NO347360B1 - Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse. - Google Patents

Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse. Download PDF

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Publication number
NO347360B1
NO347360B1 NO20150450A NO20150450A NO347360B1 NO 347360 B1 NO347360 B1 NO 347360B1 NO 20150450 A NO20150450 A NO 20150450A NO 20150450 A NO20150450 A NO 20150450A NO 347360 B1 NO347360 B1 NO 347360B1
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Norway
Prior art keywords
maytansinoid
binding agent
conjugate
cell
cell binding
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Application number
NO20150450A
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English (en)
Norwegian (no)
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NO20150450L (no
Inventor
Ravi V J Chari
Rita Steeves
Walter A Blättler
Wayne Widdison
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Immunogen Inc
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Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Priority claimed from PCT/US2004/030917 external-priority patent/WO2005037992A2/en
Publication of NO20150450L publication Critical patent/NO20150450L/no
Publication of NO347360B1 publication Critical patent/NO347360B1/no

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K—PEPTIDES
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NO20150450A 2003-10-10 2004-10-12 Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse. NO347360B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
PCT/US2004/030917 WO2005037992A2 (en) 2003-10-10 2004-10-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

Publications (2)

Publication Number Publication Date
NO20150450L NO20150450L (no) 2006-04-21
NO347360B1 true NO347360B1 (no) 2023-09-25

Family

ID=38938205

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20150450A NO347360B1 (no) 2003-10-10 2004-10-12 Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse.
NO20160447A NO20160447A1 (no) 2003-10-10 2016-03-16 Fremgangsmåte for målsøking av spesifikke cellepopulasjoner ved å benytte cellebindings-middelmaytansinoidkonjugater bundet via en ikke-kløyvbar linker, nevnte konjugater og fremstilling av nevnte konjugater
NO20231301A NO20231301A1 (no) 2003-10-10 2023-11-29 Fremgangsmåte for målsøking av spesifikke cellepopulasjoner ved å benytte cellebindingsmiddel-maytansinoidkonjugater bundet via en ikke-kløyvbar linker, nevnte konjugater og fremstilling av nevnte konjugater.

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO20160447A NO20160447A1 (no) 2003-10-10 2016-03-16 Fremgangsmåte for målsøking av spesifikke cellepopulasjoner ved å benytte cellebindings-middelmaytansinoidkonjugater bundet via en ikke-kløyvbar linker, nevnte konjugater og fremstilling av nevnte konjugater
NO20231301A NO20231301A1 (no) 2003-10-10 2023-11-29 Fremgangsmåte for målsøking av spesifikke cellepopulasjoner ved å benytte cellebindingsmiddel-maytansinoidkonjugater bundet via en ikke-kløyvbar linker, nevnte konjugater og fremstilling av nevnte konjugater.

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CN (1) CN101087611B (zh)
NO (3) NO347360B1 (zh)
ZA (1) ZA200601182B (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1993146A (zh) * 2004-06-01 2007-07-04 健泰科生物技术公司 抗体－药物偶联物和方法
AU2005249490B2 (en) * 2004-06-01 2010-07-29 Genentech, Inc. Antibody drug conjugates and methods
KR20100137585A (ko) * 2008-04-30 2010-12-30 이뮤노젠 아이엔씨 강력한 복합체 및 친수성 링커
CA2816426A1 (en) * 2010-11-17 2012-06-07 Genentech, Inc. Alaninyl maytansinol antibody conjugates
CN103619357A (zh) * 2011-03-29 2014-03-05 伊缪诺金公司 用于制造具有改善的同质性的缀合物的方法
WO2013173393A1 (en) * 2012-05-15 2013-11-21 Concortis Biosystems, Corp Drug-conjugates, conjugation methods, and uses thereof
CN104650113A (zh) * 2012-12-21 2015-05-27 百奥泰生物科技(广州)有限公司 类美登素衍生物及其制备方法和用途
US9498532B2 (en) * 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
EP3514178A1 (en) * 2013-03-15 2019-07-24 Novartis AG Antibody drug conjugates
CN103254311B (zh) * 2013-05-09 2015-05-13 齐鲁制药有限公司 一种制备抗体-美登素类生物碱药物偶联物的方法
CN110177569A (zh) 2017-03-30 2019-08-27 江苏恒瑞医药股份有限公司 抗体药物偶联物的制备方法
CN110075315B (zh) * 2018-01-26 2023-08-11 上海复旦张江生物医药股份有限公司 一种抗体偶联物及其制备方法和应用
CN109652376B (zh) * 2019-01-08 2021-10-15 创芯国际生物科技(广州)有限公司 一种用于卵巢癌组织3d培养的培养基
US20220226334A1 (en) * 2019-05-21 2022-07-21 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. Antibody conjugate and application of pharmaceutical composition thereof
CN112691190A (zh) * 2019-10-23 2021-04-23 东曜药业有限公司 抗体-高活性细胞毒小分子药物偶联药物及制备和应用
CN113336823A (zh) * 2021-05-28 2021-09-03 联宁（苏州）生物制药有限公司 一种用于抗体偶联药物连接子lnd1067的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024763A2 (en) * 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2002098883A1 (en) * 2001-05-31 2002-12-12 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
EP1354896A1 (en) * 2000-12-28 2003-10-22 Kirin Beer Kabushiki Kaisha Novel monoclonal antibody

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208020A (en) * 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6531131B1 (en) * 1999-08-10 2003-03-11 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for Neisseria meningitidis
US7097840B2 (en) * 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
ATE506965T1 (de) * 2001-09-05 2011-05-15 Genentech Inc Verfahren zur identifikation von polypeptid- antigenen im zusammenhang mit störungen durch aberrante zellproliferation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024763A2 (en) * 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
EP1354896A1 (en) * 2000-12-28 2003-10-22 Kirin Beer Kabushiki Kaisha Novel monoclonal antibody
WO2002098883A1 (en) * 2001-05-31 2002-12-12 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHARI RAVI V.J. ET AL.; "Immunoconjugates containing novel maytansinoids: promising anticancer drugs"; Cancer Research, vol. 52, nr. 1, 1992, s. 127-131, ISSN 0008-5472., Dated: 01.01.0001 *

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