NO20055863L - W-carboxyaryl-substituted diphenylurea compounds as raf kinase inhibitors - Google Patents

W-carboxyaryl-substituted diphenylurea compounds as raf kinase inhibitors

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Publication number
NO20055863L
NO20055863L NO20055863A NO20055863A NO20055863L NO 20055863 L NO20055863 L NO 20055863L NO 20055863 A NO20055863 A NO 20055863A NO 20055863 A NO20055863 A NO 20055863A NO 20055863 L NO20055863 L NO 20055863L
Authority
NO
Norway
Prior art keywords
carboxyaryl
kinase inhibitors
raf kinase
diphenylurea compounds
substituted diphenylurea
Prior art date
Application number
NO20055863A
Other languages
Norwegian (no)
Other versions
NO337326B1 (en
Inventor
Bernd Riedl
Jacques Dumas
Uday Khire
Timothy Bruno Lowinger
William J Scott
Roger A Smith
Robert N Sibley
Mary-Katherine Monahan
Reina Natero
Joel Renick
Jill Elizabeth Wood
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27381740&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20055863(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2000/000648 external-priority patent/WO2000042012A1/en
Publication of NO20055863L publication Critical patent/NO20055863L/en
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO337326B1 publication Critical patent/NO337326B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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Abstract

Denne oppfinnelsen vedrører anvendelsen av en gruppe arylurea-forbindelser ved behandling av raf-medierte sykdommer, og farmasøytiske preparater for anvendelse i slik terapi.This invention relates to the use of a group of arylurea compounds in the treatment of raf mediated diseases, and pharmaceutical compositions for use in such therapy.

NO20055863A 1999-01-13 2005-12-09 ω-carboxyaryl-substituted diphenylurea compounds such as raf kinase inhibitors, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and use of the compounds for the manufacture of a medicament for the treatment of solid cancers NO337326B1 (en)

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US11587799P 1999-01-13 1999-01-13
US25726699A 1999-02-25 1999-02-25
US42522899A 1999-10-22 1999-10-22
PCT/US2000/000648 WO2000042012A1 (en) 1999-01-13 2000-01-12 φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS

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NO20055863L true NO20055863L (en) 2001-09-12
NO337326B1 NO337326B1 (en) 2016-03-07

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NO20055863A NO337326B1 (en) 1999-01-13 2005-12-09 ω-carboxyaryl-substituted diphenylurea compounds such as raf kinase inhibitors, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and use of the compounds for the manufacture of a medicament for the treatment of solid cancers
NO2007002C NO2007002I2 (en) 1999-01-13 2007-01-05 sorafenib

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