NO20075846L - Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine, and their use in the treatment of diseases and disorders - Google Patents

Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine, and their use in the treatment of diseases and disorders

Info

Publication number
NO20075846L
NO20075846L NO20075846A NO20075846A NO20075846L NO 20075846 L NO20075846 L NO 20075846L NO 20075846 A NO20075846 A NO 20075846A NO 20075846 A NO20075846 A NO 20075846A NO 20075846 L NO20075846 L NO 20075846L
Authority
NO
Norway
Prior art keywords
pharmaceutical compositions
lactose
descarboethoxyloratadine
hygroscopic
free
Prior art date
Application number
NO20075846A
Other languages
Norwegian (no)
Inventor
Paul D Rubin
Martin P Redmon
Hal T Butler
Stephen A Wald
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27365195&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20075846(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of NO20075846L publication Critical patent/NO20075846L/en
Application filed by Sepracor Inc filed Critical Sepracor Inc

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Stabile farmasøytiske sammensetninger av deskarboetoksyloratadin (DCL), et metabolsk derivat av loratadin, for behandlingen av allergisk rhinitt og andre histamininduserte forstyrrelser er fremlagt. Sammensetningene er formulert for å urmgå inkompatibiliteten mellom DCL og reaktive eksipienter slike som laktose og andre mono- og disakkarider. Fremlagte sammensetninger inkluderer laktosefiie, ikkehygroskopiske og vannfrie stabile farmasøytiske sammensetninger av DCL.Stable pharmaceutical compositions of descarboethoxyloratadine (DCL), a metabolic derivative of loratadine, for the treatment of allergic rhinitis and other histamine-induced disorders have been presented. The compositions are formulated to eliminate the incompatibility between DCL and reactive excipients such as lactose and other mono- and disaccharides. Submitted compositions include lactose-free, non-hygroscopic and anhydrous stable pharmaceutical compositions of DCL.

NO20075846A 1997-02-07 2007-11-14 Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine, and their use in the treatment of diseases and disorders NO20075846L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3732597P 1997-02-07 1997-02-07
US4518497P 1997-04-30 1997-04-30
US5305097P 1997-07-21 1997-07-21
PCT/US1998/002328 WO1998034614A1 (en) 1997-02-07 1998-02-06 Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine

Publications (1)

Publication Number Publication Date
NO20075846L true NO20075846L (en) 1999-05-04

Family

ID=27365195

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19992157A NO325611B1 (en) 1997-02-07 1999-05-04 Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine, and their use in the treatment of diseases and disorders
NO20075846A NO20075846L (en) 1997-02-07 2007-11-14 Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine, and their use in the treatment of diseases and disorders

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19992157A NO325611B1 (en) 1997-02-07 1999-05-04 Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine, and their use in the treatment of diseases and disorders

Country Status (29)

Country Link
US (2) US20020123504A1 (en)
EP (2) EP0969836B1 (en)
JP (1) JP2001511184A (en)
KR (5) KR20080003012A (en)
CN (1) CN1132579C (en)
AR (3) AR011114A1 (en)
AT (1) ATE345133T1 (en)
AU (1) AU6271998A (en)
BR (1) BR9806157A (en)
CA (1) CA2267136C (en)
CO (1) CO4940445A1 (en)
CZ (1) CZ119499A3 (en)
DE (1) DE69836424T2 (en)
DK (1) DK0969836T3 (en)
ES (1) ES2271986T3 (en)
HK (1) HK1024187A1 (en)
HU (1) HUP0001527A3 (en)
MY (1) MY136999A (en)
NO (2) NO325611B1 (en)
NZ (1) NZ335041A (en)
PE (1) PE71699A1 (en)
PL (1) PL192075B1 (en)
PT (1) PT969836E (en)
RU (1) RU2209627C2 (en)
SK (1) SK286035B6 (en)
TW (1) TW522014B (en)
UA (1) UA70290C2 (en)
WO (1) WO1998034614A1 (en)
ZA (1) ZA98977B (en)

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CN102813640B (en) * 2012-09-06 2016-12-21 无锡万全医药技术有限公司 A kind of soft capsule containing Desloratadine and preparation method thereof
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Also Published As

Publication number Publication date
DK0969836T3 (en) 2007-03-19
HUP0001527A2 (en) 2001-04-28
RU2209627C2 (en) 2003-08-10
KR20080003012A (en) 2008-01-04
EP0969836B1 (en) 2006-11-15
CN1132579C (en) 2003-12-31
SK286035B6 (en) 2008-01-07
CN1246794A (en) 2000-03-08
BR9806157A (en) 2001-01-09
AU6271998A (en) 1998-08-26
KR100624259B1 (en) 2006-09-13
CA2267136C (en) 2000-11-28
KR20070086880A (en) 2007-08-27
DE69836424T2 (en) 2007-09-27
KR20060076330A (en) 2006-07-04
EP0969836A1 (en) 2000-01-12
KR20060132053A (en) 2006-12-20
US20020123504A1 (en) 2002-09-05
NZ335041A (en) 2000-09-29
TW522014B (en) 2003-03-01
PE71699A1 (en) 1999-08-03
SK47299A3 (en) 2000-03-13
WO1998034614A1 (en) 1998-08-13
ES2271986T3 (en) 2007-04-16
ATE345133T1 (en) 2006-12-15
UA70290C2 (en) 2004-10-15
EP1614421A2 (en) 2006-01-11
HK1024187A1 (en) 2000-10-05
CO4940445A1 (en) 2000-07-24
AR011114A1 (en) 2000-08-02
HUP0001527A3 (en) 2002-01-28
EP1614421A3 (en) 2006-02-15
ZA98977B (en) 1998-07-30
MY136999A (en) 2008-12-31
PT969836E (en) 2007-01-31
AR064896A2 (en) 2009-05-06
US20060079489A1 (en) 2006-04-13
NO992157L (en) 1999-05-04
NO325611B1 (en) 2008-06-23
PL192075B1 (en) 2006-08-31
PL334232A1 (en) 2000-02-14
KR20000068914A (en) 2000-11-25
CZ119499A3 (en) 1999-08-11
DE69836424D1 (en) 2006-12-28
NO992157D0 (en) 1999-05-04
JP2001511184A (en) 2001-08-07
AR064895A2 (en) 2009-05-06

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