NO331816B1 - Blandinger som inneholder terapeutisk aktive komponenter som har foroket loselighet - Google Patents
Blandinger som inneholder terapeutisk aktive komponenter som har foroket loselighet Download PDFInfo
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- NO331816B1 NO331816B1 NO20030153A NO20030153A NO331816B1 NO 331816 B1 NO331816 B1 NO 331816B1 NO 20030153 A NO20030153 A NO 20030153A NO 20030153 A NO20030153 A NO 20030153A NO 331816 B1 NO331816 B1 NO 331816B1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21820600P | 2000-07-14 | 2000-07-14 | |
PCT/US2001/021551 WO2002005822A2 (en) | 2000-07-14 | 2001-07-09 | Compositions containing therapeutically active components having enhanced solubility |
Publications (3)
Publication Number | Publication Date |
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NO20030153D0 NO20030153D0 (no) | 2003-01-13 |
NO20030153L NO20030153L (no) | 2003-01-13 |
NO331816B1 true NO331816B1 (no) | 2012-04-10 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20030153A NO331816B1 (no) | 2000-07-14 | 2003-01-13 | Blandinger som inneholder terapeutisk aktive komponenter som har foroket loselighet |
Country Status (23)
Country | Link |
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US (2) | US6562873B2 (pt) |
EP (2) | EP1301210A2 (pt) |
JP (1) | JP2004503593A (pt) |
KR (1) | KR20030023700A (pt) |
CN (1) | CN1441679A (pt) |
AR (1) | AR035039A1 (pt) |
AU (2) | AU7326801A (pt) |
BR (1) | BR0112461A (pt) |
CA (1) | CA2416169C (pt) |
CY (1) | CY1113391T1 (pt) |
DK (1) | DK2153819T3 (pt) |
ES (1) | ES2392636T3 (pt) |
HU (1) | HU230383B1 (pt) |
IL (2) | IL153322A0 (pt) |
MX (1) | MXPA02012206A (pt) |
NO (1) | NO331816B1 (pt) |
NZ (1) | NZ522610A (pt) |
PL (1) | PL361027A1 (pt) |
PT (1) | PT2153819E (pt) |
RU (1) | RU2291685C2 (pt) |
TW (1) | TWI287992B (pt) |
WO (1) | WO2002005822A2 (pt) |
ZA (1) | ZA200209877B (pt) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1301210A2 (en) * | 2000-07-14 | 2003-04-16 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
NZ521185A (en) * | 2000-07-14 | 2005-02-25 | Allergan Inc | Compositions containing alpha-2-adrenergic agonist components |
US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US8858961B2 (en) | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US20050282774A1 (en) * | 2000-10-31 | 2005-12-22 | Eek Bjorn C | Method and pharmaceutical to treat spinal discs |
US20030114460A1 (en) * | 2001-12-14 | 2003-06-19 | Allergan Sales, Inc. | Pharmaceutical conjugates with enhanced pharmacokinetic characteristics |
US7030149B2 (en) | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
US7642258B2 (en) * | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
US6982079B2 (en) * | 2002-04-26 | 2006-01-03 | Allergan, Inc. | Compositions for treating hyperemia |
WO2004010894A2 (en) | 2002-07-30 | 2004-02-05 | Omeros Corporation | Ophthalmologic irrigation solutions and method |
US20040137079A1 (en) * | 2003-01-08 | 2004-07-15 | Cook James N. | Contact lens and eye drop rewetter compositions and methods |
US20040191332A1 (en) * | 2003-03-27 | 2004-09-30 | Allergan, Inc. | Preserved ophthalmic compositions |
US8912174B2 (en) * | 2003-04-16 | 2014-12-16 | Mylan Pharmaceuticals Inc. | Formulations and methods for treating rhinosinusitis |
US7811606B2 (en) * | 2003-04-16 | 2010-10-12 | Dey, L.P. | Nasal pharmaceutical formulations and methods of using the same |
US9808471B2 (en) * | 2003-04-16 | 2017-11-07 | Mylan Specialty Lp | Nasal pharmaceutical formulations and methods of using the same |
US6933289B2 (en) * | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
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CA2505836C (en) * | 2004-05-06 | 2013-08-27 | Alcon Inc. | Topical brimonidine tartrate formulations that lack chlorine dioxide |
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US20070238732A1 (en) * | 2006-04-10 | 2007-10-11 | Allergan, Inc. | Brimonidine and timolol compositions |
US9561178B2 (en) * | 2006-07-25 | 2017-02-07 | Allergan, Inc. | Cyclosporin compositions |
