NO772940L - Nye behensyre-estere. - Google Patents

Nye behensyre-estere.

Info

Publication number: NO772940L
Authority: NO; Norway
Prior art keywords: behenic acid; formula; ester; acid; phenothiazine
Prior art date: 1976-08-25

Application number

NO772940A

Other languages

English (en)

Norwegian (no)

Inventor

Joern Lasse Martin Buus

Niels Lassen

Original Assignee

Kefalas As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-08-25

Filing date

1977-08-24

Publication date

1978-02-28

1977-08-24 Application filed by Kefalas As filed Critical Kefalas As

1978-02-28 Publication of NO772940L publication Critical patent/NO772940L/no

Links

UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical class CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 title claims description 19
239000002253 acid Substances 0.000 claims description 21
-1 behenic acid ester Chemical class 0.000 claims description 14
150000002148 esters Chemical class 0.000 claims description 14
150000001875 compounds Chemical class 0.000 claims description 12
235000021357 Behenic acid Nutrition 0.000 claims description 11
229940116226 behenic acid Drugs 0.000 claims description 11
150000003839 salts Chemical class 0.000 claims description 11
238000000034 method Methods 0.000 claims description 9
231100000252 nontoxic Toxicity 0.000 claims description 9
230000003000 nontoxic effect Effects 0.000 claims description 9
229950000688 phenothiazine Drugs 0.000 claims description 8
239000000203 mixture Substances 0.000 claims description 7
WJFKNYWRSNBZNX-UHFFFAOYSA-N 10H-phenothiazine Chemical compound C1=CC=C2NC3=CC=CC=C3SC2=C1 WJFKNYWRSNBZNX-UHFFFAOYSA-N 0.000 claims description 6
239000004480 active ingredient Substances 0.000 claims description 6
239000012458 free base Substances 0.000 claims description 6
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
150000007513 acids Chemical class 0.000 claims description 4
238000006243 chemical reaction Methods 0.000 claims description 3
QTHQYNCAWSGBCE-UHFFFAOYSA-N docosanoyl chloride Chemical compound CCCCCCCCCCCCCCCCCCCCCC(Cl)=O QTHQYNCAWSGBCE-UHFFFAOYSA-N 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 2
150000001805 chlorine compounds Chemical class 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
241000282472 Canis lupus familiaris Species 0.000 description 14
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 13
239000000243 solution Substances 0.000 description 11
239000003921 oil Substances 0.000 description 6
235000019198 oils Nutrition 0.000 description 6
230000008673 vomiting Effects 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
206010047700 Vomiting Diseases 0.000 description 5
239000007924 injection Substances 0.000 description 5
238000002347 injection Methods 0.000 description 5
238000012360 testing method Methods 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
241001465754 Metazoa Species 0.000 description 4
229960004046 apomorphine Drugs 0.000 description 4
VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 4
230000002035 prolonged effect Effects 0.000 description 4
230000001624 sedative effect Effects 0.000 description 4
235000015112 vegetable and seed oil Nutrition 0.000 description 4
239000008158 vegetable oil Substances 0.000 description 4
FWFBVSNMBCKTIL-UHFFFAOYSA-N 2-[1-[3-[7-fluoro-2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperidin-4-yl]ethanol Chemical compound C1CC(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC(F)=CC=C21 FWFBVSNMBCKTIL-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
229960002690 fluphenazine Drugs 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
230000000701 neuroleptic effect Effects 0.000 description 3
239000008174 sterile solution Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
TWXOVTBDDMZMSK-UHFFFAOYSA-N 2-[4-[3-[7-fluoro-2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC(F)=CC=C21 TWXOVTBDDMZMSK-UHFFFAOYSA-N 0.000 description 2
241000282414 Homo sapiens Species 0.000 description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
150000007933 aliphatic carboxylic acids Chemical class 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
150000004820 halides Chemical class 0.000 description 2
238000010255 intramuscular injection Methods 0.000 description 2
239000007927 intramuscular injection Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
239000003176 neuroleptic agent Substances 0.000 description 2
150000002942 palmitic acid derivatives Chemical class 0.000 description 2
150000002990 phenothiazines Chemical class 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
ULIAPOFMBCCSPE-UHFFFAOYSA-N tridecan-7-one Chemical compound CCCCCCC(=O)CCCCCC ULIAPOFMBCCSPE-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
SKYZYDSNJIOXRL-BTQNPOSSSA-N (6ar)-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol;hydrochloride Chemical compound Cl.C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 SKYZYDSNJIOXRL-BTQNPOSSSA-N 0.000 description 1
GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 1
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
235000003911 Arachis Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
LRWSFOSWNAQHHW-UHFFFAOYSA-N Fluphenazine enanthate Chemical compound C1CN(CCOC(=O)CCCCCC)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 LRWSFOSWNAQHHW-UHFFFAOYSA-N 0.000 description 1
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
206010039897 Sedation Diseases 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
150000008065 acid anhydrides Chemical class 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
229940063655 aluminum stearate Drugs 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
230000008485 antagonism Effects 0.000 description 1
229960003990 apomorphine hydrochloride Drugs 0.000 description 1
239000002585 base Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
JDPQWHLMBJZURR-UHFFFAOYSA-N decan-5-one Chemical compound CCCCCC(=O)CCCC JDPQWHLMBJZURR-UHFFFAOYSA-N 0.000 description 1
150000001954 decanoic acid esters Chemical class 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
229960000787 fluphenazine enanthate Drugs 0.000 description 1
230000006698 induction Effects 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
ZAJNGDIORYACQU-UHFFFAOYSA-N methyl n-octyl ketone Natural products CCCCCCCCC(C)=O ZAJNGDIORYACQU-UHFFFAOYSA-N 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000008024 pharmaceutical diluent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
125000004193 piperazinyl group Chemical group 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000036280 sedation Effects 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000001519 thymoleptic effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
210000004916 vomit Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO772940A 1976-08-25 1977-08-24 Nye behensyre-estere. NO772940L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB35411/76A GB1540842A (en)	1976-08-25	1976-08-25	Phenothiazines

Publications (1)

Publication Number	Publication Date
NO772940L true NO772940L (no)	1978-02-28

Family

ID=10377428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO772940A NO772940L (no)	1976-08-25	1977-08-24	Nye behensyre-estere.

Country Status (20)

Country	Link
US (1)	US4153694A (de)
JP (1)	JPS5350185A (de)
AT (1)	AT347964B (de)
AU (1)	AU508252B2 (de)
BE (1)	BE857576A (de)
CA (1)	CA1088936A (de)
CH (1)	CH628632A5 (de)
DE (1)	DE2731680A1 (de)
DK (1)	DK363177A (de)
ES (1)	ES461785A1 (de)
FI (1)	FI772394A (de)
FR (1)	FR2362852A1 (de)
GB (1)	GB1540842A (de)
IE (1)	IE45178B1 (de)
LU (1)	LU78019A1 (de)
NL (1)	NL7707558A (de)
NO (1)	NO772940L (de)
NZ (1)	NZ184858A (de)
SE (1)	SE7709507L (de)
ZA (1)	ZA774756B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8628903D0 (en) *	1986-12-03	1987-01-07	Lunbeck A S H	Neuroleptic compounds
KR20100097224A (ko) *	2001-09-27	2010-09-02	라모트 앳 텔 아비브 유니버시티 리미티드	접합된 항-정신병 약물 및 그의 용도
US7544681B2 (en) *	2001-09-27	2009-06-09	Ramot At Tel Aviv University Ltd.	Conjugated psychotropic drugs and uses thereof
ES2400772T3 (es) *	2005-06-07	2013-04-12	Ramot At Tel Aviv University Ltd.	Sales novedosas de fármacos psicotrópicos conjugados y procedimientos para la preparación de las mismas
EP2051735B1 (de) *	2006-07-17	2012-08-29	Ramot, at Tel Aviv University Ltd.	Konjugate mit einem psychotropische heilmittel oder einem gaba agonist und eine organische säure und ihre behandlung von schmerzen und andere erkrankungen des zns
WO2009101616A1 (en) *	2008-02-11	2009-08-20	Ramot At Tel Aviv University Ltd.	Novel conjugates for treating neurodegenerative diseases and disorders
WO2011070579A1 (en) *	2009-12-09	2011-06-16	Biolinerx Ltd.	Methods of improving cognitive functions
WO2012038963A1 (en)	2010-09-22	2012-03-29	Ramot At Tel-Aviv University Ltd.	An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE795517A (fr)	1972-02-17	1973-08-16	Ciba Geigy	Nouveaux sels de peptides de l'acth et leurs procedes de preparation
GB1460713A (en) *	1973-06-08	1977-01-06	Kefalas As	7-fluoro substituted phenothiazines method for preparation thereof and compositions bladed rotor for a gas turbine engine

