NO20072051L - Nye pyrimidinderivater og deres anvendelse som PPAR-alfa modulatorar - Google Patents
Nye pyrimidinderivater og deres anvendelse som PPAR-alfa modulatorarInfo
- Publication number
- NO20072051L NO20072051L NO20072051A NO20072051A NO20072051L NO 20072051 L NO20072051 L NO 20072051L NO 20072051 A NO20072051 A NO 20072051A NO 20072051 A NO20072051 A NO 20072051A NO 20072051 L NO20072051 L NO 20072051L
- Authority
- NO
- Norway
- Prior art keywords
- pyrimidine derivatives
- ppar
- novel pyrimidine
- alpha modulators
- therapy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Det beskrives nye pyrimidinderivater med den generelle formel (I), fremgangsmåter for fremstilling derav, deres anvendelse for terapi og/eller prevensjon av sykdommer og deres anvendelse for fremstilling av medikamenter for terapi og/eller prevensjon av sykdommer, særlig for terapi og/eller prevensjon av kardiovaskulære sykdommer og særlig dyslipidemi, arteriosklerose, hjerteinsuffisiens, trombose og metabolsk syndrom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004046623A DE102004046623A1 (de) | 2004-09-25 | 2004-09-25 | Neue Pyrimidin-Derivate und ihre Verwendung |
PCT/EP2005/009734 WO2006032384A1 (de) | 2004-09-25 | 2005-09-10 | Neue pyrimidin-derivate und ihre verwendung als ppar-alpha-modulatoren |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20072051L true NO20072051L (no) | 2007-06-07 |
Family
ID=35063041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20072051A NO20072051L (no) | 2004-09-25 | 2007-04-20 | Nye pyrimidinderivater og deres anvendelse som PPAR-alfa modulatorar |
Country Status (22)
Country | Link |
---|---|
US (1) | US20080261990A1 (no) |
EP (1) | EP1797045A1 (no) |
JP (1) | JP2008514559A (no) |
KR (1) | KR20070055621A (no) |
CN (1) | CN101065364A (no) |
AR (1) | AR051295A1 (no) |
AU (1) | AU2005287589A1 (no) |
BR (1) | BRPI0517327A (no) |
CA (1) | CA2582492A1 (no) |
DE (1) | DE102004046623A1 (no) |
EC (1) | ECSP077340A (no) |
GT (1) | GT200500266A (no) |
IL (1) | IL182136A0 (no) |
MA (1) | MA28882B1 (no) |
MX (1) | MX2007003428A (no) |
NO (1) | NO20072051L (no) |
PE (1) | PE20060657A1 (no) |
RU (1) | RU2007115215A (no) |
SV (1) | SV2007002235A (no) |
TW (1) | TW200628451A (no) |
UY (1) | UY29127A1 (no) |
WO (1) | WO2006032384A1 (no) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101743001B (zh) * | 2007-04-13 | 2013-02-06 | 千年药品公司 | 用起因子xa抑制剂作用的化合物的组合抗凝治疗 |
KR100813387B1 (ko) * | 2007-06-26 | 2008-03-12 | 신명곤 | 부형제 첨가없이 인삼농축액으로 유동성 및 저장성이우수한 인삼농축액환 제조 방법 |
WO2011150286A2 (en) | 2010-05-26 | 2011-12-01 | Satiogen Pharmaceuticals,Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
WO2012030165A2 (ko) | 2010-08-31 | 2012-03-08 | 서울대학교산학협력단 | P P A R δ 활성물질의 태자재프로그래밍용도 |
CA2852957C (en) | 2011-10-28 | 2020-08-04 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
CA2853285C (en) | 2011-10-28 | 2020-05-05 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
CN103130732A (zh) * | 2011-11-22 | 2013-06-05 | 上海博康精细化工有限公司 | 3,5-二甲基-4-氯甲基异噁唑的制备方法 |
KR20160002773A (ko) | 2013-03-15 | 2016-01-08 | 루메나 파마수티컬즈, 인코포레이티드 | 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제 |
RU2015139732A (ru) | 2013-03-15 | 2017-04-24 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Ингибиторы рециркуляции желчных кислот для лечения пищевода барретта и гастроэзофагеальной рефлюксной болезни |
WO2017190050A1 (en) * | 2016-04-28 | 2017-11-02 | Cornell University | Inhibitors of soluble adenylyl cyclase |
WO2020167964A1 (en) | 2019-02-12 | 2020-08-20 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency |
CN115598267B (zh) * | 2022-12-13 | 2023-05-09 | 山东省食品药品检验研究院 | 一种格列齐特中潜在遗传毒性杂质的分析方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU72201A (sh) * | 1999-04-28 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | Derivati di-aril kiseline kao ppar receptorski ligandi |
GB0214254D0 (en) * | 2002-06-20 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
-
2004
- 2004-09-25 DE DE102004046623A patent/DE102004046623A1/de not_active Withdrawn
-
2005
- 2005-09-10 CN CNA2005800404273A patent/CN101065364A/zh active Pending
- 2005-09-10 RU RU2007115215/04A patent/RU2007115215A/ru not_active Application Discontinuation
- 2005-09-10 CA CA002582492A patent/CA2582492A1/en not_active Abandoned
- 2005-09-10 EP EP05782757A patent/EP1797045A1/de not_active Withdrawn
- 2005-09-10 US US11/663,813 patent/US20080261990A1/en not_active Abandoned
- 2005-09-10 JP JP2007532798A patent/JP2008514559A/ja active Pending
- 2005-09-10 KR KR1020077009268A patent/KR20070055621A/ko not_active Application Discontinuation
- 2005-09-10 WO PCT/EP2005/009734 patent/WO2006032384A1/de active Application Filing
- 2005-09-10 AU AU2005287589A patent/AU2005287589A1/en not_active Abandoned
- 2005-09-10 MX MX2007003428A patent/MX2007003428A/es not_active Application Discontinuation
- 2005-09-10 BR BRPI0517327-2A patent/BRPI0517327A/pt not_active Application Discontinuation
- 2005-09-20 AR ARP050103930A patent/AR051295A1/es unknown
- 2005-09-23 SV SV2005002235A patent/SV2007002235A/es not_active Application Discontinuation
- 2005-09-23 UY UY29127A patent/UY29127A1/es not_active Application Discontinuation
- 2005-09-23 TW TW094132926A patent/TW200628451A/zh unknown
- 2005-09-23 GT GT200500266A patent/GT200500266A/es unknown
- 2005-09-23 PE PE2005001101A patent/PE20060657A1/es not_active Application Discontinuation
-
2007
- 2007-03-22 IL IL182136A patent/IL182136A0/en unknown
- 2007-03-23 EC EC2007007340A patent/ECSP077340A/es unknown
- 2007-03-30 MA MA29787A patent/MA28882B1/fr unknown
- 2007-04-20 NO NO20072051A patent/NO20072051L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL182136A0 (en) | 2007-07-24 |
TW200628451A (en) | 2006-08-16 |
DE102004046623A1 (de) | 2006-03-30 |
RU2007115215A (ru) | 2008-11-10 |
AR051295A1 (es) | 2007-01-03 |
AU2005287589A1 (en) | 2006-03-30 |
US20080261990A1 (en) | 2008-10-23 |
WO2006032384A1 (de) | 2006-03-30 |
UY29127A1 (es) | 2006-04-28 |
CN101065364A (zh) | 2007-10-31 |
EP1797045A1 (de) | 2007-06-20 |
GT200500266A (es) | 2006-05-11 |
KR20070055621A (ko) | 2007-05-30 |
BRPI0517327A (pt) | 2008-10-07 |
MX2007003428A (es) | 2008-03-13 |
ECSP077340A (es) | 2007-04-26 |
MA28882B1 (fr) | 2007-09-03 |
CA2582492A1 (en) | 2006-03-30 |
JP2008514559A (ja) | 2008-05-08 |
PE20060657A1 (es) | 2006-08-12 |
SV2007002235A (es) | 2007-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |