NO841580L - Kompleksdannelse av biologisk aktive eller funksjonelle forbindelser og fremstilling og bruk derav - Google Patents

Kompleksdannelse av biologisk aktive eller funksjonelle forbindelser og fremstilling og bruk derav

Info

Publication number: NO841580L
Authority: NO; Norway
Prior art keywords: compound; complex; attached; substrate; contact
Prior art date: 1983-04-20

Application number

NO841580A

Other languages

English (en)

Norwegian (no)

Inventor

Kenneth H Johnston

Original Assignee

Enzo Biochem Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-20

Filing date

1984-04-18

Publication date

1984-10-22

1984-04-18 Application filed by Enzo Biochem Inc filed Critical Enzo Biochem Inc

1984-10-22 Publication of NO841580L publication Critical patent/NO841580L/no

Links

150000001875 compounds Chemical class 0.000 title claims description 98
238000004519 manufacturing process Methods 0.000 title description 4
230000000536 complexating effect Effects 0.000 title 1
102000004190 Enzymes Human genes 0.000 claims description 87
108090000790 Enzymes Proteins 0.000 claims description 87
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 51
239000000758 substrate Substances 0.000 claims description 51
229960002685 biotin Drugs 0.000 claims description 29
239000011616 biotin Substances 0.000 claims description 29
239000003112 inhibitor Substances 0.000 claims description 29
235000020958 biotin Nutrition 0.000 claims description 26
238000000034 method Methods 0.000 claims description 25
108010090804 Streptavidin Proteins 0.000 claims description 20
239000002773 nucleotide Substances 0.000 claims description 20
125000003729 nucleotide group Chemical group 0.000 claims description 20
239000007787 solid Substances 0.000 claims description 18
239000000427 antigen Substances 0.000 claims description 17
108091007433 antigens Proteins 0.000 claims description 17
102000036639 antigens Human genes 0.000 claims description 17
239000005556 hormone Substances 0.000 claims description 15
229940088597 hormone Drugs 0.000 claims description 15
239000000126 substance Substances 0.000 claims description 15
239000000463 material Substances 0.000 claims description 11
108091008039 hormone receptors Proteins 0.000 claims description 10
230000027455 binding Effects 0.000 claims description 9
230000002860 competitive effect Effects 0.000 claims description 9
102000005744 Glycoside Hydrolases Human genes 0.000 claims description 8
108010031186 Glycoside Hydrolases Proteins 0.000 claims description 8
238000001212 derivatisation Methods 0.000 claims description 6
229920002684 Sepharose Polymers 0.000 claims description 5
230000000694 effects Effects 0.000 claims description 5
230000001747 exhibiting effect Effects 0.000 claims description 3
239000005547 deoxyribonucleotide Substances 0.000 claims 1
125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
238000002372 labelling Methods 0.000 claims 1
230000009870 specific binding Effects 0.000 claims 1
229940088598 enzyme Drugs 0.000 description 86
102000002260 Alkaline Phosphatase Human genes 0.000 description 41
108020004774 Alkaline Phosphatase Proteins 0.000 description 41
230000006287 biotinylation Effects 0.000 description 18
238000007413 biotinylation Methods 0.000 description 18
108090001008 Avidin Chemical group 0.000 description 16
NEKHKXMBGWNTOO-UHFFFAOYSA-N (4-aminophenyl)methylphosphonic acid Chemical compound NC1=CC=C(CP(O)(O)=O)C=C1 NEKHKXMBGWNTOO-UHFFFAOYSA-N 0.000 description 14
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 14
239000000872 buffer Substances 0.000 description 9
239000011324 bead Substances 0.000 description 8
GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 7
102000013563 Acid Phosphatase Human genes 0.000 description 7
108010051457 Acid Phosphatase Proteins 0.000 description 7
AYXZIZMZXAORLO-UFLZEWODSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid;1-hydroxypyrrolidine-2,5-dione Chemical compound ON1C(=O)CCC1=O.N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 AYXZIZMZXAORLO-UFLZEWODSA-N 0.000 description 6