1976
- 1976-08-25 GB GB35411/76A patent/GB1540842A/en not_active Expired
1977
- 1977-07-07 NL NL7707558A patent/NL7707558A/xx not_active Application Discontinuation
- 1977-07-12 AT AT498677A patent/AT347964B/de not_active IP Right Cessation
- 1977-07-13 DE DE19772731680 patent/DE2731680A1/de not_active Withdrawn
- 1977-08-02 IE IE1603/77A patent/IE45178B1/en unknown
- 1977-08-05 ZA ZA00774756A patent/ZA774756B/xx unknown
- 1977-08-05 NZ NZ184858A patent/NZ184858A/xx unknown
- 1977-08-08 BE BE179985A patent/BE857576A/xx unknown
- 1977-08-09 FI FI772394A patent/FI772394A/fi not_active Application Discontinuation
- 1977-08-16 DK DK363177A patent/DK363177A/da unknown
- 1977-08-19 US US05/826,049 patent/US4153694A/en not_active Expired - Lifetime
- 1977-08-19 AU AU28054/77A patent/AU508252B2/en not_active Expired
- 1977-08-20 ES ES461785A patent/ES461785A1/es not_active Expired
- 1977-08-23 CA CA285,276A patent/CA1088936A/en not_active Expired
- 1977-08-23 CH CH1032577A patent/CH628632A5/de not_active IP Right Cessation
- 1977-08-24 SE SE7709507A patent/SE7709507L/xx unknown
- 1977-08-24 NO NO772940A patent/NO772940L/no unknown
- 1977-08-24 LU LU78019A patent/LU78019A1/xx unknown
- 1977-08-25 JP JP10118277A patent/JPS5350185A/ja active Pending
- 1977-08-25 FR FR7725990A patent/FR2362852A1/fr active Granted

Also Published As

Publication number	Publication date
JPS5350185A (en)	1978-05-08
IE45178L (en)	1978-02-25
ZA774756B (en)	1978-06-28
FI772394A (fi)	1978-02-26
US4153694A (en)	1979-05-08
ES461785A1 (es)	1978-06-16
CA1088936A (en)	1980-11-04
AT347964B (de)	1979-01-25
AU2805477A (en)	1979-03-08
IE45178B1 (en)	1982-06-30
DK363177A (da)	1978-02-26
GB1540842A (en)	1979-02-14
CH628632A5 (de)	1982-03-15
NZ184858A (en)	1979-03-28
SE7709507L (sv)	1978-02-26
FR2362852B1 (de)	1980-09-05
BE857576A (fr)	1978-02-08
ATA498677A (de)	1978-06-15
NL7707558A (nl)	1978-02-28
AU508252B2 (en)	1980-03-13
DE2731680A1 (de)	1978-03-02
LU78019A1 (de)	1978-04-27
FR2362852A1 (fr)	1978-03-24

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CZ452390A3 (cs)	1998-11-11	Estery thienylkarboxylových kyselin s aminoalkoholy, způsob jejich výroby, jejich použití a farmaceutický prostředek s jejich obsahem
NO171453B (no)	1992-12-07	Fremgangsmaate for fremstilling av krystallinsk paroxetin-hydroklorid-hemihydrat
NO772940L (no)	1978-02-28	Nye behensyre-estere.
US3998832A (en)	1976-12-21	Anti-diarrheal compounds
US3681346A (en)	1972-08-01	{60 -isomer of the decanoic acid ester of 10-{8 3,-(4-hydroxyethyl-1-piperazinyl)propylidene{9 -2-trifluoro-methyl thiaxanthene, acid addition salts thereof, method of use and compositions
US3996211A (en)	1976-12-07	Alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof and acid addition salts of these compounds
US6004983A (en)	1999-12-21	N-substituted azaheterocyclic compounds
US4654352A (en)	1987-03-31	Method for treating diarrhea with benzothiophene derivatives
NO762748L (de)	1977-02-15
US3974285A (en)	1976-08-10	10,11-Furo-derivatives of cyproheptadine
US4057549A (en)	1977-11-08	Triarylpropyl-azabicyclooctanes
US4333939A (en)	1982-06-08	Tetrahydropyridinyl-indoles
US3408355A (en)	1968-10-29	Thiaxanthene derivatives
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