NO20060650L - Kinazolinderivater som angiogeneseinhibitorer - Google Patents
Kinazolinderivater som angiogeneseinhibitorerInfo
- Publication number
- NO20060650L NO20060650L NO20060650A NO20060650A NO20060650L NO 20060650 L NO20060650 L NO 20060650L NO 20060650 A NO20060650 A NO 20060650A NO 20060650 A NO20060650 A NO 20060650A NO 20060650 L NO20060650 L NO 20060650L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compounds
- aromatic
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Foreliggende oppfinnelse angår forbindelser med formel I: hvor: ring C er en 8-, 9-, 10-, 12- eller 13-leddet bicyklisk eller tricyklisk gruppe, hvilken gruppe kan være mettet eller umettet, kan være aromatisk eller ikkearomatisk og som eventuelt kan inneholde 1-3 heteroatomer uavhengig valgt fra O, N og S; Z er -O-, -NH- eller -S-; n er 0, 1, 2, 3, 4 eller 5; m er 0, 1, 2 eller 3; og R1 og R2 er som definert her; og salter derav; anvendelse av dem ved fremstilling av et medikament for anvendelse for å produsere en antiangiogen og/eller vaskulær permeabilitetsreduserende effekt hos varmblodige dyr; fremgangsmåter for fremstilling av slike forbindelser; farmasøytiske preparater inneholdende en forbindelse med formel (I) eller et farmasøytisk akseptabelt salt derav og metoder for behandling av sykdomstilstander som involverer angiogenese ved administrering av en forbindelse med formel (I) eller et farmasøytisk akseptabelt salt derav. Forbindelsene med formel (I) hemmer virkningene av VEGF, en egenskap verdifull ved behandling av flere sykdomstilstander omfattende kreft og revmatoid artritt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0318422.3A GB0318422D0 (en) | 2003-08-06 | 2003-08-06 | Chemical compounds |
PCT/GB2004/003376 WO2005014582A1 (en) | 2003-08-06 | 2004-08-05 | Quinazoline derivatives as angiogenesis inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20060650L true NO20060650L (no) | 2006-04-24 |
Family
ID=27839732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20060650A NO20060650L (no) | 2003-08-06 | 2006-02-09 | Kinazolinderivater som angiogeneseinhibitorer |
Country Status (14)
Country | Link |
---|---|
US (2) | US7989460B2 (no) |
EP (1) | EP1658280A1 (no) |
JP (1) | JP4890249B2 (no) |
KR (1) | KR20060058705A (no) |
CN (1) | CN1863794B (no) |
AU (1) | AU2004263360A1 (no) |
BR (1) | BRPI0413284A (no) |
CA (1) | CA2534811A1 (no) |
GB (1) | GB0318422D0 (no) |
IL (1) | IL173484A0 (no) |
MX (1) | MXPA06001395A (no) |
NO (1) | NO20060650L (no) |
WO (1) | WO2005014582A1 (no) |
ZA (1) | ZA200601025B (no) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE05345B1 (et) | 1999-02-10 | 2010-10-15 | Astrazeneca Ab | Kinasoliini derivaadid angiogeneesi inhibiitoritena |
PE20021011A1 (es) * | 2001-03-23 | 2003-02-01 | Bayer Corp | Derivados quinazolinicos como inhibidores de la rho-quinasa |
UA81619C2 (ru) * | 2002-02-01 | 2008-01-25 | Астразенека Аб | Хиназолиновые соединения, способ их получения (варианты), фармацевтическая композиция на их основе |
CN101072758B (zh) | 2004-10-12 | 2013-07-31 | 阿斯利康(瑞典)有限公司 | 喹唑啉衍生物 |
UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
US7851623B2 (en) * | 2006-11-02 | 2010-12-14 | Astrazeneca Ab | Chemical process |
BRPI0818244A2 (pt) * | 2007-10-24 | 2015-06-16 | Merck Sharp & Dohme | Composto, composição farmacêutica, uso de um composto, e, método para tratamento de um distúrbio ou doença |
US8211911B2 (en) * | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
US9353123B2 (en) * | 2013-02-20 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
USD746538S1 (en) * | 2014-02-03 | 2015-12-29 | Nautilus Hyosung Inc. | Automated teller machine |
USD765340S1 (en) * | 2014-03-24 | 2016-08-30 | Nautilus Hyosung Inc. | Automated teller machine |
USD746539S1 (en) * | 2014-03-24 | 2015-12-29 | Nautilus Hyosung Inc. | Automated teller machine |
KR20180086187A (ko) | 2015-10-05 | 2018-07-30 | 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료 |
CN112996784B (zh) * | 2018-09-18 | 2023-05-30 | 北京越之康泰生物医药科技有限公司 | 吲哚衍生物及其在医药上的应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
GB9514265D0 (en) * | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
EE05345B1 (et) * | 1999-02-10 | 2010-10-15 | Astrazeneca Ab | Kinasoliini derivaadid angiogeneesi inhibiitoritena |
GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
JP2004505966A (ja) * | 2000-08-09 | 2004-02-26 | アストラゼネカ アクチボラグ | シンノリン化合物 |
