidinyl, piperazinyl, morpholinyl, thio-morpholinyl or R 5 where is C 1-4 alkyl or optionally substituted phenyl, R 1 H, CH or CHOH, Z is hydrogen, optionally substituted C-alkyl wherein the substituent is selected from phenyl, dimethylamino and acetylamino, or 2,3-hydroxypropyl, and a is a single bond or a double bond, and is pharmaceutically acceptable salts of compound (II) wherein Z is hydrogen. The compounds are HMG-CoA reductase inhibitors. Intermediates and the preparation of the compounds are described.