229920002307 Dextran Polymers 0.000 description 6
150000001615 biotins Chemical class 0.000 description 6
102000004169 proteins and genes Human genes 0.000 description 6
108090000623 proteins and genes Proteins 0.000 description 6
239000000523 sample Substances 0.000 description 6
239000000243 solution Substances 0.000 description 6
239000011248 coating agent Substances 0.000 description 5
238000000576 coating method Methods 0.000 description 5
230000004048 modification Effects 0.000 description 5
238000012986 modification Methods 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
108090001090 Lectins Proteins 0.000 description 4
102000004856 Lectins Human genes 0.000 description 4
-1 antibodies Substances 0.000 description 4
239000002523 lectin Substances 0.000 description 4
239000000203 mixture Substances 0.000 description 4
238000011084 recovery Methods 0.000 description 4
239000000020 Nitrocellulose Substances 0.000 description 3
229920001213 Polysorbate 20 Polymers 0.000 description 3
238000001514 detection method Methods 0.000 description 3
125000003147 glycosyl group Chemical group 0.000 description 3
238000011534 incubation Methods 0.000 description 3
230000004807 localization Effects 0.000 description 3
229920001220 nitrocellulos Polymers 0.000 description 3
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
239000002002 slurry Substances 0.000 description 3
OGBVRMYSNSKIEF-UHFFFAOYSA-N Benzylphosphonic acid Chemical compound OP(O)(=O)CC1=CC=CC=C1 OGBVRMYSNSKIEF-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
108010015776 Glucose oxidase Proteins 0.000 description 2
239000004366 Glucose oxidase Substances 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000002253 acid Substances 0.000 description 2
125000003277 amino group Chemical group 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
239000011521 glass Substances 0.000 description 2
229940116332 glucose oxidase Drugs 0.000 description 2
235000019420 glucose oxidase Nutrition 0.000 description 2
239000003446 ligand Substances 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
239000000712 neurohormone Substances 0.000 description 2
LVKZSFMYNWRPJX-UHFFFAOYSA-N phenylarsonic acid Chemical compound O[As](O)(=O)C1=CC=CC=C1 LVKZSFMYNWRPJX-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
238000000926 separation method Methods 0.000 description 2
230000011664 signaling Effects 0.000 description 2
239000011343 solid material Substances 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
238000006467 substitution reaction Methods 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
238000005406 washing Methods 0.000 description 2
FZNXRFYRXBFQMX-UHFFFAOYSA-N (4-nitrophenyl)methylphosphonic acid Chemical compound OP(O)(=O)CC1=CC=C([N+]([O-])=O)C=C1 FZNXRFYRXBFQMX-UHFFFAOYSA-N 0.000 description 1
KHUFHLFHOQVFGB-UHFFFAOYSA-N 1-aminoanthracene-9,10-dione Chemical class O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2N KHUFHLFHOQVFGB-UHFFFAOYSA-N 0.000 description 1
GVBHRNIWBGTNQA-UHFFFAOYSA-N 2-methoxy-4-nitroaniline Chemical compound COC1=CC([N+]([O-])=O)=CC=C1N GVBHRNIWBGTNQA-UHFFFAOYSA-N 0.000 description 1
NIPDVSLAMPAWTP-UHFFFAOYSA-N 2-methoxy-5-nitroaniline Chemical compound COC1=CC=C([N+]([O-])=O)C=C1N NIPDVSLAMPAWTP-UHFFFAOYSA-N 0.000 description 1
HFCFJYRLBAANKN-UHFFFAOYSA-N 2-methyl-3-nitroaniline Chemical compound CC1=C(N)C=CC=C1[N+]([O-])=O HFCFJYRLBAANKN-UHFFFAOYSA-N 0.000 description 1
BFDYSJCMAFSRDH-UHFFFAOYSA-N 2-phenylethylphosphonic acid Chemical compound OP(O)(=O)CCC1=CC=CC=C1 BFDYSJCMAFSRDH-UHFFFAOYSA-N 0.000 description 1
JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 description 1
GDIIPKWHAQGCJF-UHFFFAOYSA-N 4-Amino-2-nitrotoluene Chemical compound CC1=CC=C(N)C=C1[N+]([O-])=O GDIIPKWHAQGCJF-UHFFFAOYSA-N 0.000 description 1
XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