US20080146497A1 (en) * | 2006-07-25 | 2008-06-19 | Graham Richard S | Cyclosporin Compositions |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
CN102026665A (zh) * | 2008-05-19 | 2011-04-20 | 爱尔康研究有限公司 | 含有羧基乙烯基聚合物和聚维酮聚合物的药物组合物 |
US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
US20110003823A1 (en) * | 2008-08-01 | 2011-01-06 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage |
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DK2320911T3 (da) * | 2008-08-01 | 2014-11-03 | Eye Therapies Llc | Vasokonstriktionspræparater og fremgangsmåder til anvendelse deraf |
US20110244058A1 (en) * | 2008-08-01 | 2011-10-06 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
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US8409606B2 (en) | 2009-02-12 | 2013-04-02 | Incept, Llc | Drug delivery through hydrogel plugs |
US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
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US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
ES2634551T3 (es) | 2010-04-03 | 2017-09-28 | Praful Doshi | Métodos para revestir una lente de contacto |
WO2011127139A2 (en) * | 2010-04-07 | 2011-10-13 | Allergan, Inc. | Combinations of preservative compositions for ophthalmic formulations |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
WO2012041910A1 (de) | 2010-10-01 | 2012-04-05 | Elektra Management S.R.O. | Lösung von guanidinium-verbindungen, verfahren unter einsatz dieser lösung sowie deren verwendung |
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US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
US8957048B2 (en) | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
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MX354990B (es) * | 2012-01-20 | 2018-03-28 | Aratana Therapeutics Nv | Composicion de gotas para los ojos. |
AU2013201465B2 (en) | 2012-10-24 | 2016-03-03 | Rayner Surgical (Ireland) Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
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AU2016233125A1 (en) * | 2015-03-19 | 2017-09-14 | Allergan, Inc. | Fixed dose combination of bromonidine and timolol |
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GR1009419B (el) | 2017-11-07 | 2018-12-14 | Φαρματεν Αβεε | Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου |
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GR1010024B (el) * | 2020-05-06 | 2021-06-01 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση που περιλαμβανει βριμονιδινη |
JP2021183606A (ja) * | 2020-05-20 | 2021-12-02 | 千寿製薬株式会社 | ブリモニジンを含有する液体製剤 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL286080A (pt) * | 1961-11-30 | |||
US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US4089969A (en) | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
JPS542338A (en) * | 1977-04-22 | 1979-01-09 | Sandoz Ag | Pharmaceutical composition |
US4474787A (en) | 1977-05-04 | 1984-10-02 | Fisons Limited | 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof |
JPS5746986A (en) | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
US4530920A (en) | 1983-11-07 | 1985-07-23 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist |
US4806556A (en) | 1985-12-12 | 1989-02-21 | Regents Of The University Of Minnesota | Gut-selective opiates |
US5089509A (en) | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
US5607698A (en) | 1988-08-04 | 1997-03-04 | Ciba-Geigy Corporation | Method of preserving ophthalmic solution and compositions therefor |
US5202128A (en) | 1989-01-06 | 1993-04-13 | F. H. Faulding & Co. Limited | Sustained release pharmaceutical composition |
CA2007181C (en) | 1989-01-06 | 1998-11-24 | Angelo Mario Morella | Sustained release pharmaceutical composition |
US5352796A (en) | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
US5021416A (en) | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
GB9017353D0 (en) | 1990-08-08 | 1990-09-19 | Merck Sharp & Dohme | Chemical process |
ATE185697T1 (de) | 1992-04-21 | 1999-11-15 | Schepens Eye Res Inst | Androgentherapie am auge beim sjögrensyndrom |
US5459133A (en) | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5922773A (en) | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
AU6124494A (en) | 1993-01-28 | 1994-08-15 | University Of Iowa Research Foundation, The | Ophthalmic uses of signa agonists |
WO1995010280A1 (en) | 1993-10-13 | 1995-04-20 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
US5994110A (en) | 1995-02-10 | 1999-11-30 | Mosbach; Klaus | Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof |
US5474979A (en) | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
ZA965837B (en) | 1995-07-11 | 1997-01-31 | Merck & Co Inc | A triazolylmethyl-indole ethylamine bisulfate salt |
US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5675024A (en) | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
EP0834308A1 (en) | 1996-09-30 | 1998-04-08 | LG Chemical Limited | Ophthalmic formulation for treating myopia comprising dopamine agonist and cyclodextrin |
JP2001522358A (ja) | 1997-04-18 | 2001-11-13 | アボツト・ラボラトリーズ | 高純度6,7−ジクロロ−5−ニトロ−2,3−ジヒドロキノキサリン−2,3−ジオンの調製方法 |
AU2870899A (en) | 1998-02-26 | 1999-09-15 | Abbott Laboratories | Oral formulation for hydrophilic drugs |
DK1069913T3 (da) | 1998-04-07 | 2003-11-17 | Alcon Mfg Ltd | Gelatinering af ophthalmiske sammensætninger indeholdende xanthangummi |
WO2000012137A1 (en) * | 1998-09-02 | 2000-03-09 | Allergan Sales, Inc. | Preserved cyclodextrin-containing compositions |
DE69923987T2 (de) * | 1998-10-08 | 2006-11-02 | Karagoezian, Hampar L., San Juan Capistrano | Synergistische antimikrobielle, dermatologische und ophtahalmologische zubereitung, die ein chlorit und wasserstoffperoxid enthalten |
US6514504B1 (en) * | 1999-08-18 | 2003-02-04 | The Procter & Gamble Company | Discontinuous films from skin care compositions |
EP1301210A2 (en) * | 2000-07-14 | 2003-04-16 | Allergan, Inc. | Compositions containing therapeutically active components having enhanced solubility |
NZ521185A (en) * | 2000-07-14 | 2005-02-25 | Allergan Inc | Compositions containing alpha-2-adrenergic agonist components |
-
2001
- 2001-07-09 EP EP01952527A patent/EP1301210A2/en not_active Ceased
- 2001-07-09 WO PCT/US2001/021551 patent/WO2002005822A2/en active Search and Examination
- 2001-07-09 CA CA002416169A patent/CA2416169C/en not_active Expired - Lifetime
- 2001-07-09 HU HU0301405A patent/HU230383B1/hu unknown
- 2001-07-09 PL PL36102701A patent/PL361027A1/xx not_active Application Discontinuation
- 2001-07-09 NZ NZ522610A patent/NZ522610A/en not_active IP Right Cessation
- 2001-07-09 KR KR10-2003-7000535A patent/KR20030023700A/ko not_active Application Discontinuation
- 2001-07-09 CN CN01812829A patent/CN1441679A/zh active Pending
- 2001-07-09 DK DK09176049.6T patent/DK2153819T3/da active
- 2001-07-09 IL IL15332201A patent/IL153322A0/xx active IP Right Grant
- 2001-07-09 MX MXPA02012206A patent/MXPA02012206A/es active IP Right Grant
- 2001-07-09 JP JP2002511754A patent/JP2004503593A/ja not_active Withdrawn
- 2001-07-09 AU AU7326801A patent/AU7326801A/xx active Pending
- 2001-07-09 AU AU2001273268A patent/AU2001273268B2/en not_active Expired
- 2001-07-09 ES ES09176049T patent/ES2392636T3/es not_active Expired - Lifetime
- 2001-07-09 BR BR0112461-7A patent/BR0112461A/pt not_active Application Discontinuation
- 2001-07-09 RU RU2003101320/15A patent/RU2291685C2/ru active
- 2001-07-09 EP EP09176049A patent/EP2153819B1/en not_active Expired - Lifetime
- 2001-07-09 PT PT09176049T patent/PT2153819E/pt unknown
- 2001-07-10 US US09/903,962 patent/US6562873B2/en not_active Expired - Lifetime
- 2001-07-13 TW TW090117219A patent/TWI287992B/zh not_active IP Right Cessation
- 2001-07-13 AR ARP010103345A patent/AR035039A1/es not_active Application Discontinuation
-
2002
- 2002-12-05 ZA ZA200209877A patent/ZA200209877B/en unknown
- 2002-12-08 IL IL153322A patent/IL153322A/en unknown
-
2003
- 2003-01-13 NO NO20030153A patent/NO331816B1/no not_active IP Right Cessation
- 2003-02-24 US US10/373,275 patent/US20030153530A1/en not_active Abandoned
-
2012
- 2012-11-21 CY CY20121101120T patent/CY1113391T1/el unknown
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