NO304372B1 - Dobbeltvirkende inhibitorer og farmas°ytiske blandinger inneholdende disse - Google Patents
Dobbeltvirkende inhibitorer og farmas°ytiske blandinger inneholdende disseInfo
- Publication number
- NO304372B1 NO304372B1 NO931795A NO931795A NO304372B1 NO 304372 B1 NO304372 B1 NO 304372B1 NO 931795 A NO931795 A NO 931795A NO 931795 A NO931795 A NO 931795A NO 304372 B1 NO304372 B1 NO 304372B1
- Authority
- NO
- Norway
- Prior art keywords
- mixtures containing
- double acting
- pharmaceutical mixtures
- acting inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88466492A | 1992-05-18 | 1992-05-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO931795D0 NO931795D0 (no) | 1993-05-18 |
NO931795L NO931795L (no) | 1993-11-19 |
NO304372B1 true NO304372B1 (no) | 1998-12-07 |
Family
ID=25385092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO931795A NO304372B1 (no) | 1992-05-18 | 1993-05-18 | Dobbeltvirkende inhibitorer og farmas°ytiske blandinger inneholdende disse |
Country Status (28)
Country | Link |
---|---|
EP (2) | EP0599444B1 (no) |
JP (1) | JP3487611B2 (no) |
KR (2) | KR100288722B1 (no) |
CN (1) | CN1039008C (no) |
AT (1) | ATE162800T1 (no) |
AU (2) | AU659550B2 (no) |
BR (1) | BR1101081A (no) |
CA (1) | CA2096460C (no) |
CY (1) | CY2093B1 (no) |
CZ (1) | CZ289824B6 (no) |
DE (1) | DE69316717T2 (no) |
DK (1) | DK0599444T3 (no) |
ES (1) | ES2111712T3 (no) |
FI (1) | FI103337B1 (no) |
GR (1) | GR3026665T3 (no) |
HK (1) | HK1003597A1 (no) |
HU (1) | HU217078B (no) |
IL (1) | IL105729A (no) |
MX (1) | MX9302876A (no) |
MY (1) | MY111370A (no) |
NO (1) | NO304372B1 (no) |
NZ (1) | NZ247642A (no) |
PL (1) | PL173036B1 (no) |
RU (1) | RU2124503C1 (no) |
SG (1) | SG54138A1 (no) |
SK (1) | SK283556B6 (no) |
TW (1) | TW290544B (no) |
ZA (1) | ZA933461B (no) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5455242A (en) * | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
EP0534363B1 (en) * | 1991-09-27 | 1997-07-09 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
CA2078759C (en) * | 1991-09-27 | 2003-09-16 | Alan M. Warshawsky | Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5674863A (en) * | 1991-10-18 | 1997-10-07 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
DE69317764T2 (de) * | 1992-02-14 | 1998-07-30 | Merrell Pharma Inc | Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
US5420271A (en) * | 1992-08-24 | 1995-05-30 | Merrell Dow Pharmaceuticals, Inc. | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
GB9310075D0 (en) * | 1993-05-17 | 1993-06-30 | Fujisawa Pharmaceutical Co | New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
NZ267161A (en) * | 1993-06-11 | 1996-12-20 | Eisai Co Ltd | Dipeptidic benzazepine derivative with ace inhibiting activity |
ES2076096B1 (es) * | 1993-07-14 | 1996-03-16 | Squibb & Sons Inc | Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos. |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
EP0746566A1 (en) * | 1994-02-14 | 1996-12-11 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
EP0750631B1 (en) * | 1994-02-14 | 2000-04-05 | Merrell Pharmaceuticals Inc. | Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace |
EP0745081B1 (en) * | 1994-02-14 | 2001-11-21 | Merrell Pharmaceuticals Inc. | indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase |
KR100357354B1 (ko) * | 1994-02-14 | 2003-01-30 | 메렐 파마슈티칼스 인크. | 엔케팔리나제및안지오텐신전환효소(ace)의억제제로서유용한신규의머캅토아세틸아미드디설파이드유도체 |
US5530013A (en) * | 1994-02-14 | 1996-06-25 | American Home Products Corporation | Venlafaxine in the inducement of cognition enhancement |
US5484783A (en) * | 1994-03-24 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives |
CA2184696C (en) * | 1994-03-24 | 2001-01-02 | Gary A. Flynn | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives |
NZ282565A (en) * | 1994-03-24 | 1999-11-29 | Merrell Pharma Inc | Condensed mercaptoacetylamidedisulphidebenzazepines used in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia |
DE69532155T2 (de) * | 1994-07-18 | 2004-08-19 | Eisai Co., Ltd. | Substituierte thiazolo [3,2-alpha]azepinderivate |
DE69533002T2 (de) * | 1994-12-21 | 2005-05-04 | Aventis Pharmaceuticals Inc. | Verfahren zur Herstellung von Zwischenprodukten von Inhibitoren Von Enkephalinase und Angiotensin konvertierendem Enzym und Zwischenprodukte davon |
US5641880A (en) * | 1994-12-21 | 1997-06-24 | Hoechst Marion Roussel, Inc. | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
CN1049830C (zh) * | 1995-01-13 | 2000-03-01 | 李勤 | 一种治疗癌痛的热力敷 |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
AU7586796A (en) * | 1995-11-13 | 1997-06-05 | Eisai Co. Ltd. | Cholesterol-lowering composition |
US6777550B1 (en) | 1996-04-12 | 2004-08-17 | Bristol-Myers Squibb Company | N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors |
WO1997038705A1 (en) * | 1996-04-12 | 1997-10-23 | Bristol-Myers Squibb Company | N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors |
US6117896A (en) * | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
US6340752B1 (en) * | 1998-01-06 | 2002-01-22 | Bristol-Myers Squibb Co. | Deprotection and recrystallization processes |
WO1999065500A1 (en) | 1998-06-17 | 1999-12-23 | Bristol-Myers Squibb Company | Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination |
US6262080B1 (en) | 1998-12-31 | 2001-07-17 | Avantis Pharmaceuticals Inc. | 3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase |
US6770640B1 (en) | 1998-12-31 | 2004-08-03 | Aventis Pharmaceuticals Inc. | 1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12 |
WO2000040564A1 (en) * | 1998-12-31 | 2000-07-13 | Aventis Pharmaceuticals Inc. | N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase |
WO2001055074A1 (fr) | 2000-01-25 | 2001-08-02 | Kaneka Corporation | Processus de production d'acide carboxylique optiquement actif substitue en position 2 |
US6509330B2 (en) | 2000-02-17 | 2003-01-21 | Bristol-Myers Squibb Company | Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors |
DE10020818A1 (de) * | 2000-04-28 | 2001-10-31 | Degussa | 2,6-Diamino-6-methyl-heptansäure und Derivate, Verfahren zu deren Herstellung und deren Verwendung |
US7388098B2 (en) | 2000-09-29 | 2008-06-17 | Bristol-Myers Squibb Company | Dynamic resolution of isomers and resolved isomers |
GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
EP1395560A1 (en) | 2001-05-23 | 2004-03-10 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
EP1443919A4 (en) | 2001-11-16 | 2006-03-22 | Bristol Myers Squibb Co | DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES |
JP2005526722A (ja) | 2002-02-14 | 2005-09-08 | ミリアド・ジェネティックス・インコーポレイテッド | β−シートミメティックならびにそれに関連する組成物および方法 |
EP2266590A3 (en) | 2002-02-22 | 2011-04-20 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
US7045653B2 (en) | 2002-12-23 | 2006-05-16 | Pfizer, Inc. | Pharmaceuticals |
US7459474B2 (en) | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
US7371759B2 (en) | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US7420059B2 (en) | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US7273881B2 (en) | 2004-01-16 | 2007-09-25 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
WO2006017295A2 (en) * | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
US7888381B2 (en) | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
US7795291B2 (en) | 2006-07-07 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method |
EP2099767A1 (en) | 2006-11-01 | 2009-09-16 | Brystol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof |
WO2008057862A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
WO2008057855A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | Heterocyclic compounds as modulators of glucocorticoid receptor, ap-i, and/or np-kappa-b activity |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP4718534B2 (ja) * | 2007-11-09 | 2011-07-06 | カルピス株式会社 | Fischer比低下抑制剤 |
EP3239170B1 (en) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
CN102149710A (zh) | 2008-06-24 | 2011-08-10 | 百时美施贵宝公司 | 糖皮质激素受体、AP-1和/或NF-κB 活性的环戊噻吩调节剂及其用途 |
EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9468637B2 (en) | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
US9801882B2 (en) | 2013-02-17 | 2017-10-31 | Intra-Cellular Therapies, Inc. | Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
US9593113B2 (en) | 2013-08-22 | 2017-03-14 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
TWI686394B (zh) | 2014-08-07 | 2020-03-01 | 美商內胞醫療公司 | 有機化合物 |
US10961258B2 (en) | 2015-12-21 | 2021-03-30 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
CN106674228B (zh) * | 2016-12-09 | 2018-12-04 | 河南农业大学 | 多元杂环化合物及其制备方法和用途 |
US11839614B2 (en) | 2018-01-31 | 2023-12-12 | Intra-Cellular Therapies, Inc. | Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105776A (en) | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4339600A (en) | 1976-05-10 | 1982-07-13 | E. R. Squibb & Sons, Inc. | Compounds for alleviating angiotensin related hypertension |
US4587050A (en) | 1980-08-18 | 1986-05-06 | Merck & Co., Inc. | Substituted enantholactam derivatives as antihypertensives |
US4629787A (en) | 1980-08-18 | 1986-12-16 | Merck & Co., Inc. | Substituted caprolactam derivatives as antihypertensives |
US4415496A (en) | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
US4587238A (en) | 1981-07-06 | 1986-05-06 | Merck & Co., Inc. | Substituted caprylolactam derivatives as anti-hypertensives |
EP0094283B1 (fr) | 1982-05-04 | 1985-11-21 | Lipha, Lyonnaise Industrielle Pharmaceutique | Forme médicamenteuse de théophylline à action prolongée |
US4873235A (en) | 1982-06-01 | 1989-10-10 | Merck & Co., Inc. | Benzofused lactams as antihypertensives |
US4473575A (en) | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
US4465679A (en) | 1983-01-31 | 1984-08-14 | Usv Pharmaceutical Corporation | 1,2-Diaza-3-one compounds, their use in treating hypertension and pharmaceutical compositions thereof |
US4477464A (en) | 1983-02-10 | 1984-10-16 | Ciba-Geigy Corporation | Hetero-benzazepine derivatives and their pharmaceutical use |
US4470988A (en) | 1983-02-10 | 1984-09-11 | Ciba-Geigy Corporation | Benzazocinone and benzazoninone derivatives, and their pharmaceutical use |
US4460579A (en) | 1983-02-28 | 1984-07-17 | E. R. Squibb & Sons, Inc. | Thiazine and thiazepine containing compounds |
US4711884A (en) | 1983-02-28 | 1987-12-08 | E. R. Squibb & Sons, Inc. | Thiazine and thiazepine containing compounds |
US4617301A (en) | 1983-06-22 | 1986-10-14 | Merck & Co., Inc. | Sulfoxide and sulfone derivatives of bicyclic lactams as antihypertensives |
US4539150A (en) | 1983-06-29 | 1985-09-03 | Mitsui Toatsu Chemicals, Inc. | Benzothiazepine derivatives and their methods of preparation |
IL72523A (en) | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
DE3402310A1 (de) | 1984-01-24 | 1985-07-25 | Bayer Ag, 5090 Leverkusen | Harte, geschlossenzellige, flammfeste polyurethanschaumstoffe |
SU1435151A3 (ru) | 1984-04-10 | 1988-10-30 | Санкио Компани Лимитед (Фирма) | Способ получени производных пергидротиазепина или их кислотно-аддитивных фармацевтически приемлемых солей |
JPH0637473B2 (ja) | 1985-10-11 | 1994-05-18 | 三共株式会社 | ラクタム化合物 |
US4801609B1 (en) | 1987-03-27 | 1993-11-09 | Mercapto-acylamino acid antihypertensives | |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
-
1993
- 1993-05-17 RU RU93036185/04A patent/RU2124503C1/ru not_active IP Right Cessation
- 1993-05-18 KR KR1019930008448A patent/KR100288722B1/ko not_active IP Right Cessation
- 1993-05-18 JP JP11587493A patent/JP3487611B2/ja not_active Expired - Fee Related
- 1993-05-18 PL PL93298988A patent/PL173036B1/pl not_active IP Right Cessation
- 1993-05-18 EP EP93303835A patent/EP0599444B1/en not_active Expired - Lifetime
- 1993-05-18 HU HU9301448A patent/HU217078B/hu not_active IP Right Cessation
- 1993-05-18 CA CA002096460A patent/CA2096460C/en not_active Expired - Fee Related
- 1993-05-18 SK SK499-93A patent/SK283556B6/sk unknown
- 1993-05-18 DK DK93303835T patent/DK0599444T3/da active
- 1993-05-18 NZ NZ247642A patent/NZ247642A/xx unknown
- 1993-05-18 DE DE69316717T patent/DE69316717T2/de not_active Expired - Fee Related
- 1993-05-18 IL IL105729A patent/IL105729A/en not_active IP Right Cessation
- 1993-05-18 MY MYPI93000910A patent/MY111370A/en unknown
- 1993-05-18 NO NO931795A patent/NO304372B1/no not_active IP Right Cessation
- 1993-05-18 AU AU38627/93A patent/AU659550B2/en not_active Ceased
- 1993-05-18 ZA ZA933461A patent/ZA933461B/xx unknown
- 1993-05-18 EP EP97200315A patent/EP0783002A3/en not_active Withdrawn
- 1993-05-18 ES ES93303835T patent/ES2111712T3/es not_active Expired - Lifetime
- 1993-05-18 CZ CZ1993936A patent/CZ289824B6/cs not_active IP Right Cessation
- 1993-05-18 AT AT93303835T patent/ATE162800T1/de not_active IP Right Cessation
- 1993-05-18 MX MX9302876A patent/MX9302876A/es not_active IP Right Cessation
- 1993-05-18 CN CN93107593A patent/CN1039008C/zh not_active Expired - Fee Related
- 1993-05-18 FI FI932249A patent/FI103337B1/fi active
- 1993-05-18 SG SG1996001951A patent/SG54138A1/en unknown
- 1993-05-19 TW TW082103946A patent/TW290544B/zh active
-
1995
- 1995-08-14 AU AU28525/95A patent/AU674629B2/en not_active Ceased
-
1997
- 1997-05-14 BR BR1101081-9A patent/BR1101081A/pt active IP Right Grant
-
1998
- 1998-03-27 HK HK98102619A patent/HK1003597A1/xx not_active IP Right Cessation
- 1998-04-15 GR GR980400870T patent/GR3026665T3/el unknown
- 1998-07-01 CY CY9800015A patent/CY2093B1/xx unknown
-
2000
- 2000-04-28 KR KR1020000022662A patent/KR100277453B1/ko not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO304372B1 (no) | Dobbeltvirkende inhibitorer og farmas°ytiske blandinger inneholdende disse | |
NO302474B1 (no) | Sakarinderivater, farmasöytisk sammensetning og anvendelse derav | |
DE69413274T3 (de) | Chinoloncarbonsäurederivate, ihre Herstellung und ihre Verwendung als Zelladhäsion Inhibitoren | |
EP0201742A3 (en) | N-acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use | |
DK490486D0 (da) | Sammensaetning til behandling af atherosclerose, tromboser og/eller perifere karsygdomme | |
NO930520L (no) | Bifenyl-substituerte kinolinderivater | |
DK0658585T3 (da) | Amidinophenylalaninderivater, fremgangsmåde til deres fremstilling, deres anvendelse og midler indeholdende disse som antik | |
NO177461C (no) | Trijodbenzenforbindelser og kontrastmidler inneholdende disse | |
MX9500228A (es) | N-oxidos de 4-arilpiperazinas y 4-arilpiperidinas. | |
DK0635491T3 (da) | (Thia)cycloalkylab indoler, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse forbindelser. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |