NO20051025L - Injectable multimodal polymer depot preparations and applications thereof - Google Patents
Injectable multimodal polymer depot preparations and applications thereofInfo
- Publication number
- NO20051025L NO20051025L NO20051025A NO20051025A NO20051025L NO 20051025 L NO20051025 L NO 20051025L NO 20051025 A NO20051025 A NO 20051025A NO 20051025 A NO20051025 A NO 20051025A NO 20051025 L NO20051025 L NO 20051025L
- Authority
- NO
- Norway
- Prior art keywords
- polymer
- polymers
- compositions
- injectable
- applications
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Abstract
Det er beskrevet injiserbare depotpreparater som omfatter en polymermatriks som har et flertall av bionedbiytbare, biokompatible polymerer hvor hver polymer av flertallet av polymerer har en spesifisert vektmidlere molekylvekt; og polymermafriksen har en bred molekylvektsfordeling av flertallet av polymerer; et oppløsningsmiddel som har en blandbarhet i vann på mindre enn eller lik 7 vekt-% ved 25°e, i en mengde effektiv for å mykne polymeren ved å danne en gel med denne og et fordelaktig middel. Preparatene har vesentlig forbedret skjærfortynningsoppførsel og redusert injeksjonskraft, hvilket gjør preparatene lett implanterbare under en pasients kroppsoverflate ved injeksjon.Injectable depot compositions are disclosed which comprise a polymer matrix having a plurality of biodegradable biocompatible polymers wherein each polymer of the plurality of polymers has a specified weight average molecular weight; and the polymer matrix has a broad molecular weight distribution of the majority of polymers; a solvent having a miscibility in water of less than or equal to 7% by weight at 25 DEG C., in an amount effective to soften the polymer by forming a gel therewith and an advantageous agent. The compositions have significantly improved shear thinning behavior and reduced injection power, making the compositions easily implantable under a patient's body surface at injection.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39983202P | 2002-07-31 | 2002-07-31 | |
PCT/US2003/023439 WO2004011054A2 (en) | 2002-07-31 | 2003-07-28 | Injectable multimodal polymer depot compositions and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20051025L true NO20051025L (en) | 2005-02-25 |
Family
ID=31188625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20051025A NO20051025L (en) | 2002-07-31 | 2005-02-25 | Injectable multimodal polymer depot preparations and applications thereof |
Country Status (20)
Country | Link |
---|---|
US (2) | US8501215B2 (en) |
EP (2) | EP2030611A1 (en) |
JP (1) | JP4639400B2 (en) |
KR (1) | KR20050083605A (en) |
CN (2) | CN1684663A (en) |
AR (1) | AR040753A1 (en) |
AT (1) | ATE419831T1 (en) |
AU (2) | AU2003256849A1 (en) |
BR (1) | BR0313539A (en) |
CA (1) | CA2494400A1 (en) |
DE (1) | DE60325742D1 (en) |
DK (1) | DK1539101T3 (en) |
ES (1) | ES2321505T3 (en) |
HK (1) | HK1079443A1 (en) |
IL (1) | IL166463A0 (en) |
MX (1) | MXPA05001244A (en) |
NO (1) | NO20051025L (en) |
NZ (1) | NZ537953A (en) |
WO (1) | WO2004011054A2 (en) |
ZA (1) | ZA200501645B (en) |
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2003
- 2003-07-28 WO PCT/US2003/023439 patent/WO2004011054A2/en active Application Filing
- 2003-07-28 ES ES03771916T patent/ES2321505T3/en not_active Expired - Lifetime
- 2003-07-28 AU AU2003256849A patent/AU2003256849A1/en not_active Abandoned
- 2003-07-28 AT AT03771916T patent/ATE419831T1/en not_active IP Right Cessation
- 2003-07-28 KR KR1020057001821A patent/KR20050083605A/en not_active Application Discontinuation
- 2003-07-28 EP EP08166077A patent/EP2030611A1/en not_active Withdrawn
- 2003-07-28 JP JP2004524891A patent/JP4639400B2/en not_active Expired - Fee Related
- 2003-07-28 DK DK03771916T patent/DK1539101T3/en active
- 2003-07-28 BR BR0313539-0A patent/BR0313539A/en not_active IP Right Cessation
- 2003-07-28 US US10/628,984 patent/US8501215B2/en not_active Expired - Fee Related
- 2003-07-28 MX MXPA05001244A patent/MXPA05001244A/en unknown
- 2003-07-28 CA CA002494400A patent/CA2494400A1/en not_active Abandoned
- 2003-07-28 CN CNA038225581A patent/CN1684663A/en active Pending
- 2003-07-28 EP EP03771916A patent/EP1539101B1/en not_active Expired - Lifetime
- 2003-07-28 NZ NZ537953A patent/NZ537953A/en not_active IP Right Cessation
- 2003-07-28 CN CNA2007101096196A patent/CN101057824A/en active Pending
- 2003-07-28 DE DE60325742T patent/DE60325742D1/en not_active Expired - Lifetime
- 2003-07-31 AR AR20030102760A patent/AR040753A1/en not_active Application Discontinuation
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- 2005-12-15 HK HK05111570.0A patent/HK1079443A1/en not_active IP Right Cessation
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KR20050083605A (en) | 2005-08-26 |
AR040753A1 (en) | 2005-04-20 |
JP4639400B2 (en) | 2011-02-23 |
EP2030611A1 (en) | 2009-03-04 |
NZ537953A (en) | 2007-02-23 |
MXPA05001244A (en) | 2005-06-08 |
WO2004011054A3 (en) | 2004-04-01 |
DK1539101T3 (en) | 2009-04-27 |
ES2321505T3 (en) | 2009-06-08 |
AU2010200348A1 (en) | 2010-02-18 |
AU2003256849A1 (en) | 2004-02-16 |
DE60325742D1 (en) | 2009-02-26 |
US20040022859A1 (en) | 2004-02-05 |
HK1079443A1 (en) | 2006-04-07 |
US20140051770A1 (en) | 2014-02-20 |
BR0313539A (en) | 2005-06-21 |
JP2005538107A (en) | 2005-12-15 |
CN1684663A (en) | 2005-10-19 |
ATE419831T1 (en) | 2009-01-15 |
EP1539101A2 (en) | 2005-06-15 |
WO2004011054A2 (en) | 2004-02-05 |
EP1539101B1 (en) | 2009-01-07 |
US8501215B2 (en) | 2013-08-06 |
CA2494400A1 (en) | 2004-02-05 |
IL166463A0 (en) | 2006-01-15 |
CN101057824A (en) | 2007-10-24 |
ZA200501645B (en) | 2006-05-31 |
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