NO2004008I1 - Patentets benevnelse - Google Patents

Patentets benevnelse

Info

Publication number
NO2004008I1
NO2004008I1 NO2004008C NO2004008C NO2004008I1 NO 2004008 I1 NO2004008 I1 NO 2004008I1 NO 2004008 C NO2004008 C NO 2004008C NO 2004008 C NO2004008 C NO 2004008C NO 2004008 I1 NO2004008 I1 NO 2004008I1
Authority
NO
Norway
Prior art keywords
molecules
thrombin
relates
moiety
csdm
Prior art date
Application number
NO2004008C
Other languages
English (en)
Other versions
NO2004008I2 (no
Original Assignee
Health Research Inc
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27015128&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2004008(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Health Research Inc, Biogen Inc filed Critical Health Research Inc
Publication of NO2004008I1 publication Critical patent/NO2004008I1/no
Publication of NO2004008I2 publication Critical patent/NO2004008I2/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/92—Method or apparatus for preparing or treating prosthetic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Fats And Perfumes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO2004008C 1989-08-18 2004-11-29 Bivalirudin NO2004008I2 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39548289A 1989-08-18 1989-08-18
US07549388 US5196404B1 (en) 1989-08-18 1990-07-06 Inhibitors of thrombin
PCT/US1990/004642 WO1991002750A1 (en) 1989-08-18 1990-08-17 Novel inhibitors of thrombin

Publications (2)

Publication Number Publication Date
NO2004008I1 true NO2004008I1 (no) 2004-12-27
NO2004008I2 NO2004008I2 (no) 2008-01-28

Family

ID=27015128

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19920616A NO310294B1 (no) 1989-08-18 1992-02-17 Nye inhibitorer for trombin
NO2004008C NO2004008I2 (no) 1989-08-18 2004-11-29 Bivalirudin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19920616A NO310294B1 (no) 1989-08-18 1992-02-17 Nye inhibitorer for trombin

Country Status (18)

Country Link
US (3) US5196404B1 (no)
EP (1) EP0489070B1 (no)
JP (1) JPH0768141B2 (no)
KR (1) KR100199534B1 (no)
AT (1) ATE137246T1 (no)
AU (1) AU652125B2 (no)
CA (1) CA2065150C (no)
DE (2) DE122004000042I2 (no)
DK (1) DK0489070T3 (no)
ES (1) ES2086411T3 (no)
FI (1) FI102183B1 (no)
HK (1) HK1001562A1 (no)
HU (2) HUT60285A (no)
LU (1) LU91119I2 (no)
NL (1) NL300162I2 (no)
NO (2) NO310294B1 (no)
SG (1) SG79180A1 (no)
WO (1) WO1991002750A1 (no)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
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US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
DE4005591A1 (de) * 1990-02-22 1991-09-05 Behringwerke Ag Die blutgerinnung inhibierende peptide, verfahren zu ihrer herstellung und ihre verwendung
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
ATE160356T1 (de) 1990-06-15 1997-12-15 Ca Nat Research Council Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
AU659432B2 (en) * 1991-03-08 1995-05-18 Novartis Ag A method for the inhibition or prevention of tumor cell metastasis with hirudin
US5500013A (en) * 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
GB9209032D0 (en) * 1992-04-25 1992-06-10 Ciba Geigy Ag New peptide derivatives
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
DK0641222T3 (da) * 1992-05-21 2000-12-11 Diatide Inc Peptider mærket med technetium-99m til trombeafbildning
US5476771A (en) * 1993-02-22 1995-12-19 The United States Of America As Represented By The Secretary Of The Army Test for quantitative thrombin time
WO1993025220A1 (en) * 1992-06-05 1993-12-23 Reid Thomas J Iii Test for quantitative thrombin time
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
FR2695562B1 (fr) * 1992-09-11 1994-10-14 Synthelabo Utilisation d'un inhibiteur direct de la thrombine pour la fabrication d'un médicament à activité thrombolytique.
DK0665853T3 (da) * 1992-10-02 2002-11-04 Diatide Inc Multimere polyvalente antitrombotiske midler
DE4303646A1 (de) * 1993-02-09 1994-08-11 Basf Ag Die Verwendung von Thrombininhibitoren zur Bekämpfung neurodegenerativer Erkrankungen
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
IT1265023B1 (it) * 1993-04-16 1996-10-28 Dev Biotechnological Processes Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
JP3532920B2 (ja) * 1993-06-11 2004-05-31 メレル ファーマスーティカルズ インコーポレイテッド 三機能性の抗血栓及び抗血小板ペプチド類
EP0725797B1 (en) * 1993-10-25 2001-01-10 National Research Council Of Canada Bivalent thrombin inhibitors
DE4337599A1 (de) * 1993-11-01 1995-05-04 Diagnostikforschung Inst Metallbindende cysteinfreie Peptide für Diagnose und Therapie, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
WO1995012408A1 (en) * 1993-11-04 1995-05-11 Brigham & Women's Hospital Plasmin-independent fibrinolysis
US6156540A (en) * 1993-12-22 2000-12-05 Human Genome Sciences, Inc. Thrombin inhibitor
CA2180140A1 (en) * 1993-12-27 1995-07-06 Jeffrey I. Weitz Methods and compositions for inhibiting thrombogenesis
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
US5510330A (en) * 1994-03-25 1996-04-23 Boehringer Mannheim Gmbh Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
US5830448A (en) * 1994-06-16 1998-11-03 Genentech, Inc. Compositions and methods for the treatment of tumors
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5606512A (en) * 1994-07-27 1997-02-25 The Dow Chemical Company Determining the biodegradability of iminodiacetic acid derivatives
GB9426038D0 (en) 1994-12-22 1995-02-22 Iaf Biochem Int Low molecular weight bicyclic thrombin inhibitors
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
US6057314A (en) * 1995-12-21 2000-05-02 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
GB9613718D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
GB9613719D0 (en) * 1996-06-29 1996-08-28 Thrombosis Res Inst Serine protease inhibitors
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US5985833A (en) * 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6011047A (en) * 1997-11-26 2000-01-04 Corvas International Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors
US6204384B1 (en) 1997-11-26 2001-03-20 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II)
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
SK287075B6 (sk) 1999-08-13 2009-11-05 Biogen Idec Ma Inc. Inhibítory bunkovej adhézie a farmaceutické prostriedky, ktoré ich obsahujú
EP1138694A1 (en) * 2000-03-30 2001-10-04 University Of Manitoba Hirulog-like peptide
AU2001259306A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
CA2424029C (en) 2000-09-29 2008-01-29 Cordis Corporation Coated medical devices
US6746773B2 (en) 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
DE10149678A1 (de) 2001-10-09 2009-03-12 Novel Science International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
US7865047B2 (en) * 2001-12-28 2011-01-04 Prysmian Cavi E Sistemi Energia S.R.L. Water-resistant telecommunication cable
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
DE10301255A1 (de) 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
US7456152B2 (en) * 2003-02-27 2008-11-25 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
US8791171B2 (en) 2003-05-01 2014-07-29 Abbott Cardiovascular Systems Inc. Biodegradable coatings for implantable medical devices
ES2375064T3 (es) * 2004-05-17 2012-02-24 Medtronic, Inc. Sistema de determinación de heparina en el lugar de atención al paciente.
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
US7244443B2 (en) 2004-08-31 2007-07-17 Advanced Cardiovascular Systems, Inc. Polymers of fluorinated monomers and hydrophilic monomers
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MX2008003552A (es) * 2005-09-14 2008-11-12 Novetide Ltd Proceso para la produccion de bivalirudina.
CN101033249B (zh) * 2006-03-10 2011-05-11 周逸明 固相多肽合成比筏芦定的制备方法
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
CN102558305B (zh) * 2007-02-08 2014-10-22 深圳信立泰药业股份有限公司 凝血酶直接抑制剂多肽水合盐及合成方法
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
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US20090062511A1 (en) * 2007-09-05 2009-03-05 Raghavendracharyulu Venkata Palle Process for the preparation of bivalirudin and its pharmaceutical compositions
US7582727B1 (en) 2008-07-27 2009-09-01 The Medicinces Company Pharmaceutical formulations of bivalirudin and processes of making the same
US7598343B1 (en) 2008-07-27 2009-10-06 The Medicines Company Pharmaceutical formulations of bivalirudin and processes of making the same
CA2736126C (en) * 2008-09-03 2016-11-29 Scinopharm Taiwan Ltd. Process for making bivalirudin
DK2382232T3 (da) 2008-12-29 2013-12-16 Lonza Braine Sa Fremgangsmåde til fremstilling af bivalirudin
US20110160431A1 (en) 2009-04-06 2011-06-30 Novetide, Ltd. Production of peptides containing poly-gly sequences using fmoc chemistry
GB0907698D0 (en) * 2009-05-05 2009-06-10 Univ Singapore Method of modifying serine protease inhibitors
CN101555274B (zh) * 2009-05-15 2013-08-21 海南双成药业股份有限公司 一种多肽固相合成比法卢定粗品的制备方法
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
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US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
US7985733B1 (en) 2010-01-06 2011-07-26 The Medicines Company Buffer-based method for preparing bivalirudin drug product
EP2471945A1 (de) * 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung
WO2013042129A1 (en) 2011-09-23 2013-03-28 Natco Pharma Limited Improved process for preparation of bivalirudin
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
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AU2016206950B2 (en) 2015-01-12 2021-05-06 Enteris Biopharma, Inc. Solid oral dosage forms
ES2886576T3 (es) * 2015-08-05 2021-12-20 Shaanxi Micot Tech Limited Company Compuesto de múltiples dianas con actividad anticoagulante y antiplaquetaria, método de preparación para el mismo y uso del mismo
WO2018234565A1 (en) 2017-06-23 2018-12-27 Chiesi Farmaceutici S.P.A. METHOD FOR PREVENTING SHUNT THROMBOSIS FROM THE SYSTEMIC-PULMONARY ARTERY
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WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
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Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55500091A (no) * 1978-02-17 1980-02-14
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
CA1340646C (en) * 1987-05-21 1999-07-13 John L. Krstenansky Cyclic anticoagulant peptides
CA1328540C (en) * 1987-05-21 1994-04-12 John L. Krstenansky Cyclic anticoagulant peptides
EP0333356A3 (en) * 1988-03-04 1990-12-19 Biogen, Inc. Hirudin peptides
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
ATE160356T1 (de) * 1990-06-15 1997-12-15 Ca Nat Research Council Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Also Published As

Publication number Publication date
NO920616L (no) 1992-04-13
EP0489070A1 (en) 1992-06-10
DE69026715T2 (de) 1996-10-17
DE122004000042I2 (de) 2008-01-24
EP0489070B1 (en) 1996-04-24
JPH0768141B2 (ja) 1995-07-26
WO1991002750A1 (en) 1991-03-07
DK0489070T3 (da) 1996-07-15
AU6284190A (en) 1991-04-03
NL300162I1 (nl) 2005-01-03
HU211158A9 (en) 1995-10-30
JPH04507253A (ja) 1992-12-17
FI102183B (fi) 1998-10-30
ES2086411T3 (es) 1996-07-01
CA2065150C (en) 1999-12-14
NO2004008I2 (no) 2008-01-28
NL300162I2 (nl) 2005-01-03
DE69026715D1 (en) 1996-05-30
SG79180A1 (en) 2001-03-20
FI102183B1 (fi) 1998-10-30
FI920672A0 (fi) 1992-02-17
CA2065150A1 (en) 1991-02-19
HU9200473D0 (en) 1992-05-28
US5433940A (en) 1995-07-18
LU91119I2 (fr) 2004-12-29
NO310294B1 (no) 2001-06-18
HK1001562A1 (en) 1998-06-26
DE122004000042I1 (de) 2005-02-24
HUT60285A (en) 1992-08-28
NO920616D0 (no) 1992-02-17
ATE137246T1 (de) 1996-05-15
US5196404A (en) 1993-03-23
US5691311A (en) 1997-11-25
AU652125B2 (en) 1994-08-18
US5196404B1 (en) 1996-09-10
KR920702372A (ko) 1992-09-03
KR100199534B1 (en) 1999-06-15

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