NO890594L - Fremgangsmaate for fremstilling av fem-leddede ringsystemer med bundne azacykliske ringsubstituenter. - Google Patents

Fremgangsmaate for fremstilling av fem-leddede ringsystemer med bundne azacykliske ringsubstituenter.

Info

Publication number
NO890594L
NO890594L NO89890594A NO890594A NO890594L NO 890594 L NO890594 L NO 890594L NO 89890594 A NO89890594 A NO 89890594A NO 890594 A NO890594 A NO 890594A NO 890594 L NO890594 L NO 890594L
Authority
NO
Norway
Prior art keywords
ring
leaded
bond
procedure
manufacture
Prior art date
Application number
NO89890594A
Other languages
English (en)
Other versions
NO890594D0 (no
Inventor
Raymond Baker
John Saunders
Christoper Swain
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888803317A external-priority patent/GB8803317D0/en
Priority claimed from GB888810789A external-priority patent/GB8810789D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NO890594D0 publication Critical patent/NO890594D0/no
Publication of NO890594L publication Critical patent/NO890594L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO89890594A 1988-02-12 1989-02-10 Fremgangsmaate for fremstilling av fem-leddede ringsystemer med bundne azacykliske ringsubstituenter. NO890594L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888803317A GB8803317D0 (en) 1988-02-12 1988-02-12 Therapeutic agents
GB888810789A GB8810789D0 (en) 1988-05-06 1988-05-06 Therapeutic agents

Publications (2)

Publication Number Publication Date
NO890594D0 NO890594D0 (no) 1989-02-10
NO890594L true NO890594L (no) 1989-08-14

Family

ID=26293485

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89890594A NO890594L (no) 1988-02-12 1989-02-10 Fremgangsmaate for fremstilling av fem-leddede ringsystemer med bundne azacykliske ringsubstituenter.

Country Status (15)

Country Link
US (2) US4952587A (no)
EP (1) EP0328200B1 (no)
JP (1) JP2505875B2 (no)
KR (1) KR890013011A (no)
AU (1) AU614027B2 (no)
CA (1) CA1337199C (no)
DE (1) DE68911162T2 (no)
DK (1) DK61689A (no)
ES (1) ES2061928T3 (no)
FI (1) FI890657A (no)
IE (1) IE890431L (no)
IL (1) IL89165A0 (no)
NO (1) NO890594L (no)
NZ (1) NZ227841A (no)
PT (1) PT89613B (no)

Families Citing this family (67)

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GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
HU209451B (en) * 1990-11-05 1994-06-28 Gyogyszerkutato Intezet Process for the production of 1-azabicyclo-alkan -derivatives and pharmaceutical preparations containing the same
AU9102991A (en) * 1990-11-29 1992-06-25 Rhone-Poulenc Rorer International (Holdings) Inc. 2,6-methano-2h-1-benzoxocincarboxamides as 5-ht3-antagonists
EP0494774A1 (en) * 1991-01-11 1992-07-15 MERCK SHARP &amp; DOHME LTD. Indazole-substituted fivemembered heteroaromatic compounds
US5317103A (en) * 1991-01-15 1994-05-31 Merck Sharp & Dohme Limited Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
DE4115215A1 (de) * 1991-05-10 1992-11-12 Merck Patent Gmbh Indolderivate
JPH06509574A (ja) * 1991-08-03 1994-10-27 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ↓４レセプターアンタゴニスト
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
AU3171493A (en) * 1991-12-31 1993-07-28 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5244906A (en) * 1992-01-23 1993-09-14 Dowelanco Insect control with substituted oxadiazole and thiadiazole compounds
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
AU3901393A (en) * 1992-04-10 1993-11-18 Zeneca Limited Biphenylylquinuclidine derivatives as squalene synthase inhibitors
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
CA2101599A1 (en) * 1992-08-31 1994-03-01 Wilhelm Bannwarth Tri- and tetracyclic compounds
EP0664805A1 (en) * 1992-10-13 1995-08-02 Smithkline Beecham Plc Heterocyclic -esters or -amides used as 5-ht 4? receptor antagonists
ES2062921B1 (es) * 1992-11-06 1995-06-16 Merck Patent Gmbh 3-(indol-2-carboxiamido)quinuclidinas.
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
GB9314973D0 (en) * 1993-07-20 1993-09-01 Smithkline Beecham Plc Medicaments
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
WO1995005379A1 (en) * 1993-08-19 1995-02-23 Novo Nordisk A/S Antipsychotic method
WO1995024399A1 (fr) * 1994-03-11 1995-09-14 Yamanouchi Pharmaceutical Co., Ltd. Agoniste de recepteur 5-ht3, nouveau derive de thiazole et intermediaire destine a son obtention
WO1995032965A1 (fr) * 1994-06-01 1995-12-07 Yamanouchi Pharmaceutical Co. Ltd. Derive de l'oxadiazole et composition medicinale a base de ce dernier
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
CN1333766A (zh) 1998-12-24 2002-01-30 阿温蒂斯药物制品公司 取代的(氨基亚氨基甲基或氨基甲基)苯并杂芳基化合物
AUPR118000A0 (en) 2000-11-02 2000-11-23 Amrad Operations Pty. Limited Therapeutic molecules and methods
CA2440842A1 (en) 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
US20040087642A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
WO2005060961A2 (en) * 2003-12-18 2005-07-07 Astrazeneca Ab Treatment of transient lower esophageal sphincter relaxations (tlesrs) and gastro-esophageal reflux disease (gerd)
WO2005077373A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
WO2005077368A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)
TWI330635B (en) * 2004-03-05 2010-09-21 Organon Nv (indol-3-yl)-heterocycle derivatives
MX2007007024A (es) * 2004-12-16 2007-07-04 Astrazeneca Ab Ligandos del receptor acetilcolina nicotinica.
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DE102008038221A1 (de) 2008-08-18 2010-02-25 Merck Patent Gmbh 7-Azaindolderivate
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US3646053A (en) * 1970-05-18 1972-02-29 American Cyanamid Co Certain-(2-amino-4-thiazolyl)indoles
US4342769A (en) * 1978-10-02 1982-08-03 Schering Corporation 2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants
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EP0038298B1 (en) * 1980-04-10 1984-07-25 Sandoz Ag Isoxazolyl indolamines
FR2548666A1 (fr) * 1983-07-08 1985-01-11 Delalande Sa Nouveaux derives du nor-tropane et du granatane, leur procede de preparation et leur application en therapeutique
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Also Published As

Publication number Publication date
EP0328200A1 (en) 1989-08-16
IE890431L (en) 1989-08-12
US4952587A (en) 1990-08-28
FI890657A0 (fi) 1989-02-10
CA1337199C (en) 1995-10-03
DK61689A (da) 1989-08-13
PT89613A (pt) 1989-10-04
JPH01268687A (ja) 1989-10-26
AU614027B2 (en) 1991-08-15
US5041456A (en) 1991-08-20
DE68911162D1 (de) 1994-01-20
KR890013011A (ko) 1989-09-20
AU2986089A (en) 1989-08-17
DE68911162T2 (de) 1994-05-26
EP0328200B1 (en) 1993-12-08
DK61689D0 (da) 1989-02-10
FI890657A (fi) 1989-08-13
JP2505875B2 (ja) 1996-06-12
ES2061928T3 (es) 1994-12-16
PT89613B (pt) 1994-05-31
NZ227841A (en) 1991-08-27
IL89165A0 (en) 1989-09-10
NO890594D0 (no) 1989-02-10

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