NO20091334L - Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav - Google Patents

Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav

Info

Publication number
NO20091334L
NO20091334L NO20091334A NO20091334A NO20091334L NO 20091334 L NO20091334 L NO 20091334L NO 20091334 A NO20091334 A NO 20091334A NO 20091334 A NO20091334 A NO 20091334A NO 20091334 L NO20091334 L NO 20091334L
Authority
NO
Norway
Prior art keywords
clopidogrel
synthesis
pharmaceutically acceptable
acceptable salts
novel forms
Prior art date
Application number
NO20091334A
Other languages
English (en)
Inventor
Rok Zupet
Igor Simonic
Primoz Benkic
Matej Smrkolj
Mitja Stukelj
Original Assignee
Krka Tovarna Zdravil Dd Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil Dd Novo Mesto filed Critical Krka Tovarna Zdravil Dd Novo Mesto
Publication of NO20091334L publication Critical patent/NO20091334L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det beskrives en ny fremgangsmåte for fremstilling av clopidogrel og nye polymorfe former av clopidogrelsalter. Videre beskrives fremgangsmåter for deres fremstilling og en farmasøytisk formulering inneholdende de nye former.
NO20091334A 2006-09-22 2009-03-31 Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav NO20091334L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200600220A SI22383A (sl) 2006-09-22 2006-09-22 Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
PCT/EP2007/060127 WO2008034912A2 (en) 2006-09-22 2007-09-24 Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof

Publications (1)

Publication Number Publication Date
NO20091334L true NO20091334L (no) 2009-04-22

Family

ID=39092310

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091334A NO20091334L (no) 2006-09-22 2009-03-31 Fremgangsmate for syntese av klopidogrel og nye former for farmasoytisk akseptable salter derav

Country Status (9)

Country Link
EP (1) EP2078025B1 (no)
ES (1) ES2577294T3 (no)
HR (1) HRP20160809T1 (no)
HU (1) HUE029319T2 (no)
NO (1) NO20091334L (no)
PL (1) PL2078025T3 (no)
SI (2) SI22383A (no)
WO (1) WO2008034912A2 (no)
ZA (1) ZA200902575B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
WO2011051976A2 (en) * 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
WO2012007019A1 (en) * 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
CN102120745B (zh) * 2011-01-31 2013-04-10 天津红日药业股份有限公司 一种盐酸氯吡格雷的晶型ⅰ及其制备方法和用途
US9815848B2 (en) * 2014-12-31 2017-11-14 Tianjin University Method for preparing spherical Clopidogrel Hydrogen Sulfate polymorph I
CN111606923B (zh) * 2020-06-24 2021-08-24 武汉理工大学 一种外消旋氯吡格雷的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
CA2436323C (en) * 2001-01-24 2012-02-21 Cadila Healthcare Ltd. Process for preparing clopidogrel
PT1467735E (pt) * 2001-12-18 2009-03-10 Teva Pharma Polimorfos de hidrogenossulfato de clopidogrel
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
GB2393181A (en) * 2002-09-19 2004-03-24 Cipla Ltd Amorphous clopidogrel
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
US20050059696A1 (en) * 2003-05-08 2005-03-17 Dr. Reddy's Laboratories Limited Process for the recovery of S -(+)-methyl- (2-chlorophenyl)- (6,7-dihydro- 4H-thieno [3,2-c] pyrid-5-yl) acetate hydrogen sulfate (clopidogrel bisulfate) from its (R) and mixture of (R) and (S)- isomers
US7291735B2 (en) * 2003-08-04 2007-11-06 The Company Of Wockhard Limited Process for the manufacture of (+)-(s)-clopidogrel bisulfate form-1
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
EA010198B1 (ru) * 2004-04-19 2008-06-30 Крка, Товарна Здравил, Д.Д., Ново Место Способы получения полиморфной формы i гидросульфата клопидогрела
CZ295920B6 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
KR20070094230A (ko) * 2006-03-17 2007-09-20 한미약품 주식회사 클로피도그렐 캄파술폰산염 또는 이의 결정다형을 함유하는약학 조성물

Also Published As

Publication number Publication date
ES2577294T3 (es) 2016-07-14
ZA200902575B (en) 2010-03-31
SI22383A (sl) 2008-04-30
HUE029319T2 (en) 2017-02-28
PL2078025T3 (pl) 2016-09-30
SI2078025T1 (sl) 2016-08-31
EP2078025B1 (en) 2016-04-13
EP2078025A2 (en) 2009-07-15
WO2008034912A3 (en) 2008-08-07
HRP20160809T1 (hr) 2016-09-23
WO2008034912A2 (en) 2008-03-27

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