NO330989B1 - New piperazine derivatives, processes for their preparation and their use as synthetic intermediates. - Google Patents

New piperazine derivatives, processes for their preparation and their use as synthetic intermediates.

Info

Publication number
NO330989B1
NO330989B1 NO20053910A NO20053910A NO330989B1 NO 330989 B1 NO330989 B1 NO 330989B1 NO 20053910 A NO20053910 A NO 20053910A NO 20053910 A NO20053910 A NO 20053910A NO 330989 B1 NO330989 B1 NO 330989B1
Authority
NO
Norway
Prior art keywords
preparation
piperazine derivatives
processes
synthetic intermediates
new piperazine
Prior art date
Application number
NO20053910A
Other languages
Norwegian (no)
Other versions
NO20053910L (en
NO20053910D0 (en
Inventor
Celal Ates
Emile Cavoy
Didier Bouvy
Original Assignee
Ucb Farchim Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Farchim Sa filed Critical Ucb Farchim Sa
Publication of NO20053910D0 publication Critical patent/NO20053910D0/en
Publication of NO20053910L publication Critical patent/NO20053910L/en
Publication of NO330989B1 publication Critical patent/NO330989B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Foreliggende oppfinnelse angår nye enantiomerisk rene piperazinderivater av formel (I) hvori Y betegner hydroksy eller en forlatende gruppe, og n er 1, 2, 3, 4 eller 5, og deres anvendelse som syntesemellomprodukter, spesielt for fremstilling av farmasøytisk aktive forbindelser.The present invention relates to novel enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and their use as synthesis intermediates, in particular for the preparation of pharmaceutically active compounds.

NO20053910A 2003-01-23 2005-08-22 New piperazine derivatives, processes for their preparation and their use as synthetic intermediates. NO330989B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03001565 2003-01-23
PCT/EP2004/000399 WO2004065360A2 (en) 2003-01-23 2004-01-20 Piperazine derivatives and their use as synthesis intermediates

Publications (3)

Publication Number Publication Date
NO20053910D0 NO20053910D0 (en) 2005-08-22
NO20053910L NO20053910L (en) 2005-10-21
NO330989B1 true NO330989B1 (en) 2011-08-29

Family

ID=32748775

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053910A NO330989B1 (en) 2003-01-23 2005-08-22 New piperazine derivatives, processes for their preparation and their use as synthetic intermediates.

Country Status (8)

Country Link
US (1) US7381821B2 (en)
EP (1) EP1590323A2 (en)
CN (1) CN100378086C (en)
AU (1) AU2004205494B2 (en)
CA (1) CA2514145A1 (en)
NO (1) NO330989B1 (en)
PL (1) PL378027A1 (en)
WO (1) WO2004065360A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381821B2 (en) 2003-01-23 2008-06-03 Ucb, S.A. Piperazine derivatives and their use as synthesis intermediates
CA2599498C (en) * 2005-03-03 2011-06-21 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
US8049011B2 (en) 2007-03-12 2011-11-01 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of levocetirizine and intermediates thereof
KR20100059836A (en) * 2007-08-15 2010-06-04 케마지스 리미티드 Novel process for preparing highly pure levocetirizine and salts thereof
US20110172425A1 (en) * 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
CN103497166A (en) * 2013-09-27 2014-01-08 盐城格瑞茵化工有限公司 Synthesis method of cetirizine hydrochloride intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
US5432179A (en) 1991-07-19 1995-07-11 Zeria Pharmaceutical Co., Ltd. Piperazine derivatives and pharmaceuticals containing the same
PE20001566A1 (en) * 1999-03-26 2001-02-05 Ucb Sa 1,4-SUBSTITUTED PIPERAZINES, 1,4-SUBSTITUTED PIPERIDINES AND 1-SUBSTITUTED 4-ALKYLIDENYL PIPERIDINES
GB0009479D0 (en) * 2000-04-17 2000-06-07 Cipla Limited Antihistaminic compounds
US7381821B2 (en) 2003-01-23 2008-06-03 Ucb, S.A. Piperazine derivatives and their use as synthesis intermediates

Also Published As

Publication number Publication date
EP1590323A2 (en) 2005-11-02
PL378027A1 (en) 2006-02-20
US7381821B2 (en) 2008-06-03
AU2004205494B2 (en) 2009-04-30
AU2004205494A1 (en) 2004-08-05
NO20053910L (en) 2005-10-21
US20060183903A1 (en) 2006-08-17
NO20053910D0 (en) 2005-08-22
WO2004065360A2 (en) 2004-08-05
WO2004065360A3 (en) 2004-11-11
CA2514145A1 (en) 2004-08-05
CN1742002A (en) 2006-03-01
CN100378086C (en) 2008-04-02

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