JP2004511480A (ja) * | 2000-10-13 | 2004-04-15 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
AU2002212436A1 (en) * | 2000-10-25 | 2002-05-06 | Astrazeneca Ab | Quinazoline derivatives |
US7501516B2 (en) * | 2001-07-16 | 2009-03-10 | Astrazeneca Ab | Quinoline derivatives and their use as tyrosine kinase inhibitors |
AU2002347336A1 (en) * | 2001-12-05 | 2003-06-17 | Astrazeneca Ab | Quinoline derivatives |
UA81619C2 (ru) * | 2002-02-01 | 2008-01-25 | Астразенека Аб | Хиназолиновые соединения, способ их получения (варианты), фармацевтическая композиция на их основе |
GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
WO2007071958A2 (en) * | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Combination of zd6474 and pemetrexed |
-
2003
- 2003-08-06 GB GBGB0318422.3A patent/GB0318422D0/en not_active Ceased
-
2004
- 2004-08-05 WO PCT/GB2004/003376 patent/WO2005014582A1/en active Application Filing
- 2004-08-05 KR KR1020067002540A patent/KR20060058705A/ko not_active Application Discontinuation
- 2004-08-05 US US10/566,842 patent/US7989460B2/en not_active Expired - Fee Related
- 2004-08-05 BR BRPI0413284-0A patent/BRPI0413284A/pt not_active IP Right Cessation
- 2004-08-05 AU AU2004263360A patent/AU2004263360A1/en not_active Abandoned
- 2004-08-05 EP EP04743664A patent/EP1658280A1/en not_active Withdrawn
- 2004-08-05 CN CN2004800290795A patent/CN1863794B/zh not_active Expired - Fee Related
- 2004-08-05 JP JP2006522400A patent/JP4890249B2/ja not_active Expired - Fee Related
- 2004-08-05 CA CA002534811A patent/CA2534811A1/en not_active Abandoned
- 2004-08-05 MX MXPA06001395A patent/MXPA06001395A/es unknown
-
2006
- 2006-01-31 IL IL173484A patent/IL173484A0/en unknown
- 2006-02-03 ZA ZA200601025A patent/ZA200601025B/en unknown
- 2006-02-09 NO NO20060650A patent/NO20060650L/no not_active Application Discontinuation
-
2011
- 2011-06-20 US US13/164,310 patent/US20120046300A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL173484A0 (en) | 2006-06-11 |
EP1658280A1 (en) | 2006-05-24 |
ZA200601025B (en) | 2007-05-30 |
WO2005014582A1 (en) | 2005-02-17 |
KR20060058705A (ko) | 2006-05-30 |
CA2534811A1 (en) | 2005-02-17 |
US7989460B2 (en) | 2011-08-02 |
JP4890249B2 (ja) | 2012-03-07 |
JP2007501210A (ja) | 2007-01-25 |
BRPI0413284A (pt) | 2006-10-10 |
CN1863794A (zh) | 2006-11-15 |
AU2004263360A1 (en) | 2005-02-17 |
US20120046300A1 (en) | 2012-02-23 |
GB0318422D0 (en) | 2003-09-10 |
US20080058342A1 (en) | 2008-03-06 |
CN1863794B (zh) | 2012-04-25 |
MXPA06001395A (es) | 2006-05-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20060650L (no) | Kinazolinderivater som angiogeneseinhibitorer | |
CN108235704B (zh) | 抗细菌化合物 | |
JP6622824B2 (ja) | キヌレニン−3−モノオキシゲナーゼインヒビターおよびその医薬組成物ならびにこれらの使用方法 | |
JP6963262B2 (ja) | 新規抗癌剤 | |
US9802951B2 (en) | Biologically active taxane analogs and methods of treatment by oral administration | |
EP3027614A1 (de) | Substituierte dihydropyrido[3,4-b]pyrazinone als duale inhibitoren von bet-proteinen und polo-like kinasen | |
JP5897566B2 (ja) | 環式n,n’−ジアリールチオ尿素及びn,n’−ジアリール尿素−アンドロゲン受容体アンタゴニスト、抗癌剤、その調製のための方法及び使用 | |
CN103896946B (zh) | 用于预防及治疗多种自身免疫疾病的新化合物 | |
EA200900388A1 (ru) | Бензоксазолы и оксазолопиридины, применимые в качестве ингибиторов киназ janus | |
NO20060641L (no) | Kinazolinderivater som inhibitorer av VEGF-reseptortyrosinkinaser | |
WO2018165614A1 (en) | Bacterial efflux pump inhibitors | |
WO2019005841A1 (en) | THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION | |
IL207669A (en) | Nitrogen compounds containing nitrogen active in chronic pain states | |
JP6155026B2 (ja) | プロテインキナーゼ阻害のための新規化合物及びその治療的使用 | |
CN115151541B (zh) | 新型化合物及其用途 | |
WO2020099929A1 (en) | A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin | |
AU2014258419A2 (en) | Dicarboxylic acid compound | |
EP3454852A1 (en) | Phosphotidylinositol 3-kinase inhibitors | |
KR20170037116A (ko) | 플루오로기가 치환된 프탈라지논 유도체 및 그 제조방법 | |
WO2008106125A3 (en) | Deuterated derivatives of silodosin as alpha la-adrenoceptor antagonists | |
BR9910628A (pt) | Uso de um composto da série da benzofuroxana, composição farmacêutica, e, processos para a preparação de uma formulação parenteral e para o tratamento de um mamìfero, incluindo um ser humano, de doenças cardìacas da coronária | |
WO2019129114A1 (zh) | 吲哚胺2,3-双加氧酶抑制剂以及它们在医学上的应用 | |
CN104487425B (zh) | 治疗细菌性疾病的嘧啶衍生物 | |
KR20080014017A (ko) | (5z)-5-(6-퀴녹살리닐메틸리덴)-2-[(2,6-디클로로페닐)아미노]-1,3-티아졸-4(5h)-온 | |
EP2406218A1 (en) | Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |