NO20040471L - 5,6,6a,1 1b-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater som NMDA-antagonister - Google Patents
5,6,6a,1 1b-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater som NMDA-antagonisterInfo
- Publication number
- NO20040471L NO20040471L NO20040471A NO20040471A NO20040471L NO 20040471 L NO20040471 L NO 20040471L NO 20040471 A NO20040471 A NO 20040471A NO 20040471 A NO20040471 A NO 20040471A NO 20040471 L NO20040471 L NO 20040471L
- Authority
- NO
- Norway
- Prior art keywords
- azabenzo
- oxa
- tetrahydro
- carboxylic acid
- acid derivatives
- Prior art date
Links
- LKAAULIYOFZTPR-UHFFFAOYSA-N 5,6,6a,11b-tetrahydro-[1]benzofuro[2,3-c]quinoline-6-carboxylic acid Chemical class C1=CC=C2C3C4=CC=CC=C4NC(C(=O)O)C3OC2=C1 LKAAULIYOFZTPR-UHFFFAOYSA-N 0.000 title abstract 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
Abstract
Det er beskrevet substituerte 5,6,6a,l lb-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater, samt fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse for fremstilling av legemidler for bestemte indikasjoner, spesielt for behandling av smerte.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10137487A DE10137487A1 (de) | 2001-08-03 | 2001-08-03 | Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate |
PCT/EP2002/008886 WO2003014124A1 (de) | 2001-08-03 | 2002-08-05 | SUBSTITUIERTE 5,6,6a,11b-TETRAHYDRO-7-OXA-5-AZA-BENZO'C!FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20040471L true NO20040471L (no) | 2004-02-02 |
Family
ID=7693857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20040471A NO20040471L (no) | 2001-08-03 | 2004-02-02 | 5,6,6a,1 1b-tetrahydro-7-oksa-5-azabenzo[c]fluoren-6-karboksylsyrederivater som NMDA-antagonister |
Country Status (21)
Country | Link |
---|---|
US (1) | US7199130B2 (no) |
EP (1) | EP1412361B1 (no) |
JP (1) | JP2005500374A (no) |
KR (1) | KR20040020078A (no) |
CN (1) | CN1697836A (no) |
AT (1) | ATE402178T1 (no) |
BR (1) | BR0211734A (no) |
CA (1) | CA2456124A1 (no) |
CO (1) | CO5550438A2 (no) |
DE (2) | DE10137487A1 (no) |
EC (1) | ECSP044968A (no) |
ES (1) | ES2310211T3 (no) |
HU (1) | HUP0400800A3 (no) |
IL (1) | IL160160A0 (no) |
MX (1) | MXPA04000953A (no) |
NO (1) | NO20040471L (no) |
NZ (1) | NZ531372A (no) |
PL (1) | PL368073A1 (no) |
RU (1) | RU2004106533A (no) |
WO (1) | WO2003014124A1 (no) |
ZA (1) | ZA200401725B (no) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10304950A1 (de) * | 2003-02-06 | 2004-08-19 | Grünenthal GmbH | Herstellung von Tetrahydrochinolinbenzofuranen |
KR20050021629A (ko) * | 2003-08-25 | 2005-03-07 | 학교법인 이화학당 | 신규한 벤조플루오렌 디온계 화합물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0386839B1 (en) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
DE19536809A1 (de) * | 1995-10-02 | 1997-04-03 | Basf Ag | Heterocyclisch substituierte Salicylsäurederivate |
US5925527A (en) * | 1997-02-04 | 1999-07-20 | Trega Biosciences, Inc. | Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
GB9706294D0 (en) * | 1997-03-26 | 1997-05-14 | Glaxo Wellcome Spa | Heterocyclic compound |
MY125037A (en) * | 1998-06-10 | 2006-07-31 | Glaxo Wellcome Spa | 1,2,3,4 tetrahydroquinoline derivatives |
DE10005302A1 (de) * | 2000-02-07 | 2002-01-17 | Gruenenthal Gmbh | Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate |
-
2001
- 2001-08-03 DE DE10137487A patent/DE10137487A1/de not_active Withdrawn
-
2002
- 2002-08-05 BR BR0211734-7A patent/BR0211734A/pt not_active IP Right Cessation
- 2002-08-05 DE DE50212538T patent/DE50212538D1/de not_active Expired - Lifetime
- 2002-08-05 WO PCT/EP2002/008886 patent/WO2003014124A1/de active IP Right Grant
- 2002-08-05 EP EP02764838A patent/EP1412361B1/de not_active Expired - Lifetime
- 2002-08-05 MX MXPA04000953A patent/MXPA04000953A/es unknown
- 2002-08-05 ES ES02764838T patent/ES2310211T3/es not_active Expired - Lifetime
- 2002-08-05 IL IL16016002A patent/IL160160A0/xx unknown
- 2002-08-05 CA CA002456124A patent/CA2456124A1/en not_active Abandoned
- 2002-08-05 KR KR10-2004-7001698A patent/KR20040020078A/ko not_active Application Discontinuation
- 2002-08-05 AT AT02764838T patent/ATE402178T1/de active
- 2002-08-05 HU HU0400800A patent/HUP0400800A3/hu unknown
- 2002-08-05 RU RU2004106533/04A patent/RU2004106533A/ru not_active Application Discontinuation
- 2002-08-05 CN CNA028195124A patent/CN1697836A/zh active Pending
- 2002-08-05 JP JP2003519073A patent/JP2005500374A/ja not_active Withdrawn
- 2002-08-05 NZ NZ531372A patent/NZ531372A/en unknown
- 2002-08-05 PL PL02368073A patent/PL368073A1/xx not_active Application Discontinuation
-
2004
- 2004-02-02 EC EC2004004968A patent/ECSP044968A/es unknown
- 2004-02-02 NO NO20040471A patent/NO20040471L/no not_active Application Discontinuation
- 2004-02-03 US US10/770,126 patent/US7199130B2/en not_active Expired - Fee Related
- 2004-02-03 CO CO04008285A patent/CO5550438A2/es not_active Application Discontinuation
- 2004-03-02 ZA ZA200401725A patent/ZA200401725B/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ531372A (en) | 2005-03-24 |
IL160160A0 (en) | 2004-07-25 |
EP1412361B1 (de) | 2008-07-23 |
DE10137487A1 (de) | 2003-03-27 |
BR0211734A (pt) | 2004-09-21 |
RU2004106533A (ru) | 2005-07-27 |
ES2310211T3 (es) | 2009-01-01 |
EP1412361A1 (de) | 2004-04-28 |
JP2005500374A (ja) | 2005-01-06 |
US20040248889A1 (en) | 2004-12-09 |
WO2003014124A1 (de) | 2003-02-20 |
CO5550438A2 (es) | 2005-08-31 |
ECSP044968A (es) | 2004-03-23 |
CA2456124A1 (en) | 2003-02-20 |
ATE402178T1 (de) | 2008-08-15 |
MXPA04000953A (es) | 2004-04-20 |
US7199130B2 (en) | 2007-04-03 |
HUP0400800A2 (hu) | 2004-07-28 |
PL368073A1 (en) | 2005-03-21 |
DE50212538D1 (de) | 2008-09-04 |
KR20040020078A (ko) | 2004-03-06 |
CN1697836A (zh) | 2005-11-16 |
HUP0400800A3 (en) | 2007-09-28 |
ZA200401725B (en) | 2005-01-31 |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |