NO20035104L - Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer - Google Patents

Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer

Info

Publication number
NO20035104L
NO20035104L NO20035104A NO20035104A NO20035104L NO 20035104 L NO20035104 L NO 20035104L NO 20035104 A NO20035104 A NO 20035104A NO 20035104 A NO20035104 A NO 20035104A NO 20035104 L NO20035104 L NO 20035104L
Authority
NO
Norway
Prior art keywords
pyrimido
gaba
imidazo
receptor modulators
benzazepine derivatives
Prior art date
Application number
NO20035104A
Other languages
English (en)
Other versions
NO20035104D0 (no
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20035104L publication Critical patent/NO20035104L/no
Publication of NO20035104D0 publication Critical patent/NO20035104D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20035104A 2001-05-18 2003-11-17 Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer NO20035104D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01112222 2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en) 2001-05-18 2002-05-08 Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (2)

Publication Number Publication Date
NO20035104L true NO20035104L (no) 2003-11-17
NO20035104D0 NO20035104D0 (no) 2003-11-17

Family

ID=8177471

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20035104A NO20035104D0 (no) 2001-05-18 2003-11-17 Imidazo [1.5-A] pyrimido [5,4-D] benzazepin-derivater som GABA A reseptor-modulatorer

Country Status (38)

Country Link
US (1) US6686352B2 (no)
EP (1) EP1399448B1 (no)
JP (1) JP4068466B2 (no)
KR (1) KR100533406B1 (no)
CN (1) CN1230436C (no)
AR (1) AR033753A1 (no)
AT (1) ATE283857T1 (no)
AU (1) AU2002338898B2 (no)
BG (1) BG108369A (no)
BR (1) BR0209859A (no)
CA (1) CA2446903C (no)
CZ (1) CZ20033355A3 (no)
DE (1) DE60202147T2 (no)
DK (1) DK1399448T3 (no)
EC (1) ECSP034851A (no)
ES (1) ES2232778T3 (no)
GT (1) GT200200087A (no)
HK (1) HK1066544A1 (no)
HR (1) HRP20030890A2 (no)
HU (1) HUP0400743A3 (no)
IL (2) IL158572A0 (no)
JO (1) JO2297B1 (no)
MA (1) MA27024A1 (no)
MX (1) MXPA03010529A (no)
MY (1) MY127570A (no)
NO (1) NO20035104D0 (no)
NZ (1) NZ529097A (no)
PA (1) PA8545201A1 (no)
PE (1) PE20030041A1 (no)
PL (1) PL366846A1 (no)
PT (1) PT1399448E (no)
RU (1) RU2287531C2 (no)
SI (1) SI1399448T1 (no)
SK (1) SK15252003A3 (no)
TW (1) TWI251489B (no)
WO (1) WO2002094834A1 (no)
YU (1) YU90003A (no)
ZA (1) ZA200308544B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104193750B (zh) 2004-05-14 2018-04-27 千禧药品公司 通过抑制极光激酶抑制有丝***的化合物和方法
JP5002460B2 (ja) * 2004-10-04 2012-08-15 ミレニアム ファーマシューティカルズ， インコーポレイテッド タンパク質キナーゼインヒビターとして有用なラクタム化合物
EP1805184B1 (en) * 2004-10-20 2013-01-09 F. Hoffmann-La Roche AG Imidazo-benzodiazepine derivatives
EP1807432A1 (en) 2004-10-20 2007-07-18 F. Hoffmann-Roche AG Halogen substituted benzodiazepine derivatives
EP1937688B1 (en) 2005-10-11 2010-08-11 F. Hoffmann-La Roche AG Imidazo benzodiazepine derivatives
PE20080145A1 (es) * 2006-03-21 2008-02-11 Janssen Pharmaceutica Nv Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
WO2009078999A1 (en) 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
CN101735211B (zh) * 2008-11-04 2012-11-14 复旦大学 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
EP2373657B1 (en) * 2008-12-05 2016-09-14 Millennium Pharmaceuticals, Inc. 5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-thiones as plk inhibitors
CN102264368B (zh) 2008-12-22 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂与抗cd20抗体的组合
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
WO2011103089A1 (en) 2010-02-19 2011-08-25 Millennium Pharmaceuticals, Inc. Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6--methoxyphenyl)-5h -pyrimido[5,4-d][2]benzazepin-2yl]amino}-2-methoxybenzoate
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) * 2011-10-31 2012-04-25 江苏阿尔法药业有限公司 一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
CA2934553C (en) * 2013-12-20 2023-10-31 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX2017015752A (es) 2015-06-19 2018-04-13 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo.
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼインヒビターと化学療法剤の投与
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
MX2020013927A (es) 2018-06-19 2021-03-02 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar el deterioro cognitivo.
CN110452172B (zh) * 2019-08-21 2021-03-26 爱斯特（成都）生物制药股份有限公司 一种苯并己内酰胺的合成方法
CN112159411A (zh) * 2020-10-15 2021-01-01 南京工业大学 一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201311B (no) 1991-06-17 1993-03-01 Hoffmann La Roche
FR2783828B1 (fr) 1998-09-29 2000-11-10 Synthelabo Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
IL149550A0 (en) 1999-11-12 2002-11-10 Neurogen Corp Bicyclic and tricyclic heteroaromatic compounds
TWI239333B (en) 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators

Also Published As

Publication number Publication date
YU90003A (sh) 2006-08-17
CA2446903C (en) 2008-12-30
PA8545201A1 (es) 2003-02-28
JP4068466B2 (ja) 2008-03-26
HK1066544A1 (en) 2005-03-24
BR0209859A (pt) 2004-06-15
JO2297B1 (en) 2005-09-12
PT1399448E (pt) 2005-03-31
CA2446903A1 (en) 2002-11-28
MA27024A1 (fr) 2004-12-20
US6686352B2 (en) 2004-02-03
EP1399448B1 (en) 2004-12-01
CN1509289A (zh) 2004-06-30
PL366846A1 (en) 2005-02-07
BG108369A (bg) 2005-01-31
MY127570A (en) 2006-12-29
JP2004531563A (ja) 2004-10-14
MXPA03010529A (es) 2004-03-02
NZ529097A (en) 2005-04-29
ZA200308544B (en) 2005-01-31
DE60202147T2 (de) 2005-12-01
DE60202147D1 (de) 2005-01-05
HRP20030890A2 (en) 2005-08-31
ES2232778T3 (es) 2005-06-01
HUP0400743A2 (hu) 2004-07-28
KR20040002975A (ko) 2004-01-07
CN1230436C (zh) 2005-12-07
AR033753A1 (es) 2004-01-07
ATE283857T1 (de) 2004-12-15
CZ20033355A3 (en) 2004-07-14
ECSP034851A (es) 2003-12-24
AU2002338898B2 (en) 2007-03-15
DK1399448T3 (da) 2005-04-11
NO20035104D0 (no) 2003-11-17
HUP0400743A3 (en) 2007-09-28
IL158572A (en) 2010-02-17
US20030055042A1 (en) 2003-03-20
IL158572A0 (en) 2004-05-12
WO2002094834A1 (en) 2002-11-28
SI1399448T1 (en) 2005-02-28
RU2287531C2 (ru) 2006-11-20
GT200200087A (es) 2003-06-19
EP1399448A1 (en) 2004-03-24
KR100533406B1 (ko) 2005-12-02
RU2003136078A (ru) 2005-05-27
SK15252003A3 (sk) 2004-08-03
AU2002338898B8 (en) 2002-12-03
TWI251489B (en) 2006-03-21
PE20030041A1 (es) 2003-02-07

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