NO322292B1 - Primaer emballasje inneholdende en vandig opplosning for parenteral administrasjon, fremgangsmate for fremstilling av emballasjen, og anvendelse av en gummiforsegling for denne - Google Patents

Primaer emballasje inneholdende en vandig opplosning for parenteral administrasjon, fremgangsmate for fremstilling av emballasjen, og anvendelse av en gummiforsegling for denne Download PDF

Info

Publication number: NO322292B1
Authority: NO; Norway
Prior art keywords: primary packaging; solution; packaging according; rubber; melagatran
Prior art date: 1998-09-01

Application number

NO20011032A

Other languages

English (en)

Norwegian (no)

Other versions

NO20011032L (no

NO20011032D0 (no

Inventor

Mats Sundgren

Anna Lundgren

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-01

Filing date

2001-02-28

Publication date

2006-09-11

2001-02-28 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2001-02-28 Publication of NO20011032D0 publication Critical patent/NO20011032D0/no

2001-04-30 Publication of NO20011032L publication Critical patent/NO20011032L/no

2006-09-11 Publication of NO322292B1 publication Critical patent/NO322292B1/no

Links

229920001971 elastomer Polymers 0.000 title claims description 45
239000005060 rubber Substances 0.000 title claims description 45
239000007864 aqueous solution Substances 0.000 title claims description 19
238000007911 parenteral administration Methods 0.000 title claims description 3
238000000034 method Methods 0.000 title description 3
238000004806 packaging method and process Methods 0.000 title description 3
239000000243 solution Substances 0.000 claims description 52
-1 bromobutyl Chemical group 0.000 claims description 39
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 38
229960002137 melagatran Drugs 0.000 claims description 38
DKWNMCUOEDMMIN-PKOBYXMFSA-N melagatran Chemical group C1=CC(C(=N)N)=CC=C1CNC(=O)[C@H]1N(C(=O)[C@H](NCC(O)=O)C2CCCCC2)CC1 DKWNMCUOEDMMIN-PKOBYXMFSA-N 0.000 claims description 38
238000009516 primary packaging Methods 0.000 claims description 33
229920005557 bromobutyl Polymers 0.000 claims description 32
239000000463 material Substances 0.000 claims description 24
229940122388 Thrombin inhibitor Drugs 0.000 claims description 22
239000003868 thrombin inhibitor Substances 0.000 claims description 22
239000011780 sodium chloride Substances 0.000 claims description 19
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 claims description 15
239000011521 glass Substances 0.000 claims description 13
108090000765 processed proteins & peptides Proteins 0.000 claims description 10
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 5
229920000858 Cyclodextrin Polymers 0.000 claims description 4
239000004471 Glycine Substances 0.000 claims description 4
239000000126 substance Substances 0.000 claims description 4
CDPROXZBMHOBTQ-SJORKVTESA-N 2-[[(2r)-3-cyclohexyl-1-[(2s)-2-[3-(diaminomethylideneamino)propylcarbamoyl]piperidin-1-yl]-1-oxopropan-2-yl]amino]acetic acid Chemical compound NC(N)=NCCCNC(=O)[C@@H]1CCCCN1C(=O)[C@H](NCC(O)=O)CC1CCCCC1 CDPROXZBMHOBTQ-SJORKVTESA-N 0.000 claims description 3
229940126062 Compound A Drugs 0.000 claims description 3
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 3
229950003291 inogatran Drugs 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
229940071643 prefilled syringe Drugs 0.000 claims description 3
125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 2
125000004494 ethyl ester group Chemical group 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
238000007789 sealing Methods 0.000 claims description 2
238000011146 sterile filtration Methods 0.000 claims description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
229920005556 chlorobutyl Polymers 0.000 description 15
230000015556 catabolic process Effects 0.000 description 6
239000007799 cork Substances 0.000 description 6
238000006731 degradation reaction Methods 0.000 description 5
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 4
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
238000004458 analytical method Methods 0.000 description 3
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
102000009123 Fibrin Human genes 0.000 description 1
108010073385 Fibrin Proteins 0.000 description 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
229950003499 fibrin Drugs 0.000 description 1
238000004811 liquid chromatography Methods 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/062—Carpules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Inorganic Chemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Infusion, Injection, And Reservoir Apparatuses (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Detergent Compositions (AREA)

NO20011032A 1998-09-01 2001-02-28 Primaer emballasje inneholdende en vandig opplosning for parenteral administrasjon, fremgangsmate for fremstilling av emballasjen, og anvendelse av en gummiforsegling for denne NO322292B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9802938A SE9802938D0 (sv)	1998-09-01	1998-09-01	Improved stability for injection solutions
PCT/SE1999/001440 WO2000012043A1 (en)	1998-09-01	1999-08-24	Improved stability for injection solutions

Publications (3)

Publication Number	Publication Date
NO20011032D0 NO20011032D0 (no)	2001-02-28
NO20011032L NO20011032L (no)	2001-04-30
NO322292B1 true NO322292B1 (no)	2006-09-11

Family

ID=20412436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20011032A NO322292B1 (no)	1998-09-01	2001-02-28	Primaer emballasje inneholdende en vandig opplosning for parenteral administrasjon, fremgangsmate for fremstilling av emballasjen, og anvendelse av en gummiforsegling for denne

Country Status (34)

Country	Link
US (4)	US6576245B1 (xx)
EP (1)	EP1109526B1 (xx)
JP (1)	JP2002523184A (xx)
KR (1)	KR100614162B1 (xx)
CN (1)	CN1230141C (xx)
AR (1)	AR033788A1 (xx)
AT (1)	ATE262882T1 (xx)
AU (1)	AU754447C (xx)
BR (1)	BR9913261A (xx)
CA (1)	CA2340238C (xx)
CZ (1)	CZ2001743A3 (xx)
DE (1)	DE69916082T2 (xx)
DK (1)	DK1109526T3 (xx)
EE (1)	EE04768B1 (xx)
ES (1)	ES2217808T3 (xx)
HK (1)	HK1035482A1 (xx)
HU (1)	HUP0104161A3 (xx)
ID (1)	ID28015A (xx)
IL (2)	IL141333A0 (xx)
IS (1)	IS2230B (xx)
MY (1)	MY120822A (xx)
NO (1)	NO322292B1 (xx)
NZ (1)	NZ509985A (xx)
PL (1)	PL195244B1 (xx)
PT (1)	PT1109526E (xx)
RU (1)	RU2224499C2 (xx)
SA (1)	SA99200573B1 (xx)
SE (1)	SE9802938D0 (xx)
SK (1)	SK285474B6 (xx)
TR (1)	TR200100679T2 (xx)
TW (1)	TWI228987B (xx)
UA (1)	UA73282C2 (xx)
WO (1)	WO2000012043A1 (xx)
ZA (1)	ZA200101590B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9802938D0 (sv) *	1998-09-01	1998-09-01	Astra Ab	Improved stability for injection solutions
US6462021B1 (en)	2000-11-06	2002-10-08	Astrazeneca Ab	Use of low molecular weight thrombin inhibitor
US7129233B2 (en)	2000-12-01	2006-10-31	Astrazeneca Ab	Mandelic acid derivatives and their use as thrombin inhibitors
AR035216A1 (es) *	2000-12-01	2004-05-05	Astrazeneca Ab	Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
AR034517A1 (es) *	2001-06-21	2004-02-25	Astrazeneca Ab	Formulacion farmaceutica
US6802828B2 (en) *	2001-11-23	2004-10-12	Duoject Medical Systems, Inc.	System for filling and assembling pharmaceutical delivery devices
SE0201659D0 (sv)	2002-05-31	2002-05-31	Astrazeneca Ab	Modified release pharmaceutical formulation
SE0201661D0 (sv)	2002-05-31	2002-05-31	Astrazeneca Ab	New salts
ES2543588T3 (es)	2002-12-03	2015-08-20	Pharmacyclics Llc	Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa
US20050008634A1 (en) *	2003-01-14	2005-01-13	Sharon Cohen-Vered	Parenteral formulations of peptides for the treatment of systemic lupus erythematosus
KR100505557B1 (ko) *	2003-02-10	2005-08-03	조을룡	약병마개 제조용 고무 조성물
US7781424B2 (en) *	2003-05-27	2010-08-24	Astrazeneca Ab	Modified release pharmaceutical formulation
US8476010B2 (en) *	2003-07-10	2013-07-02	App Pharmaceuticals Llc	Propofol formulations with non-reactive container closures
US7524354B2 (en) *	2005-07-07	2009-04-28	Research Foundation Of State University Of New York	Controlled synthesis of highly monodispersed gold nanoparticles
US20070166187A1 (en) *	2006-01-18	2007-07-19	Song Jing F	Stabilization of paricalcitol using chlorobutyl or chlorinated butyl stoppers
TW200827336A (en) *	2006-12-06	2008-07-01	Astrazeneca Ab	New crystalline forms
US20090061000A1 (en) *	2007-08-31	2009-03-05	Astrazeneca Ab	Pharmaceutical formulation use 030
US8939943B2 (en)	2011-01-26	2015-01-27	Kaleo, Inc.	Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en)	2011-02-28	2014-01-14	Intelliject, Inc.	Medicament delivery device for administration of opioid antagonists including formulations for naloxone
KR20200003228A (ko) *	2011-09-27	2020-01-08	벡톤 디킨슨 프랑스	플라즈마 처리된 실리콘 오일을 코팅물로서 활용한 의료 주사 장치 및 의료 주사 장치의 처리 방법
US9517307B2 (en)	2014-07-18	2016-12-13	Kaleo, Inc.	Devices and methods for delivering opioid antagonists including formulations for naloxone

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4381779A (en)	1981-07-16	1983-05-03	Sterling Drug Inc.	Deformable slidable piston to provide self-aspiration in hypodermic cartridge ampoules
ATE84205T1 (de) *	1989-03-28	1993-01-15	Duphar Int Res	Vorgefuellte injektionsvorrichtung mit einem fass, das mit einer fluessigen diazepam-formulierung gefuellt ist.
SE9103612D0 (sv)	1991-12-04	1991-12-04	Astra Ab	New peptide derivatives
SE9301916D0 (sv)	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
SE9402332D0 (sv) *	1994-07-01	1994-07-01	Pharmacia Ab	Igf-1
SE9501472D0 (sv) *	1995-04-21	1995-04-21	Pharmacia Ab	Truncated IGF-I
SA96170106A (ar)	1995-07-06	2005-12-03	أسترا أكتيبولاج	مشتقات حامض أميني جديدة
AR005245A1 (es)	1995-12-21	1999-04-28	Astrazeneca Ab	Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9601556D0 (sv) *	1996-04-24	1996-04-24	Astra Ab	New pharmaceutical formulation of a thrombin inhibitor for parenteral use
SE9802938D0 (sv)	1998-09-01	1998-09-01	Astra Ab	Improved stability for injection solutions

1998
- 1998-09-01 SE SE9802938A patent/SE9802938D0/xx unknown
1999
- 1999-08-18 AR ARP990104129 patent/AR033788A1/es active IP Right Grant
- 1999-08-20 TW TW088114257A patent/TWI228987B/zh not_active IP Right Cessation
- 1999-08-24 PT PT99946504T patent/PT1109526E/pt unknown
- 1999-08-24 EP EP99946504A patent/EP1109526B1/en not_active Expired - Lifetime
- 1999-08-24 ID ID20010430A patent/ID28015A/id unknown
- 1999-08-24 TR TR200100679T patent/TR200100679T2/xx unknown
- 1999-08-24 CZ CZ2001743A patent/CZ2001743A3/cs unknown
- 1999-08-24 CA CA 2340238 patent/CA2340238C/en not_active Expired - Fee Related
- 1999-08-24 PL PL99346471A patent/PL195244B1/pl not_active IP Right Cessation
- 1999-08-24 SK SK282-2001A patent/SK285474B6/sk not_active IP Right Cessation
- 1999-08-24 KR KR1020017002618A patent/KR100614162B1/ko not_active IP Right Cessation
- 1999-08-24 UA UA2001021045A patent/UA73282C2/uk unknown
- 1999-08-24 AU AU58903/99A patent/AU754447C/en not_active Ceased
- 1999-08-24 US US09/423,185 patent/US6576245B1/en not_active Expired - Fee Related
- 1999-08-24 NZ NZ50998599A patent/NZ509985A/xx not_active IP Right Cessation
- 1999-08-24 HU HU0104161A patent/HUP0104161A3/hu unknown
- 1999-08-24 BR BR9913261A patent/BR9913261A/pt not_active IP Right Cessation
- 1999-08-24 JP JP2000567167A patent/JP2002523184A/ja active Pending
- 1999-08-24 AT AT99946504T patent/ATE262882T1/de not_active IP Right Cessation
- 1999-08-24 DK DK99946504T patent/DK1109526T3/da active
- 1999-08-24 WO PCT/SE1999/001440 patent/WO2000012043A1/en active IP Right Grant
- 1999-08-24 DE DE1999616082 patent/DE69916082T2/de not_active Expired - Lifetime
- 1999-08-24 IL IL14133399A patent/IL141333A0/xx active IP Right Grant
- 1999-08-24 EE EEP200100131A patent/EE04768B1/xx not_active IP Right Cessation
- 1999-08-24 CN CNB998101931A patent/CN1230141C/zh not_active Expired - Fee Related
