NO840102L - Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroxylaminoeddiksyrederivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroxylaminoeddiksyrederivater

Info

Publication number: NO840102L
Authority: NO; Norway
Prior art keywords: ethoxycarbonyl; hydroxylamino; alanyl; acetic acid; fused
Prior art date: 1983-01-12

Application number

NO840102A

Other languages

English (en)

Norwegian (no)

Inventor

Fu-Chih Huang

Howard Jones

Clara J Lin

Bernard Loev

Original Assignee

Usv Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-01-12

Filing date

1984-01-12

Publication date

1984-07-13

1984-01-12 Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp

1984-07-13 Publication of NO840102L publication Critical patent/NO840102L/no

Links

239000002253 acid Substances 0.000 title claims description 18
238000000034 method Methods 0.000 title claims description 9
238000002360 preparation method Methods 0.000 title claims description 9
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 44
QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 25
125000000217 alkyl group Chemical group 0.000 claims description 24
125000003118 aryl group Chemical group 0.000 claims description 19
125000000753 cycloalkyl group Chemical group 0.000 claims description 15
150000003839 salts Chemical class 0.000 claims description 15
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239000001257 hydrogen Substances 0.000 claims description 12
229910052739 hydrogen Inorganic materials 0.000 claims description 12
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
-1 alkenoxy Chemical group 0.000 claims description 11
150000002431 hydrogen Chemical class 0.000 claims description 11
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125000001424 substituent group Chemical group 0.000 claims description 7
125000004367 cycloalkylaryl group Chemical group 0.000 claims description 6
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims description 6
150000007513 acids Chemical class 0.000 claims description 5
125000004103 aminoalkyl group Chemical group 0.000 claims description 5
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MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 description 2
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
239000013543 active substance Substances 0.000 description 2
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150000001408 amides Chemical class 0.000 description 2
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ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 description 2
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
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125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 1
238000006193 diazotization reaction Methods 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
125000005805 dimethoxy phenyl group Chemical group 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
230000001882 diuretic effect Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000010685 fatty oil Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000001640 fractional crystallisation Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
125000002541 furyl group Chemical group 0.000 description 1
239000007789 gas Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000004475 heteroaralkyl group Chemical group 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
125000006289 hydroxybenzyl group Chemical group 0.000 description 1
125000002883 imidazolyl group Chemical group 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 1
125000001041 indolyl group Chemical group 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
125000002757 morpholinyl group Chemical group 0.000 description 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
238000006396 nitration reaction Methods 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 description 1
XYEOALKITRFCJJ-UHFFFAOYSA-N o-benzylhydroxylamine Chemical compound NOCC1=CC=CC=C1 XYEOALKITRFCJJ-UHFFFAOYSA-N 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
125000003367 polycyclic group Chemical group 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
238000000746 purification Methods 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000004208 shellac Substances 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000707 stereoselective effect Effects 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
BNWCETAHAJSBFG-UHFFFAOYSA-N tert-butyl 2-bromoacetate Chemical compound CC(C)(C)OC(=O)CBr BNWCETAHAJSBFG-UHFFFAOYSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Stereophonic System (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Indole Compounds (AREA)
Magnetic Resonance Imaging Apparatus (AREA)

NO840102A 1983-01-12 1984-01-12 Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroxylaminoeddiksyrederivater NO840102L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/457,611 US4496541A (en)	1983-01-12	1983-01-12	Compounds for treating hypertension

Publications (1)

Publication Number	Publication Date
NO840102L true NO840102L (no)	1984-07-13

Family

ID=23817424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO840102A NO840102L (no)	1983-01-12	1984-01-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroxylaminoeddiksyrederivater

Country Status (16)

Country	Link
US (1)	US4496541A (fi)
EP (1)	EP0114067B1 (fi)
JP (1)	JPS59130844A (fi)
KR (1)	KR840007713A (fi)
AT (1)	ATE26841T1 (fi)
AU (1)	AU560330B2 (fi)
CA (1)	CA1257749A (fi)
DE (1)	DE3463385D1 (fi)
DK (1)	DK13484A (fi)
ES (1)	ES528816A0 (fi)
FI (1)	FI85012C (fi)
IE (1)	IE56586B1 (fi)
IL (1)	IL70676A (fi)
NO (1)	NO840102L (fi)
NZ (1)	NZ206826A (fi)
ZA (1)	ZA84262B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4686295A (en) *	1982-03-10	1987-08-11	Usv Pharmaceutical Corporation	N-carboxy anhydride intermediates
JPS6248696A (ja) *	1985-08-27	1987-03-03	Kanegafuchi Chem Ind Co Ltd	Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
SI9200213A (en) *	1992-09-16	1994-03-31	Krka	Process for preparing alkyl-l-alanil-l-proline derivates
US6262274B1 (en) *	2000-10-13	2001-07-17	Everlight Usa, Inc.	Process for preparing N-[1-(S)-ethyoxycarbonyl-3-phenylpropyl]-L-ananine N-carboxyanhydride
FR2815962B1 (fr) *	2000-10-30	2003-03-07	Isochem Sa	Procede de preparation des n-carboxyanhydrides
US7973173B2 (en) *	2005-07-05	2011-07-05	Cipla Limited	Process for the synthesis of an ACE inhibitor
EP2044010B1 (en)	2006-05-12	2014-01-08	EGIS Gyógyszergyár Nyilvánosan Müködõ Részvénytársaság	New pharmaceutical intermediates in the synthesis of ace-inihibitors and the use thereof
EP2216949B1 (en) *	2008-04-30	2015-04-22	B & Plus K.K.	Input/output signal controller
US8443112B2 (en) *	2009-03-24	2013-05-14	B & Plus K.K.	Input/output signal controller and input/output signal control system employing the input/output controller

