NO20074143L - Phuman T2R reseptorer for Acetaminophen, Ranitidine, Strychnine og Denatonium og relaterte analyser for identifisering av human bitter smak modulatorer - Google Patents

Phuman T2R reseptorer for Acetaminophen, Ranitidine, Strychnine og Denatonium og relaterte analyser for identifisering av human bitter smak modulatorer

Info

Publication number
NO20074143L
NO20074143L NO20074143A NO20074143A NO20074143L NO 20074143 L NO20074143 L NO 20074143L NO 20074143 A NO20074143 A NO 20074143A NO 20074143 A NO20074143 A NO 20074143A NO 20074143 L NO20074143 L NO 20074143L
Authority
NO
Norway
Prior art keywords
receptors
denatonium
strychnine
ranitidine
acetaminophen
Prior art date
Application number
NO20074143A
Other languages
English (en)
Inventor
Hong Xu
Li Xiaodong
Huixiang Tang
Qing Li
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of NO20074143L publication Critical patent/NO20074143L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives det funnet at spesifikke humane smaksreseptorer i T2R smaksreseptorfamilien responderer til bestemte bitter ligander, dvs., acetaminofen, ranitidin, stryknin og denatonium. Det beskrives videre anvendelse av disse reseptorene i analyser for å identifisere ligander som modulerer aktiveringen av disse smaksreseptorene og som kan anvendes som tilsetningsstoffer i matvarer, drikkevarer og medisinske midler for modifisering (blokkering) av T2R-assosiert bitter smak.
NO20074143A 2005-02-08 2007-08-10 Phuman T2R reseptorer for Acetaminophen, Ranitidine, Strychnine og Denatonium og relaterte analyser for identifisering av human bitter smak modulatorer NO20074143L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65055505P 2005-02-08 2005-02-08
PCT/US2006/002509 WO2006086150A2 (en) 2005-02-08 2006-01-06 Phuman t2r receptors for acetaminophen, ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators

Publications (1)

Publication Number Publication Date
NO20074143L true NO20074143L (no) 2007-11-05

Family

ID=36793558

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074143A NO20074143L (no) 2005-02-08 2007-08-10 Phuman T2R reseptorer for Acetaminophen, Ranitidine, Strychnine og Denatonium og relaterte analyser for identifisering av human bitter smak modulatorer

Country Status (10)

Country Link
US (3) US7407765B2 (no)
EP (1) EP1851548A4 (no)
JP (1) JP2008537473A (no)
CN (1) CN101467040A (no)
AU (1) AU2006213039A1 (no)
CA (1) CA2597085A1 (no)
IL (1) IL185109A0 (no)
MX (1) MX2007009497A (no)
NO (1) NO20074143L (no)
WO (1) WO2006086150A2 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006262399A1 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human T2R recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
EP1975612A1 (en) * 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
US20110003711A1 (en) * 2008-02-01 2011-01-06 Chromocell Corporation Cell lines expressing gaba receptor and methods using them
EP2329263A1 (en) * 2008-08-07 2011-06-08 Givaudan SA Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
US8557530B2 (en) 2008-08-29 2013-10-15 Givaudan Sa Use of a TAS2R7 nucleic acid sequence to identify modulators
EP2323502B1 (en) * 2008-09-05 2012-09-05 Unilever PLC Flavan-3-ol containing foodstuffs
JP2013533310A (ja) * 2010-08-09 2013-08-22 ユニバーシティー オブ メリーランド，ボルティモア 苦味物質を使用して閉塞性肺疾患を処置する方法
US9128079B2 (en) 2011-08-08 2015-09-08 The Coca-Cola Company Methods of using lung or bronchial epithelial cells to identify bitter taste modulators
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
ES2797547T3 (es) 2013-03-15 2020-12-02 Applied Food Biotech Inc Receptores del sabor amargo felino y métodos.
ES2802376T3 (es) 2014-02-12 2021-01-19 Firmenich Incorporated Procedimiento mejorado para la síntesis de 1-bencil-3-(1-(isoxazol-4-ilmetil)-1h-pirazol-4-il)imidazolidin-2,4-dionas sustituidas
DE102016009766A1 (de) * 2016-08-11 2018-02-15 Julius-Maximilians-Universität Würzburg Herstellung von Bitterstoffderivaten
CN113230256A (zh) * 2021-06-08 2021-08-10 广州医科大学附属中医医院 ***在制备肝细胞代谢药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU773600B2 (en) * 1999-09-10 2004-05-27 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The T2R, taste receptor family
AU2001251258B2 (en) * 2000-04-07 2008-06-05 Senomyx, Inc. T2r taste receptors and genes encoding same
US7022488B2 (en) * 2003-02-03 2006-04-04 Senomyx, Inc. Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators
CA2452337A1 (en) * 2001-07-10 2003-01-23 Senomyx, Inc. Use of specific t2r taste receptors to identify compounds that block bitter taste

Also Published As

Publication number Publication date
US20090087866A1 (en) 2009-04-02
CA2597085A1 (en) 2006-08-17
US8273542B2 (en) 2012-09-25
US20060199227A1 (en) 2006-09-07
WO2006086150A2 (en) 2006-08-17
WO2006086150A3 (en) 2009-02-26
MX2007009497A (es) 2008-01-18
AU2006213039A1 (en) 2006-08-17
JP2008537473A (ja) 2008-09-18
EP1851548A2 (en) 2007-11-07
CN101467040A (zh) 2009-06-24
EP1851548A4 (en) 2010-04-28
US20110281749A1 (en) 2011-11-17
US7407765B2 (en) 2008-08-05
IL185109A0 (en) 2007-12-03
US7915003B2 (en) 2011-03-29

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