NO823672L - Immunkompleks-fjerning og utvikling av tumorspesifikt antilegeme ved immobilisert protein a perfusjon og postperfusjon-legemiddelinfusjon - Google Patents
Immunkompleks-fjerning og utvikling av tumorspesifikt antilegeme ved immobilisert protein a perfusjon og postperfusjon-legemiddelinfusjonInfo
- Publication number
- NO823672L NO823672L NO823672A NO823672A NO823672L NO 823672 L NO823672 L NO 823672L NO 823672 A NO823672 A NO 823672A NO 823672 A NO823672 A NO 823672A NO 823672 L NO823672 L NO 823672L
- Authority
- NO
- Norway
- Prior art keywords
- plasma
- immobilized
- perfusion
- protein
- spa
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 90
- 102000004169 proteins and genes Human genes 0.000 title claims description 85
- 108090000623 proteins and genes Proteins 0.000 title claims description 85
- 230000010412 perfusion Effects 0.000 title claims description 71
- 238000001802 infusion Methods 0.000 title description 15
- 238000011161 development Methods 0.000 title description 8
- 108010058683 Immobilized Proteins Proteins 0.000 claims description 62
- 239000002245 particle Substances 0.000 claims description 59
- 238000000034 method Methods 0.000 claims description 47
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 43
- 210000004369 blood Anatomy 0.000 claims description 31
- 239000008280 blood Substances 0.000 claims description 31
- 210000004027 cell Anatomy 0.000 claims description 31
- 230000001225 therapeutic effect Effects 0.000 claims description 26
- 201000011510 cancer Diseases 0.000 claims description 22
- 239000012528 membrane Substances 0.000 claims description 18
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 12
- 238000012360 testing method Methods 0.000 claims description 11
- 210000004881 tumor cell Anatomy 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 8
- 230000002285 radioactive effect Effects 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 5
- 230000037396 body weight Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 4
- 229940009456 adriamycin Drugs 0.000 claims description 4
- 229960004397 cyclophosphamide Drugs 0.000 claims description 4
- -1 plasma Substances 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 231100000252 nontoxic Toxicity 0.000 claims description 3
- 230000003000 nontoxic effect Effects 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 208000007536 Thrombosis Diseases 0.000 claims description 2
- 230000000541 pulsatile effect Effects 0.000 claims description 2
- STUSTWKEFDQFFZ-UHFFFAOYSA-N Chlordimeform Chemical compound CN(C)C=NC1=CC=C(Cl)C=C1C STUSTWKEFDQFFZ-UHFFFAOYSA-N 0.000 claims 7
- 239000003550 marker Substances 0.000 claims 5
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 210000002381 plasma Anatomy 0.000 description 94
- 238000011282 treatment Methods 0.000 description 81
- 239000003610 charcoal Substances 0.000 description 53
- 210000002966 serum Anatomy 0.000 description 27
- 241000282472 Canis lupus familiaris Species 0.000 description 21
- 230000004044 response Effects 0.000 description 20
- 239000002953 phosphate buffered saline Substances 0.000 description 16
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 14
- 210000000779 thoracic wall Anatomy 0.000 description 14
- 230000002476 tumorcidal effect Effects 0.000 description 14
- 210000004379 membrane Anatomy 0.000 description 12
- 206010006187 Breast cancer Diseases 0.000 description 11
- 230000036772 blood pressure Effects 0.000 description 11
- 201000008274 breast adenocarcinoma Diseases 0.000 description 10
- 230000000747 cardiac effect Effects 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- 230000004087 circulation Effects 0.000 description 9
- 230000009467 reduction Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000006378 damage Effects 0.000 description 8
- 210000001165 lymph node Anatomy 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 238000009169 immunotherapy Methods 0.000 description 7
- 230000003902 lesion Effects 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 210000003462 vein Anatomy 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 230000004872 arterial blood pressure Effects 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- 238000011835 investigation Methods 0.000 description 6
- 210000004180 plasmocyte Anatomy 0.000 description 6
- 230000002269 spontaneous effect Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000005909 tumor killing Effects 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 5
- 102000053602 DNA Human genes 0.000 description 5
- 241000282414 Homo sapiens Species 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 229940027941 immunoglobulin g Drugs 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 230000001394 metastastic effect Effects 0.000 description 5
- 206010061289 metastatic neoplasm Diseases 0.000 description 5
- 238000003127 radioimmunoassay Methods 0.000 description 5
- 206010072960 Chest wall tumour Diseases 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 210000002758 humerus Anatomy 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 208000018223 neoplasm of chest wall Diseases 0.000 description 4