WOXLPNAOCCIZGP-UHFFFAOYSA-N 4-chloro-2-methoxyaniline Chemical compound COC1=CC(Cl)=CC=C1N WOXLPNAOCCIZGP-UHFFFAOYSA-N 0.000 description 1
PBGKNXWGYQPUJK-UHFFFAOYSA-N 4-chloro-2-nitroaniline Chemical compound NC1=CC=C(Cl)C=C1[N+]([O-])=O PBGKNXWGYQPUJK-UHFFFAOYSA-N 0.000 description 1
QFMJFXFXQAFGBO-UHFFFAOYSA-N 4-methoxy-2-nitroaniline Chemical compound COC1=CC=C(N)C([N+]([O-])=O)=C1 QFMJFXFXQAFGBO-UHFFFAOYSA-N 0.000 description 1
QZHXKQKKEBXYRG-UHFFFAOYSA-N 4-n-(4-aminophenyl)benzene-1,4-diamine Chemical compound C1=CC(N)=CC=C1NC1=CC=C(N)C=C1 QZHXKQKKEBXYRG-UHFFFAOYSA-N 0.000 description 1
RBLUJIWKMSZIMK-UHFFFAOYSA-N 4-n-(4-methoxyphenyl)benzene-1,4-diamine Chemical compound C1=CC(OC)=CC=C1NC1=CC=C(N)C=C1 RBLUJIWKMSZIMK-UHFFFAOYSA-N 0.000 description 1
TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 description 1
WRZOMWDJOLIVQP-UHFFFAOYSA-N 5-Chloro-ortho-toluidine Chemical compound CC1=CC=C(Cl)C=C1N WRZOMWDJOLIVQP-UHFFFAOYSA-N 0.000 description 1
SHWZFPFHYGKWIW-UFLZEWODSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid;3-hydroxypyrrolidine-2,5-dione Chemical compound OC1CC(=O)NC1=O.N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 SHWZFPFHYGKWIW-UFLZEWODSA-N 0.000 description 1
229920000936 Agarose Polymers 0.000 description 1
108010062580 Concanavalin A Proteins 0.000 description 1
102000018832 Cytochromes Human genes 0.000 description 1
108010052832 Cytochromes Proteins 0.000 description 1
102000002464 Galactosidases Human genes 0.000 description 1
108010093031 Galactosidases Proteins 0.000 description 1
241001494479 Pecora Species 0.000 description 1
102000003992 Peroxidases Human genes 0.000 description 1
QLZHNIAADXEJJP-UHFFFAOYSA-N Phenylphosphonic acid Chemical compound OP(O)(=O)C1=CC=CC=C1 QLZHNIAADXEJJP-UHFFFAOYSA-N 0.000 description 1
102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
XKNKHVGWJDPIRJ-UHFFFAOYSA-N arsanilic acid Chemical compound NC1=CC=C([As](O)(O)=O)C=C1 XKNKHVGWJDPIRJ-UHFFFAOYSA-N 0.000 description 1
BUSBFZWLPXDYIC-UHFFFAOYSA-N arsonic acid Chemical class O[AsH](O)=O BUSBFZWLPXDYIC-UHFFFAOYSA-N 0.000 description 1
229960002319 barbital Drugs 0.000 description 1
108010027090 biotin-streptavidin complex Proteins 0.000 description 1
SWYGLBJVTQMYSE-UHFFFAOYSA-N cyclohexyloxy(methyl)phosphinic acid Chemical compound CP(O)(=O)OC1CCCCC1 SWYGLBJVTQMYSE-UHFFFAOYSA-N 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
239000012954 diazonium Substances 0.000 description 1
150000001989 diazonium salts Chemical class 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
CCAFPWNGIUBUSD-UHFFFAOYSA-N diethyl sulfoxide Chemical compound CCS(=O)CC CCAFPWNGIUBUSD-UHFFFAOYSA-N 0.000 description 1
239000001177 diphosphate Substances 0.000 description 1
235000011180 diphosphates Nutrition 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000002532 enzyme inhibitor Substances 0.000 description 1
229940125532 enzyme inhibitor Drugs 0.000 description 1
GATNOFPXSDHULC-UHFFFAOYSA-N ethylphosphonic acid Chemical compound CCP(O)(O)=O GATNOFPXSDHULC-UHFFFAOYSA-N 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
238000002156 mixing Methods 0.000 description 1
VKKZGJIXTDWXBM-UHFFFAOYSA-N n-(6-amino-3-methoxy-1-methylcyclohexa-2,4-dien-1-yl)benzamide Chemical compound NC1C=CC(OC)=CC1(C)NC(=O)C1=CC=CC=C1 VKKZGJIXTDWXBM-UHFFFAOYSA-N 0.000 description 1
ATGUVEKSASEFFO-UHFFFAOYSA-N p-aminodiphenylamine Chemical compound C1=CC(N)=CC=C1NC1=CC=CC=C1 ATGUVEKSASEFFO-UHFFFAOYSA-N 0.000 description 1
230000007170 pathology Effects 0.000 description 1
239000012466 permeate Substances 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
239000000047 product Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Cell Biology (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Physics & Mathematics (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NO841580A 1983-04-20 1984-04-18 Kompleksdannelse av biologisk aktive eller funksjonelle forbindelser og fremstilling og bruk derav NO841580L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48692483A	1983-04-20	1983-04-20

Publications (1)

Publication Number	Publication Date
NO841580L true NO841580L (no)	1984-10-22

Family

ID=23933679

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO841580A NO841580L (no)	1983-04-20	1984-04-18	Kompleksdannelse av biologisk aktive eller funksjonelle forbindelser og fremstilling og bruk derav

Country Status (7)

Country	Link
EP (1)	EP0123300A3 (da)
JP (1)	JPS59224564A (da)
AU (1)	AU2716184A (da)
DK (1)	DK188184A (da)
ES (1)	ES8600393A1 (da)
IL (1)	IL71577A0 (da)
NO (1)	NO841580L (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1985003356A1 (en) *	1984-01-27	1985-08-01	Molecular Biosystems, Inc.	Assay for immobilized reporter groups
AU3844485A (en) *	1984-02-09	1985-08-15	Enzo Biochem Inc.	Heterologous detection of cabeled dna
US4868105A (en) *	1985-12-11	1989-09-19	Chiron Corporation	Solution phase nucleic acid sandwich assay
US5093232A (en) *	1985-12-11	1992-03-03	Chiron Corporation	Nucleic acid probes
US4910300A (en) *	1985-12-11	1990-03-20	Chiron Corporation	Method for making nucleic acid probes
US5190864A (en) *	1986-04-15	1993-03-02	Northeastern University	Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
US4937188A (en) *	1986-04-15	1990-06-26	Northeastern University	Enzyme activity amplification method for increasing assay sensitivity
US5047523A (en) *	1988-08-02	1991-09-10	Ortho Diagnostic Systems Inc.	Nucleic acid probe for detection of neisseria gonorrhoea
US5099011A (en) *	1988-08-02	1992-03-24	Ortho Diagnostic Systems Inc.	Nucleic acid probe for detection of Neisseria gonorrhoea
US5324829A (en) *	1988-12-16	1994-06-28	Ortho Diagnostic Systems, Inc.	High specific activity nucleic acid probes having target recognition and signal generating moieties
IT1238214B (it) *	1989-10-31	1993-07-12	Lorenzo Ferrari	Formulazioni solide di sistemi complessi tipo sostanza avidinica-marcatore biotinilato utili in analisi biologiche.
BE1006179A3 (fr) *	1992-09-22	1994-05-31	Lambdatech S A	Conjugue destine a la detection et/ou au dosage d'un compose biologique.
US5446137B1 (en) *	1993-12-09	1998-10-06	Behringwerke Ag	Oligonucleotides containing 4'-substituted nucleotides
JP3781934B2 (ja) *	1999-12-22	2006-06-07	株式会社ニチレイバイオサイエンス	酵素−タンパク質複合体
US7767394B2 (en)	2005-02-09	2010-08-03	Pacific Biosciences Of California, Inc.	Nucleotide compositions and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4228237A (en) *	1978-09-21	1980-10-14	Calbiochem-Behring Corp.	Methods for the detection and determination of ligands
US4371515A (en) *	1978-12-26	1983-02-01	E-Y Laboratories, Inc.	Method for forming an isolated lectin-immunological conjugate
AU8594382A (en) *	1981-08-05	1983-02-10	F. Hoffmann-La Roche Ag	Immunoassay using biotin-avidin-enzyme complex
US4617261A (en) *	1984-03-21	1986-10-14	Cetus Corporation	Process for labeling nucleic acids and hybridization probes

1984
- 1984-04-11 DK DK188184A patent/DK188184A/da not_active Application Discontinuation
- 1984-04-18 NO NO841580A patent/NO841580L/no unknown
- 1984-04-18 ES ES531734A patent/ES8600393A1/es not_active Expired
- 1984-04-19 AU AU27161/84A patent/AU2716184A/en not_active Abandoned
- 1984-04-19 JP JP59079318A patent/JPS59224564A/ja active Pending
- 1984-04-19 IL IL71577A patent/IL71577A0/xx unknown
- 1984-04-19 EP EP84104488A patent/EP0123300A3/en not_active Withdrawn

Also Published As

Publication number	Publication date
AU2716184A (en)	1984-10-25
ES531734A0 (es)	1985-10-01
EP0123300A3 (en)	1988-01-20
EP0123300A2 (en)	1984-10-31
IL71577A0 (en)	1984-07-31
DK188184A (da)	1984-10-21
JPS59224564A (ja)	1984-12-17
DK188184D0 (da)	1984-04-11
ES8600393A1 (es)	1985-10-01

Publication	Publication Date	Title
NO841580L (no)	1984-10-22	Kompleksdannelse av biologisk aktive eller funksjonelle forbindelser og fremstilling og bruk derav
EP0151492B1 (en)	1996-01-17	Heterologous system for the detection of labeled DNA
Diamandis et al.	1991	The biotin-(strept) avidin system: principles and applications in biotechnology
US5109124A (en)	1992-04-28	Nucleic acid probe linked to a label having a terminal cysteine
JP2746484B2 (ja)	1998-05-06	少なくとも二つの結合成分に対する結合部位を有する測定物質の検出
JP3093116B2 (ja)	2000-10-03	核酸検出方法
JPH09510289A (ja)	1997-10-14	イムノアッセイで使用するための干渉除去剤
JPH08336400A (ja)	1996-12-24	標的遺伝物質の検出方法
Brown et al.	1993	Affinity purification of a somatostatin receptor-G-protein complex demonstrates specificity in receptor-G-protein coupling.
EP1813948A1 (en)	2007-08-01	Method of detecting target substances
US5702893A (en)	1997-12-30	Hydrophobic nucleic acid probe
JPH06506768A (ja)	1994-07-28	タンパク質―核酸プローブおよびそれを用いたイムノアッセイ
US6635420B1 (en)	2003-10-21	Purification of substances from a biological sample
JPH05149949A (ja)	1993-06-15	新規な微量物質測定法
Witkowski et al.	1993	Enzyme-linked immunosorbent assay for an octapeptide based on a genetically engineered fusion protein
JPS58502206A (ja)	1983-12-22	修飾されたアデノシン５′−トリリン酸及び該アデノシン５′−トリリン酸の減成生成物を固定し得る生物学的物質の定量法
KR102338690B1 (ko)	2021-12-14	항체결합단백질 및 우라실 dna 글리코실레이즈 효소를 포함하는 융합 단백질, 및 상기 융합 단백질의 용도
JPH0812699A (ja)	1996-01-16	Ｐｅｇ修飾アビジン及びそれを用いた抗原又は抗体の分離方法
EP1634074B1 (en)	2009-08-12	Hydrolytic substrates for an analyte-dependent enzyme activation system
AU2537688A (en)	1989-04-17	Solid-phase non-separation enzyme assay
EP0797778B1 (en)	2000-10-18	A method for preparing non-proteinaceous strongly negatively charged macrobiomolecules, which are linked to plastic
JP2009124990A (ja)	2009-06-11	抗原定量方法
US20050239078A1 (en)	2005-10-27	Sequence tag microarray and method for detection of multiple proteins through DNA methods
JPH0560761A (ja)	1993-03-12	重合体の分析方法
Duan et al.	1998	Generation of carbohydrate-deficient transferrin by enzymatic deglycosylation of human transferrin