NO20030748L - Prodruger av betulinsyrederivater for behandlingen av kreft og HIV - Google Patents
Prodruger av betulinsyrederivater for behandlingen av kreft og HIVInfo
- Publication number
- NO20030748L NO20030748L NO20030748A NO20030748A NO20030748L NO 20030748 L NO20030748 L NO 20030748L NO 20030748 A NO20030748 A NO 20030748A NO 20030748 A NO20030748 A NO 20030748A NO 20030748 L NO20030748 L NO 20030748L
- Authority
- NO
- Norway
- Prior art keywords
- prodrugs
- hiv
- cancer
- treatment
- acid derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22653600P | 2000-08-18 | 2000-08-18 | |
PCT/US2001/025581 WO2002016395A1 (en) | 2000-08-18 | 2001-08-15 | Prodrugs of betulinic acid derivatives for the treatment of cancer and hiv |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20030748D0 NO20030748D0 (no) | 2003-02-17 |
NO20030748L true NO20030748L (no) | 2003-04-15 |
Family
ID=22849310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20030748A NO20030748L (no) | 2000-08-18 | 2003-02-17 | Prodruger av betulinsyrederivater for behandlingen av kreft og HIV |
Country Status (9)
Country | Link |
---|---|
US (3) | US6569842B2 (no) |
EP (1) | EP1309605A1 (no) |
JP (1) | JP2004517045A (no) |
AU (2) | AU2001284946B2 (no) |
CA (1) | CA2418479C (no) |
NO (1) | NO20030748L (no) |
NZ (1) | NZ524087A (no) |
WO (1) | WO2002016395A1 (no) |
ZA (1) | ZA200301269B (no) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6943260B2 (en) * | 2002-02-02 | 2005-09-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for obtaining betulinic acid |
JP4791183B2 (ja) * | 2002-08-23 | 2011-10-12 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロン、その中間体、類似体の合成およびその使用 |
US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
DE502004008819D1 (de) * | 2003-02-11 | 2009-02-26 | Novelix Pharmaceuticals Inc | Medikament zur wachstumsinhibierung von tumoren |
WO2004085459A1 (en) * | 2003-03-24 | 2004-10-07 | Sterix Limited | Oestrogen derivatives as inhibitors of steroid sulphatase |
SG145693A1 (en) * | 2003-07-29 | 2008-09-29 | Signature R & D Holdings Llc | Amino acid prodrugs |
US20060019934A1 (en) * | 2004-05-20 | 2006-01-26 | Saxena Brij B | Anti-HIV-1 activity of betulinol derivatives |
JP4579970B2 (ja) * | 2004-08-02 | 2010-11-10 | アンブリリア・バイオファーマ・インコーポレーテッド | リシンをベースにした化合物類 |
EP1802648A2 (en) * | 2004-09-10 | 2007-07-04 | Cornell Research Foundation, Inc. | Betulinol derivatives as anti-cancer agents |
AR051475A1 (es) * | 2004-11-05 | 2007-01-17 | Merck & Co Inc | Procedimiento para acido{3- [2 (r) -[(1r) - 1-[ 3,5- bis( trifluorometil)- fenil] etoxi] -3 (s) - (4- fluorfenil) morfolin -4- il]metil -5-oxo-4,5-dihidro- [1,2,4]-triazol-1-il} fosfonico |
JP4810642B2 (ja) * | 2004-11-30 | 2011-11-09 | 秋田県 | 癌転移抑制用トリテルペン誘導体及び該トリテルペン誘導体を用いた癌転移抑制用組成物 |
US20090023698A1 (en) * | 2005-03-29 | 2009-01-22 | Krasutsky Pavel A | Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid |
US20070111936A1 (en) | 2005-11-15 | 2007-05-17 | Vladimir Pak | Complex of alpha-fetoprotein and inducers of apoptosis for the treatment of cancer |
CN101374527A (zh) * | 2005-12-16 | 2009-02-25 | 帕纳克斯医药公司 | 3-o-(3’,3’-二甲基琥珀酰基)桦木酸的药物盐的制备方法 |
GB0604535D0 (en) | 2006-03-07 | 2006-04-12 | Sndv Sprl | Betulonic acid derivatives |
US20110152229A1 (en) * | 2006-11-22 | 2011-06-23 | Duke University | Betulinic acid derivatives as anti-hiv agents |
US20090062243A1 (en) * | 2007-08-03 | 2009-03-05 | Advanced Life Sciences, Inc. | Lupane-Type Triterpenoids Modified at 30-Position and Analogues Thereof |
EP2303280A2 (en) * | 2008-05-30 | 2011-04-06 | Novelix Pharmaceuticals, Inc. | Compositions and methods for treatment of inflammation and hyperkeratotic lesions |
US8372808B2 (en) * | 2008-10-31 | 2013-02-12 | Wisconsin Alumni Research Foundation | Suppression of glial fibrillary acidic protein |
US20100144688A1 (en) * | 2008-12-10 | 2010-06-10 | Advanced Life Sciences, Inc. | 23-Substituted Derivatives of Lupane-type Pentacyclic Triterpenoids |
RU2551647C2 (ru) * | 2012-11-12 | 2015-05-27 | Федеральное государственное бюджетное учреждение науки Институт нефтехимии и катализа Российской академии наук | Трифенилфосфониевые соли лупановых тритерпеноидов, способ получения и применение в качестве противоопухолевых веществ |
KR101531821B1 (ko) * | 2013-11-27 | 2015-06-24 | 주식회사 휴메딕스 | 페길레이션된 베튤린 유도체를 포함하는 경구 투여용 항암제 조성물 |
CN107011406A (zh) * | 2016-01-28 | 2017-08-04 | 思路迪(北京)医药科技有限公司 | 一种具有抗肿瘤作用的化合物及其制备方法和应用 |
CN111417384A (zh) | 2017-09-14 | 2020-07-14 | 菲尼克斯生物技术公司 | 用于治疗神经***病况的方法和改进的神经保护性组合物 |
IL285232B (en) | 2017-09-14 | 2022-07-01 | Phoenix Biotechnology Inc | Preparations containing oleandrin for the treatment of viral infection |
EP3796900A4 (en) | 2018-06-29 | 2022-03-30 | DFH Therapeutics | TRITERPENE AMINE DERIVATIVES |
WO2020124043A1 (en) * | 2018-12-13 | 2020-06-18 | Gordon Erlinda M | Methods of exploiting oncogenic drivers along the human cyclin g1 pathway for cancer gene therapy |
KR20220151038A (ko) | 2020-03-31 | 2022-11-11 | 피닉스 바이오테크놀러지 인코포레이티드. | 코로나바이러스 감염 예방를 위한 조성물 |
EP4009981B1 (en) | 2020-03-31 | 2023-08-16 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2683531B1 (fr) | 1991-11-13 | 1993-12-31 | Rhone Poulenc Rorer Sa | Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent. |
FR2705097B1 (fr) | 1993-05-11 | 1995-08-04 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du lupane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US5962527A (en) | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
US5869535A (en) | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
US5658947A (en) | 1995-03-21 | 1997-08-19 | Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma using betalinic acid |
JPH0987156A (ja) * | 1995-09-19 | 1997-03-31 | Pola Chem Ind Inc | 光老化防止剤及び皮膚化粧料 |
US5804575A (en) | 1997-03-27 | 1998-09-08 | The Board Of Trustees Of The University Of Illinois | Methods of manufacturing betulinic acid |
US6048847A (en) * | 1997-09-30 | 2000-04-11 | Dabur Research Foundation | Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this |
US6670345B1 (en) * | 1997-09-30 | 2003-12-30 | Dabur Research Foundation | Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid |
DE69832363D1 (de) | 1998-03-18 | 2005-12-22 | Dabur Pharma Ltd | Betulinsauer Derivate zur Hemmung von Krebswachstum |
WO2000046235A1 (en) | 1998-11-18 | 2000-08-10 | Dabur Research Foundation | Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors |
WO2000059492A2 (en) | 1999-04-07 | 2000-10-12 | Washington State University Research Foundation | Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives |
EP1321145A4 (en) | 2000-07-31 | 2006-03-22 | Nisshin Oillio Ltd | ANTITUMOR SUBSTANCES |
-
2001
- 2001-08-15 EP EP01964047A patent/EP1309605A1/en not_active Ceased
- 2001-08-15 AU AU2001284946A patent/AU2001284946B2/en not_active Ceased
- 2001-08-15 NZ NZ524087A patent/NZ524087A/en unknown
- 2001-08-15 CA CA002418479A patent/CA2418479C/en not_active Expired - Fee Related
- 2001-08-15 WO PCT/US2001/025581 patent/WO2002016395A1/en active IP Right Grant
- 2001-08-15 JP JP2002521491A patent/JP2004517045A/ja active Pending
- 2001-08-15 AU AU8494601A patent/AU8494601A/xx active Pending
- 2001-08-15 US US09/930,656 patent/US6569842B2/en not_active Expired - Fee Related
-
2003
- 2003-01-13 US US10/340,934 patent/US7091195B2/en not_active Expired - Fee Related
- 2003-02-17 NO NO20030748A patent/NO20030748L/no not_active Application Discontinuation
- 2003-02-17 ZA ZA200301269A patent/ZA200301269B/xx unknown
-
2006
- 2006-06-28 US US11/477,177 patent/US20070072835A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2004517045A (ja) | 2004-06-10 |
US7091195B2 (en) | 2006-08-15 |
US20020052352A1 (en) | 2002-05-02 |
AU2001284946B2 (en) | 2007-02-01 |
WO2002016395A1 (en) | 2002-02-28 |
EP1309605A1 (en) | 2003-05-14 |
NO20030748D0 (no) | 2003-02-17 |
ZA200301269B (en) | 2003-11-03 |
US6569842B2 (en) | 2003-05-27 |
US20030186945A1 (en) | 2003-10-02 |
AU8494601A (en) | 2002-03-04 |
US20070072835A1 (en) | 2007-03-29 |
NZ524087A (en) | 2004-08-27 |
CA2418479A1 (en) | 2002-02-28 |
CA2418479C (en) | 2007-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |