NO834056L - Roentgenkontrastmidler - Google Patents

Roentgenkontrastmidler

Info

Publication number
NO834056L
NO834056L NO834056A NO834056A NO834056L NO 834056 L NO834056 L NO 834056L NO 834056 A NO834056 A NO 834056A NO 834056 A NO834056 A NO 834056A NO 834056 L NO834056 L NO 834056L
Authority
NO
Norway
Prior art keywords
ch2ch
group
ch2oh
compounds
appropriate
Prior art date
Application number
NO834056A
Other languages
English (en)
Other versions
NO161368B (no
NO161368C (no
Inventor
Per-Egil Hansen
Hugo Holtermann
Knut Wille
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Publication of NO834056L publication Critical patent/NO834056L/no
Publication of NO161368B publication Critical patent/NO161368B/no
Publication of NO161368C publication Critical patent/NO161368C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicinal Preparation (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
NO834056A 1982-11-08 1983-11-07 Roentgenkontrastmidler samt radiologiske preparater derav. NO161368C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8231796 1982-11-08

Publications (3)

Publication Number Publication Date
NO834056L true NO834056L (no) 1984-05-09
NO161368B NO161368B (no) 1989-05-02
NO161368C NO161368C (no) 1989-08-09

Family

ID=10534110

Family Applications (2)

Application Number Title Priority Date Filing Date
NO834056A NO161368C (no) 1982-11-08 1983-11-07 Roentgenkontrastmidler samt radiologiske preparater derav.
NO1994015C NO1994015I1 (no) 1982-11-08 1994-09-05 Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1994015C NO1994015I1 (no) 1982-11-08 1994-09-05 Iodixanol/ 1,3-bis(acetylamino-N,N<O>1</O>-bis[3,5-bis(2,3-dihydroksypropylaminokrabonyl)-2,4,6-trijod-fenyl]-2-hydroksypropan

Country Status (10)

Country Link
US (1) US5349085A (no)
EP (1) EP0108638B1 (no)
JP (1) JPS59104352A (no)
AT (1) ATE20733T1 (no)
DE (1) DE3364536D1 (no)
DK (1) DK160868C (no)
HK (1) HK46791A (no)
LU (1) LU88639I2 (no)
NL (1) NL950010I2 (no)
NO (2) NO161368C (no)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8919929D0 (en) * 1989-09-04 1989-10-18 Nycomed As Compositions
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
WO1994022810A1 (es) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
DK1836239T3 (da) 2005-01-13 2009-01-19 Cinv Ag Kompositmaterialer, der indeholder carbonnanopartikler
ES2413761T3 (es) 2005-12-19 2013-07-17 Ge Healthcare As Procedimiento de purificación de iodixanol
EP1989179B1 (en) 2006-02-15 2011-01-26 Ge Healthcare As Contrast agents
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
AU2008273037B2 (en) * 2007-07-12 2012-11-15 Ge Healthcare As Contrast agents
JP2011500530A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
CN101820923A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 对比剂
ES2413160T3 (es) 2007-10-12 2013-07-15 Ge Healthcare As Agentes de contraste
ES2389975T3 (es) 2007-10-12 2012-11-05 Ge Healthcare As Agentes de contraste
WO2009106552A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
WO2009106551A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
US20110256068A1 (en) * 2009-01-09 2011-10-20 Wistand Lars-Goeran Contrast media compositions
US8969619B2 (en) * 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US7696381B1 (en) * 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US8962886B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US7999134B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
AU2010311478B2 (en) * 2009-10-29 2015-09-24 Ge Healthcare As Diagnostic composition comprising plasma cations having superior safety profile
CN102725249B (zh) * 2009-11-26 2014-12-10 好利安中国控股有限公司 碘克沙醇的制备和纯化
MX2013000476A (es) 2010-07-12 2013-02-11 Ge Healthcare As Generacion de imagenes de rayos x en bajas concentraciones de agente y/o dosis de radiacion.
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102816125B (zh) * 2011-06-08 2014-03-26 浙江司太立制药股份有限公司 一种造影剂
SG11201403963XA (en) 2012-01-11 2014-08-28 Ge Healthcare As X-ray imaging contrast media with low iodine concentration and x-ray imaging process
CN104661996A (zh) 2012-09-27 2015-05-27 通用电气医疗集团股份有限公司 Ioforminol的中间体化合物的制备
CA2881707C (en) 2012-11-12 2021-01-12 Ge Healthcare As Preparation of intermediates of x-ray contrast agents
WO2016079330A1 (en) 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for local drug release
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
EP3458029A1 (en) 2016-05-20 2019-03-27 Technical University of Denmark Palpable marker composition
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
CA3143104A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (no) * 1966-12-13 1972-04-04 Pharmacia Ab
US3763227A (en) * 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
US3804892A (en) * 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
SE315975B (no) * 1967-12-28 1969-10-13 Pharmacia Ab
SE315974B (no) * 1967-12-28 1969-10-13 Pharmacia Ab
IL34803A (en) * 1969-06-27 1975-03-13 Nyegaard & Co As N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them
NL7102816A (no) * 1970-03-12 1971-09-14
DD104193A5 (no) * 1972-12-22 1974-03-05
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
FR2511871A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus

Also Published As

Publication number Publication date
DK508283D0 (da) 1983-11-07
NO161368B (no) 1989-05-02
DK508283A (da) 1984-05-09
DK160868B (da) 1991-04-29
ATE20733T1 (de) 1986-08-15
JPS59104352A (ja) 1984-06-16
DE3364536D1 (en) 1986-08-21
US5349085A (en) 1994-09-20
LU88639I2 (fr) 1996-02-01
HK46791A (en) 1991-06-21
JPS6355509B2 (no) 1988-11-02
NL950010I1 (nl) 1997-02-03
NL950010I2 (nl) 1997-02-03
DK160868C (da) 1991-10-14
NO1994015I1 (no) 1994-09-05
EP0108638B1 (en) 1986-07-16
NO161368C (no) 1989-08-09
EP0108638A1 (en) 1984-05-16

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MK1K Patent expired

Free format text: EXPIRED IN NOVEMBER 2003

MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN NOVEMBER 2003