NO20071117L - Substituted propenyl-piperazine derivatives as novel inhibitors of histone deacetylase - Google Patents
Substituted propenyl-piperazine derivatives as novel inhibitors of histone deacetylaseInfo
- Publication number
- NO20071117L NO20071117L NO20071117A NO20071117A NO20071117L NO 20071117 L NO20071117 L NO 20071117L NO 20071117 A NO20071117 A NO 20071117A NO 20071117 A NO20071117 A NO 20071117A NO 20071117 L NO20071117 L NO 20071117L
- Authority
- NO
- Norway
- Prior art keywords
- histone deacetylase
- piperazine derivatives
- novel inhibitors
- substituted propenyl
- propenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Denne oppfinnelse omfatter de nye forbindelser med formel (I) hvori R\ R^, R^, r'* og X har definerte betydninger, som har histondeacetylasehemmende enzymatisk aktivitet; deres fremstilling, sammensetninger inneholdende dem og deres anvendelse som en medisin.This invention encompasses the novel compounds of formula (I) wherein R 1, R 2, R 2, R 4 and X have defined meanings which have histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04077171 | 2004-07-28 | ||
US59235704P | 2004-07-29 | 2004-07-29 | |
PCT/EP2005/053611 WO2006010749A2 (en) | 2004-07-28 | 2005-07-25 | Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20071117L true NO20071117L (en) | 2007-02-27 |
Family
ID=39294123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20071117A NO20071117L (en) | 2004-07-28 | 2007-02-27 | Substituted propenyl-piperazine derivatives as novel inhibitors of histone deacetylase |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1776358B1 (en) |
JP (1) | JP5279268B2 (en) |
KR (1) | KR101282833B1 (en) |
CN (1) | CN1993356B (en) |
AR (1) | AR050189A1 (en) |
AT (1) | ATE432274T1 (en) |
AU (1) | AU2005266311B2 (en) |
BR (1) | BRPI0513891B8 (en) |
CA (1) | CA2572971C (en) |
CY (1) | CY1110358T1 (en) |
DE (1) | DE602005014646D1 (en) |
DK (1) | DK1776358T3 (en) |
EA (1) | EA011932B1 (en) |
ES (1) | ES2327253T3 (en) |
HK (1) | HK1106236A1 (en) |
HR (1) | HRP20090439T1 (en) |
IL (1) | IL180961A0 (en) |
MX (1) | MX2007001119A (en) |
MY (1) | MY142831A (en) |
NO (1) | NO20071117L (en) |
NZ (1) | NZ552758A (en) |
PL (1) | PL1776358T3 (en) |
PT (1) | PT1776358E (en) |
SI (1) | SI1776358T1 (en) |
TW (1) | TWI394752B (en) |
WO (1) | WO2006010749A2 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1485354T3 (en) | 2002-03-13 | 2008-09-01 | Janssen Pharmaceutica Nv | Sulfonylamino derivatives as novel inhibitors of histane deacetylase |
DK1485353T3 (en) | 2002-03-13 | 2011-11-28 | Janssen Pharmaceutica Nv | Novel inhibitors of histone deacetylase |
WO2003076438A1 (en) | 2002-03-13 | 2003-09-18 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
EP1781639B1 (en) | 2004-07-28 | 2012-01-25 | Janssen Pharmaceutica NV | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
CA2605272C (en) | 2005-05-18 | 2013-12-10 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
WO2007049262A1 (en) * | 2005-10-27 | 2007-05-03 | Berand Limited | Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders |
WO2007082878A1 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Aminophenyl derivatives as novel inhibitors of histone deacetylase |
EP1981875B1 (en) | 2006-01-19 | 2014-04-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
AU2007206942B2 (en) * | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
US8101616B2 (en) | 2006-01-19 | 2012-01-24 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