- 1999-08-24 RU RU2001104425A patent/RU2224499C2/ru not_active IP Right Cessation
- 1999-08-24 ES ES99946504T patent/ES2217808T3/es not_active Expired - Lifetime
- 1999-08-30 MY MYPI9903750 patent/MY120822A/en unknown
- 1999-09-14 SA SA99200573A patent/SA99200573B1/ar unknown
2001
- 2001-02-08 IL IL141333A patent/IL141333A/en not_active IP Right Cessation
- 2001-02-15 IS IS5845A patent/IS2230B/is unknown
- 2001-02-26 ZA ZA200101590A patent/ZA200101590B/xx unknown
- 2001-02-28 NO NO20011032A patent/NO322292B1/no not_active IP Right Cessation
- 2001-08-23 HK HK01105969A patent/HK1035482A1/xx not_active IP Right Cessation
2003
- 2003-01-17 US US10/347,046 patent/US6660279B2/en not_active Expired - Fee Related
- 2003-10-15 US US10/687,540 patent/US6998136B2/en not_active Expired - Fee Related
2005
- 2005-11-08 US US11/270,309 patent/US20060233778A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL346471A1 (en)	2002-02-11
SA99200573B1 (ar)	2006-09-20
PT1109526E (pt)	2004-07-30
SK2822001A3 (en)	2001-08-06
PL195244B1 (pl)	2007-08-31
IS2230B (is)	2007-04-15
ATE262882T1 (de)	2004-04-15
CA2340238C (en)	2009-01-06
BR9913261A (pt)	2001-05-22
IS5845A (is)	2001-02-15
HUP0104161A2 (hu)	2002-04-29
AU754447B2 (en)	2002-11-14
KR100614162B1 (ko)	2006-08-25
NZ509985A (en)	2002-12-20
EE200100131A (et)	2002-06-17
EP1109526B1 (en)	2004-03-31
AU5890399A (en)	2000-03-21
EE04768B1 (et)	2007-02-15
HK1035482A1 (en)	2001-11-30
CN1314804A (zh)	2001-09-26
IL141333A0 (en)	2002-03-10
US20030190310A1 (en)	2003-10-09
TR200100679T2 (tr)	2001-07-23
ZA200101590B (en)	2002-05-27
SA99200573A (ar)	2005-12-03
AU754447C (en)	2006-10-19
MY120822A (en)	2005-11-30
ES2217808T3 (es)	2004-11-01
UA73282C2 (en)	2005-07-15
AR033788A1 (es)	2004-01-07
SK285474B6 (sk)	2007-02-01
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NO20011032L (no)	2001-04-30
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ID28015A (id)	2001-05-03
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DE69916082T2 (de)	2004-10-21
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TWI228987B (en)	2005-03-11
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US20040235731A1 (en)	2004-11-25
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Publication	Publication Date	Title
NO322292B1 (no)	2006-09-11	Primaer emballasje inneholdende en vandig opplosning for parenteral administrasjon, fremgangsmate for fremstilling av emballasjen, og anvendelse av en gummiforsegling for denne
EP3606504B1 (en)	2023-07-19	Stable antibody formulation
US9193801B2 (en)	2015-11-24	Stabilized formulations containing anti-PCSK9 antibodies
JP2023511080A (ja)	2023-03-16	安定な抗体製剤
AU2003200467B2 (en)	2005-10-06	Improved stability for injection solutions
MXPA01001930A (en)	2001-12-04	Improved stability for injection solutions
NZ619379B2 (en)	2015-09-01	Stabilized formulations containing anti-pcsk9 antibodies