NO313912B1 - Guanidinylheterocykelforbindelser anvendelige som <alfa>-2 adrenoceptoragonister - Google Patents

Guanidinylheterocykelforbindelser anvendelige som <alfa>-2 adrenoceptoragonister Download PDF

Info

Publication number: NO313912B1
Authority: NO; Norway
Prior art keywords: guanidine; compounds; dosage range; hydrogen; compound according
Prior art date: 1996-11-25

Application number

NO19992498A

Other languages

English (en)

Norwegian (no)

Other versions

NO992498L (no

NO992498D0 (no

Inventor

Thomas Lee Cupps

Sophie Eva Bogdan

Raymond Todd Henry

Russell James Sheldon

William Lee Seibel

Jeffrey Joseph Ares

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-25

Filing date

1999-05-25

Publication date

2002-12-23

1999-05-25 Application filed by Procter & Gamble filed Critical Procter & Gamble

1999-05-25 Publication of NO992498D0 publication Critical patent/NO992498D0/no

1999-07-26 Publication of NO992498L publication Critical patent/NO992498L/no

2002-12-23 Publication of NO313912B1 publication Critical patent/NO313912B1/no

Links

239000000556 agonist Substances 0.000 title description 15
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150000003839 salts Chemical class 0.000 claims description 53
238000011282 treatment Methods 0.000 claims description 35
-1 guanidinyl Chemical group 0.000 claims description 28
239000001257 hydrogen Substances 0.000 claims description 28
229910052739 hydrogen Inorganic materials 0.000 claims description 28
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
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KXKOEIOYGZGLGV-UHFFFAOYSA-N 2-(4-methyl-1h-benzimidazol-5-yl)guanidine Chemical compound CC1=C(NC(N)=N)C=CC2=C1NC=N2 KXKOEIOYGZGLGV-UHFFFAOYSA-N 0.000 claims description 5
150000002148 esters Chemical class 0.000 claims description 5
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MKDGSBIWCWLWBI-UHFFFAOYSA-N 2-(1,4-dimethylbenzimidazol-5-yl)guanidine Chemical compound CC1=C(NC(N)=N)C=CC2=C1N=CN2C MKDGSBIWCWLWBI-UHFFFAOYSA-N 0.000 claims description 4
OYUIDCLGIJAROB-UHFFFAOYSA-N 2-(2,4-dimethyl-1h-benzimidazol-5-yl)guanidine Chemical compound C1=C(NC(N)=N)C(C)=C2NC(C)=NC2=C1 OYUIDCLGIJAROB-UHFFFAOYSA-N 0.000 claims description 4
OAGSCXZEGUZELV-UHFFFAOYSA-N 2-(4,7-dimethyl-3h-benzimidazol-5-yl)guanidine Chemical compound CC1=CC(NC(N)=N)=C(C)C2=C1N=CN2 OAGSCXZEGUZELV-UHFFFAOYSA-N 0.000 claims description 4
JTNJXYPRYVWRLU-UHFFFAOYSA-N 2-(4-bromo-1,3-benzothiazol-5-yl)guanidine Chemical compound NC(=N)NC1=CC=C2SC=NC2=C1Br JTNJXYPRYVWRLU-UHFFFAOYSA-N 0.000 claims description 4
ARMHVRVRVOHHIA-UHFFFAOYSA-N 2-(4-bromo-1h-benzimidazol-5-yl)guanidine Chemical compound NC(=N)NC1=CC=C2N=CNC2=C1Br ARMHVRVRVOHHIA-UHFFFAOYSA-N 0.000 claims description 4
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231100000027 toxicology Toxicity 0.000 description 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
229960003223 tripelennamine Drugs 0.000 description 1
229960001128 triprolidine Drugs 0.000 description 1
CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 description 1
210000001944 turbinate Anatomy 0.000 description 1
230000007306 turnover Effects 0.000 description 1
238000010200 validation analysis Methods 0.000 description 1
208000027185 varicose disease Diseases 0.000 description 1
230000002792 vascular Effects 0.000 description 1
238000007631 vascular surgery Methods 0.000 description 1
210000005166 vasculature Anatomy 0.000 description 1
230000025033 vasoconstriction Effects 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
208000001319 vasomotor rhinitis Diseases 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
201000002282 venous insufficiency Diseases 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1
MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
229960005332 zileuton Drugs 0.000 description 1
229960000568 zipeprol Drugs 0.000 description 1
VSTNNAYSCJQCQI-UHFFFAOYSA-N zipeprol Chemical compound C=1C=CC=CC=1C(OC)CN(CC1)CCN1CC(O)C(OC)C1=CC=CC=C1 VSTNNAYSCJQCQI-UHFFFAOYSA-N 0.000 description 1
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19992498A 1996-11-25 1999-05-25 Guanidinylheterocykelforbindelser anvendelige som <alfa>-2 adrenoceptoragonister NO313912B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3202396P	1996-11-25	1996-11-25
PCT/US1997/020802 WO1998023596A1 (en)	1996-11-25	1997-11-21	Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists

Publications (3)

Publication Number	Publication Date
NO992498D0 NO992498D0 (no)	1999-05-25
NO992498L NO992498L (no)	1999-07-26
NO313912B1 true NO313912B1 (no)	2002-12-23

Family

ID=21862692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19992498A NO313912B1 (no)	1996-11-25	1999-05-25	Guanidinylheterocykelforbindelser anvendelige som <alfa>-2 adrenoceptoragonister

Country Status (25)

Country	Link
US (3)	US6225331B1 (es)
EP (1)	EP0944604B1 (es)
JP (1)	JP2001506600A (es)
KR (1)	KR20000069131A (es)
CN (1)	CN1104422C (es)
AR (1)	AR009145A1 (es)
AT (1)	ATE286885T1 (es)
AU (1)	AU730369B2 (es)
BR (1)	BR9713536A (es)
CA (1)	CA2272640C (es)
CO (1)	CO4910148A1 (es)
CZ (1)	CZ184099A3 (es)
DE (1)	DE69732244T2 (es)
ES (1)	ES2236833T3 (es)
HU (1)	HUP0000312A3 (es)
ID (1)	ID23857A (es)
IL (1)	IL130077A0 (es)
NO (1)	NO313912B1 (es)
NZ (1)	NZ336010A (es)
PE (1)	PE16399A1 (es)
RU (1)	RU2194700C2 (es)
SK (1)	SK69799A3 (es)
TR (1)	TR199901468T2 (es)
WO (1)	WO1998023596A1 (es)
ZA (1)	ZA9710578B (es)

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KR20000069131A (ko)	1996-11-25	2000-11-25	데이비드 엠 모이어	알파-2 아드레날린수용체 아고니스트로서 유용한 구아니디닐 헤테로사이클 화합물
US6291514B1 (en) *	1998-02-09	2001-09-18	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
DZ3415A1 (fr) *	2000-08-31	2002-03-07	Chiron Corp	Guanidinobenzamides comme mc4-r agonistes.
AU2001279999A1 (en) *	2000-09-08	2002-03-22	Warner-Lambert Compan Llc	Prevention of acute sinusitis and sinus attack
DE60216747T2 (de) *	2001-04-09	2007-10-04	Novartis Vaccines and Diagnostics, Inc., Emeryville	Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten
US20030195187A1 (en) *	2002-02-04	2003-10-16	Chiron Corporation	Guanidino compounds
US20050124652A1 (en) *	2002-02-04	2005-06-09	Rustum Boyce	Guanidino compounds
US20030207814A1 (en) *	2002-02-04	2003-11-06	Chiron Corporation	Novel guanidinyl derivatives
JP2005524649A (ja) *	2002-02-25	2005-08-18	カイロンコーポレーション	Ｍｃ４−ｒアゴニストの鼻腔内投与
US7858631B2 (en)	2002-05-23	2010-12-28	Novartis Vaccines And Diagnostics, Inc.	Substituted pyrido [2,3-d] pyrimidinone compounds
EP1651229A1 (en)	2003-05-23	2006-05-03	Chiron Corporation	Guanidino-substituted quinazolinone compounds as mc4-r agonists
EP1686996A4 (en) *	2003-11-19	2008-11-12	Novartis Vaccines & Diagnostic	QUINAZOLINONE COMPOUNDS WITH REDUCED BIOACCUMULATION
TWI466879B (zh) *	2005-04-13	2015-01-01	Neuraxon Inc	具有一氧化氮合成酶抑制活性之取代的吲哚化合物
ZA200804550B (en)	2005-11-09	2009-08-26	Combinatorx Inc	Methods, compositions, and kits for the treatment of medical conditions
US8173813B2 (en) *	2007-03-23	2012-05-08	Neuraxon, Inc.	Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
EP2220074A4 (en) *	2007-11-16	2012-01-04	Neuraxon Inc	3,5-SUBSTITUTED INDOL COMPOUNDS WITH NOS AND NOREPINEPHRINE RECOVERY-HEMDERING EFFECT
US20100196286A1 (en) *	2008-12-01	2010-08-05	Armer Thomas A	Inhalation delivery methods and devices
WO2010074753A1 (en)	2008-12-23	2010-07-01	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
GB0919889D0 (en) *	2009-11-13	2009-12-30	Biocopea Ltd	Drug composition and its use in therapy
EP2668177B1 (en) *	2011-01-28	2014-10-22	Boehringer Ingelheim International GmbH	Substituted pyridinyl-pyrimidines and their use as medicaments
CN112047947A (zh) *	2020-10-13	2020-12-08	石药集团新诺威制药股份有限公司	一种茶碱的合成方法

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US3908013A (en)	1970-09-17	1975-09-23	Armour Pharma	Pharmaceutical aromatic guanidine compositions and methods of using same
BE795970A (fr)	1972-02-29	1973-08-27	Pfizer	Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US3947455A (en)	1974-04-15	1976-03-30	Armour Pharmaceutical Company	5'-(8'-Hydroxyquinolyl)guanidine compounds
US4000279A (en)	1974-10-29	1976-12-28	Armour Pharmaceutical Company	Pharmaceutical preparations containing 5'-(8'-hydroxyquinolyl)guanidine compounds and methods of using same
US5091528A (en)	1990-09-12	1992-02-25	Allergan, Inc.	6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
CZ175496A3 (en) *	1993-12-17	1996-11-13	Procter & Gamble	6-(2-imidazolinylamino)quinoxaline compounds usable as alpha-2 adrenoceptor agonists
US5478858A (en) *	1993-12-17	1995-12-26	The Procter & Gamble Company	5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
KR20000069131A (ko)	1996-11-25	2000-11-25	데이비드 엠 모이어	알파-2 아드레날린수용체 아고니스트로서 유용한 구아니디닐 헤테로사이클 화합물
AU5330698A (en) *	1996-12-23	1998-07-17	Celltech Therapeutics Limited	Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors

1997
- 1997-11-21 KR KR1019997004619A patent/KR20000069131A/ko not_active Application Discontinuation
- 1997-11-21 TR TR1999/01468T patent/TR199901468T2/xx unknown
- 1997-11-21 CZ CZ991840A patent/CZ184099A3/cs unknown
- 1997-11-21 RU RU99113446/04A patent/RU2194700C2/ru not_active IP Right Cessation
- 1997-11-21 AU AU54381/98A patent/AU730369B2/en not_active Ceased
- 1997-11-21 US US09/308,788 patent/US6225331B1/en not_active Expired - Lifetime
- 1997-11-21 CN CN97181078A patent/CN1104422C/zh not_active Expired - Fee Related
- 1997-11-21 BR BR9713536-4A patent/BR9713536A/pt not_active IP Right Cessation
- 1997-11-21 ES ES97948290T patent/ES2236833T3/es not_active Expired - Lifetime
- 1997-11-21 AT AT97948290T patent/ATE286885T1/de not_active IP Right Cessation
- 1997-11-21 HU HU0000312A patent/HUP0000312A3/hu unknown
- 1997-11-21 ID IDW990410A patent/ID23857A/id unknown
- 1997-11-21 IL IL13007797A patent/IL130077A0/xx unknown
- 1997-11-21 DE DE69732244T patent/DE69732244T2/de not_active Expired - Lifetime
- 1997-11-21 SK SK697-99A patent/SK69799A3/sk unknown
- 1997-11-21 WO PCT/US1997/020802 patent/WO1998023596A1/en active IP Right Grant
- 1997-11-21 JP JP52469498A patent/JP2001506600A/ja active Pending
- 1997-11-21 EP EP97948290A patent/EP0944604B1/en not_active Expired - Lifetime
- 1997-11-21 CA CA002272640A patent/CA2272640C/en not_active Expired - Fee Related
- 1997-11-21 NZ NZ336010A patent/NZ336010A/en unknown
- 1997-11-24 CO CO97068606A patent/CO4910148A1/es unknown
- 1997-11-25 AR ARP970105530A patent/AR009145A1/es unknown
- 1997-11-25 PE PE1997001070A patent/PE16399A1/es not_active Application Discontinuation
- 1997-11-25 ZA ZA9710578A patent/ZA9710578B/xx unknown
1999
- 1999-05-25 NO NO19992498A patent/NO313912B1/no unknown
2000
- 2000-12-01 US US09/727,900 patent/US6391878B2/en not_active Expired - Lifetime
2002
- 2002-02-08 US US10/071,284 patent/US20020128481A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE286885T1 (de)	2005-01-15
KR20000069131A (ko)	2000-11-25
DE69732244D1 (de)	2005-02-17
WO1998023596A1 (en)	1998-06-04
PE16399A1 (es)	1999-03-12
AU730369B2 (en)	2001-03-08
AR009145A1 (es)	2000-03-08
NZ336010A (en)	2001-05-25
ID23857A (id)	2000-05-25
US6391878B2 (en)	2002-05-21
DE69732244T2 (de)	2006-06-29
JP2001506600A (ja)	2001-05-22
TR199901468T2 (xx)	1999-10-21
EP0944604B1 (en)	2005-01-12
US20010000345A1 (en)	2001-04-19
SK69799A3 (en)	2000-06-12
CA2272640C (en)	2003-07-08
US6225331B1 (en)	2001-05-01
ZA9710578B (en)	1998-06-25
HUP0000312A2 (hu)	2000-09-28
US20020128481A1 (en)	2002-09-12
NO992498L (no)	1999-07-26
CN1104422C (zh)	2003-04-02
ES2236833T3 (es)	2005-07-16
CA2272640A1 (en)	1998-06-04
IL130077A0 (en)	2000-02-29
AU5438198A (en)	1998-06-22
EP0944604A1 (en)	1999-09-29
RU2194700C2 (ru)	2002-12-20
CZ184099A3 (cs)	1999-11-17
NO992498D0 (no)	1999-05-25
CN1242006A (zh)	2000-01-19
CO4910148A1 (es)	2000-04-24
HUP0000312A3 (en)	2001-12-28
BR9713536A (pt)	2000-11-07

Publication	Publication Date	Title
US6225331B1 (en)	2001-05-01	Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
EP0944621B1 (en)	2004-09-01	2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists
US5965595A (en)	1999-10-12	2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US6423724B1 (en)	2002-07-23	7-(2-imidazolinylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
US5804587A (en)	1998-09-08	6-(2-imidazolinylamino) quinolines useful as alpha-2 adrenoceptor agonists
AU736992B2 (en)	2001-08-09	2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists
US5914342A (en)	1999-06-22	2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
US6172095B1 (en)	2001-01-09	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
US6306877B1 (en)	2001-10-23	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
EP0944601B1 (en)	2003-02-12	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
WO1998046595A1 (en)	1998-10-22	5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2 adrenoceptor agonists
AU5433998A (en)	1998-06-22	2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonis ts
WO1998023612A1 (en)	1998-06-04	2-imidazolinylaminobenzothiazole compounds useful as alpha-2 adrenoceptor agonists