NO20063926L - N-terminale monopegylerte humane veksthormonkonjugater, fremgangsmater for fremstilling og anvendelse av disse - Google Patents
N-terminale monopegylerte humane veksthormonkonjugater, fremgangsmater for fremstilling og anvendelse av disseInfo
- Publication number
- NO20063926L NO20063926L NO20063926A NO20063926A NO20063926L NO 20063926 L NO20063926 L NO 20063926L NO 20063926 A NO20063926 A NO 20063926A NO 20063926 A NO20063926 A NO 20063926A NO 20063926 L NO20063926 L NO 20063926L
- Authority
- NO
- Norway
- Prior art keywords
- growth hormone
- human growth
- preparation
- methods
- present
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract 5
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract 5
- 239000000854 Human Growth Hormone Substances 0.000 title abstract 5
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 230000002045 lasting effect Effects 0.000 abstract 1
- 102000035118 modified proteins Human genes 0.000 abstract 1
- 108091005573 modified proteins Proteins 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Den foreliggende oppfinnelsen tilveiebringer et kjemisk modifisert humant veksthormon (hGH) preparert ved å feste en poly-etylenglykolbutyraldehyd halvdel til det N-terminale fenylalaninet av proteinet. Det kjemisk modifiserte proteinet i henhold til den foreliggende oppfinnelsen kan ha en mye lenger varende hGH-aktivitet enn den av ikke-modifisert hGH, som muliggjør en reduserende dose og tidsplanleggingsmuligheter. Den foreliggende oppfinnelsen inkluderer også fremgangsmåter av anvendelser og behandlingen og/eller forebyggingen av sykdommer eller lidelser hvor anvendelse av veksthormon er fordelaktig.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/771,895 US20040142870A1 (en) | 2002-11-20 | 2004-02-04 | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
PCT/IB2005/000171 WO2005079838A1 (en) | 2004-02-04 | 2005-01-24 | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20063926L true NO20063926L (no) | 2006-10-30 |
Family
ID=34886516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20063926A NO20063926L (no) | 2004-02-04 | 2006-09-01 | N-terminale monopegylerte humane veksthormonkonjugater, fremgangsmater for fremstilling og anvendelse av disse |
Country Status (21)
Country | Link |
---|---|
US (1) | US20040142870A1 (no) |
EP (2) | EP1715887B1 (no) |
JP (3) | JP2007520544A (no) |
KR (2) | KR100776862B1 (no) |
CN (1) | CN1929857A (no) |
AT (1) | ATE365047T1 (no) |
AU (1) | AU2005215250A1 (no) |
BR (1) | BRPI0507427A (no) |
CA (1) | CA2555772A1 (no) |
CY (1) | CY1106723T1 (no) |
DE (1) | DE602005001445T2 (no) |
DK (1) | DK1715887T3 (no) |
ES (1) | ES2286787T3 (no) |
IL (1) | IL176998A0 (no) |
NO (1) | NO20063926L (no) |
PL (1) | PL1715887T3 (no) |
PT (1) | PT1715887E (no) |
RU (1) | RU2006128293A (no) |
TW (2) | TW200812610A (no) |
WO (1) | WO2005079838A1 (no) |
ZA (2) | ZA200706349B (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
AP2005003246A0 (en) | 2002-09-09 | 2005-03-31 | Nektar Therapeutics Al Corp | Water-soluble polymer alkanals |
DE60332358D1 (de) * | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
EA008866B1 (ru) * | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
KR101162908B1 (ko) * | 2002-12-26 | 2012-07-06 | 마운틴 뷰 파마슈티컬즈, 인크. | 수용체-결합 활성이 보존된, 사이토카인, 케모카인,성장인자, 폴리펩티드 호르몬 및 이들의 길항제의 중합체접합체 |
JP2008510706A (ja) * | 2004-08-18 | 2008-04-10 | エリクシアー ファーマシューティカルズ, インコーポレイテッド | 成長ホルモン分泌促進物質 |
US20090269843A1 (en) * | 2004-08-20 | 2009-10-29 | Novo Nordisk A/S | Hemopexin fusion proteins |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
EP1850878A2 (en) * | 2005-02-10 | 2007-11-07 | Novo Nordisk A/S | C-terminally pegylated growth hormones |