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1904M (fr) *	1962-03-01	1963-07-08	Merck & Co Inc	Médicament a base d'acide n-acyl-hydroxyamino-acétique pour le traitement des tumeurs.
AT293358B (de) *	1968-03-30	1971-10-11	Richter Gedeon Vegyeszet	Verfahren zur Herstellung von neuen N-Acyl-hydroxylaminderivaten
JPS4843726A (fi) *	1971-10-05	1973-06-23
US4098903A (en) *	1976-06-01	1978-07-04	Research Corporation	Anti-hypertensive compounds
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4820729A (en) *	1981-03-30	1989-04-11	Rorer Pharmaceutical Corporation	N-substituted-amido-amino acids

1983
- 1983-01-12 US US06/457,611 patent/US4496541A/en not_active Expired - Fee Related
1984
- 1984-01-11 JP JP59002110A patent/JPS59130844A/ja active Pending
- 1984-01-12 ZA ZA84262A patent/ZA84262B/xx unknown
- 1984-01-12 IL IL70676A patent/IL70676A/xx not_active IP Right Cessation
- 1984-01-12 AT AT84100300T patent/ATE26841T1/de not_active IP Right Cessation
- 1984-01-12 AU AU23254/84A patent/AU560330B2/en not_active Expired - Fee Related
- 1984-01-12 EP EP84100300A patent/EP0114067B1/en not_active Expired
- 1984-01-12 CA CA000445192A patent/CA1257749A/en not_active Expired
- 1984-01-12 NZ NZ206826A patent/NZ206826A/en unknown
- 1984-01-12 NO NO840102A patent/NO840102L/no unknown
- 1984-01-12 FI FI840109A patent/FI85012C/fi not_active IP Right Cessation
- 1984-01-12 ES ES528816A patent/ES528816A0/es active Granted
- 1984-01-12 DE DE8484100300T patent/DE3463385D1/de not_active Expired
- 1984-01-12 IE IE54/84A patent/IE56586B1/en not_active IP Right Cessation
- 1984-01-12 KR KR1019840000106A patent/KR840007713A/ko not_active Application Discontinuation
- 1984-01-12 DK DK13484A patent/DK13484A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
FI85012B (fi)	1991-11-15
FI840109A (fi)	1984-07-13
FI85012C (fi)	1992-02-25
ES8504109A1 (es)	1985-05-01
IL70676A (en)	1988-09-30
FI840109A0 (fi)	1984-01-12
IL70676A0 (en)	1984-04-30
KR840007713A (ko)	1984-12-10
EP0114067A1 (en)	1984-07-25
ATE26841T1 (de)	1987-05-15
DE3463385D1 (en)	1987-06-04
IE840054L (en)	1984-07-12
DK13484D0 (da)	1984-01-12
ZA84262B (en)	1984-08-29
CA1257749A (en)	1989-07-18
JPS59130844A (ja)	1984-07-27
AU2325484A (en)	1984-07-19
DK13484A (da)	1984-07-13
EP0114067B1 (en)	1987-04-29
NZ206826A (en)	1986-03-14
IE56586B1 (en)	1991-10-09
AU560330B2 (en)	1987-04-02
ES528816A0 (es)	1985-05-01
US4496541A (en)	1985-01-29

Publication	Publication Date	Title
EP0132304B1 (en)	1989-06-07	Hydroxy substituted peptide compounds
KR850000302B1 (ko)	1985-03-18	옥타히드로-1h-인돌-2-카복실산 치환 아실유도체의 제조방법
US4668797A (en)	1987-05-26	Bicyclic aminoacids as intermediates and processes for their preparation
EP0223437A2 (en)	1987-05-27	Aminocarbonyl renin inhibitors
US4496542A (en)	1985-01-29	N-substituted-amido-amino acids
US4468396A (en)	1984-08-28	Antihypertensive benzothiadiazines
NO840102L (no)	1984-07-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive hydroxylaminoeddiksyrederivater
EP0068173B1 (en)	1984-09-26	Perhydro-1,4-thiazepin-5-one and perhydro-1,4-thiazocin-5-one derivatives, process for preparing and pharmceutical composition containing the same
EP0142335A2 (en)	1985-05-22	Lactam containing compounds
NO820903L (no)	1982-09-20	Fremgangsmaate ved fremstilling av amido-aminosyrer.
EP0103496A1 (en)	1984-03-21	Acylalkylaminocarbonyl substituted amino and imino acid compounds
EP0159156A1 (en)	1985-10-23	Hydroxy substituted ureido amino and imino acids
JPS617295A (ja)	1986-01-13	メルカプトシクロアルキルカルボニルおよびメルカプトアリールカルボニルジペプチド類
NO841024L (no)	1984-09-17	Fremgangsmaate for fremstilling av nye forbindelser med virkning mot hypertensjon
JPS63295597A (ja)	1988-12-01	トリペプタイド誘導体及びそれを有効成分とする心血管系疾患治療剤
NO834387L (no)	1984-05-30	Fremgangsmaate ved fremstilling av terapeutisk virksomme glycinforbindelser
EP0158947B1 (en)	1991-02-06	Amino thiol dipeptides
EP0322633A1 (en)	1989-07-05	Mercapto-acylamino acid antihypertensives
US4725617A (en)	1988-02-16	Alkylamino-furanon-derivatives
JPH0247480B2 (fi)	1990-10-19
CA1295333C (en)	1992-02-04	Acylaminoalkanoyl compounds
JPH0448800B2 (fi)	1992-08-07
US4766109A (en)	1988-08-23	Hydrophobic peptides
US4558038A (en)	1985-12-10	N-Substituted-amindo-amino acids
EP0202776A1 (en)	1986-11-26	Ureidoalkanoylaminocarbonyl amino and imino acids and esters