NO320150B1 - Protein med evne til a inhibere kollagenstimulert blodplateaggregering og forhindre interaksjoner mellom kollagen og von Willebrands faktor (vWF), fremgangsmate for fremstilling derav, farmasoytisk preparat som omfatter det, medisinsk anordning som er belagt med det, samt anvendelser derav for fremstilling av medikamenter. - Google Patents

Protein med evne til a inhibere kollagenstimulert blodplateaggregering og forhindre interaksjoner mellom kollagen og von Willebrands faktor (vWF), fremgangsmate for fremstilling derav, farmasoytisk preparat som omfatter det, medisinsk anordning som er belagt med det, samt anvendelser derav for fremstilling av medikamenter. Download PDF

Info

Publication number: NO320150B1
Authority: NO; Norway
Prior art keywords: collagen; protein; platelet aggregation; vwf; von willebrand
Prior art date: 1993-07-01

Application number

NO19950732A

Other languages

English (en)

Norwegian (no)

Other versions

NO950732L (no

NO950732D0 (no

Inventor

Guido Melzer

Juergen Hemberger

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-01

Filing date

1995-02-27

Publication date

2005-10-31

1995-02-27 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1995-02-27 Publication of NO950732L publication Critical patent/NO950732L/no

1995-02-27 Publication of NO950732D0 publication Critical patent/NO950732D0/no

2005-10-31 Publication of NO320150B1 publication Critical patent/NO320150B1/no

Links

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OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
230000008901 benefit Effects 0.000 description 1
JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
238000005842 biochemical reaction Methods 0.000 description 1
230000008033 biological extinction Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
150000001734 carboxylic acid salts Chemical class 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
238000011210 chromatographic step Methods 0.000 description 1
238000011097 chromatography purification Methods 0.000 description 1
235000013985 cinnamic acid Nutrition 0.000 description 1
229930016911 cinnamic acid Natural products 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
230000006378 damage Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
238000001085 differential centrifugation Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical compound NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 description 1
229950003499 fibrin Drugs 0.000 description 1
229940012952 fibrinogen Drugs 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
235000011087 fumaric acid Nutrition 0.000 description 1
108020001507 fusion proteins Proteins 0.000 description 1
102000037865 fusion proteins Human genes 0.000 description 1
229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
230000036541 health Effects 0.000 description 1
108010005808 hementin Proteins 0.000 description 1
230000023597 hemostasis Effects 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
238000009236 leech therapy Methods 0.000 description 1
230000007774 longterm Effects 0.000 description 1
206010025135 lupus erythematosus Diseases 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
230000035772 mutation Effects 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000037361 pathway Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229940127126 plasminogen activator Drugs 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
230000010118 platelet activation Effects 0.000 description 1
208000030428 polyarticular arthritis Diseases 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000013641 positive control Substances 0.000 description 1
230000031915 positive regulation of coagulation Effects 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
229910000343 potassium bisulfate Inorganic materials 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
239000012488 sample solution Substances 0.000 description 1
230000007017 scission Effects 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000012209 synthetic fiber Substances 0.000 description 1
229920002994 synthetic fiber Polymers 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
210000002435 tendon Anatomy 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000003848 thrombocyte activating factor antagonist Substances 0.000 description 1
150000003628 tricarboxylic acids Chemical class 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
229940086542 triethylamine Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
- Y10S530/858—Proteins from animals other than mammals or birds insects; venom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO19950732A 1993-07-01 1995-02-27 Protein med evne til a inhibere kollagenstimulert blodplateaggregering og forhindre interaksjoner mellom kollagen og von Willebrands faktor (vWF), fremgangsmate for fremstilling derav, farmasoytisk preparat som omfatter det, medisinsk anordning som er belagt med det, samt anvendelser derav for fremstilling av medikamenter. NO320150B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP93110528		1993-07-01
PCT/EP1994/002087 WO1995001375A1 (en)	1993-07-01	1994-06-28	Inhibitor of collagen-stimulated platelet aggregation

Publications (3)

Publication Number	Publication Date
NO950732L NO950732L (no)	1995-02-27
NO950732D0 NO950732D0 (no)	1995-02-27
NO320150B1 true NO320150B1 (no)	2005-10-31

Family

ID=8213032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19950732A NO320150B1 (no)	1993-07-01	1995-02-27	Protein med evne til a inhibere kollagenstimulert blodplateaggregering og forhindre interaksjoner mellom kollagen og von Willebrands faktor (vWF), fremgangsmate for fremstilling derav, farmasoytisk preparat som omfatter det, medisinsk anordning som er belagt med det, samt anvendelser derav for fremstilling av medikamenter.

Country Status (22)

Country	Link
US (1)	US5710131A (ja)
EP (1)	EP0662088B1 (ja)
JP (1)	JP3742429B2 (ja)
KR (2)	KR100455639B1 (ja)
CN (1)	CN1134451C (ja)
AT (1)	ATE210679T1 (ja)
AU (1)	AU680929B2 (ja)
CA (1)	CA2143416C (ja)
CZ (1)	CZ287472B6 (ja)
DE (1)	DE69429419T2 (ja)
DK (1)	DK0662088T3 (ja)
ES (1)	ES2169080T3 (ja)
HU (1)	HU214580B (ja)
NO (1)	NO320150B1 (ja)
PL (1)	PL180752B1 (ja)
PT (1)	PT662088E (ja)
RU (1)	RU2160280C2 (ja)
SK (1)	SK282961B6 (ja)
TW (1)	TW281678B (ja)
UA (1)	UA41332C2 (ja)
WO (1)	WO1995001375A1 (ja)
ZA (1)	ZA944738B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2153760B1 (es) *	1998-11-25	2001-07-01	Univ Barcelona Autonoma	Inhibidor de metalocarboxipeptidasas como agente fibrinolitico.
HU228068B1 (en) *	1999-03-18	2012-09-28	Merck Patent Gmbh	Protein for blocking platelet adhesion
CA2372515C (en)	1999-05-07	2015-12-01	Merck Patent Gesellschaft Mit Beschraenkter Haftung	Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use
MY128992A (en) *	2000-08-25	2007-03-30	Merck Patent Gmbh	Saratin for inhibiting platelet adhesion to collagen
GB0031448D0 (en) *	2000-12-22	2001-02-07	Leuven K U Res & Dev	Inhibition of the vWF-collagen interaction by anti-human vWF monoclonal antibody (82D6A3) results in abolition of in vivo arterial platelet thrombus formation
CA2578046A1 (en) *	2004-09-07	2006-03-16	Archemix Corp.	Aptamer medicinal chemistry
WO2006033854A2 (en)	2004-09-07	2006-03-30	Archemix Corp.	Aptamers to von willebrand factor and their use as thrombotic disease therapeutics
US7566701B2 (en) *	2004-09-07	2009-07-28	Archemix Corp.	Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
US20060286548A1 (en) *	2005-06-16	2006-12-21	Gregory Liposky	Method of making recombinant human antibodies for use in biosensor technology
US20110034396A1 (en) *	2005-09-28	2011-02-10	Biovascular, Inc.	Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
JP2009510105A (ja) *	2005-09-28	2009-03-12	バイオバスキュラーインコーポレーティッド	血小板および細胞の接着、細胞移動、および炎症を阻止するための方法および組成物
TWI391143B (zh) *	2005-11-04	2013-04-01	Otsuka Pharma Co Ltd	血小板凝集抑制劑組成物
US20080015145A1 (en)	2006-07-11	2008-01-17	Maria Gyongyossy-Issa	Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
WO2008150495A2 (en) *	2007-06-01	2008-12-11	Archemix Corp.	Vwf aptamer formulations and methods for use
EP2316465A1 (en) *	2009-10-15	2011-05-04	Centre National De La Recherche Scientifique	Use of extract of leeches' saliva as anti-bacterial agent for the manufacture of different compositons
EP2670722B1 (en)	2011-01-31	2016-10-12	Council of Scientific & Industrial Research	Chiral 1-(4-methylphenylmethyl)-5-oxo-{n-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3751179T2 (de) *	1986-05-30	1995-07-27	Scripps Research Inst	Peptide, die die Bindung des Von-Willebrand-Faktors inhibieren.
US5238919A (en) *	1986-05-30	1993-08-24	Scipps Clinic And Research Foundation	Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
IL86856A0 (en) *	1988-06-24	1988-11-30	Yissum Res Dev Co	Bovine xa factor and pharmaceutical compositions containing the same
JPH04503660A (ja) *	1988-12-05	1992-07-02	バイオジェンインコーポレイテッド	血小板凝集抑制の方法及び組成物
CA2008116C (en) *	1989-02-23	2001-11-20	Thomas Weller	Glycine derivatives
CA2052486A1 (en) *	1990-10-09	1992-04-10	Thomas M. Connolly	Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) *	1990-10-10	1990-11-21	Biopharm Ltd	Platelet adhesion inhibitor
US5342830A (en) *	1990-11-16	1994-08-30	Cor Therapeutics, Inc.	Antithrombosis agents

1994
- 1994-06-28 UA UA95028198A patent/UA41332C2/uk unknown
- 1994-06-28 KR KR10-2004-7002282A patent/KR100455639B1/ko not_active IP Right Cessation
- 1994-06-28 PL PL94307726A patent/PL180752B1/pl not_active IP Right Cessation
- 1994-06-28 AU AU73836/94A patent/AU680929B2/en not_active Ceased
- 1994-06-28 DK DK94923690T patent/DK0662088T3/da active
- 1994-06-28 AT AT94923690T patent/ATE210679T1/de not_active IP Right Cessation
- 1994-06-28 RU RU95108596/13A patent/RU2160280C2/ru not_active IP Right Cessation
- 1994-06-28 KR KR1019950700766A patent/KR100445309B1/ko not_active IP Right Cessation
- 1994-06-28 DE DE69429419T patent/DE69429419T2/de not_active Expired - Fee Related
- 1994-06-28 CA CA002143416A patent/CA2143416C/en not_active Expired - Fee Related
- 1994-06-28 ES ES94923690T patent/ES2169080T3/es not_active Expired - Lifetime
- 1994-06-28 SK SK270-95A patent/SK282961B6/sk unknown
- 1994-06-28 CZ CZ1995528A patent/CZ287472B6/cs not_active IP Right Cessation
- 1994-06-28 EP EP94923690A patent/EP0662088B1/en not_active Expired - Lifetime
- 1994-06-28 HU HU9500613A patent/HU214580B/hu not_active IP Right Cessation
- 1994-06-28 CN CNB941904229A patent/CN1134451C/zh not_active Expired - Fee Related
- 1994-06-28 WO PCT/EP1994/002087 patent/WO1995001375A1/en active Application Filing
- 1994-06-28 US US08/392,970 patent/US5710131A/en not_active Expired - Fee Related
- 1994-06-28 PT PT94923690T patent/PT662088E/pt unknown
- 1994-06-28 JP JP50326095A patent/JP3742429B2/ja not_active Expired - Fee Related
- 1994-06-30 ZA ZA944738A patent/ZA944738B/xx unknown
- 1994-07-18 TW TW083106615A patent/TW281678B/zh active
1995
- 1995-02-27 NO NO19950732A patent/NO320150B1/no unknown

Also Published As

Publication number	Publication date
PL180752B1 (pl)	2001-04-30
WO1995001375A1 (en)	1995-01-12
SK282961B6 (sk)	2003-01-09
CZ52895A3 (en)	1995-09-13
US5710131A (en)	1998-01-20
KR100455639B1 (ko)	2004-11-09
KR950703004A (ko)	1995-08-23
NO950732L (no)	1995-02-27
TW281678B (ja)	1996-07-21
ATE210679T1 (de)	2001-12-15
DE69429419T2 (de)	2002-08-01
DK0662088T3 (da)	2002-02-25
NO950732D0 (no)	1995-02-27
HU9500613D0 (en)	1995-04-28
ES2169080T3 (es)	2002-07-01
PT662088E (pt)	2002-06-28
KR20040030124A (ko)	2004-04-08
ZA944738B (en)	1995-02-15
CA2143416A1 (en)	1995-01-12
RU2160280C2 (ru)	2000-12-10
EP0662088A1 (en)	1995-07-12
CN1134451C (zh)	2004-01-14
EP0662088B1 (en)	2001-12-12
JPH08500848A (ja)	1996-01-30
HUT71399A (en)	1995-11-28
CA2143416C (en)	2003-06-10
AU680929B2 (en)	1997-08-14
CN1111058A (zh)	1995-11-01
CZ287472B6 (en)	2000-12-13
KR100445309B1 (ko)	2004-11-12
JP3742429B2 (ja)	2006-02-01
UA41332C2 (uk)	2001-09-17
HU214580B (hu)	1998-04-28
DE69429419D1 (de)	2002-01-24
SK27095A3 (en)	1995-08-09
AU7383694A (en)	1995-01-24
PL307726A1 (en)	1995-06-12

Publication	Publication Date	Title
NO320150B1 (no)	2005-10-31	Protein med evne til a inhibere kollagenstimulert blodplateaggregering og forhindre interaksjoner mellom kollagen og von Willebrands faktor (vWF), fremgangsmate for fremstilling derav, farmasoytisk preparat som omfatter det, medisinsk anordning som er belagt med det, samt anvendelser derav for fremstilling av medikamenter.
CA1335666C (en)	1995-05-23	Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii
US6774107B1 (en)	2004-08-10	Protein for blocking platelet adhesion
JP2008289498A (ja)	2008-12-04	精製されたマルチメラ−ゼ
US6025330A (en)	2000-02-15	Inhibitors of fibrin cross-linking and/or transglutaminases
EP0652900B1 (en)	2001-11-14	Thrombin inhibitors
AU659807B2 (en)	1995-06-01	Platelet adhesion inhibitor
Mitchell et al.	1987	Cleavage of protein S by a platelet membrane protease.
Iatridis et al.	1964	Thrombogenic Properties of Surface Factor; Evidence for an Anti-Surface Factor Activity in Canine Plasma.
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