WO2006102659A2 (en) * | 2005-03-23 | 2006-09-28 | Nektar Therapeutics Al, Corporation | CONJUGATES OF AN hGH MOIETY AND A POLYMER |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
EP1968625A2 (en) * | 2005-12-15 | 2008-09-17 | Laboratoires Serono SA | New chemokine antagonists |
WO2007139997A2 (en) * | 2006-05-26 | 2007-12-06 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Methods for site-specific pegylation |
MX2010010953A (es) * | 2008-04-03 | 2011-04-21 | Biosteed Gene Expression Tech Co Ltd | Hormona de crecimiento modificada con glicol de polietileno de doble cadena, metodo de preparacion y aplicación del a misma. |
SI3050576T1 (sl) | 2008-04-29 | 2021-08-31 | Ascendis Pharma Endocrinology Division A/S | Spojine pegiliranega rekombinantnega humanega rastnega hormona |
EP2113256A1 (en) | 2008-04-29 | 2009-11-04 | Ascendis Pharma AS | PEGylated rhGH compounds |
AU2009276458B2 (en) * | 2008-07-31 | 2014-06-19 | Pharmaessentia Corp. | Peptide-polymer conjugates |
WO2010091122A1 (en) | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
US8680050B2 (en) * | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
WO2011018515A1 (en) * | 2009-08-14 | 2011-02-17 | Novo Nordisk Health Care Ag | Method of purifying pegylated proteins |
HUE038405T2 (hu) | 2009-12-15 | 2018-10-29 | Ascendis Pharma Endocrinology Div A/S | Átmenetileg polimer hordozóhoz kapcsolt száraz növekedési hormon készítmény |
CN102453089B (zh) * | 2010-10-25 | 2014-06-04 | 北京凯因科技股份有限公司 | 重组集成干扰素变异体聚乙二醇偶联物的制备和应用 |
CA2857686C (en) * | 2011-12-09 | 2023-01-17 | Metabolic Pharmaceuticals Pty Ltd | Use of growth hormone fragments |
CN102964588A (zh) * | 2012-11-09 | 2013-03-13 | 河南工业大学 | 末端连接氨基苯丙酸的聚乙二醇的酸或活性酯的制法和应用 |
EP3988083A1 (en) | 2014-11-21 | 2022-04-27 | Ascendis Pharma Endocrinology Division A/S | Long-acting growth hormone dosage forms |
KR101599415B1 (ko) | 2015-05-29 | 2016-03-03 | (주)신명이앤씨 | 건축물 층간 바닥 전기 케이블 보호관 |
CN114539384A (zh) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化长效生长激素及其制备方法和医药应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL162031A0 (en) * | 2001-11-20 | 2005-11-20 | Pharmacia Corp | Chemically-modified human growth hormone conjugates |
US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
-
2004
- 2004-02-04 US US10/771,895 patent/US20040142870A1/en not_active Abandoned
-
2005
- 2005-01-24 CN CNA2005800073938A patent/CN1929857A/zh active Pending
- 2005-01-24 ES ES05702331T patent/ES2286787T3/es active Active
- 2005-01-24 PT PT05702331T patent/PT1715887E/pt unknown
- 2005-01-24 ZA ZA200706349A patent/ZA200706349B/xx unknown
- 2005-01-24 PL PL05702331T patent/PL1715887T3/pl unknown
- 2005-01-24 KR KR1020067015733A patent/KR100776862B1/ko not_active IP Right Cessation
- 2005-01-24 DE DE602005001445T patent/DE602005001445T2/de not_active Expired - Fee Related
- 2005-01-24 DK DK05702331T patent/DK1715887T3/da active
- 2005-01-24 EP EP05702331A patent/EP1715887B1/en active Active
- 2005-01-24 WO PCT/IB2005/000171 patent/WO2005079838A1/en active IP Right Grant
- 2005-01-24 BR BRPI0507427-4A patent/BRPI0507427A/pt not_active IP Right Cessation
- 2005-01-24 AU AU2005215250A patent/AU2005215250A1/en not_active Abandoned
- 2005-01-24 JP JP2006551943A patent/JP2007520544A/ja active Pending
- 2005-01-24 RU RU2006128293/14A patent/RU2006128293A/ru not_active Application Discontinuation
- 2005-01-24 EP EP07110559A patent/EP1915999A1/en not_active Withdrawn
- 2005-01-24 KR KR1020077007102A patent/KR20070039623A/ko not_active Application Discontinuation
- 2005-01-24 CA CA002555772A patent/CA2555772A1/en not_active Abandoned
- 2005-01-24 AT AT05702331T patent/ATE365047T1/de not_active IP Right Cessation
- 2005-02-03 TW TW096134157A patent/TW200812610A/zh unknown
- 2005-02-03 TW TW094103308A patent/TW200529868A/zh unknown
-
2006
- 2006-07-20 IL IL176998A patent/IL176998A0/en unknown
- 2006-08-01 ZA ZA200606375A patent/ZA200606375B/xx unknown
- 2006-09-01 NO NO20063926A patent/NO20063926L/no not_active Application Discontinuation
-
2007
- 2007-07-12 CY CY20071100928T patent/CY1106723T1/el unknown
- 2007-08-15 JP JP2007211676A patent/JP2008001713A/ja not_active Withdrawn
- 2007-08-15 JP JP2007211682A patent/JP2008037872A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ZA200706349B (en) | 2008-06-25 |
KR20070039623A (ko) | 2007-04-12 |
IL176998A0 (en) | 2006-12-10 |
ZA200606375B (en) | 2007-11-28 |
ATE365047T1 (de) | 2007-07-15 |
DK1715887T3 (da) | 2007-09-17 |
US20040142870A1 (en) | 2004-07-22 |
RU2006128293A (ru) | 2008-02-10 |
PL1715887T3 (pl) | 2007-12-31 |
DE602005001445T2 (de) | 2008-02-14 |
JP2008001713A (ja) | 2008-01-10 |
AU2005215250A1 (en) | 2005-09-01 |
PT1715887E (pt) | 2007-08-29 |
KR100776862B1 (ko) | 2007-11-28 |
JP2007520544A (ja) | 2007-07-26 |
EP1915999A1 (en) | 2008-04-30 |
WO2005079838A1 (en) | 2005-09-01 |
CA2555772A1 (en) | 2005-09-01 |
BRPI0507427A (pt) | 2007-06-26 |
EP1715887A1 (en) | 2006-11-02 |
KR20060120240A (ko) | 2006-11-24 |
CY1106723T1 (el) | 2012-05-23 |
JP2008037872A (ja) | 2008-02-21 |
EP1715887B1 (en) | 2007-06-20 |
TW200812610A (en) | 2008-03-16 |
DE602005001445D1 (de) | 2007-08-02 |
CN1929857A (zh) | 2007-03-14 |
ES2286787T3 (es) | 2007-12-01 |
TW200529868A (en) | 2005-09-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20063926L (no) | N-terminale monopegylerte humane veksthormonkonjugater, fremgangsmater for fremstilling og anvendelse av disse | |
MX344559B (es) | Compuestos de hormona de crecimiento humana recombinante unidos al peg. | |
AP2004003050A0 (en) | Chemically modified human growth hormone conjugates | |
GEP20105059B (en) | Anti-cd154 antibodies | |
ATE376559T1 (de) | Methoden der verhinderung und behandlung der alzheimer'schen krankheit | |
EA200800050A1 (ru) | Самобуферирующиеся композиции белков | |
WO2005116051A3 (de) | An mhc-moleküle bindende tumor-assoziierte peptide | |
RS54215B1 (en) | COMPOSITIONS AND PROCEDURES FOR DIAGNOSIS AND TREATMENT OF CANCER | |
JP2013503205A5 (no) | ||
WO2004043361A3 (en) | Compositions and methods for the treatment of natural killer cell related diseases | |
ATE405564T1 (de) | 1h-imidazoä4,5-cüchinolinderivate zur behandlung von protein kinase-abhängigen krankheiten | |
TW201129379A (en) | Anti-Orai1 antigen binding proteins and uses thereof | |
EP1940866A4 (en) | PEPTIDES THAT PROMOTE CAPILLARY REPELLENCE AND IMPROVES WRINKLES, AND COSMETIC COMPOSITIONS CONTAINING THE SAME | |
WO2011003100A4 (en) | Compositions and methods for diagnosing and/or treating influenza infection | |
WO2004074486A3 (en) | Fusion proteins of interferon alpha muteins with improved properties | |
DK1599215T3 (da) | Anvendelse af tryptophanrige peptider fra mælkeproteinhydrolysat til behandling af overvægt og fedme | |
WO2004037175A3 (en) | Compositions and methods for treating human papillomavirus-mediated disease | |
WO2007134118A3 (en) | Protein based composition and methods of using same | |
PL1636261T3 (pl) | Białka trombopoetynowe o ulepszonych właściwościach | |
WO2006029343A3 (en) | Peptides that selectively home to heart vasculature and related conjugates and methods | |
WO2004113386A3 (en) | Modified hirudin proteins and t-cell epitopes in hirudin | |
ATE282704T1 (de) | Isolierte und gereinigte humane lösliche guanylylcyclase alpha1/beta1 (hsgc alpha1/beta1) | |
WO2004011496A3 (en) | Novel t-cell proteins, peptides and antibodies derived therefrom and uses thereof | |
WO2005005668A3 (en) | Diagnosis and treatment methods related to aging (8a) | |
WO2001082948A3 (en) | Uses of tgap7 for the modulation of leucocyte activation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |