NO20085398L - New 1,4-diazabicyclo [3.2 2] nonyloxadiazolyl derivatives and their medical use - Google Patents

New 1,4-diazabicyclo [3.2 2] nonyloxadiazolyl derivatives and their medical use

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Publication number
NO20085398L
NO20085398L NO20085398A NO20085398A NO20085398L NO 20085398 L NO20085398 L NO 20085398L NO 20085398 A NO20085398 A NO 20085398A NO 20085398 A NO20085398 A NO 20085398A NO 20085398 L NO20085398 L NO 20085398L
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NO
Norway
Prior art keywords
diseases
disorders
derivatives
compounds
nonyloxadiazolyl
Prior art date
Application number
NO20085398A
Other languages
Norwegian (no)
Inventor
Gunnar M Olsen
Dan Peters
Elsebet Ostergaard Nielsen
Daniel B Timmermann
Steven Charles Loechel
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Neurosearch As
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Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO20085398L publication Critical patent/NO20085398L/en

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
NO20085398A 2006-05-30 2008-12-29 New 1,4-diazabicyclo [3.2 2] nonyloxadiazolyl derivatives and their medical use NO20085398L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80902406P 2006-05-30 2006-05-30
DKPA200600731 2006-05-30
PCT/EP2007/055169 WO2007138038A1 (en) 2006-05-30 2007-05-29 Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use

Publications (1)

Publication Number Publication Date
NO20085398L true NO20085398L (en) 2008-12-29

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NO20085398A NO20085398L (en) 2006-05-30 2008-12-29 New 1,4-diazabicyclo [3.2 2] nonyloxadiazolyl derivatives and their medical use

Country Status (23)

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US (4) US8158619B2 (en)
EP (3) EP2032574B1 (en)
JP (2) JP5290964B2 (en)
KR (1) KR101458194B1 (en)
CN (2) CN101426790B (en)
AT (3) ATE463497T1 (en)
AU (2) AU2007267174B2 (en)
BR (1) BRPI0708843A2 (en)
CA (2) CA2653818A1 (en)
DE (2) DE602007006486D1 (en)
DK (2) DK2032574T3 (en)
ES (1) ES2342334T3 (en)
IL (1) IL193925A (en)
MX (2) MX2008014886A (en)
MY (1) MY147764A (en)
NO (1) NO20085398L (en)
NZ (1) NZ571288A (en)
PL (1) PL2032575T3 (en)
PT (1) PT2032575E (en)
RU (1) RU2427581C2 (en)
UA (1) UA95946C2 (en)
WO (2) WO2007138038A1 (en)
ZA (1) ZA200807756B (en)

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AU2018309187C1 (en) 2017-08-04 2023-09-07 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
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WO2019226491A1 (en) 2018-05-21 2019-11-28 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
KR20210135242A (en) * 2019-02-04 2021-11-12 스카이호크 테라퓨틱스, 인코포레이티드 Methods and compositions for controlling splicing
JP2022521467A (en) 2019-02-05 2022-04-08 スカイホーク・セラピューティクス・インコーポレーテッド Methods and compositions for regulating splicing
JP2022519323A (en) 2019-02-06 2022-03-22 スカイホーク・セラピューティクス・インコーポレーテッド Methods and compositions for regulating splicing

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