EP1839656A1 (en) * | 2006-03-31 | 2007-10-03 | TopoTarget Germany AG | Use of valproic acid for the topical treatment of mild to moderate acne vulgaris |
CN101918389A (en) * | 2007-11-02 | 2010-12-15 | 梅特希尔基因公司 | Histone deacetylase inhibitor |
CN101723896B (en) * | 2009-11-03 | 2012-10-31 | 山东大学 | Tyrosine derivative histone deacetylases inhibitor and application thereof |
WO2012117421A1 (en) | 2011-03-02 | 2012-09-07 | Orchid Research Laboratories Ltd | Histone deacetylase inhibitors |
KR101419836B1 (en) * | 2012-05-10 | 2014-07-16 | 서울대학교산학협력단 | Composition comprising Δ5-2-oxopiperazine derivative for inducing differentiation of mesenchymal stem cells into chondrocytes |
KR101586045B1 (en) | 2013-07-30 | 2016-01-15 | 충북대학교 산학협력단 | Novel Phenylthiazole-Based Hydroxamic Acids and Anti-Cancer Composition Comprising the Same As Active Ingredient |
KR102132078B1 (en) | 2018-09-20 | 2020-07-08 | 원광대학교산학협력단 | A method for producing 1-ethyl-4-phenylpiperazine derivative by three-component reaction using aromatic compounds, amines and nucleophiles |
KR20230155310A (en) | 2022-05-03 | 2023-11-10 | 충북대학교 산학협력단 | Novel N-hydroxypropenamide compound and pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient |
KR20230155311A (en) | 2022-05-03 | 2023-11-10 | 충북대학교 산학협력단 | Novel N-hydroxypropenamide compound and pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
DK1485353T3 (en) * | 2002-03-13 | 2011-11-28 | Janssen Pharmaceutica Nv | Novel inhibitors of histone deacetylase |
WO2003076438A1 (en) * | 2002-03-13 | 2003-09-18 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
US7629343B2 (en) * | 2002-04-03 | 2009-12-08 | Topotarget Uk Limited | Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors |
-
2005
- 2005-07-25 KR KR1020077001641A patent/KR101282833B1/en active IP Right Grant
- 2005-07-25 MX MX2007001119A patent/MX2007001119A/en active IP Right Grant
- 2005-07-25 CN CN2005800254878A patent/CN1993356B/en active Active
- 2005-07-25 CA CA2572971A patent/CA2572971C/en active Active
- 2005-07-25 AU AU2005266311A patent/AU2005266311B2/en active Active
- 2005-07-25 ES ES05777776T patent/ES2327253T3/en active Active
- 2005-07-25 WO PCT/EP2005/053611 patent/WO2006010749A2/en active Application Filing
- 2005-07-25 BR BRPI0513891A patent/BRPI0513891B8/en active IP Right Grant
- 2005-07-25 DK DK05777776T patent/DK1776358T3/en active
- 2005-07-25 PT PT05777776T patent/PT1776358E/en unknown
- 2005-07-25 PL PL05777776T patent/PL1776358T3/en unknown
- 2005-07-25 SI SI200530748T patent/SI1776358T1/en unknown
- 2005-07-25 AT AT05777776T patent/ATE432274T1/en active
- 2005-07-25 EP EP05777776A patent/EP1776358B1/en active Active
- 2005-07-25 JP JP2007523072A patent/JP5279268B2/en active Active
- 2005-07-25 EA EA200700143A patent/EA011932B1/en unknown
- 2005-07-25 DE DE602005014646T patent/DE602005014646D1/en active Active
- 2005-07-25 NZ NZ552758A patent/NZ552758A/en unknown
- 2005-07-27 TW TW094125340A patent/TWI394752B/en active
- 2005-07-28 MY MYPI20053492A patent/MY142831A/en unknown
- 2005-07-28 AR ARP050103145A patent/AR050189A1/en active IP Right Grant
-
2007
- 2007-01-25 IL IL180961A patent/IL180961A0/en active IP Right Grant
- 2007-02-27 NO NO20071117A patent/NO20071117L/en not_active Application Discontinuation
- 2007-10-30 HK HK07111697.6A patent/HK1106236A1/en unknown
-
2009
- 2009-08-06 CY CY20091100839T patent/CY1110358T1/en unknown
- 2009-08-13 HR HR20090439T patent/HRP20090439T1/en unknown
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |