NO20063401L - Fremgangsmate for fremstillingen av (3R,3AS,6AR)-heksahydrofuro [2,3-B]furan-3-yl (1S,2R)-3-[[(4-aminofenyl)sulfonyl](isobutyl) amino]-1-benzyl-2-hydroksypropylkarbamat - Google Patents

Fremgangsmate for fremstillingen av (3R,3AS,6AR)-heksahydrofuro [2,3-B]furan-3-yl (1S,2R)-3-[[(4-aminofenyl)sulfonyl](isobutyl) amino]-1-benzyl-2-hydroksypropylkarbamat

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Publication number
NO20063401L
NO20063401L NO20063401A NO20063401A NO20063401L NO 20063401 L NO20063401 L NO 20063401L NO 20063401 A NO20063401 A NO 20063401A NO 20063401 A NO20063401 A NO 20063401A NO 20063401 L NO20063401 L NO 20063401L
Authority
NO
Norway
Prior art keywords
amino
isobutyl
hydroxypropylcarbamate
hexahydrofuro
aminophenyl
Prior art date
Application number
NO20063401A
Other languages
English (en)
Other versions
NO337636B1 (no
Inventor
Piet Tom Bert Paul Wigerinck
Nicolaas Martha Feli Goyvaerts
Hartmund Burghard Zinser
Birgit M Ebert
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20063401L publication Critical patent/NO20063401L/no
Publication of NO337636B1 publication Critical patent/NO337636B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører en fremgangsmåte for fremstillingen av (3R,3aS,6aR)-heksahydrofuro [2,3-b] furan-3-yl (lS,2R)-3-[[(4-aminofenyl) sulfonyl] (isobutyl) amino]- 1 -benzyl-2-hydroksypropylkarbamat så vel som intermediater for anvendelse i nevnte fremgangsmåte. Mer spesielt vedrører oppfinnelsen fremgangsmåter for fremstillingen av (3R,3aS,6aR)-heksahydrofuro [2,3-b] furan-3-yl (lS,2R)-3-[[(4-aminofenyl) sulfonyll (isobutyl) amino]-l-benzyl-2-hydroksypropylkarbamat som anvender 4-ammo-N-((2R,3S)-3-amino-2-hydroksy-4-fenylbutyl)-N-(isobutyl)benzensulfonamidmtem og to fremgangsmåter mottakelige for industriell opparbeiding. (3R,3aS,6aR)-heksahydrofuro [2,3-b] furan-3-yl (lS,2R)-3-[[(4-aminofényl) sulfonyl] (isobutyl) amino]-l-benzyl-2-hydroksypropylkarbamat er spesielt nyttig som HIV-proteaseinhibitorer.
NO20063401A 2003-12-23 2006-07-21 Fremgangsmåte for fremstillingen av (3R,3aS,6aR)-heksahydrofuro [2,3-b]furan-3-yl (1S,2R)-3-[[(4-aminofenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroksypropylkarbamat NO337636B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03104949 2003-12-23
US56818304P 2004-05-04 2004-05-04
PCT/EP2004/053692 WO2005063770A1 (en) 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate

Publications (2)

Publication Number Publication Date
NO20063401L true NO20063401L (no) 2006-07-21
NO337636B1 NO337636B1 (no) 2016-05-23

Family

ID=34740665

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063401A NO337636B1 (no) 2003-12-23 2006-07-21 Fremgangsmåte for fremstillingen av (3R,3aS,6aR)-heksahydrofuro [2,3-b]furan-3-yl (1S,2R)-3-[[(4-aminofenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroksypropylkarbamat

Country Status (21)

Country Link
EP (1) EP1725566B1 (no)
KR (1) KR101192859B1 (no)
CN (1) CN1898248B (no)
AT (1) ATE433982T1 (no)
AU (1) AU2004309122B2 (no)
BR (1) BRPI0417272B8 (no)
CA (1) CA2549460C (no)
CY (1) CY1109379T1 (no)
DE (1) DE602004021640D1 (no)
DK (1) DK1725566T3 (no)
ES (1) ES2328701T3 (no)
HR (1) HRP20090488T1 (no)
IL (1) IL174960A (no)
MX (1) MXPA06007211A (no)
NO (1) NO337636B1 (no)
PL (1) PL1725566T3 (no)
PT (1) PT1725566E (no)
RU (1) RU2376308C2 (no)
SI (1) SI1725566T1 (no)
WO (1) WO2005063770A1 (no)
ZA (1) ZA200605163B (no)

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AR058238A1 (es) 2005-11-28 2008-01-23 Tibotec Pharm Ltd Compuestos y derivados de aminofenilsulfonamida sustituida como inhibidores de proteasa del vih
RS51675B (en) 2006-11-09 2011-10-31 Tibotec Pharmaceuticals METHODS FOR THE PREPARATION OF HEXAHIDROFURO [2,3-B] FURAN-3-OLA
WO2008132154A1 (en) 2007-04-27 2008-11-06 Tibotec Pharmaceuticals Ltd. Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
WO2009055006A1 (en) * 2007-10-26 2009-04-30 Concert Pharmaceuticals, Inc. Deuterated darunavir
TWI482775B (zh) * 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
CN102348706B (zh) * 2009-05-13 2015-03-04 明治制果药业株式会社 生产啶南平衍生物的方法
PL2477992T3 (pl) 2009-09-17 2017-07-31 Mylan Laboratories Limited Proces przygotowania Darunawiru i jego amorficznych postaci
WO2011083287A2 (en) 2010-01-05 2011-07-14 Cipla Limited Darunavir polymorph and process for preparation thereof
WO2011092687A1 (en) 2010-01-28 2011-08-04 Mapi Pharma Hk Limited Process for the preparation of darunavir and darunavir intermediates
CN102584844B (zh) * 2011-01-11 2016-04-13 浙江九洲药业股份有限公司 一种达芦那韦晶型及其制备方法
EP2877474B1 (en) 2012-07-24 2020-11-04 Laurus Labs Limited A process for preparation of darunavir
CN103893178B (zh) * 2014-03-19 2016-06-01 中山大学 苯-磺酰胺类化合物在制备抗hiv-1病毒药物中的应用
US20160075643A1 (en) * 2014-09-16 2016-03-17 Zcl Chemicals Limited Novel process to prepare intermediates of hiv-protease inhibitors thereof
US10633390B2 (en) * 2015-06-25 2020-04-28 Msn Laboratories Private Limited Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
EP3532478B1 (en) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
SI3541819T1 (sl) * 2016-11-17 2021-02-26 Janssen Sciences Ireland Unlimited Company Poenostavljen postopek za pripravo darunavira
CN117142989A (zh) * 2020-12-30 2023-12-01 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体a的生长方法和所得晶体
CN113896658A (zh) * 2021-09-24 2022-01-07 上药康丽（常州）药业有限公司 一种利用微通道反应器合成地瑞那韦中间体的方法

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JP4014220B2 (ja) 1995-01-20 2007-11-28 ジー．ディー．サール アンド カンパニー ビス−スルホンアミドヒドロキシエチルアミノ レトロ ウイルスプロテアーゼインヒビター
JP3665343B2 (ja) 1995-02-03 2005-06-29 株式会社カネカ α−ハロケトン、α−ハロヒドリン及びエポキシドの製造法
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
JP4124818B2 (ja) 1995-03-10 2008-07-23 ジー．ディー．サール アンド カンパニー ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
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Also Published As

Publication number Publication date
IL174960A0 (en) 2006-08-20
ATE433982T1 (de) 2009-07-15
PL1725566T3 (pl) 2009-11-30
IL174960A (en) 2011-06-30
DE602004021640D1 (de) 2009-07-30
AU2004309122A1 (en) 2005-07-14
AU2004309122B2 (en) 2011-07-21
NO337636B1 (no) 2016-05-23
RU2376308C2 (ru) 2009-12-20
ES2328701T3 (es) 2009-11-17
KR101192859B1 (ko) 2012-10-19
DK1725566T3 (da) 2009-10-05
CA2549460C (en) 2014-08-05
BRPI0417272B1 (pt) 2020-08-18
ZA200605163B (en) 2007-12-27
RU2006126670A (ru) 2008-01-27
CN1898248B (zh) 2011-08-17
KR20060123740A (ko) 2006-12-04
WO2005063770A1 (en) 2005-07-14
CN1898248A (zh) 2007-01-17
HRP20090488T1 (en) 2009-10-31
MXPA06007211A (es) 2006-08-18
BRPI0417272A (pt) 2007-03-27
BRPI0417272B8 (pt) 2021-05-25
CY1109379T1 (el) 2014-07-02
SI1725566T1 (sl) 2009-12-31
EP1725566B1 (en) 2009-06-17
CA2549460A1 (en) 2005-07-14
PT1725566E (pt) 2009-09-16
EP1725566A1 (en) 2006-11-29

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Owner name: JANSSEN SCIENCES IRELAND UC, IE