- 230000036581 peripheral resistance Effects 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 230000001698 pyrogenic effect Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 239000008223 sterile water Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 208000024434 abnormal chest sound Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000002146 bilateral effect Effects 0.000 description 3
- 210000003109 clavicle Anatomy 0.000 description 3
- 230000000004 hemodynamic effect Effects 0.000 description 3
- 230000003100 immobilizing effect Effects 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000002956 necrotizing effect Effects 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 210000001147 pulmonary artery Anatomy 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 230000019432 tissue death Effects 0.000 description 3
- 230000036269 ulceration Effects 0.000 description 3
- 101710164309 56 kDa type-specific antigen Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 206010027458 Metastases to lung Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 231100000313 clinical toxicology Toxicity 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000010324 immunological assay Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 210000005075 mammary gland Anatomy 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 230000004660 morphological change Effects 0.000 description 2
- GPXLMGHLHQJAGZ-JTDSTZFVSA-N nafcillin Chemical compound C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C(O)=O)=O)C(OCC)=CC=C21 GPXLMGHLHQJAGZ-JTDSTZFVSA-N 0.000 description 2
- 229960000515 nafcillin Drugs 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 210000004224 pleura Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 239000000700 radioactive tracer Substances 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000001709 templated self-assembly Methods 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- RSGFPIWWSCWCFJ-VAXZQHAWSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O RSGFPIWWSCWCFJ-VAXZQHAWSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 101100204059 Caenorhabditis elegans trap-2 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010009208 Cirrhosis alcoholic Diseases 0.000 description 1
- 206010010075 Coma hepatic Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 210000000712 G cell Anatomy 0.000 description 1
- 206010018364 Glomerulonephritis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000024781 Immune Complex disease Diseases 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010027457 Metastases to liver Diseases 0.000 description 1
- 206010027463 Metastases to pleura Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 241001077673 Mylon Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 108091093105 Nuclear DNA Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 208000002151 Pleural effusion Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 206010051017 Staphylococcal bacteraemia Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 210000004712 air sac Anatomy 0.000 description 1
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003172 anti-dna Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000007681 cardiovascular toxicity Effects 0.000 description 1
- 231100000060 cardiovascular toxicity Toxicity 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000349 chemoimmunotherapeutic effect Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000011976 chest X-ray Methods 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 201000001059 hepatic coma Diseases 0.000 description 1
- 208000007386 hepatic encephalopathy Diseases 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 208000024326 hypersensitivity reaction type III disease Diseases 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002624 low-dose chemotherapy Methods 0.000 description 1
- 231100000516 lung damage Toxicity 0.000 description 1
- 210000001349 mammary artery Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 238000009629 microbiological culture Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000003589 nefrotoxic effect Effects 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 231100000381 nephrotoxic Toxicity 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 235000021542 oral nutrition Nutrition 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 230000035485 pulse pressure Effects 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 208000025883 type III hypersensitivity disease Diseases 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32332681A | 1981-11-06 | 1981-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO823672L true NO823672L (no) | 1983-05-09 |
Family
ID=23258717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO823672A NO823672L (no) | 1981-11-06 | 1982-11-04 | Immunkompleks-fjerning og utvikling av tumorspesifikt antilegeme ved immobilisert protein a perfusjon og postperfusjon-legemiddelinfusjon |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0079221A3 (fr) |
JP (1) | JPS5886168A (fr) |
KR (1) | KR840002244A (fr) |
AU (1) | AU570911B2 (fr) |
CA (1) | CA1197460A (fr) |
DK (1) | DK487382A (fr) |
ES (3) | ES517174A0 (fr) |
FI (1) | FI823761L (fr) |
IL (1) | IL66959A0 (fr) |
NO (1) | NO823672L (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60120821A (ja) * | 1983-12-05 | 1985-06-28 | Asahi Chem Ind Co Ltd | 悪性腫瘍治療用白血球刺激材および刺激方法 |
DE3422435A1 (de) * | 1984-06-16 | 1986-01-16 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren und vorrichtung zur selektiven abtrennung pathologischer und/oder toxischer spezies aus blut oder blutplasma unter verwendung von filterkerzen |
US4704366A (en) * | 1984-06-22 | 1987-11-03 | Bio-Rad Laboratories, Inc. | Process for binding IgG to protein A |
US4614513A (en) * | 1984-08-13 | 1986-09-30 | Fred Hutchinson Cancer Research Center | Method and apparatus for treatment to remove immunoreactive substances from blood |
US5122112A (en) * | 1986-11-21 | 1992-06-16 | Imre Corporation | Antigen-specific removal of circulating immune complexes |
SE8801426D0 (sv) * | 1988-04-15 | 1988-04-15 | Ulf Rothman | Forfarande och medel for blodbehandling |
-
1982
- 1982-10-07 AU AU89189/82A patent/AU570911B2/en not_active Ceased
- 1982-10-11 IL IL66959A patent/IL66959A0/xx unknown
- 1982-11-03 DK DK487382A patent/DK487382A/da not_active Application Discontinuation
- 1982-11-03 FI FI823761A patent/FI823761L/fi not_active Application Discontinuation
- 1982-11-04 NO NO823672A patent/NO823672L/no unknown
- 1982-11-05 CA CA000415005A patent/CA1197460A/fr not_active Expired
- 1982-11-05 EP EP82305913A patent/EP0079221A3/fr not_active Withdrawn
- 1982-11-05 ES ES517174A patent/ES517174A0/es active Granted
- 1982-11-06 JP JP57195196A patent/JPS5886168A/ja active Pending
- 1982-11-06 KR KR1019820005015A patent/KR840002244A/ko unknown
-
1983
- 1983-07-01 ES ES523791A patent/ES523791A0/es active Granted
- 1983-07-01 ES ES523790A patent/ES8501984A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI823761A0 (fi) | 1982-11-03 |
ES523790A0 (es) | 1984-12-16 |
AU8918982A (en) | 1985-02-07 |
ES8402506A1 (es) | 1983-12-01 |
ES517174A0 (es) | 1983-12-01 |
FI823761L (fi) | 1983-05-07 |
CA1197460A (fr) | 1985-12-03 |
AU570911B2 (en) | 1988-03-31 |
JPS5886168A (ja) | 1983-05-23 |
EP0079221A2 (fr) | 1983-05-18 |
EP0079221A3 (fr) | 1986-01-22 |
ES8503202A1 (es) | 1984-12-16 |
IL66959A0 (en) | 1983-02-23 |
DK487382A (da) | 1983-05-07 |
ES8501984A1 (es) | 1984-12-16 |
ES523791A0 (es) | 1984-12-16 |
KR840002244A (ko) | 1984-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5091091A (en) | Protein A perfusion and post perfusion drug infusion | |
Pollak et al. | Renal vein thrombosis and the nephrotic syndrome | |
Greaves et al. | Immunosuppressive potency and in-vitro activity of antilymphocyte globulin | |
Smart et al. | Large-volume crystalloid fluid is associated with increased hyaluronan shedding and inflammation in a canine hemorrhagic shock model | |
Smith | Neutrophil activation and mediators of inflammation in chronic venous insufficiency | |
Cooper et al. | Hypothermic circulatory arrest causes multisystem vascular endothelial dysfunction and apoptosis | |
JPH09501066A (ja) | 全血またはその成分からの選択された因子の除去 | |
Stableforth et al. | Acquired von Willebrand syndrome with inhibitors both to factor VIII clotting activity and ristocetin‐induced platelet aggregation | |
Terman et al. | Specific removal of antibody by extracorporeal circulation over antigen immobilized in collodion-charcoal. | |
Kellum et al. | Blood purification in non-renal critical illness | |
Smith et al. | The early diagnosis of acute and latent plumbism | |
Staubach et al. | A new endotoxin adsorption device in Gram-negative sepsis: use of immobilized albumin with the MATISSE® adsorber | |
Christensen | A reversible vascular abnormality associated with diabetic ketosis | |
NO823672L (no) | Immunkompleks-fjerning og utvikling av tumorspesifikt antilegeme ved immobilisert protein a perfusjon og postperfusjon-legemiddelinfusjon | |
Parving et al. | Increased transcapillary escape rate of albumin, IgG, and IgM during angiotensin-II-induced hypertension in man | |
RAYNER et al. | Intestinal tissue blood flow in shock due to endotoxin | |
Fischer et al. | Arterial stiffness and renal replacement therapy: a controversial topic | |
Dieter et al. | Studies on an undetermined circulating anticoagulant. Case report and laboratory findings | |
Burns-Cox et al. | Risk factors and the absence of coronary heart disease in aborigines in West Malaysia. | |
NZ202367A (en) | Therapeutic immunoadsorbent based on non-covalently immobilised protein a; blood plasma perfusion method and perfusion system | |
Sargent et al. | Studies of cryoprecipitation: III. Hemodynamic and metabolic adaptation to a circulating single component cryoglobulin | |
Dagli et al. | Relation of neutrophil/lymphocyte ratio to resistant hypertension | |
Sideman et al. | Removal of bilirubin from the blood of jaundiced infants | |
SAHIN | Relationships between the Microvascular Complications of Diabetes Mellitus (DM) and Natural Coagulation Inhibitors and Anticardiolipin (ACA) Antibodies | |
Kawana et al. | Value of the assay for IgA-containing circulating immune complexes in Henoch-Schönlein purpura |